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Nature Immunology, ISSN 1529-2908, 09/2018, Volume 19, Issue 9, p. 986
Gain-of-function mutations in the gene encoding the phosphatidylinositol-3-OH kinase catalytic subunit p110[delta] (PI3K[delta]) result in a human primary... 
Models | Rats as laboratory animals | Research | Gene mutations | Immunity
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 03/2009, Volume 206, Issue 3, pp. 561 - 576
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 32, Issue 2, pp. 253 - 265
CD4 T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to... 
MOLIMMUNO | RESTING NK CELLS | B-CELLS | SAP | FOLLICULAR-HELPER-CELLS | AUTOIMMUNITY | HUMORAL IMMUNITY | MOLECULAR DISSECTION | IMMUNOLOGY | RECEPTORS | CUTTING EDGE | FAMILY | Antigens, CD - immunology | Cell Proliferation | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Cell Differentiation - genetics | Lymphocyte Activation - genetics | Signaling Lymphocytic Activation Molecule Family Member 1 | T-Lymphocytes - metabolism | Antigens, Ly - metabolism | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Intracellular Signaling Peptides and Proteins - genetics | B-Lymphocytes - metabolism | Cell Adhesion - genetics | Interferon-gamma - secretion | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Germinal Center - pathology | Signaling Lymphocytic Activation Molecule Family | Receptors, Cell Surface - immunology | Mice, Knockout | Cell Adhesion - immunology | Cell Differentiation - immunology | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Antigens, Ly - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | T-Lymphocytes - immunology | Mice | Interleukins - secretion | Receptors, Cell Surface - genetics | Dendritic cells | T cells | Integrins | Proteins | Antigens | Flow cytometry | Rodents | Ligands | Software | Immune system | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2014, Volume 15, Issue 1, pp. 88 - 97
Journal Article
Immunity, ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 986 - 1002
Humans and mice deficient in the adaptor protein SAP ( ) have a major defect in humoral immunity, resulting from a lack of T cell help for B cells. The role of... 
SLAM FAMILY RECEPTORS | NATURAL-KILLER-CELLS | HUMORAL IMMUNITY | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | MOLECULE-ASSOCIATED PROTEIN | LINKED LYMPHOPROLIFERATIVE-DISEASE | PROTEIN-TYROSINE-PHOSPHATASE | GERMINAL-CENTER | GENE-PRODUCT | CUTTING EDGE | Phosphorylation | Germinal Center - immunology | Antigens, Ly - genetics | Inositol Polyphosphate 5-Phosphatases | CD4-Positive T-Lymphocytes - immunology | Intracellular Signaling Peptides and Proteins - deficiency | Lymphopoiesis - physiology | Phosphotyrosine - physiology | Antigens, Ly - physiology | Immunologic Deficiency Syndromes - immunology | Intracellular Signaling Peptides and Proteins - genetics | Mice, Inbred C57BL | Natural Killer T-Cells - cytology | Mice, Transgenic | Phosphoric Monoester Hydrolases - physiology | Amino Acid Motifs | Mice, Knockout | Animals | B-Lymphocytes - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | Immunological Synapses - immunology | Immunologic Deficiency Syndromes - genetics | Mice | Protein Processing, Post-Translational | Intracellular Signaling Peptides and Proteins - physiology | Lymphocyte Cooperation - physiology | Computer software industry | T cells | Genetic disorders | Proteins | Confidence intervals | Biomedical research | Lymphocytes | Rodents | Viral infections | Immune system | Cell adhesion & migration | Index Medicus | Germinal centers | Lymphocytes B | SHP-1 protein | Cell adhesion | Immunity (humoral) | Immunological synapses | Lymphocytes T | Natural killer cells | Differentiation | adaptor proteins | SAP protein | CD4 antigen
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2011, Volume 365, Issue 7, pp. 611 - 619
Journal Article
Immunity, ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 1003 - 1016
X-linked lymphoproliferative syndrome, characterized by fatal responses to Epstein-Barr virus infection, is caused by mutations affecting the adaptor SAP,... 
NATURAL-KILLER-CELLS | CYTOKINE PRODUCTION | SECRETORY DOMAIN | INFECTED CELLS | IMMUNE SYNAPSE | ENCODING GENE | T-CELL | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | LINKED LYMPHOPROLIFERATIVE-DISEASE | PROTEIN-TYROSINE-PHOSPHATASE | Antigens, CD - immunology | Phosphorylation | Inositol Polyphosphate 5-Phosphatases | B-Lymphocytes | Intracellular Signaling Peptides and Proteins - immunology | Centrosome - ultrastructure | Intracellular Signaling Peptides and Proteins - deficiency | Fibrosarcoma - pathology | Actins - analysis | src-Family Kinases - metabolism | Receptors, Immunologic - immunology | Intracellular Signaling Peptides and Proteins - genetics | Phosphoric Monoester Hydrolases - antagonists & inhibitors | T-Lymphocytes, Cytotoxic - immunology | T-Lymphocytes | Cytoskeleton - ultrastructure | Phosphoric Monoester Hydrolases - physiology | Signaling Lymphocytic Activation Molecule Family | Cell Adhesion | Animals | Antigens, Ly - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | Immunological Synapses - immunology | Lymphoma, T-Cell - pathology | Cell Line, Tumor | Mice | Protein Processing, Post-Translational | Cytotoxicity, Immunologic | Virus diseases | Genetic disorders | Phosphatases | Sarcoma | Lymphocytes | Muscle proteins | T cells | Health aspects | Phosphotransferases | Signal transduction | Biomedical research | Peptides | Microscopy | Glycerol | Cytotoxicity | Software | Kinases | Immune system | Defects | Index Medicus | Cytolysis | SHP-1 protein | CD8 antigen | X chromosome | Fibrosarcoma | Immunological synapses | Lymphocytes T | CD150 antigen | Src protein | adaptor proteins | SAP protein | Infection | Lymphocytes B | Actin | Mutation
Journal Article
Journal Article