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Journal Article
Pulmonary Pharmacology and Therapeutics, ISSN 1094-5539, 2014, Volume 28, Issue 2, pp. 114 - 121
This study characterised the invitro and invivo profiles of two novel long-acting muscarinic antagonists, aclidinium bromide and glycopyrronium bromide, using... 
SAMA | Raw | LAMA | Muscarinic receptors | Glycopyrronium bromide (PubChem CID: 11693) | Long-acting muscarinic antagonists | Aclidinium bromide (PubChem CID: 11519741) | Preclinical | Tiotropium bromide (PubChem CID: 5487426) | Aclidinium | Glycopyrronium | Ipratropium bromide (PubChem CID: 31098) | COPD
Journal Article
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 2014, Volume 28, Issue 2, pp. 114 - 121
Journal Article
Experimental Dermatology, ISSN 0906-6705, 11/2017, Volume 26, Issue 11, pp. 1105 - 1111
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of... 
screening | animal model | drugs | scratching | locomotion | DRUG | DESLORATADINE | DERMATOLOGY | SCRATCHING BEHAVIOR | ASIMADOLINE | ITCH | THERAPY | NEURONS | MICE | TOFACITINIB | BRAIN | Chloroquine - metabolism | Skin - metabolism | Motor Activity - drug effects | Male | Antipruritics - pharmacology | Dose-Response Relationship, Drug | Pruritus - physiopathology | Cyproheptadine - pharmacology | Neurokinin-1 Receptor Antagonists - pharmacology | Injections, Subcutaneous | Signal Processing, Computer-Assisted | Behavior, Animal - drug effects | Pruritus - psychology | Morphinans - pharmacology | Pruritus - chemically induced | Disease Models, Animal | Aprepitant | Drug Administration Routes | Vibration | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Animals | Antidepressive Agents, Tricyclic - pharmacology | Narcotic Antagonists - pharmacology | Video Recording | Chloroquine - administration & dosage | Mice | Amitriptyline - pharmacology | Pattern Recognition, Automated - methods | Spiro Compounds - pharmacology | Usage | Analysis | Pruritus | Automation | Animal models | Amitriptyline | Antiinflammatory agents | Toxicity | Chloroquine | Inflammation | Drug development | Cyproheptadine | Skin | Drug dosages | Locomotor activity | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 6, pp. 2472 - 2489
Rational design of a novel template of naphthyridinones rapidly led to PDE4 inhibitors with subnanomolar enzymatic potencies. X-ray crystallography confirmed... 
OBSTRUCTIVE PULMONARY-DISEASE | ANTIINFLAMMATORY ACTIVITY | DESIGN | POTENT | CHEMISTRY, MEDICINAL | BINDING-KINETICS | DRUG DISCOVERY | OPTIMIZATION | DERIVATIVES | TARGET RESIDENCE TIME | ONCE-DAILY TREATMENT
Journal Article
Journal Article
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 10/2017, Volume 46, pp. 1 - 10
LAS190792 is a novel muscarinic antagonist and β2-adrenoceptor agonist in development for chronic respiratory diseases. This study investigated the... 
Long-acting β2-adrenoceptor agonist | Long-acting muscarinic antagonist | Bronchodilator | COPD | Long-acting β | adrenoceptor agonist
Journal Article
The Journal of pharmacology and experimental therapeutics, 07/2019, Volume 370, Issue 1, p. 127
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 03/2011, Volume 21, Issue 5, pp. 1545 - 1548
The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β /β -adrenergic activities and the corresponding... 
Adrenoreceptor agonist | Bronchodilator | LABA | Asthma | COPD | Duration of action | Phenol - chemical synthesis | Phenol - chemistry | Molecular Structure | Phenol - pharmacology | Adrenergic beta-2 Receptor Agonists | Urea - chemical synthesis | Drug Discovery | Quantitative Structure-Activity Relationship | Urea - chemistry | Urea - pharmacology
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 03/2011, Volume 21, Issue 5, pp. 1545 - 1548
The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their beta sub(1/ beta ) sub(2)-adrenergic activities and the... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 5, pp. 1545 - 1548
The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β 1/β 2-adrenergic activities and the corresponding... 
Bronchodilator | LABA | Adrenoreceptor agonist | β 2 | Asthma | COPD | Duration of action
Journal Article
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