Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 8, pp. 856 - 860
Over a quarter of drugs that enter clinical development fail because they are ineffective. Growing insight into genes that influence human disease may affect...
RATES | PHASE-II | VARIANTS | DATABASE | GENETICS & HEREDITY | Drug Approval - statistics & numerical data | Genetic Predisposition to Disease - genetics | Genetics, Medical - methods | Humans | Chromosome Mapping | Genome-Wide Association Study - statistics & numerical data | Databases, Genetic - statistics & numerical data | Genetics, Medical - statistics & numerical data | Linkage Disequilibrium | Medical Subject Headings - utilization | Genetic Association Studies - statistics & numerical data | Molecular Targeted Therapy - statistics & numerical data | Polymorphism, Single Nucleotide | Molecular targeted therapy | Pharmacology, Experimental | Drug interactions | Innovations | Drug metabolism | Genetic research | Genetic aspects | Research | Drugs | Genetics | Pharmacology | Genes
RATES | PHASE-II | VARIANTS | DATABASE | GENETICS & HEREDITY | Drug Approval - statistics & numerical data | Genetic Predisposition to Disease - genetics | Genetics, Medical - methods | Humans | Chromosome Mapping | Genome-Wide Association Study - statistics & numerical data | Databases, Genetic - statistics & numerical data | Genetics, Medical - statistics & numerical data | Linkage Disequilibrium | Medical Subject Headings - utilization | Genetic Association Studies - statistics & numerical data | Molecular Targeted Therapy - statistics & numerical data | Polymorphism, Single Nucleotide | Molecular targeted therapy | Pharmacology, Experimental | Drug interactions | Innovations | Drug metabolism | Genetic research | Genetic aspects | Research | Drugs | Genetics | Pharmacology | Genes
Journal Article
2004, ISBN 9789057821738, 3 v.
Book
Tetrahedron, ISSN 0040-4020, 02/2019, Volume 75, Issue 8, pp. 945 - 948
Attempts to perform the OsO -catalyzed enantioselective base-free aminohydroxylation of β,β-disubstituted enoates are described. Low yields and racemic...
Density functional theory | Osmium tetroxide | Enantioselective reaction | β-Hydroxy amino acids | Aminohydroxylation | beta-Hydroxy amino acids | ACID | CHEMISTRY, ORGANIC | USTILOXIN | DENSITY FUNCTIONALS | PEPTIDES | CATALYTIC ASYMMETRIC DIHYDROXYLATION | FALSE SMUT BALLS | OLEFINS | OXYAMINATION
Density functional theory | Osmium tetroxide | Enantioselective reaction | β-Hydroxy amino acids | Aminohydroxylation | beta-Hydroxy amino acids | ACID | CHEMISTRY, ORGANIC | USTILOXIN | DENSITY FUNCTIONALS | PEPTIDES | CATALYTIC ASYMMETRIC DIHYDROXYLATION | FALSE SMUT BALLS | OLEFINS | OXYAMINATION
Journal Article
Nature, ISSN 0028-0836, 06/2007, Volume 447, Issue 7145, pp. 661 - 678
There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human...
INFLAMMATORY-BOWEL-DISEASE | MULTILOCUS GENOTYPE DATA | TYPE-1 DIABETES LOCUS | MULTIDISCIPLINARY SCIENCES | RHEUMATOID-ARTHRITIS FAMILIES | MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE | AFFECTED SIBLING PAIRS | BIPOLAR DISORDER | LYMPHOID TYROSINE PHOSPHATASE | SINGLE-NUCLEOTIDE POLYMORPHISMS | CORONARY-ARTERY-DISEASE | Geography | Crohn Disease - genetics | Genetics, Population | Genetic Predisposition to Disease - genetics | Diabetes Mellitus - genetics | Chromosomes, Human - genetics | Gene Frequency | Humans | United Kingdom | Bipolar Disorder - genetics | Case-Control Studies | Genome, Human - genetics | Arthritis, Rheumatoid - genetics | Genetic Markers - genetics | Coronary Artery Disease - genetics | Hypertension - genetics | Data analysis | Disease | Genomics | Data collection | Gene loci | Epidemiology | Risk factors
INFLAMMATORY-BOWEL-DISEASE | MULTILOCUS GENOTYPE DATA | TYPE-1 DIABETES LOCUS | MULTIDISCIPLINARY SCIENCES | RHEUMATOID-ARTHRITIS FAMILIES | MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE | AFFECTED SIBLING PAIRS | BIPOLAR DISORDER | LYMPHOID TYROSINE PHOSPHATASE | SINGLE-NUCLEOTIDE POLYMORPHISMS | CORONARY-ARTERY-DISEASE | Geography | Crohn Disease - genetics | Genetics, Population | Genetic Predisposition to Disease - genetics | Diabetes Mellitus - genetics | Chromosomes, Human - genetics | Gene Frequency | Humans | United Kingdom | Bipolar Disorder - genetics | Case-Control Studies | Genome, Human - genetics | Arthritis, Rheumatoid - genetics | Genetic Markers - genetics | Coronary Artery Disease - genetics | Hypertension - genetics | Data analysis | Disease | Genomics | Data collection | Gene loci | Epidemiology | Risk factors
Journal Article
Nature Genetics, ISSN 1061-4036, 05/2009, Volume 41, Issue 5, pp. 527 - 534
To identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples from...
CELLS | OBESITY | VARIANTS | MASS | GENETICS & HEREDITY | LOCI | HEIGHT | PROTEINS | PLASMA-MEMBRANE | EXPRESSION | ARRAYS | Body Mass Index | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Genotype | Bone Density - genetics | Genome, Human - genetics | Adult | Aged | Polymorphism, Single Nucleotide | Waist-Hip Ratio | Cohort Studies | Quantitative Trait Loci - genetics | Quantitative trait loci | Demographic aspects | Physiological aspects | Bones | Genetic aspects | Research | Identification and classification | Density | Genetics | Principal components analysis | Bone density | Genomics
CELLS | OBESITY | VARIANTS | MASS | GENETICS & HEREDITY | LOCI | HEIGHT | PROTEINS | PLASMA-MEMBRANE | EXPRESSION | ARRAYS | Body Mass Index | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Genotype | Bone Density - genetics | Genome, Human - genetics | Adult | Aged | Polymorphism, Single Nucleotide | Waist-Hip Ratio | Cohort Studies | Quantitative Trait Loci - genetics | Quantitative trait loci | Demographic aspects | Physiological aspects | Bones | Genetic aspects | Research | Identification and classification | Density | Genetics | Principal components analysis | Bone density | Genomics
Journal Article
International Journal of Public Health, ISSN 1661-8556, 11/2019
Journal Article
Nature Genetics, ISSN 1061-4036, 2008, Volume 40, Issue 8, pp. 955 - 962
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data...
GENETIC-VARIATION | CELLS | VARIANTS | COLITIS | GENETICS & HEREDITY | RISK | LARGE-SCALE | NONSYNONYMOUS SNPS | IL-23 | EXPRESSION | MULTIPLE | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome, Human | Quantitative Trait Loci | Humans | Physiological aspects | Crohn's disease | Genetic aspects | Research | Genetic susceptibility | Risk factors | Inflammatory bowel disease | Studies | Medical research | Genetics | Genomics | Crohns disease
GENETIC-VARIATION | CELLS | VARIANTS | COLITIS | GENETICS & HEREDITY | RISK | LARGE-SCALE | NONSYNONYMOUS SNPS | IL-23 | EXPRESSION | MULTIPLE | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome, Human | Quantitative Trait Loci | Humans | Physiological aspects | Crohn's disease | Genetic aspects | Research | Genetic susceptibility | Risk factors | Inflammatory bowel disease | Studies | Medical research | Genetics | Genomics | Crohns disease
Journal Article
International Journal of Behavioral Nutrition and Physical Activity, ISSN 1479-5868, 2015, Volume 12, Issue 1, p. 127
Background: Older adults are the most sedentary segment of society and high sedentary time is associated with poor health and wellbeing outcomes in this...
System-based approach | Obesity | Physical activity | Sedentary behaviour | Ageing | Life-course | Sitting | Determinants | Environment | Older adults | PHYSICAL-ACTIVITY PATTERNS | PHYSIOLOGY | ASSOCIATIONS | RETIREMENT | SITTING TIME | LEISURE-TIME | WOMEN | NUTRITION & DIETETICS | CARDIOVASCULAR-DISEASE | TELEVISION VIEWING TIME | HEALTH | AGE | Exercise | Recreation | Humans | Aged | Sedentary Lifestyle | Health Status | Health Behavior | Retirement | Medicine, Experimental | Medical research | Physical fitness | Television viewers | Analysis | Health behavior | Life Sciences
System-based approach | Obesity | Physical activity | Sedentary behaviour | Ageing | Life-course | Sitting | Determinants | Environment | Older adults | PHYSICAL-ACTIVITY PATTERNS | PHYSIOLOGY | ASSOCIATIONS | RETIREMENT | SITTING TIME | LEISURE-TIME | WOMEN | NUTRITION & DIETETICS | CARDIOVASCULAR-DISEASE | TELEVISION VIEWING TIME | HEALTH | AGE | Exercise | Recreation | Humans | Aged | Sedentary Lifestyle | Health Status | Health Behavior | Retirement | Medicine, Experimental | Medical research | Physical fitness | Television viewers | Analysis | Health behavior | Life Sciences
Journal Article