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Nature Medicine, ISSN 1078-8956, 12/2016, Volume 22, Issue 12, pp. 1428 - 1438
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria | Kardiologi | Biological Sciences | Clinical Medicine | Cardiac and Cardiovascular Systems | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2011, Volume 30, Issue 14, pp. 2779 - 2792
Mitochondrial outer membrane permeabilization is a watershed event in the process of apoptosis, which is tightly regulated by a series of pro‐ and... 
MOMP | ageing | BH3 domain | yeast | mitochondrial apoptosis | Ageing | OXIDATIVE-STRESS | BUDDING YEAST | ADENINE-NUCLEOTIDE TRANSLOCATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY PROTEINS | SACCHAROMYCES-CEREVISIAE | CELL-DEATH | PERMEABILITY TRANSITION | CELL BIOLOGY | BAX-EXPRESSION | CYCLOPHILIN-D | CYTOCHROME-C RELEASE | RNA, Small Interfering - genetics | Immunoprecipitation | Saccharomyces cerevisiae - genetics | Humans | Lung Neoplasms - metabolism | Phosphate Transport Proteins - metabolism | bcl-X Protein - genetics | Molecular Sequence Data | Peptide Fragments - pharmacology | Mitochondrial Proteins - genetics | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Flow Cytometry | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Membrane Potential, Mitochondrial | Apoptosis Regulatory Proteins - genetics | Bone Neoplasms - genetics | Tumor Cells, Cultured | Phosphate Transport Proteins - genetics | bcl-2-Associated X Protein - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - pharmacology | Amino Acid Sequence | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Messenger - genetics | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Sequence Homology, Amino Acid | Animals | Cell Cycle | Apoptosis Regulatory Proteins - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - metabolism | Mice | bcl-X Protein - metabolism | Apoptosis | Proteins | Mitochondria | Yeast
Journal Article
by Galluzzi, Lorenzo and Vitale, Ilio and Aaronson, Stuart A and Abrams, John M and Adam, Dieter and Agostinis, Patrizia and Alnemri, Emad S and Altucci, Lucia and Amelio, Ivano and Andrews, David W and Annicchiarico-Petruzzelli, Margherita and Antonov, Alexey V and Arama, Eli and Baehrecke, Eric H and Barlev, Nickolai A and Bazan, Nicolas G and Bernassola, Francesca and Bertrand, Mathieu J. M and Bianchi, Katiuscia and Blagosklonny, Mikhail V and Blomgren, Klas and Borner, Christoph and Boya, Patricia and Brenner, Catherine and Campanella, Michelangelo and Candi, Eleonora and Carmona-Gutierrez, Didac and Cecconi, Francesco and Chan, Francis K.-M and Chandel, Navdeep S and Cheng, Emily H and Chipuk, Jerry E and Cidlowski, John A and Ciechanover, Aaron and Cohen, Gerald M and Conrad, Marcus and Cubillos-Ruiz, Juan R and Czabotar, Peter E and D'Angiolella, Vincenzo and Dawson, Ted M and Dawson, Valina L and De Laurenzi, Vincenzo and De Maria, Ruggero and Debatin, Klaus-Michael and Deberardinis, Ralph J and Deshmukh, Mohanish and Di Daniele, Nicola and Di Virgilio, Francesco and Dixit, Vishva M and Dixon, Scott J and Duckett, Colin S and Dynlacht, Brian D and El-Deiry, Wafik S and Elrod, John W and Fimia, Gian Maria and Fulda, Simone and García-Sáez, Ana J and Garg, Abhishek D and Garrido, Carmen and Gavathiotis, Evripidis and Golstein, Pierre and Gottlieb, Eyal and Green, Douglas R and Greene, Lloyd A and Gronemeyer, Hinrich and Gross, Atan and Hajnoczky, Gyorgy and Hardwick, J. Marie and Harris, Isaac S and Hengartner, Michael O and Hetz, Claudio and Ichijo, Hidenori and Jäättelä, Marja and Joseph, Bertrand and Jost, Philipp J and Juin, Philippe P and Kaiser, William J and Karin, Michael and Kaufmann, Thomas and Kepp, Oliver and Kimchi, Adi and Kitsis, Richard N and Klionsky, Daniel J and Knight, Richard A and Kumar, Sharad and Lee, Sam W and Lemasters, John J and Levine, Beth and Linkermann, Andreas and Lipton, Stuart A and Lockshin, Richard A and López-Otín, Carlos and Lowe, Scott W and Luedde, Tom and Lugli, Enrico and MacFarlane, Marion and Madeo, Frank and Malewicz, Michal and Malorni, Walter and Manic, Gwenola and ...
Cell Death and Differentiation, ISSN 1350-9047, 03/2018, Volume 25, Issue 3, pp. 486 - 541
Journal Article