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1. Full Text A‐kinase anchoring proteins: From protein complexes to physiology and disease
by Carnegie, Graeme K and Means, Christopher K and Scott, John D
IUBMB life, ISSN 1521-6543, 04/2009, Volume 61, Issue 4, pp. 394 - 406
protein function | signaling | genetic models | signal transduction | Signal transduction | Signaling | Genetic models | Protein function | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cyclic AMP-Dependent Protein Kinases - metabolism | Oocytes - metabolism | Male | Signal Transduction - genetics | Spermatozoa - metabolism | A Kinase Anchor Proteins - genetics | Multiprotein Complexes - metabolism | Animals | Myocardium - metabolism | Female | Signal Transduction - physiology | Models, Genetic | Cyclic AMP - metabolism | Melanosomes - metabolism | A Kinase Anchor Proteins - metabolism | Index Medicus
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2. Full Text Molecular evolution of a-kinase anchoring protein (AKAP)-7: Implications in comparative PKA compartmentalization
by Johnson, Keven R and Nicodemus-Johnson, Jessie and Carnegie, Graeme K and Danziger, Robert S
BMC evolutionary biology, ISSN 1471-2148, 2012, Volume 12, Issue 1, pp. 125 - 125
Protein evolution | PKA compartmentalization | A-Kinase anchoring protein | AKAP15/18 | PKA regulatory subunit | Genetics & Heredity | Life Sciences & Biomedicine | Evolutionary Biology | Science & Technology | Cyclic AMP-Dependent Protein Kinases - metabolism | Amino Acid Sequence | Membrane Proteins - genetics | Humans | Molecular Sequence Data | Rats | A Kinase Anchor Proteins - chemistry | Phylogeny | A Kinase Anchor Proteins - genetics | RNA Splicing | Sequence Alignment | Animals | Base Sequence | Mice | Protein Interaction Domains and Motifs | Evolution, Molecular | Proteins | Molecular evolution | Phosphatases | Evolutionary biology | Genetic research | Cyclic adenylic acid | Nucleotide sequencing | Comparative analysis | Protein kinases | DNA sequencing | Enzymes | Phosphorylation | Colleges & universities | Kinases | Binding sites | Manuscripts | Molecular weight | Index Medicus
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3. Full Text A-Kinase Anchoring Proteins That Regulate Cardiac Remodeling
by Carnegie, Graeme K and Burmeister, Brian T
Journal of cardiovascular pharmacology, ISSN 0160-2446, 11/2011, Volume 58, Issue 5, pp. 451 - 458
heart failure | pathological hypertrophy | A-kinase anchoring protein (AKAP) | signal transduction | cardiac remodeling | cAMP protein kinase | sarcomeric regulation | protein phosphorylation | excitation-contraction coupling | protein phosphatase | Cardiac & Cardiovascular Systems | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Excitation Contraction Coupling - physiology | A Kinase Anchor Proteins - physiology | Animals | Sarcomeres - metabolism | Humans | Ventricular Remodeling - physiology | Cardiomegaly - metabolism | Index Medicus | cAMP | protein kinase
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4. Full Text AKAP-Lbc Mobilizes a Cardiac Hypertrophy Signaling Pathway
by Carnegie, Graeme K and Soughayer, Joseph and Smith, F. Donelson and Pedroja, Benjamin S and Zhang, Fang and Diviani, Dario and Bristow, Michael R and Kunkel, Maya T and Newton, Alexandra C and Langeberg, Lorene K and Scott, John D
Molecular cell, ISSN 1097-2765, 10/2008, Volume 32, Issue 2, pp. 169 - 179
HUMDISEASE | SIGNALING | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Guanine Nucleotide Exchange Factors - physiology | Phosphorylation | Minor Histocompatibility Antigens | Humans | Cercopithecus aethiops | A Kinase Anchor Proteins - genetics | A Kinase Anchor Proteins - physiology | Phenylephrine - pharmacology | RNA Interference | Guanine Nucleotide Exchange Factors - metabolism | Protein Kinase C - metabolism | Active Transport, Cell Nucleus | A Kinase Anchor Proteins - metabolism | MEF2 Transcription Factors | Cyclic AMP-Dependent Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Gene Expression Regulation | Myogenic Regulatory Factors - metabolism | Rats | Histone Deacetylases - metabolism | Proto-Oncogene Proteins - genetics | 14-3-3 Proteins - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Models, Biological | Proto-Oncogene Proteins - physiology | Myocytes, Cardiac - metabolism | COS Cells | Cardiomegaly - metabolism | Heart Ventricles - drug effects | Proteins | Catecholamines | RNA | Cardiology | Heart enlargement | Protein kinases | Index Medicus
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5. Full Text Dynamic Regulation of cAMP Synthesis through Anchored PKA-Adenylyl Cyclase V/VI Complexes
by Bauman, Andrea L and Soughayer, Joseph and Nguyen, Bao T and Willoughby, Debbie and Carnegie, Graeme K and Wong, Wei and Hoshi, Naoto and Langeberg, Lorene K and Cooper, Dermot M.F and Dessauer, Carmen W and Scott, John D
Molecular cell, ISSN 1097-2765, 09/2006, Volume 23, Issue 6, pp. 925 - 931
SIGNALING | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cyclic AMP-Dependent Protein Kinases - metabolism | Phosphorylation | Humans | Cells, Cultured | Adenylyl Cyclases - metabolism | Adaptor Proteins, Signal Transducing - physiology | Cyclic AMP-Dependent Protein Kinases - physiology | Feedback, Physiological | Cyclic AMP - biosynthesis | Isoenzymes - metabolism | Models, Biological | A Kinase Anchor Proteins | Signal Transduction - physiology | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Enzymes | Index Medicus
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6. Full Text Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart
by Burmeister, Brian T and Taglieri, Domenico M and Wang, Li and Carnegie, Graeme K
The Journal of biological chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 48, pp. 40535 - 40546
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cyclic AMP-Dependent Protein Kinases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Proto-Oncogene Proteins - metabolism | Minor Histocompatibility Antigens | Humans | Cardiomegaly - pathology | Male | Proto-Oncogene Proteins - genetics | Cardiomegaly - enzymology | A Kinase Anchor Proteins - genetics | Animals | Cyclic AMP-Dependent Protein Kinases - genetics | Protein Binding | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Cardiomegaly - genetics | A Kinase Anchor Proteins - metabolism | Index Medicus | Protein Phosphatase | Protein Kinase A (PKA) | Signal Transduction | AKAP | Scaffold Proteins | Protein Phosphorylation | Cardiac Hypertrophy
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7. Full Text Flow cytometric analysis of bimolecular fluorescence complementation: A high throughput Quantitative method to study protein-protein interaction
by Wang, Li and Carnegie, Graeme K
Journal of visualized experiments : JoVE, ISSN 1940-087X, 2013, Issue 78
BRET | Flow cytometry | Förster resonance energy transfer | Protein-protein interaction | Fluorescence | Quantative analysis | Biochemistry | Pharmacology | Bioluminescence resonance energy transfer | Protein | Proteins | Transfection | Cellular biology | Microscopy | Issue 78 | Genetics | FRET | BIFC | Molecular biology | Bimolecular fluorescence complementation | Cell | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Flow Cytometry - methods | Proteins - metabolism | Humans | HEK293 Cells | Cytological Techniques - methods | Proteins - chemistry | Binding Sites | Optical Imaging - methods | High-Throughput Screening Assays - methods | Protein Interaction Maps | Index Medicus | Molecular Biology | quantative analysis | transfection | Cellular Biology | cell | Bimolecular Fluorescence Complementation | Bioluminescence Resonance Energy Transfer | Flow Cytometry | fluorescence | protein | protein-protein interaction | microscopy | BiFC
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8. Full Text UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy
by Wang, Li and Burmeister, Brian T and Johnson, Keven R and Baillie, George S and Karginov, Andrei V and Skidgel, Randal A and O'Bryan, John P and Carnegie, Graeme K
Cellular signalling, ISSN 0898-6568, 05/2015, Volume 27, Issue 5, pp. 908 - 922
protein kinase A (PKA) | Compartmentalized signaling | A-kinase anchoring protein (AKAP) | cardiomyocyte hypertrophy | 3′,5′-cyclic monophosphate (cAMP) | Phosphodiesterase 4 (PDE4) activation | 3',5'-cyclic monophosphate (cAMP) | Cardiomyocyte hypertrophy | Protein kinase A (PKA) | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Molecular Sequence Data | Cardiomegaly - pathology | Protein Isoforms - metabolism | Protein Isoforms - chemistry | HEK293 Cells | Phosphorylation - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | A Kinase Anchor Proteins - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Amino Acid Sequence | Peptides - chemistry | Cardiomegaly - drug therapy | Cells, Cultured | Rats | Enzyme Activation - drug effects | Peptides - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Cardiomegaly - metabolism | Protein binding | Hypertrophy | Index Medicus | Heart | Proteins | Receptors | Upstream | Stimulation | Kinases | Failure | Anchoring | compartmentalized signaling | 3′, 5′-cyclic monophosphate (cAMP) | A-Kinase Anchoring Protein (AKAP)-Lbc
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9. Full Text AKAP-Lbc Nucleates a Protein Kinase D Activation Scaffold
by Carnegie, Graeme K and Smith, F.Donelson and McConnachie, George and Langeberg, Lorene K and Scott, John D
Molecular cell, ISSN 1097-2765, 2004, Volume 15, Issue 6, pp. 889 - 899
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cyclic AMP-Dependent Protein Kinases - metabolism | Immunohistochemistry | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins | Peptide Fragments - metabolism | Phosphorylation | Isoenzymes - genetics | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Molecular Sequence Data | Serine - chemistry | Precipitin Tests | Peptide Fragments - chemistry | Isoenzymes - metabolism | Models, Biological | Protein Kinase C - metabolism | Protein Binding | Protein Kinase C - isolation & purification | Enzyme Activation | HeLa Cells | Binding Sites | Luminescent Proteins - metabolism | Index Medicus
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