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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2006, Volume 34, Issue 1, pp. 75 - 83
Most human hepatocyte cell lines lack a substantial set of liver-specific functions, especially major cytochrome P450 (P450)-related enzyme activities, making... 
MAINTENANCE | RAT HEPATOCYTES | ADULT HUMAN HEPATOCYTES | LIVER | LINE | CULTURED HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | AFLATOXIN B-1 | DIMETHYL-SULFOXIDE | INDUCTION | DRUG-METABOLIZING-ENZYMES | Aflatoxin B1 - pharmacology | Cell Survival - drug effects | Gene Expression - drug effects | Isoenzymes - genetics | Humans | RNA, Messenger - genetics | RNA, Messenger - analysis | Chlorpromazine - pharmacology | Dimethyl Sulfoxide - pharmacology | Gene Expression Profiling | Receptors, Cytoplasmic and Nuclear - genetics | Hepatocytes - metabolism | Xenobiotics - pharmacology | Glucuronosyltransferase - genetics | Hepatocytes - cytology | Acetaminophen - pharmacology | Carcinoma, Hepatocellular - genetics | Reverse Transcriptase Polymerase Chain Reaction - methods | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Inhibitory Concentration 50 | Hepatocytes - drug effects | Amiodarone - pharmacology | Gene Expression | Isoenzymes | Cell Survival | Amiodarone | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Cytoplasmic and Nuclear | Chlorpromazine | Cytochrome P-450 Enzyme System | Life Sciences | Microbiology and Parasitology | Hepatocytes | Acetaminophen | Aflatoxin B1 | Dimethyl Sulfoxide | Carcinoma, Hepatocellular | Xenobiotics | RNA, Messenger | Glucuronosyltransferase
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2007, Volume 168, Issue 1, pp. 66 - 73
Although they have several important limitations primary human hepatocytes still represent the gold standard model for xenobiotic metabolism and toxicity... 
Human hepatoma cells | Liver-specific functions | HepaRG cells | Constitutive androstane receptor | Hepatotoxicity | Cytochromes P450 | CAPACITY | RAT HEPATOCYTES | TRANSPORTERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | human hepatoma cells | CULTURE | PRIMARY HUMAN HEPATOCYTES | cytochromes P450 | constitutive androstane receptor | hepatotoxicity | ENZYMES | LINE | SYSTEMS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RECEPTORS | liver-specific functions | EXPRESSION | Aflatoxin B1 - poisoning | Receptors, Steroid - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | RNA, Messenger - analysis | Hepatocytes - metabolism | Xenobiotics - toxicity | Hepatocytes - cytology | Carcinoma, Hepatocellular - genetics | Inhibitory Concentration 50 | Female | Liver Neoplasms - pathology | Cell Differentiation | Liver Neoplasms - enzymology | Hepatocytes - drug effects | Biomarkers - metabolism | Metabolic Detoxication, Phase II | Liver Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Carcinoma, Hepatocellular - enzymology | Transcription Factors - genetics | Transcription Factors - metabolism | Receptors, Steroid - genetics | Models, Biological | Metabolic Detoxication, Phase I | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Carcinoma, Hepatocellular - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Albumin | Cell research | Hepatoma | Liver | Adenosine triphosphatase
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167543 - e0167543
Glutathione S-transferases (GSTs) detoxify toxic molecules by conjugation with reduced glutathione and regulate cell signaling. Single nucleotide polymorphisms... 
CELLS | POLYMORPHISMS | BREAST-CANCER RISK | PROGNOSIS | GENOTYPE | MULTIDISCIPLINARY SCIENCES | COLLAGEN-XVIII | ENDOSTATIN PRECURSOR | EXPRESSION | PROGRESSION | SOFTWARE | Humans | Gene Expression Regulation, Neoplastic | Hepatocytes - metabolism | Glutathione Transferase - genetics | Carcinoma, Hepatocellular - genetics | Polymerase Chain Reaction | Gene Ontology | Carcinoma, Hepatocellular - ethnology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Liver Neoplasms - genetics | Europe | Gene Frequency | Liver - metabolism | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Gene Expression Profiling - methods | Genotype | Reverse Transcriptase Polymerase Chain Reaction | Linkage Disequilibrium | Liver Neoplasms - ethnology | Gene Expression Profiling - statistics & numerical data | Polymorphism, Restriction Fragment Length | Genetic Predisposition to Disease - ethnology | Polymorphism, Single Nucleotide | Health sciences | Liver | Genes | Risk | Hepatocellular carcinoma | Single-nucleotide polymorphism | Kinases | Blood | Liver cancer | Medical laboratories | Hepatology | DNA methylation | Bioinformatics | Deoxyribonucleic acid--DNA | Genotypes | Glutathione | Enzymes | Procollagen | Metabolism | Gene expression | Patients | Studies | Signaling | Restriction fragment length polymorphism | DNA microarrays | Hepatocytes | Conjugation | Polymorphism | Index Medicus | Life Sciences | Human health and pathology | Hépatology and Gastroenterology | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 02/2013, Volume 110, Issue 2, pp. 597 - 608
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 07/2011, Volume 108, Issue 7, pp. 1704 - 1715
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 05/2016, Volume 193, Issue 10, pp. 1184 - 1184
Journal Article