PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e24584
Background: Through negative regulation of gene expression, microRNAs (miRNAs) can function as oncosuppressors in cancers, and can themselves show altered...
INITIATING CELLS | IN-VITRO | ACTIVATION | MOUSE MODEL | BIOLOGY | PROLIFERATION | EXPRESSION | PERIVASCULAR NICHE | CANCER STEM-CELLS | MICRORNA | P53 | Cell Proliferation | Peptides | Signal Transduction | Antigens, CD - biosynthesis | Humans | Tumor Suppressor Protein p53 - metabolism | MicroRNAs - metabolism | Neurons - cytology | Medulloblastoma - metabolism | AC133 Antigen | Glycoproteins - biosynthesis | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Lewis X Antigen - biosynthesis | Cell Line, Tumor | Cell Differentiation | Membrane Proteins - metabolism | Mice | Apoptosis | Cerebellum | Cell proliferation | Brain | Pediatrics | Phosphorylation | Laboratories | Toxicity | Pathogenesis | p53 Protein | Brain tumors | Brain cancer | Genes | Clinical trials | AKT protein | Cyclin D1 | Neurogenesis | Cyclin-dependent kinase 4 | Signal transduction | Cell growth | Allografts | Xenografts | Biocompatibility | Tumorigenesis | Deoxyribonucleic acid--DNA | Hematology | Stat3 protein | MiRNA | Gene expression | Endothelium | Signaling | DELTA protein | Medulloblastoma | Adenoviruses | Stem cells | Ligands | Notch protein | Differentiation | Tumors | Cancer | Deoxyribonucleic acid | DNA
INITIATING CELLS | IN-VITRO | ACTIVATION | MOUSE MODEL | BIOLOGY | PROLIFERATION | EXPRESSION | PERIVASCULAR NICHE | CANCER STEM-CELLS | MICRORNA | P53 | Cell Proliferation | Peptides | Signal Transduction | Antigens, CD - biosynthesis | Humans | Tumor Suppressor Protein p53 - metabolism | MicroRNAs - metabolism | Neurons - cytology | Medulloblastoma - metabolism | AC133 Antigen | Glycoproteins - biosynthesis | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Lewis X Antigen - biosynthesis | Cell Line, Tumor | Cell Differentiation | Membrane Proteins - metabolism | Mice | Apoptosis | Cerebellum | Cell proliferation | Brain | Pediatrics | Phosphorylation | Laboratories | Toxicity | Pathogenesis | p53 Protein | Brain tumors | Brain cancer | Genes | Clinical trials | AKT protein | Cyclin D1 | Neurogenesis | Cyclin-dependent kinase 4 | Signal transduction | Cell growth | Allografts | Xenografts | Biocompatibility | Tumorigenesis | Deoxyribonucleic acid--DNA | Hematology | Stat3 protein | MiRNA | Gene expression | Endothelium | Signaling | DELTA protein | Medulloblastoma | Adenoviruses | Stem cells | Ligands | Notch protein | Differentiation | Tumors | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 09/2013, Volume 19, Issue 37, pp. 12217 - 12220
Get well prune: The C‐terminal third domain of h‐prune is largely unfolded and involved in relevant protein–protein interactions, particularly with Nm23‐H1...
protein–protein interactions | human cell lysates | structure elucidation | NMR spectroscopy | intrinsically disordered proteins | protein-protein interactions | OVEREXPRESSION | COMPLEX | NM23-H1 | PROTEIN H-PRUNE | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | Glycogen Synthase Kinase 3 - chemistry | NM23 Nucleoside Diphosphate Kinases - chemistry | Carrier Proteins - metabolism | Magnetic Resonance Spectroscopy | Humans | Carrier Proteins - chemistry | Glycogen Synthase Kinase 3 beta | Gelsolin - chemistry | Glycogen Synthase Kinase 3 - metabolism | Drug Discovery | NM23 Nucleoside Diphosphate Kinases - metabolism | Cell Biology | Proteins | Nuclear magnetic resonance spectroscopy | Cells | Human | Prunes | Strategy | Mapping | Nuclear magnetic resonance
protein–protein interactions | human cell lysates | structure elucidation | NMR spectroscopy | intrinsically disordered proteins | protein-protein interactions | OVEREXPRESSION | COMPLEX | NM23-H1 | PROTEIN H-PRUNE | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | Glycogen Synthase Kinase 3 - chemistry | NM23 Nucleoside Diphosphate Kinases - chemistry | Carrier Proteins - metabolism | Magnetic Resonance Spectroscopy | Humans | Carrier Proteins - chemistry | Glycogen Synthase Kinase 3 beta | Gelsolin - chemistry | Glycogen Synthase Kinase 3 - metabolism | Drug Discovery | NM23 Nucleoside Diphosphate Kinases - metabolism | Cell Biology | Proteins | Nuclear magnetic resonance spectroscopy | Cells | Human | Prunes | Strategy | Mapping | Nuclear magnetic resonance
Journal Article
CANCERS, ISSN 2072-6694, 06/2019, Volume 11, Issue 6, p. 859
Previous findings suggest that metastatic colorectal carcinoma (mCRC) patients with KRAS/NRAS/BRAF/PIK3CA wild-type (quadruple-wt) tumors are highly sensitive...
genomic profiling | colorectal cancer | LIQUID BIOPSY | PRIMARY TUMOR | PTEN | anti-EGFR monoclonal antibodies | resistance | CHEMOTHERAPY | HETEROGENEITY | TARGETED THERAPIES | ONCOLOGY | RAS MUTATIONS | FOLFIRI PLUS CETUXIMAB | KRAS | MONOCLONAL-ANTIBODIES | Immunoglobulins | Epidermal growth factor receptors | Copy number | Colorectal carcinoma | Genes | Colorectal cancer | Clinical trials | Metastasis | Drug resistance | Cancer therapies | Cdc4 protein | Metastases | Chemotherapy | Epidermal growth factor | Precision medicine | Medical prognosis | Monoclonal antibodies | Biomarkers | Mutation | Tumors
genomic profiling | colorectal cancer | LIQUID BIOPSY | PRIMARY TUMOR | PTEN | anti-EGFR monoclonal antibodies | resistance | CHEMOTHERAPY | HETEROGENEITY | TARGETED THERAPIES | ONCOLOGY | RAS MUTATIONS | FOLFIRI PLUS CETUXIMAB | KRAS | MONOCLONAL-ANTIBODIES | Immunoglobulins | Epidermal growth factor receptors | Copy number | Colorectal carcinoma | Genes | Colorectal cancer | Clinical trials | Metastasis | Drug resistance | Cancer therapies | Cdc4 protein | Metastases | Chemotherapy | Epidermal growth factor | Precision medicine | Medical prognosis | Monoclonal antibodies | Biomarkers | Mutation | Tumors
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 4/2013, Volume 386, Issue 4, pp. 287 - 302
MicroRNA (miR)-199b-5p has been shown to regulate Hes-1, a downstream effector of the canonical Notch and noncanonical SHH pathways, whereby it impairs...
Neurosciences | Biomedicine | Pharmacology/Toxicology | SNALP | Hes-1 | Cancer stem cells | MiR-199b-5p | Caspase 7 - metabolism | Lipids - chemistry | Cell Proliferation | MicroRNAs - administration & dosage | Humans | Caspase 3 - metabolism | HEK293 Cells | Cell Line, Tumor | Liposomes | MicroRNAs - chemistry | Apoptosis | NONHUMAN-PRIMATES | NOTCH | SIRNA DELIVERY | TUMOR-INITIATING CELLS | CANCER STEM-CELLS | COLON-CANCER | NANOPARTICLES | HEPATOCELLULAR-CARCINOMA | IN-VIVO | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | Fluorescence | MicroRNA | Gliomas | Analysis | Stem cells
Neurosciences | Biomedicine | Pharmacology/Toxicology | SNALP | Hes-1 | Cancer stem cells | MiR-199b-5p | Caspase 7 - metabolism | Lipids - chemistry | Cell Proliferation | MicroRNAs - administration & dosage | Humans | Caspase 3 - metabolism | HEK293 Cells | Cell Line, Tumor | Liposomes | MicroRNAs - chemistry | Apoptosis | NONHUMAN-PRIMATES | NOTCH | SIRNA DELIVERY | TUMOR-INITIATING CELLS | CANCER STEM-CELLS | COLON-CANCER | NANOPARTICLES | HEPATOCELLULAR-CARCINOMA | IN-VIVO | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | Fluorescence | MicroRNA | Gliomas | Analysis | Stem cells
Journal Article
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, p. 1351
Nm23-H1 is one of the most interesting candidate genes for a relevant role in Neuroblastoma pathogenesis. H-Prune is the most characterized Nm23-H1 binding...
BREAST-CARCINOMA | PROTEIN | GENE | NM23-H1 | CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | N-MYC | H-PRUNE | EXPRESSION | TYROSINE-PHOSPHATASE-ALPHA | Immunohistochemistry | Humans | Gene Expression Regulation, Neoplastic | Peptides - genetics | Transplantation, Heterologous | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Cell Movement - genetics | Neoplasm Metastasis | Peptides - metabolism | Cell Transformation, Neoplastic - genetics | HEK293 Cells | Carrier Proteins - chemistry | Female | Neuroblastoma - pathology | Protein Structure, Tertiary | NM23 Nucleoside Diphosphate Kinases - chemistry | Magnetic Resonance Spectroscopy | Neuroblastoma - genetics | Models, Molecular | Binding Sites - genetics | Cell Transformation, Neoplastic - metabolism | Blotting, Western | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mice, Nude | Cell Line, Tumor | Protein Binding | Mice | Neuroblastoma - metabolism | Mutation | Cell Transformation, Neoplastic - pathology | Magnetic resonance spectroscopy | Spectroscopy | Nuclear magnetic resonance--NMR | Conformational analysis | Data processing | Tumorigenesis | Neuroblastoma | Nucleoside-diphosphate kinase | Metastases
BREAST-CARCINOMA | PROTEIN | GENE | NM23-H1 | CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | N-MYC | H-PRUNE | EXPRESSION | TYROSINE-PHOSPHATASE-ALPHA | Immunohistochemistry | Humans | Gene Expression Regulation, Neoplastic | Peptides - genetics | Transplantation, Heterologous | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Cell Movement - genetics | Neoplasm Metastasis | Peptides - metabolism | Cell Transformation, Neoplastic - genetics | HEK293 Cells | Carrier Proteins - chemistry | Female | Neuroblastoma - pathology | Protein Structure, Tertiary | NM23 Nucleoside Diphosphate Kinases - chemistry | Magnetic Resonance Spectroscopy | Neuroblastoma - genetics | Models, Molecular | Binding Sites - genetics | Cell Transformation, Neoplastic - metabolism | Blotting, Western | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mice, Nude | Cell Line, Tumor | Protein Binding | Mice | Neuroblastoma - metabolism | Mutation | Cell Transformation, Neoplastic - pathology | Magnetic resonance spectroscopy | Spectroscopy | Nuclear magnetic resonance--NMR | Conformational analysis | Data processing | Tumorigenesis | Neuroblastoma | Nucleoside-diphosphate kinase | Metastases
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 2015, Volume 35, pp. S276 - S304
Abstract Targeted therapies and the consequent adoption of “personalized” oncology have achieved notable successes in some cancers; however, significant...
Hematology, Oncology and Palliative Medicine | Cancer hallmarks | Phytochemicals | Targeted therapy | Multi-targeted | Integrative medicine | DRUG-RESISTANCE | ANTIOXIDANT SUPPLEMENTATION | BREAST-CANCER | ONCOLOGY | PHASE-I TRIAL | PROSTATE-CANCER | PHYSICAL-ACTIVITY | ENDOTHELIAL-CELL-GROWTH | LOW-FAT DIETS | TUMOR-GROWTH | PERIOPERATIVE IMMUNOMODULATION | Drug Resistance, Neoplasm - genetics | Neoplasms - therapy | Tumor Microenvironment - genetics | Neoplasms - genetics | Signal Transduction | Humans | Neoplasms - prevention & control | Antineoplastic Agents, Phytogenic - therapeutic use | Molecular Targeted Therapy | Neoplasms - pathology | Genetic Heterogeneity | Precision Medicine | Prevention | Care and treatment | Cancer | Index Medicus | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cancer and Oncology | Klinisk medicin | Multi-targeted; Cancer hallmarks; Phytochemicals; Targeted therapy; Integrative medicine | Cancer och onkologi
Hematology, Oncology and Palliative Medicine | Cancer hallmarks | Phytochemicals | Targeted therapy | Multi-targeted | Integrative medicine | DRUG-RESISTANCE | ANTIOXIDANT SUPPLEMENTATION | BREAST-CANCER | ONCOLOGY | PHASE-I TRIAL | PROSTATE-CANCER | PHYSICAL-ACTIVITY | ENDOTHELIAL-CELL-GROWTH | LOW-FAT DIETS | TUMOR-GROWTH | PERIOPERATIVE IMMUNOMODULATION | Drug Resistance, Neoplasm - genetics | Neoplasms - therapy | Tumor Microenvironment - genetics | Neoplasms - genetics | Signal Transduction | Humans | Neoplasms - prevention & control | Antineoplastic Agents, Phytogenic - therapeutic use | Molecular Targeted Therapy | Neoplasms - pathology | Genetic Heterogeneity | Precision Medicine | Prevention | Care and treatment | Cancer | Index Medicus | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cancer and Oncology | Klinisk medicin | Multi-targeted; Cancer hallmarks; Phytochemicals; Targeted therapy; Integrative medicine | Cancer och onkologi
Journal Article
Expert Opinion on Drug Metabolism & Toxicology, ISSN 1742-5255, 09/2018, Volume 14, Issue 9, pp. 891 - 900
Introduction: Cyclin-dependent kinases (CDKs) 4 and 6 regulate the transition from G0/G1-phase to S-phase of the cell cycle and have been identified as key...
breast cancer | hormone receptor | cell cycle | CDK4/6 inhibitors | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDK4/6 INHIBITION | COMBINATION | INHIBITOR PALBOCICLIB | DEPENDENT KINASE 4/6 | MOLECULAR PORTRAITS | FULVESTRANT | RESISTANCE | PHARMACOLOGY & PHARMACY | CELL-CYCLE | TOXICOLOGY | PHASE-I | PD 0332991
breast cancer | hormone receptor | cell cycle | CDK4/6 inhibitors | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDK4/6 INHIBITION | COMBINATION | INHIBITOR PALBOCICLIB | DEPENDENT KINASE 4/6 | MOLECULAR PORTRAITS | FULVESTRANT | RESISTANCE | PHARMACOLOGY & PHARMACY | CELL-CYCLE | TOXICOLOGY | PHASE-I | PD 0332991
Journal Article
Expert opinion on drug metabolism & toxicology, 09/2018, p. 1
Cyclin-dependent kinases (CDKs) 4 and 6 regulate the transition from G0/G1-phase to S-phase of the cell cycle and have been identified as key drivers of...
Journal Article
JOURNAL OF TRANSLATIONAL MEDICINE, ISSN 1479-5876, 01/2018, Volume 16, Issue S1, pp. 1 - 15
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 01/2012, Volume 106, Issue 1, p. 59
Medulloblastoma is one of the leading causes of morbidity and mortality in pediatric cancer. Wnt-active tumors, an independent molecular subgroup in...
Neurons | Growth | Medulloblastoma | Analysis | Tumors
Neurons | Growth | Medulloblastoma | Analysis | Tumors
Journal Article
Brain, ISSN 0006-8950, 04/2017, Volume 140, Issue 4, pp. 940 - 952
PRUNE is a member of the DHH (Asp-His-His) phosphoesterase protein superfamily of molecules important for cell motility, and implicated in cancer progression....
PRUNE1 | Normal brain development | Microtubule polymerization | Microcephaly | Developmental delay | Tubulinopathy | microcephaly | PROTEIN | normal brain development | PERTURB MICROTUBULE DYNAMICS | CRYSTAL-STRUCTURE | CORTICAL DEVELOPMENT | CANCER | NEUROSCIENCES | microtubule polymerization | CLINICAL NEUROLOGY | tubulinopathy | SECKEL-SYNDROME | developmental delay | MUTATIONS | H-PRUNE | PEHO SYNDROME | TRANSGENIC MICE | Heredodegenerative Disorders, Nervous System - genetics | Microcephaly - genetics | Humans | Cytoskeleton - genetics | Child, Preschool | Infant | Male | Developmental Disabilities - genetics | Brain - growth & development | Cytoskeleton - ultrastructure | Mutation - genetics | Genes, Recessive | Cell Movement - genetics | Young Adult | Carrier Proteins - genetics | Cell Differentiation - genetics | Microtubules - genetics | Pedigree | Adolescent | Microtubules - ultrastructure | Cerebral Cortex - growth & development | Female | Child | microtubule polymerization, tubulinopathy | Original
PRUNE1 | Normal brain development | Microtubule polymerization | Microcephaly | Developmental delay | Tubulinopathy | microcephaly | PROTEIN | normal brain development | PERTURB MICROTUBULE DYNAMICS | CRYSTAL-STRUCTURE | CORTICAL DEVELOPMENT | CANCER | NEUROSCIENCES | microtubule polymerization | CLINICAL NEUROLOGY | tubulinopathy | SECKEL-SYNDROME | developmental delay | MUTATIONS | H-PRUNE | PEHO SYNDROME | TRANSGENIC MICE | Heredodegenerative Disorders, Nervous System - genetics | Microcephaly - genetics | Humans | Cytoskeleton - genetics | Child, Preschool | Infant | Male | Developmental Disabilities - genetics | Brain - growth & development | Cytoskeleton - ultrastructure | Mutation - genetics | Genes, Recessive | Cell Movement - genetics | Young Adult | Carrier Proteins - genetics | Cell Differentiation - genetics | Microtubules - genetics | Pedigree | Adolescent | Microtubules - ultrastructure | Cerebral Cortex - growth & development | Female | Child | microtubule polymerization, tubulinopathy | Original
Journal Article
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 14, pp. 5736 - 5749
Journal Article