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1. Full Text Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study
by Marin, Jose M and Carrizo, Santiago J and Vicente, Eugenio and Agusti, Alvar G.N
Lancet, ISSN 0140-6736, 03/2005, Volume 365, Issue 9464, pp. 1046 - 1053
Background: The effect of obstructive sleep apnoea-hypopnoea as a cardiovascular risk factor and the potential protective effect of its treatment with... 
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2. Full Text Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: The overlap syndrome
by Marin, Jose M and Soriano, Joan B and Carrizo, Santiago J and Boldova, Ana and Celli, Bartolome R
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2010, Volume 182, Issue 3, pp. 325 - 331
Rationale Patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) (overlap syndrome) are more likely to develop pulmonary... 
Chronic obstructive pulmonary disease | Hospitalization | Obstructive sleep apnea | Cohort studies | UNITED-STATES | hospitalization | RISK-FACTOR | RESPIRATORY SYSTEM | LUNG-FUNCTION | ATHEROSCLEROSIS | ADULTS | obstructive sleep apnea, cohort studies | MECHANISMS | ASSOCIATION | chronic obstructive pulmonary disease | CRITICAL CARE MEDICINE | Continuous Positive Airway Pressure | Pulmonary Disease, Chronic Obstructive - mortality | Severity of Illness Index | Sleep Apnea, Obstructive - therapy | Prospective Studies | Age Factors | Follow-Up Studies | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Sleep Apnea, Obstructive - complications | Pulmonary Disease, Chronic Obstructive - complications | Sleep Apnea, Obstructive - mortality | Female
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3. Full Text Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension
by Marin, José M and Agusti, Alvar and Villar, Isabel and Forner, Marta and Nieto, David and Carrizo, Santiago J and Barbé, Ferran and Vicente, Eugenio and Wei, Ying and Nieto, F. Javier and Jelic, Sanja
JAMA, ISSN 0098-7484, 05/2012, Volume 307, Issue 20, pp. 2169 - 2176
CONTEXT Systemic hypertension is prevalent among patients with obstructive sleep apnea (OSA). Short-term studies indicate that continuous positive airway... 
REGRESSION | MORTALITY | STROKE | MEDICINE, GENERAL & INTERNAL | OBESITY | THERAPY | COMMITTEE | POSITIVE AIRWAY PRESSURE | MULTIPLE IMPUTATION | HIGH BLOOD-PRESSURE | ADHERENCE | Continuous Positive Airway Pressure | Sleep Apnea, Obstructive - therapy | Prospective Studies | Humans | Middle Aged | Male | Risk | Case-Control Studies | Incidence | Spain - epidemiology | Adult | Female | Hypertension - epidemiology | Hypertension | Care and treatment | Continuous positive airway pressure | Causes of | Sleep apnea syndromes | Health aspects | Risk factors | Airway management | Sleep apnea | Blood pressure | Medical treatment
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4. Full Text Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study
by Marin, Jose M and Carrizo, Santiago J and Vicente, Eugenio and Agusti, Alvar GN
The Lancet, ISSN 0140-6736, 2005, Volume 365, Issue 9464, pp. 1046 - 1053
The effect of obstructive sleep apnoea-hypopnoea as a cardiovascular risk factor and the potential protective effect of its treatment with continuous positive... 
CONTROLLED-TRIALS | MORTALITY | POPULATION | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | CEREBRAL-INFARCTION | FOLLOW-UP | ISCHEMIC-HEART-DISEASE | HEALTH | HYPERTENSION | CORONARY-ARTERY-DISEASE | Continuous Positive Airway Pressure | Sleep Apnea, Obstructive - therapy | Cardiovascular Diseases - etiology | Humans | Middle Aged | Risk Factors | Snoring - complications | Cardiovascular Diseases - mortality | Male | Sleep Apnea, Obstructive - complications | Sleep apnea syndromes | Cardiovascular diseases | Health aspects | Patient outcomes | Risk factors | Comparative studies | Sleep disorders | Cardiovascular disease | Men
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5. Full Text Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive ventilation therapy in patients with obesity hypoventilation syndrome: a multicentre, open-label, randomised controlled trial
by Masa, Juan F and Mokhlesi, Babak and Benítez, Iván and Benítez, José M and Gomez de Terreros, Francisco Javier and Sánchez-Quiroga, Maria Ángeles and Romero, Auxiliadora and Romero, Odile and Caballero-Eraso, Candela and Terán-Santos, Joaquin and Alonso-Álvarez, Maria Luz and Troncoso, Maria F and González, Mónica and López-Martín, Soledad and Marin, José M and Martí, Sergi and Díaz-Cambriles, Trinidad and Chiner, Eusebi and Egea, Carlos and Barca, Javier and Vázquez-Polo, Francisco-José and Negrín, Miguel A and Martel-Escobar, María and Barbe, Ferran and Corral, Jaime and Fernández, Galo and Ordax-Carbajo, Estrella and González-Mangado, Nicolás and Gómez-García, Teresa and Martínez-Martínez, María-Ángeles and Ojeda-Castillejo, Elena and López Padilla, Daniel and Carrizo, Santiago J and Gallego, Begoña and Pallero, Mercedes and Ramón, María Antonia and Arias, Eva and Muñoz-Méndez, Jesús and Senent, Cristina and Sancho-Chust, José N and Navarro Soriano, Nieves Belén and Barrot, Emilia and Sánchez-Gómez, Jesús and Golpe, Rafael and Santiago-Recuerda, Ana and Gómez, Silvia and Bengoa, Mónica and Spanish Sleep Network
The Lancet, ISSN 0140-6736, 04/2019, Volume 393, Issue 10182, pp. 1721 - 1732
Obesity hypoventilation syndrome is commonly treated with continuous positive airway pressure or non-invasive ventilation during sleep. Non-invasive... 
SUPPORT | MEDICINE, GENERAL & INTERNAL | IMPACT | CPAP | EFFICACY | MECHANICAL VENTILATION | PREVALENCE | ADHERENCE | RESPIRATORY-FAILURE | Obesity hypoventilation syndrome | Continuous positive airway pressure | Care and treatment | Respiratory therapy | Ventilators | Obesity | Therapy | Oxygen therapy | Mortality | Medical services | Clinical trials | Patients | Pressure | Morbidity | Sleep deprivation | Complexity | Respiratory tract | Restless legs syndrome | Sleep disorders | Randomization | Hypoventilation | Sleep | Apnea | Motivation | Ventilation
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6. Full Text Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea
by Masa, Juan F and Masa, Juan F and Corral, Jaime and Corral, Jaime and Caballero, Candela and Caballero, Candela and Barrot, Emilia and Barrot, Emilia and Terán-Santos, Joaquin and Terán-Santos, Joaquin and Alonso-álvarez, Maria L and Alonso-Álvarez, Maria L and Gomez-Garcia, Teresa and Gomez-Garcia, Teresa and González, Mónica and González, Mónica and López-Martín, Soledad and López-Martín, Soledad and De Lucas, Pilar and De Lucas, Pilar and Marin, José M and Marin, José M and Marti, Sergi and Marti, Sergi and Díaz-Cambriles, Trinidad and Díaz-Cambriles, Trinidad and Chiner, Eusebi and Chiner, Eusebi and Egea, Carlos and Egea, Carlos and Miranda, Erika and Miranda, Erika and Mokhlesi, Babak and Mokhlesi, Babak and García-Ledesma, Estefanía and García-Ledesma, Estefanía and Sánchez-Quiroga, M.-ángeles and Sánchez-Quiroga, M-Ángeles and Ordax, Estrella and Ordax, Estrella and González-Mangado, Nicolás and González-Mangado, Nicolás and Troncoso, Maria F and Troncoso, Maria F and Martinez-Martinez, Maria-ángeles and Martinez-Martinez, Maria-Ángeles and Cantalejo, Olga and Cantalejo, Olga and Ojeda, Elena and Ojeda, Elena and Carrizo, Santiago J and Carrizo, Santiago J and Gallego, Begoña and Gallego, Begoña and Pallero, Mercedes and Pallero, Mercedes and Ramón, M. Antonia and Ramón, M. Antonia and Díaz-De-atauri, Josefa and Díaz-de-Atauri, Josefa and Muñoz-Méndez, Jesús and Muñoz-Méndez, Jesús and Senent, Cristina and Senent, Cristina and Sancho-Chust, Jose N and Sancho-Chust, Jose N and Ribas-Solís, Francisco J and Ribas-Solís, Francisco J and Romero, Auxiliadora and Romero, Auxiliadora and Benítez, José M and Benítez, José M and Sanchez-Gómez, Jesús and Sanchez-Gómez, Jesús and Golpe, Rafael and Golpe, Rafael and Santiago-Recuerda, Ana and Santiago-Recuerda, Ana and Gomez, Silvia and Gomez, Silvia and Bengoa, Mónica and Bengoa, Mónica and Spanish Sleep Network and on behalf of the Spanish Sleep Network
Thorax, ISSN 0040-6376, 07/2016, Volume 71, Issue 10, pp. 899 - 906
Background Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe... 
SUPPORT | PROGNOSTIC-FACTORS | EFFICACY | RESPIRATORY SYSTEM | MECHANICAL VENTILATION | RANDOMIZED CONTROLLED-TRIAL | POSITIVE-PRESSURE VENTILATION | Life Style | Forced Expiratory Volume - physiology | Humans | Middle Aged | Obesity Hypoventilation Syndrome - complications | Respiratory Function Tests - methods | Male | Sleep Apnea, Obstructive - complications | Treatment Outcome | Noninvasive Ventilation - methods | Polysomnography | Carbon Dioxide - blood | Obesity Hypoventilation Syndrome - therapy | Partial Pressure | Vital Capacity - physiology | Aged, 80 and over | Female | Aged | Blood Pressure - physiology | Obesity Hypoventilation Syndrome - physiopathology | Complications and side effects | Care and treatment | Usage | Medical examination | Obesity hypoventilation syndrome | Sleep apnea syndromes | Ventilator weaning | Patients | Sleep apnoea | Non-Invasive Ventilation | 1506 | Non invasive ventilation
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7. Upper airway and systemic inflammation in obstructive sleep apnoea
by Vicente, Eugenio and Marin, Jose M and Carrizo, Santiago J and Osuna, Carlos S and González, Ricardo and Marin-Oto, Marta and Forner, Marta and Vicente, Paul and Cubero, Pablo and Gil, Ana V and Soler, Xavier
European Respiratory Journal, ISSN 0903-1936, 10/2016, Volume 48, Issue 4, pp. 1108 - 1117
Obstructive sleep apnoea (OSA) is associated with pharyngeal inflammation, but the coexistence of systemic inflammation is controversial. This study... 
C-REACTIVE PROTEIN | EXHALED BREATH CONDENSATE | OXIDATIVE STRESS | INTERMITTENT HYPOXIA | CPAP | RESPIRATORY SYSTEM | MEDIATORS | MINIMALLY SYMPTOMATIC OSA | VASCULAR ENDOTHELIUM | ASSOCIATION | PRESSURE THERAPY | Biomarkers - metabolism | Continuous Positive Airway Pressure | Tumor Necrosis Factor-alpha - metabolism | Immunoassay | Sleep Apnea, Obstructive - physiopathology | Prospective Studies | Anthropometry | CD4-Positive T-Lymphocytes - cytology | Humans | Middle Aged | Male | Sleep Apnea, Obstructive - complications | Treatment Outcome | Case-Control Studies | Snoring | Young Adult | Inflammation - complications | Flow Cytometry | Adolescent | Adult | Female | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Inflammation - physiopathology
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8. Full Text Protective Cardiovascular Effect of Sleep Apnea Severity in Obesity Hypoventilation Syndrome
by Masa, Juan F., MD, PhD and Corral, Jaime, MD and Romero, Auxiliadora, MD and Caballero, Candela, MD and Terán-Santos, Joaquin, MD, PhD and Alonso-Álvarez, Maria L., MD, PhD and Gomez-Garcia, Teresa, MD and González, Mónica, MD, PhD and López-Martín, Soledad, MD and De Lucas, Pilar, MD, PhD and Marin, José M., MD, PhD and Marti, Sergi, MD, PhD and Díaz-Cambriles, Trinidad, MD and Chiner, Eusebi, MD, PhD and Merchan, Miguel, MStat and Egea, Carlos, MD, PhD and Obeso, Ana, MD and Mokhlesi, Babak, MD and Spanish Sleep Network and Spanish Sleep Network(∗)
Chest, ISSN 0012-3692, 2016, Volume 150, Issue 1, pp. 68 - 79
Background Obesity hypoventilation syndrome (OHS) is associated with a high burden of cardiovascular morbidity (CVM) and mortality. The majority of patients... 
Pulmonary/Respiratory | precision medicine | sleep apnea | cardiovascular risk | obesity hypoventilation syndrome | sleep apnea | MORTALITY | PROGNOSTIC-FACTORS | AIRWAY PRESSURE | NATIONWIDE INPATIENT SAMPLE | TERM | INTERMITTENT HYPOXIA | SURGERY ANALYSIS | RESPIRATORY SYSTEM | POSTOPERATIVE OUTCOMES | POSITIVE-PRESSURE VENTILATION | INDEXES | CRITICAL CARE MEDICINE | Severity of Illness Index | Cardiovascular Diseases - etiology | Prevalence | Cross-Sectional Studies | Humans | Hypoxia - etiology | Middle Aged | Obesity Hypoventilation Syndrome - complications | Male | Hypoxia - diagnosis | Obesity Hypoventilation Syndrome - diagnosis | Protective Factors | Spain | Polysomnography - methods | Cardiovascular Diseases - mortality | Female | Obesity Hypoventilation Syndrome - blood | Aged | Obesity Hypoventilation Syndrome - epidemiology | Blood Gas Analysis - methods | Complications and side effects | Care and treatment | Obesity hypoventilation syndrome | Patient outcomes | Sleep apnea syndromes | Cardiovascular diseases | Risk factors
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9. Full Text Prediction of risk of COPD exacerbations by the BODE index
by Marin, Jose M and Carrizo, Santiago J and Casanova, Ciro and Martinez-Camblor, Pablo and Soriano, Joan B and Agusti, Alvar G.N and Celli, Bartolome R
Respiratory Medicine, ISSN 0954-6111, 2008, Volume 103, Issue 3, pp. 373 - 378
Summary Objectives This study assesses the power of the BODE index, a multidimensional grading system that predicts mortality, to predict subsequent... 
Pulmonary/Respiratory | BODE index | Exacerbations | Emphysema | Chronic bronchitis | COPD | MORTALITY | CONTROLLED-TRIAL | CAPACITY | CARDIAC & CARDIOVASCULAR SYSTEMS | PHARMACOECONOMIC EVALUATION | DYSPNEA | DECLINE | HOSPITALIZATION | OBSTRUCTIVE PULMONARY-DISEASE | FLUTICASONE PROPIONATE | RESPIRATORY SYSTEM | OUTCOMES | Severity of Illness Index | Recurrence | Risk Assessment - methods | Prognosis | Area Under Curve | Humans | Middle Aged | Emergencies | Male | Hospitalization | Lung - physiopathology | Pulmonary Disease, Chronic Obstructive - physiopathology | Activities of Daily Living | Forced Expiratory Volume | Time Factors | Exercise Tolerance | Statistics, Nonparametric | Female | Aged | Health Status | Cohort Studies | Lung diseases, Obstructive
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10. Full Text Prognostic assessment in COPD: Health related quality of life and the BODE index
by Marin, Jose M and Cote, Claudia G and Diaz, Orlando and Lisboa, Carmen and Casanova, Ciro and Lopez, Maria V and Carrizo, Santiago J and Pinto-Plata, Victor and Dordelly, Luis J and Nekach, Hafida and Celli, Bartolome R
Respiratory Medicine, ISSN 0954-6111, 2011, Volume 105, Issue 6, pp. 916 - 921
Summary Rationale COPD is a debilitating disease with increasing mortality worldwide. The BODE index evaluates disease severity and the St George’s Respiratory... 
Pulmonary/Respiratory | BODE index | Mortality | COPD | Quality of life | DIAGNOSIS | DISTANCE | CARDIAC & CARDIOVASCULAR SYSTEMS | PREDICTOR | DYSPNEA | EXERCISE CAPACITY | TIME | OBSTRUCTIVE PULMONARY-DISEASE | RESPIRATORY SYSTEM | REHABILITATION | Pulmonary Disease, Chronic Obstructive - mortality | Severity of Illness Index | Prognosis | Health Status Indicators | Humans | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Analysis of Variance | Pulmonary Disease, Chronic Obstructive - psychology | Spirometry - methods | Female | Surveys and Questionnaires | Aged | Quality of Life - psychology | Cohort Studies | Lung diseases, Obstructive | Studies | Body mass index | Drug therapy
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11. Full Text Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease
by Marin, J.M and Carrizo, S.J and Gascon, M and Sanchez, A and Gallego, B and Celli, B.R
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 2001, Volume 163, Issue 6, pp. 1395 - 1399
Patients with severe chronic obstructive pulmonary disease (COPD) develop dynamic lung hyperinflation (DH) during symptom-limited incremental and constant work... 
CHEST-WALL | MECHANICS | DISTANCE | DYSPNEA RATINGS | RESPIRATORY SYSTEM | VOLUME | LUNG-FUNCTION | DISABILITY | PATTERNS | SYMPTOMS | RESPIRATORY MUSCLE | CRITICAL CARE MEDICINE | Predictive Value of Tests | Humans | Lung Diseases, Obstructive - classification | Middle Aged | Male | Dyspnea - etiology | Lung Diseases, Obstructive - metabolism | Activities of Daily Living | Forced Expiratory Volume | Rest | Spirometry - methods | Exercise Test - methods | Lung Diseases, Obstructive - diagnosis | Inspiratory Capacity | Severity of Illness Index | Blood Gas Analysis | Lung Diseases, Obstructive - physiopathology | Vital Capacity | Walking | Analysis of Variance | Exercise Tolerance | Exercise Test - standards | Aged | Plethysmography | Spirometry - standards | Lung Diseases, Obstructive - complications
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12. Full Text The effect of supplemental oxygen in obesity hypoventilation syndrome
by Masa, Juan F and Corral, Jaime and Romero, Auxiliadora and Caballero, Candela and Terán-Santos, Joaquin and Alonso-Álvarez, Maria L and Gomez-Garcia, Teresa and González, Mónica and López-Martínez, Soledad and De Lucas, Pilar and Marin, José M and Marti, Sergi and Díaz-Cambriles, Trinidad and Chiner, Eusebi and Merchan, Miguel and Egea, Carlos and Obeso, Ana and Mokhlesi, Babak and García-Ledesma, Estefanía and Sánchez-Quiroga, M-Ángeles and Ordax, Estrella and González-Mangado, Nicolás and Troncoso, Maria F and Martinez-Martinez, Maria-Ángeles and Cantalejo, Olga and Ojeda, Elena and Carrizo, Santiago J and Gallego, Begoña and Pallero, Mercedes and Ramón, Maria Antonia and Díaz-De-Atauri, Josefa and Muñoz-Méndez, Jesús and Senent, Cristina and Sancho-Chust, Jose N and Ribas, Francisco J and Barrot, Emilia and Benítez, José M and Sanchez-Gómez, Jesús and Golpe, Rafael and Santiago-Recuerda, Ana and Gomez, Silvia and Bengoa, Mónica and Spanish Sleep Network
Journal of Clinical Sleep Medicine, ISSN 1550-9389, 2016, Volume 12, Issue 10, pp. 1379 - 1388
Study Objectives: Low flow supplemental oxygen is commonly prescribed to patients with obesity hypoventilation syndrome ( OHS). However, there is a paucity of... 
Noninvasive ventilation | Sleep apnea | Oxygen therapy | Obesity hypoventilation syndrome | OBSTRUCTIVE SLEEP-APNEA | CPAP | noninvasive ventilation | AIRWAY PRESSURE | obesity hypoventilation syndrome | CLINICAL NEUROLOGY | oxygen therapy | TRIAL | THERAPY | CROSSOVER | HYPERCAPNIA | sleep apnea | POSITIVE-PRESSURE VENTILATION | Blood Pressure | Follow-Up Studies | Humans | Middle Aged | Male | Treatment Outcome | Polysomnography - statistics & numerical data | Spirometry - statistics & numerical data | Blood Gas Analysis - statistics & numerical data | Spain | Young Adult | Obesity Hypoventilation Syndrome - therapy | Adolescent | Aged, 80 and over | Quality of Life | Adult | Female | Aged | Oxygen Inhalation Therapy - methods | Walking - statistics & numerical data
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13. Full Text Epigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study
by Marin, Jose M and Artal, Jorge and Martin, Teresa and Carrizo, Santiago J and Andres, Marta and Martin-Burriel, Inmaculada and Bolea, Rosa and Sanz, Arianne and Varona, Luis and Godino, Javier and Gallego, Begoña and Garcia-Erce, Jose A and Villar, Isabel and Gil, Victoria and Forner, Marta and Cubero, Jose P and Ros, Luis
BMC Pulmonary Medicine, ISSN 1471-2466, 07/2014, Volume 14, Issue 1, pp. 114 - 114
Background: Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular morbidity and mortality. Epidemiological and animal models... 
Epigenetics | Sleep apnea | Subclinical atherosclerosis | Systemic inflammation | C-REACTIVE PROTEIN | DNA METHYLATION | RISK | INTERLEUKIN-6 | OBESITY | RESPIRATORY SYSTEM | INFLAMMATION | REGULATORY T-CELLS | CARDIOVASCULAR-DISEASE | POSITIVE AIRWAY PRESSURE | ASSOCIATION | Gene Expression | Prospective Studies | Epigenesis, Genetic | Humans | Middle Aged | Sleep Apnea, Obstructive - genetics | Biomarkers - analysis | RNA, Messenger - analysis | Biomarkers - blood | Polysomnography | Sleep Apnea, Obstructive - metabolism | Young Adult | DNA Methylation | Carotid Artery Diseases - diagnostic imaging | DNA - analysis | MicroRNAs - analysis | Carotid Artery Diseases - genetics | Ultrasonography | Adult | Surveys and Questionnaires | Longitudinal Studies | Research Design | Medical records | Development and progression | Sleep apnea syndromes | Inflammation | Health aspects | Atherosclerosis
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