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humans (12) 12
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induced pluripotent stem cells - metabolism (5) 5
multiple myeloma - pathology (5) 5
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b-all; cancer reprogramming; dna methylome; ipsc; mll-af4; sendai virus; transcriptome; animals; biomarkers; cell line, transformed; cell line, tumor; cell transdifferentiation; cluster analysis; dna methylation; gene expression; gene expression profiling; hematopoietic stem cells; heterografts; humans; induced pluripotent stem cells; mice; myeloid progenitor cells; myeloid-lymphoid leukemia protein; oncogene proteins, fusion; phenotype; precursor b-cell lymphoblastic leukemia-lymphoma; precursor cells, b-lymphoid; transcriptome; translocation, genetic; cellular reprogramming; gene rearrangement; biochemistry; genetics; developmental biology; cell biology (1) 1
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1. Full Text Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
by Carvajal-Vergara, Xonia and Sevilla, Ana and Dsouza, Sunita L and Ang, Yen-Sin and Schaniel, Christoph and Lee, Dung-Fang and Yang, Lei and Kaplan, Aaron D and Adler, Eric D and Rozov, Roye and Ge, Yongchao and Cohen, Ninette and Edelmann, Lisa J and Chang, Betty and Waghray, Avinash and Su, Jie and Pardo, Sherly and Lichtenbelt, Klaske D and Tartaglia, Marco and Gelb, Bruce D and Lemischka, Ihor R
Nature, ISSN 0028-0836, 06/2010, Volume 465, Issue 7299, pp. 808 - 812
The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders holds the promise of increased understanding... 
SOMATIC PTPN11 MUTATIONS | SHP2 MUTATIONS | HUMAN ES | HEMATOPOIESIS | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | DISEASE | LEUKEMOGENESIS | DIFFERENTIATION | LEUKEMIA | FIBROBLASTS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Embryonic Stem Cells - metabolism | Humans | Male | Gene Expression Profiling | LEOPARD Syndrome - drug therapy | Octamer Transcription Factor-3 - genetics | Phosphoproteins - analysis | SOXB1 Transcription Factors - genetics | Polymerase Chain Reaction | Adult | Female | Cell Differentiation | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Precision Medicine | Induced Pluripotent Stem Cells - pathology | Cell Line | Induced Pluripotent Stem Cells - enzymology | Nanog Homeobox Protein | LEOPARD Syndrome - metabolism | NFATC Transcription Factors - metabolism | Cells, Cultured | Fibroblasts - pathology | Homeodomain Proteins - genetics | Cell Lineage | Myocytes, Cardiac - pathology | Models, Biological | LEOPARD Syndrome - pathology | Myocytes, Cardiac - metabolism | Enzyme Activation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Mitogen-Activated Protein Kinases - metabolism | NFATC Transcription Factors - genetics | Proteins | Signal transduction | Insects | Genes | Cardiomyocytes | Mutation | Kinases
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2. Full Text Generation of iPSC from cardiac and tail-tip fibroblasts derived from a second heart field reporter mouse
by Linares, Javier and Arellano-Viera, Estibaliz and Iglesias-García, Olalla and Ferreira, Carmen and Iglesias, Elena and Abizanda, Gloria and Prósper, Felipe and Carvajal-Vergara, Xonia
Stem Cell Research, ISSN 1873-5061, 05/2016, Volume 16, Issue 3, pp. 617 - 621
Mef2c Anterior Heart Field (AHF) enhancer is activated during embryonic heart development and it is expressed in multipotent cardiovascular progenitors (CVP)... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MEF2 Transcription Factors - genetics | Mice, Inbred C57BL | Genotype | Mice, Transgenic | Transcription Factors - genetics | Cellular Reprogramming | Myocardium - cytology | Teratoma - metabolism | Embryoid Bodies - metabolism | Transcription Factors - metabolism | Teratoma - pathology | Animals | Embryoid Bodies - cytology | Cell Differentiation | Fibroblasts - cytology | Mice | Induced Pluripotent Stem Cells - cytology | Karyotype | Induced Pluripotent Stem Cells - metabolism
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3. Full Text Generation of two transgene-free human iPSC lines from CD133+ cord blood cells
by Arellano-Viera, Estibaliz and Zabaleta, Lorea and Castaño, Julio and Azkona, Garikoitz and Carvajal-Vergara, Xonia and Giorgetti, Alessandra
Stem Cell Research, ISSN 1873-5061, 04/2019, Volume 36, p. 101410
We have generated two human induced pluripotent stem cell (iPSC) lines from CD133 cells isolated from umbilical cord blood (CB) of a female child using... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY
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4. Full Text Generation of two transgene-free human iPSC lines from CD133.sup.+ cord blood cells
by Arellano-Viera, Estibaliz and Zabaleta, Lorea and Castano, Julio and Azkona, Garikoitz and Carvajal-Vergara, Xonia and Giorgetti, Alessandra
Stem Cell Research, ISSN 1873-5061, 04/2019, Volume 36
We have generated two human induced pluripotent stem cell (iPSC) lines from CD133.sup.+ cells isolated from umbilical cord blood (CB) of a female child using... 
Blood cells | Analysis | Stem cells | Cell lines | Research | Umbilical cord
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5. Full Text Generation of four Isl1 reporter iPSC lines from cardiac and tail-tip fibroblasts derived from Ai6IslCre mouse
by Linares, Javier and López-Muneta, Leyre and Arellano-Viera, Estibaliz and Ripalda-Cemboráin, Purificación and Iglesias, Elena and Abizanda, Gloria and Aranguren, Xabier L and Prósper, Felipe and Carvajal-Vergara, Xonia
Stem Cell Research, ISSN 1873-5061, 12/2018, Volume 33, pp. 125 - 129
Islet-1 (Isl1) is a transcription factor essential for life expressed in specific cells with different developmental origins. We have generated iPSC lines from... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Fibroblasts | Transcription factors | Research | Stem cells
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6. Full Text High-purity enrichment of functional cardiovascular cells from human iPS cells
by Lin, Bo and Kim, Jong and Li, Yanxin and Pan, Haiying and Carvajal-Vergara, Xonia and Salama, Guy and Cheng, Tao and Li, Yong and Lo, Cecilia W and Yang, Lei
Cardiovascular Research, ISSN 0008-6363, 2012, Volume 95, Issue 3, pp. 327 - 335
A variety of human inherited heart diseases affect the normal functions of cardiomyocytes (CMs), endothelial cells (ECs), or smooth muscle cells (SMCs). To... 
Differentiation | Embryonic stem cells | Induced pluripotent stem cells | Cardiovascular cells | PROGENITOR CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | MOUSE | ALCAM CD166 | SURFACE-MARKER | CARDIOMYOCYTES | PLURIPOTENT STEM-CELLS | HEART | ENDOTHELIAL-CELLS | SELECTION | CARDIAC MORPHOGENESIS | LEOPARD Syndrome - physiopathology | Humans | Multipotent Stem Cells - metabolism | LEOPARD Syndrome - genetics | Cardiomegaly - pathology | Fetal Proteins - metabolism | RNA, Messenger - metabolism | Antigens, CD - metabolism | Flow Cytometry | Time Factors | Cell Adhesion Molecules, Neuronal - metabolism | Cell Differentiation | Multipotent Stem Cells - physiology | Myocytes, Smooth Muscle - metabolism | Induced Pluripotent Stem Cells - metabolism | Biomarkers - metabolism | Reproducibility of Results | Induced Pluripotent Stem Cells - physiology | Cells, Cultured | Gene Expression Regulation | Myocytes, Smooth Muscle - physiology | Cardiomegaly - physiopathology | Genotype | Cell Separation - methods | Mice, SCID | Cell Lineage | Phenotype | Animals | Myocytes, Cardiac - physiology | LEOPARD Syndrome - pathology | Myocytes, Cardiac - metabolism | Mice, Inbred NOD | Mice | Cardiomegaly - genetics | Original
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7. Full Text Generation of Macaca fascicularis iPS cell line ATCi-MF1 from adult skin fibroblasts using non-integrative Sendai viruses
by Coppiello, Giulia and Abizanda, Gloria and Aguado, Natalia and Iglesias, Elena and Arellano-Viera, Estibaliz and Rodriguez-Madoz, Juan R and Carvajal-Vergara, Xonia and Prosper, Felipe and Aranguren, Xabier L
Stem Cell Research, ISSN 1873-5061, 05/2017, Volume 21, Issue C, pp. 1 - 4
We generated ATCi-MF1 induced pluripotent stem (iPS) cell line from adult skin fibroblasts using non-integrative Sendai viruses carrying OCT3/4, KLF4, SOX2 and... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cell Line | Skin - cytology | Transduction, Genetic | Sendai virus | Skin - metabolism | Macaca fascicularis | Transcription Factors - biosynthesis | Transcription Factors - genetics | Animals | Fibroblasts - cytology | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Usage | Parainfluenza viruses | Stem cells | Physiological aspects | Fibroblasts | Kra | Research
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8. Full Text The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance
by Maiso, Patricia and Carvajal-Vergara, Xonia and Ocio, Enrique M and López-Pérez, Ricardo and Mateo, Gema and Gutiérrez, Norma and Atadja, Peter and Pandiella, Atanasio and San Miguel, Jesus F
Cancer Research, ISSN 0008-5472, 06/2006, Volume 66, Issue 11, pp. 5781 - 5789
Multiple myeloma represents an incurable disease, for which development of new therapies is required. Here, we report the effect on myeloma cells of LBH589, a... 
MOLECULAR SEQUELAE | PROTEIN | PROMYELOCYTIC LEUKEMIA | ONCOLOGY | SUBEROYLANILIDE HYDROXAMIC ACID | INDUCED APOPTOSIS | DOWN-REGULATION | SURFACE | DEATH | MECHANISMS | MULTIPLE-MYELOMA CELLS | Apoptosis - drug effects | Humans | Pyrazines - administration & dosage | Drug Resistance, Neoplasm | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Multiple Myeloma - drug therapy | Dexamethasone - pharmacology | Hydroxamic Acids - administration & dosage | Melphalan - pharmacology | bcl-X Protein - biosynthesis | Boronic Acids - administration & dosage | Indoles | Multiple Myeloma - enzymology | Hydroxamic Acids - pharmacology | Bortezomib | Dexamethasone - administration & dosage | Histone Deacetylases - metabolism | Drug Synergism | Acetylation - drug effects | Melphalan - administration & dosage | Multiple Myeloma - pathology | Cell Line, Tumor | Histone Deacetylase Inhibitors | Cell Cycle - drug effects | Pyrazines - pharmacology | Boronic Acids - pharmacology
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9. Full Text Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency
by Muñoz-López, Alvaro and Romero-Moya, Damià and Prieto, Cristina and Ramos-Mejía, Verónica and Agraz-Doblas, Antonio and Varela, Ignacio and Buschbeck, Marcus and Palau, Anna and Carvajal-Vergara, Xonia and Giorgetti, Alessandra and Ford, Anthony and Lako, Majlinda and Granada, Isabel and Ruiz-Xivillé, Neus and Rodríguez-Perales, Sandra and Torres-Ruíz, Raul and Stam, Ronald W and Fuster, Jose Luis and Fraga, Mario F and Nakanishi, Mahito and Cazzaniga, Gianni and Bardini, Michela and Cobo, Isabel and Bayon, Gustavo F and Fernandez, Agustin F and Bueno, Clara and Menendez, Pablo
Stem Cell Reports, ISSN 2213-6711, 10/2016, Volume 7, Issue 4, pp. 602 - 618
Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple... 
cancer reprogramming | B-ALL | DNA methylome | Sendai virus | transcriptome | iPSC | MLL-AF4 | CANCER-CELLS | MAINTENANCE | ACTIVATION | X-CHROMOSOME | ABNORMALITIES | EMBRYONIC STEM-CELLS | ADAPTATION | GENERATION | PROMOTES | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Translocation, Genetic | Humans | Precursor Cells, B-Lymphoid - metabolism | Transcriptome | Cell Transdifferentiation - genetics | Gene Expression Profiling | Cellular Reprogramming | DNA Methylation | Heterografts | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Myeloid Progenitor Cells - metabolism | Gene Expression | Hematopoietic Stem Cells - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Phenotype | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Gene Rearrangement | Biomarkers | Cell Line, Tumor | Mice | Cell Line, Transformed | Cluster Analysis
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10. Full Text Fast and Efficient Neural Conversion of Human Hematopoietic Cells
by Castaño, Julio and Menendez, Pablo and Bruzos-Cidon, Cristina and Straccia, Marco and Sousa, Amaia and Zabaleta, Lorea and Vazquez, Nerea and Zubiarrain, Amaia and Sonntag, Kai-Christian and Ugedo, Luisa and Carvajal-Vergara, Xonia and Canals, Josep Maria and Torrecilla, Maria and Sanchez-Pernaute, Rosario and Giorgetti, Alessandra
Stem Cell Reports, ISSN 2213-6711, 12/2014, Volume 3, Issue 6, pp. 1118 - 1131
Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of... 
PLURIPOTENT STEM-CELLS | MOUSE FIBROBLASTS | PROGENITOR CELLS | DEFINED FACTORS | INDUCED NEURONAL CELLS | FUNCTIONAL-NEURONS | CORD BLOOD | IN-VIVO | ADULT HUMAN FIBROBLASTS | DOPAMINERGIC-NEURONS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cellular Senescence - genetics | Leukocytes, Mononuclear - metabolism | Gene Expression | Cell Proliferation | Humans | Cells, Cultured | Glycoproteins - metabolism | Immunophenotyping | Neurons - cytology | Gene Expression Profiling | Fetal Blood - cytology | AC133 Antigen | Antigens, CD - metabolism | Phenotype | Peptides - metabolism | Membrane Potentials | Cell Transdifferentiation | Leukocytes, Mononuclear - cytology | Neurons - metabolism | Leucòcits | Leucocytes | Xarxes neuronals (Neurobiologia) | Cell physiology | Fisiologia cel·lular | Neural networks (Neurobiology)
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11. Full Text Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling
by Lee, Dung-Fang and Su, Jie and Ang, Yen-Sin and Carvajal-Vergara, Xonia and Mulero-Navarro, Sonia and Pereira, Carlos F and Gingold, Julian and Wang, Hung-Liang and Zhao, Ruiying and Sevilla, Ana and Darr, Henia and Williamson, Andrew J.K and Chang, Betty and Niu, Xiaohong and Aguilo, Francesca and Flores, Elsa R and Sher, Yuh-Pyng and Hung, Mien-Chie and Whetton, Anthony D and Gelb, Bruce D and Moore, Kateri A and Snoeck, Hans-Willem and Ma’ayan, Avi and Schaniel, Christoph and Lemischka, Ihor R
Cell Stem Cell, ISSN 1934-5909, 08/2012, Volume 11, Issue 2, pp. 179 - 194
Many signals must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC)... 
PHOSPHORYLATION | PATHWAY | GENES | SELF-RENEWAL | A KINASE | PATIENT | INDUCTION | STEM-CELL DIFFERENTIATION | NANOG EXPRESSION | P53 | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Xenopus | Cell Line | Embryonic Stem Cells - metabolism | Phosphorylation | Cell Proliferation | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Signal Transduction | Humans | Tumor Suppressor Protein p53 - metabolism | Aurora Kinases | Tumor Suppressor Protein p53 - deficiency | Tumor Suppressor Protein p53 - genetics | Mice, Knockout | Aurora Kinase A | Pluripotent Stem Cells - metabolism | Animals | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Differentiation | Mice | Protein-Serine-Threonine Kinases - metabolism | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
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12. Full Text Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines
by Blanco, Belén and Pérez-Simón, José A and Sánchez-Abarca, Luis I and Carvajal-Vergara, Xonia and Mateos, Juan and Vidriales, Belén and López-Holgado, Natalia and Maiso, Patricia and Alberca, Mercedes and Villarón, Eva and Schenkein, David and Pandiella, Atanasio and San Miguel, Jesús
Blood, ISSN 0006-4971, 05/2006, Volume 107, Issue 9, pp. 3575 - 3583
We explored the ability of the proteasome inhibitor bortezomib, which prevents nuclear factor kappa B (NF-kappa B) activation, to block T-cell activation,... 
TRANSCRIPTION FACTORS | MULTIPLE-MYELOMA | ALLOGENEIC TRANSPLANTATION | CELLS | APOPTOSIS | ACTIVATION | LEUKEMIA | INHIBITOR | HEMATOLOGY | NF-KAPPA-B | VERSUS-HOST-DISEASE | Isoantigens | Cell Survival - drug effects | Th1 Cells - drug effects | Bortezomib | Apoptosis - drug effects | Humans | Th1 Cells - immunology | Lymphocyte Culture Test, Mixed | Protease Inhibitors - pharmacology | Graft vs Host Disease - drug therapy | T-Lymphocytes - cytology | Lymphocyte Activation - drug effects | T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Th1 Cells - cytology | In Vitro Techniques | Pyrazines - pharmacology | Cytokines - biosynthesis | Boronic Acids - pharmacology
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13. Full Text Imatinib mesylate (STI571) inhibits multiple myeloma cell proliferation and potentiates the effect of common antimyeloma agents
by Pandiella, Atanasio and Carvajal‐Vergara, Xonia and Tabera, Soraya and Mateo, Gema and Gutiérrez, Norma and San Miguel, Jesús F
British Journal of Haematology, ISSN 0007-1048, 12/2003, Volume 123, Issue 5, pp. 858 - 868
c‐Kit has been shown to be mutated in several types of tumours, and its activity has been correlated with increased proliferation rates in a subset of multiple... 
imatinib mesylate | multiple myeloma | tyrosine kinase inhibitor | Tyrosine kinase inhibitor | Imatinib mesylate | Multiple myeloma | TYROSINE KINASE | GROWTH | TUMOR | PTEN | C-KIT | LEUKEMIA | LIGAND | HEMATOLOGY | EXPRESSION | Humans | Antineoplastic Agents - therapeutic use | Piperazines - therapeutic use | Multiple Myeloma - metabolism | Imatinib Mesylate | Cell Division - drug effects | Drug Synergism | Dexamethasone - therapeutic use | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Flow Cytometry | Pyrimidines - therapeutic use | Cell Line, Tumor | Benzamides | Enzyme Activation | Cell Cycle - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors
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14. Full Text Induced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders
by Josowitz, Rebecca and Carvajal-Vergara, Xonia and Lemischka, Ihor R and Gelb, Bruce D
Current Opinion in Cardiology, ISSN 0268-4705, 05/2011, Volume 26, Issue 3, pp. 223 - 229
PURPOSE OF REVIEWThe development of induced pluripotent stem cell (iPSC) technology has led to many advances in the areas of directed cell differentiation and... 
hypertrophic cardiomyopathy | induced pluripotent stem cells | LEOPARD syndrome | long-QT syndrome | LEOPARD-SYNDROME | PROGENITORS | DEFINED FACTORS | CARDIAC & CARDIOVASCULAR SYSTEMS | PTPN11 | NOONAN-SYNDROME | FIBROBLASTS | BODIES | DIFFERENTIATION | MUTATIONS | Myocytes, Cardiac | Humans | Fibroblasts | Long QT Syndrome - genetics | Cell Differentiation | Models, Genetic | Cardiovascular Diseases - genetics | Induced Pluripotent Stem Cells
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15. Full Text Role of metalloproteinases MMP‐9 and MT1‐MMP in CXCL12‐promoted myeloma cell invasion across basement membranes
by Parmo‐Cabañas, Marisa and Molina‐Ortiz, Isabel and Matías‐Román, Salomón and García‐Bernal, David and Carvajal‐Vergara, Xonia and Valle, Inmaculada and Pandiella, Atanasio and Arroyo, Alicia G and Teixidó, Joaquin
The Journal of Pathology, ISSN 0022-3417, 01/2006, Volume 208, Issue 1, pp. 108 - 118
Malignant plasma cells in multiple myeloma home to the bone marrow (BM), accumulate in different niches and, in late disease, migrate from the BM into blood.... 
migration | multiple myeloma | chemokines, metalloproteinases | invasion | Metalloproteinases | Migration | Chemokines | Invasion | Multiple myeloma | 1-MATRIX METALLOPROTEINASE | metalloproteinases | PATHOLOGY | chemokines | CANCER | MATRIX METALLOPROTEINASES | ADHESION | MARROW ENDOTHELIAL-CELLS | UP-REGULATION | EXPRESSION | HUMAN MULTIPLE-MYELOMA | Stromal Cells - pathology | Humans | Gene Expression Regulation, Neoplastic | Extracellular Matrix - metabolism | Neoplasm Proteins - metabolism | Basement Membrane - pathology | Cell Movement - physiology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Matrix Metalloproteinase 9 - metabolism | Laminin | Matrix Metalloproteinases, Membrane-Associated | Chemokine CXCL12 | Collagen Type I - metabolism | Proteoglycans | Neoplasm Invasiveness | Stromal Cells - metabolism | Matrix Metalloproteinases - analysis | Multiple Myeloma - metabolism | Basement Membrane - metabolism | Multiple Myeloma - pathology | Collagen | Chemokines, CXC - metabolism | Cell Line, Tumor | Biocompatible Materials | Matrix Metalloproteinases - metabolism | Drug Combinations
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16. Full Text Multifunctional role of Erk5 in multiple myeloma
by Carvajal-Vergara, Xonia and Tabera, Soraya and Montero, Juan C and Esparís-Ogando, Azucena and López-Pérez, Ricardo and Mateo, Gema and Gutiérrez, Norma and Parmo-Cabañas, Marisa and Teixidó, Joaquín and San Miguel, Jesús F and Pandiella, Atanasio
Blood, ISSN 0006-4971, 06/2005, Volume 105, Issue 11, pp. 4492 - 4499
Multiple myeloma is characterized by the accumulation of terminally differentiated B cells in the bone marrow, due to increased proliferation and restricted... 
SIGNAL-TRANSDUCTION | MAMMALIAN MAP KINASE | ACTIVATED PROTEIN-KINASE | INDUCED APOPTOSIS | ENDOTHELIAL-CELLS | GENE-EXPRESSION | CELL-PROLIFERATION | TYROSINE KINASES | GROWTH-FACTOR | HEMATOLOGY | 1 BMK1 | Bortezomib | Cell Proliferation | Signal Transduction | Humans | Enzyme Activation - drug effects | Multiple Myeloma - etiology | Multiple Myeloma - pathology | Dexamethasone - pharmacology | Interleukin-6 - pharmacology | Mitogen-Activated Protein Kinase 7 - analysis | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Multiple Myeloma - enzymology | Pyrazines - pharmacology | Mitogen-Activated Protein Kinase 7 - physiology | Apoptosis | Boronic Acids - pharmacology
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