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1. Full Text Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial
by Petrylak, Daniel and Petrylak, Daniel P and de Wit, Ronald and Chi, Kim Nguyen and Chi, Kim N and Drakaki, Alexandra and Sternberg, Cora N and Nishiyama, Hiroyuki and Castellano, Daniel and Hussain, Syed and Fléchon, Aude and Bamias, Aristotelis and Yu, Evan Y and van der Heijden, Michiel S and Matsubara, Nobuaki and Alekseev, Boris and Necchi, Andrea and Géczi, Lajos and Ou, Yen-Chuan and Coskun, Hasan Senol and Su, Yu-Li and Su, Wen-Pin and Hegemann, Miriam and Percent, Ivor and Percent, Ivor J and Lee, Yun-Gyoo and Lee, Hyo Jin and Lee, Jae-Lyun and Tucci, Marcello and Semenov, Andrey and Laestadius, Fredrik and Peer, Avivit and Tortora, Giampaolo and Safina, Sufia Z and Safina, Sufia and del Muro, Xavier Garcia and Rodriguez-Vida, Alejo and Cicin, Irfan and Harputluoglu, Hakan and Widau, Ryan C and Liepa, Astra M and Walgren, Richard A and Hamid, Oday and Zimmermann, Annamaria H and Bell-McGuinn, Katherine M and Powles, Thomas and Wong, Suet-Lai Shirley and Tan, Thean Hsiang and Hovey, Elizabeth Jane and Clay, Timothy Dudley and Ng, Siobhan Su Wan and Rutten, Annemie and Machiels, Jean-Pascal and Dumez, Herlinde and Cheng, Susanna Yee-Shan and Ferrario, Cristiano and Sengeloev, Lisa and Jensen, Niels Viggo and Thibault, Constance and Laguerre, Brigitte and Joly, Florence and Flechon, Aude and Culine, Stéphane and Becht, Catherine and Niegisch, Günter and Stöckle, Michael and Grimm, Marc-Oliver and Gakis, Georgios and Schultze-Seemann, Wolfgang and Kalofonos, Haralambos and Mavroudis, Dimitrios and Papandreou, Christos and Karavasilis, Vasilis and Révész, Janos and Geczi, Lajos and Rosenbaum, Eli and Leibowitz-Amit, Raya and Kejzman, Daniel and Sarid, David and Scagliotti, Giorgio Vittorio and Bracarda, Sergio and Massari, Francesco and Osawa, Takahiro and Miyajima, Naoto and Shinohara, Nobuo and Fukuta, Fumimasa and Ohyama, Chikara and Obara, Wataru and Yamashita, Shinichi and Tomita, Yoshihiko and Kawai, Koji and Fukasawa, Satoshi and Oyama, Masafumi and Yonese, Junji and Nagata, Masayoshi and Uemura, Motohide and Nishimura, Kazuo and Kawakita, Mutsushi and Tsunemori, Hiroyuki and Hashine, Katsuyoshi and ... and RANGE Study Investigators and RANGE study investigators
The Lancet, ISSN 0140-6736, 11/2017, Volume 390, Issue 10109, pp. 2266 - 2277
Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed... 
BLADDER-CANCER | MEDICINE, GENERAL & INTERNAL | 2ND-LINE THERAPY | TRANSITIONAL-CELL-CARCINOMA | CISPLATIN | DOXORUBICIN | METHOTREXATE | VINBLASTINE | OPEN-LABEL | COMBINATION | ENDOTHELIAL GROWTH-FACTOR | Carcinoma, Transitional Cell - mortality | Prognosis | Humans | Middle Aged | Male | Neoplasm Invasiveness - pathology | Urinary Bladder Neoplasms - pathology | Adult | Female | Urinary Bladder Neoplasms - mortality | Double-Blind Method | Risk Assessment | Docetaxel | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Urinary Bladder Neoplasms - drug therapy | Disease-Free Survival | Taxoids - administration & dosage | Carcinoma, Transitional Cell - pathology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Internationality | Neoadjuvant Therapy - methods | Carcinoma, Transitional Cell - drug therapy | Survival Analysis | Aged | Neoplasm Staging | Antimitotic agents | Care and treatment | Carcinoma | Analysis | Clinical trials | Product development | Metastasis | Antineoplastic agents | Cancer | Cytotoxicity | Oncology | Patients | Cancer therapies | Metastases | Angiogenesis | Chemotherapy | Platinum | Medical prognosis | Ligands | Clinical medicine | Urothelial carcinoma | Vascular endothelial growth factor | Apoptosis
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2. Full Text Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
by Rosenberg, Jonathan E, Dr and Hoffman-Censits, Jean, MD and Powles, Tom, Prof and van der Heijden, Michiel S, Prof and Balar, Arjun V, MD and Necchi, Andrea, MD and Dawson, Nancy, Prof and O'Donnell, Peter H, MD and Balmanoukian, Ani, MD and Loriot, Yohann, MD and Srinivas, Sandy, MD and Retz, Margitta M, Prof and Grivas, Petros, MD and Joseph, Richard W, MD and Galsky, Matthew D, MD and Fleming, Mark T, MD and Petrylak, Daniel P, Prof and Perez-Gracia, Jose Luis, MD and Burris, Howard A, MD and Castellano, Daniel, MD and Canil, Christina, MD and Bellmunt, Joaquim, MD and Bajorin, Dean, Prof and Nickles, Dorothee, PhD and Bourgon, Richard, PhD and Frampton, Garrett M, PhD and Cui, Na, PhD and Mariathasan, Sanjeev, PhD and Abidoye, Oyewale, MD and Fine, Gregg D, MD and Dreicer, Robert, Prof
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10031, pp. 1909 - 1920
Summary Background Patients with metastatic urothelial carcinoma have few treatment options after failure of platinum-based chemotherapy. In this trial, we... 
Internal Medicine | CELL LUNG-CANCER | UNTREATED MELANOMA | CTLA-4 BLOCKADE | BLADDER-CANCER | MEDICINE, GENERAL & INTERNAL | SOLID TUMORS | PROGRAMMED DEATH-1 | PD-1 BLOCKADE | IMMUNE-RELATED RESPONSE | RANDOMIZED-TRIAL | NIVOLUMAB | Humans | Middle Aged | Immunoglobulins, Intravenous - administration & dosage | Male | Response Evaluation Criteria in Solid Tumors | Antineoplastic Agents - administration & dosage | Cisplatin - administration & dosage | Neoplasm Metastasis | Antibodies, Monoclonal, Humanized - administration & dosage | Urologic Neoplasms - drug therapy | Urologic Neoplasms - genetics | Aged, 80 and over | Adult | Female | Drug Administration Schedule | Carboplatin - administration & dosage | Treatment Outcome | Mutation - genetics | B7-H1 Antigen - immunology | Disease Progression | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Infusions, Intravenous | Medical colleges | Care and treatment | Chemotherapy | Carcinoma | Clinical trials | Monoclonal antibodies | Metastasis | Research institutes | Cancer | Analysis | Immunotherapy | Medical prognosis | Ligands | Genomes | Mutation | Gene expression | Cancer therapies | Bladder cancer | Tumors
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3. Full Text Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study
by Leiter, L. A and Lundman, P and da Silva, P. M and xel, H and Jünger, C and Gitt, A. K and Absenger, Guun and Albrich, Ernst and Allinger, Berndt and Allinger, Stephan and Anacher, Gerald and Angermayr, Gertraud and Angermeier, Hermann and Anzengruber, Aneas and Archimanitis, Gabriele and Arnsteiner, Patricia and Auberger, Wolfgang and Azhary, Mawaheb and Barfuss, Michael and Bauer, Christian and Bauer, Birgit Elisabeth and Beclin, Thomas and Binder, Thomas and Binder, Gabriele and Böhler, Dietmar and Brändle, Johann and Breslmair, Jörg and Brettlecker, Marlis and Bürger, Michael and Calvi, Inge and Dorfinger, Werner and Doringer-Schnepf, Elisabeth and Eer, Anton and Eckmayr, Christine and Eder, Franz and Egermann, Margit and Erath, Michael and Etzinger, Michael and Etzinger, Claudia and Fiedler, Lothar and Filip, Wolfgang and Filip, Michaela and Föchterle, Johann and Fodor, Anita and Frieden, Thomas and Gareiss, Mertens and Gföllner, Peter and Ghamarian, Thomas and Goritschan, Michael and Haar, Klaus and Habeler, Gerhard and Hadjiivanov, Valery and Haiböck, Christian and Hammer, Regina and Hartmann, Siegfried and Haschkovitz, Herbert and Hauer, Walter and Hauer, Josef and Haunschmidt, Christian and Heimayr, Christine and Hengl, Wolfgang and Hengl, Gunter and Hermann, Rudolf and Herrmann, Rainer and Hillebrand, Roswitha and Hintersteininger, Otto and Hirsch, Michael and Hitzinger, Martin and Hochegger, Tanja and Hockl, Wolfgang and Hoi, Michael and Hörmann, Jan and Hudler, Brigitte and Imb, Gerhard and Joichl, Anea and Jungbauer, Karl and Kapl, Gerlinde and Kerschbaum, Margit and Kienesberger, Franz and Killinger, Gerhard and Kitzler, Gerhard and Klein, Franz and Kleinbichler, Dietmar and Kohr, Anton and Kopetzky, Michael and Korthals, Christian and Kortschak, Werner and Koschutnik, Martin and Kraus, Werner A and Kurzemann, Susanne and Lavicka, Claus and Lehner, Guido and Lenz, Jürgen and Lepuschütz, Sabine and Lichtenwallner, Michael and Lober, Reinhard and Loidl, Christine and Lopatka, Eduard and Ludwig, Rudolf and Maca, Thomas and ... and DYSIS Investigators and DYSIS investigators
Diabetic medicine, ISSN 0742-3071, 2011, Volume 28, Issue 11, pp. 1343 - 1351
To assess the prevalence of persistent lipid abnormalities in statin-treated patients with diabetes with and without the metabolic syndrome. This was a... 
metabolic syndrome | cardiovascular disease | diabetes mellitus | dyslipidaemia | statins | Cardiovascular disease | Dyslipidaemia | Metabolic syndrome | Diabetes mellitus | Statins | METAANALYSIS | GUIDELINES | PREVENTION | DENSITY-LIPOPROTEIN CHOLESTEROL | THERAPY | REDUCTION | ENDOCRINOLOGY & METABOLISM | CORONARY-HEART-DISEASE | CLINICAL-PRACTICE | CARDIOVASCULAR RISK | LOW HDL-CHOLESTEROL | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Humans | Diabetic Angiopathies - etiology | Male | Metabolic Syndrome - drug therapy | Diabetes Mellitus, Type 2 - epidemiology | Metabolic Syndrome - blood | Canada - epidemiology | Cardiovascular Diseases - epidemiology | Cholesterol, LDL - blood | Female | Dyslipidemias - etiology | Diabetes Mellitus, Type 2 - complications | Metabolic Syndrome - epidemiology | Cardiovascular Diseases - etiology | Diabetic Angiopathies - chemically induced | Cross-Sectional Studies | Cholesterol, HDL - drug effects | Europe - epidemiology | Cholesterol, LDL - drug effects | Diabetic Angiopathies - blood | Anticholesteremic Agents - adverse effects | Metabolic Syndrome - complications | Diabetes Mellitus, Type 2 - blood | Dyslipidemias - epidemiology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Anticholesteremic Agents - administration & dosage | Dyslipidemias - chemically induced | Cholesterol, HDL - blood | Diabetic Angiopathies - epidemiology | Aged | Cardiovascular Diseases - chemically induced | Diabetes Mellitus, Type 2 - drug therapy | Diabetics | Blood cholesterol | Simvastatin | Low density lipoproteins | Triglycerides | Diabetes | Risk factors | Trans fatty acids
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