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1. Full Text Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase
by Rizo, Alexandrea N and Lin, JiaBei and Gates, Stephanie N and Tse, Eric and Bart, Stephen M and Castellano, Laura M and DiMaio, Frank and Shorter, James and Southworth, Daniel R
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2393 - 12
Bacterial ClpB and yeast Hsp104 are homologous Hsp100 protein disaggregases that serve critical functions in proteostasis by solubilizing protein aggregates.... 
Binding | Translocation | Yeast | Polypeptides | ClpB protein | Homology | Trimers | Substrates | Proteins | Domains | Casein | HSP100 protein | Adenosine triphosphate
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2. Full Text Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases
by Durie, Clarissa L and Lin, JiaBei and Scull, Nathaniel W and Mack, Korrie L and Jackrel, Meredith E and Sweeny, Elizabeth A and Castellano, Laura M and Shorter, James and Lucius, Aaron L
Biophysical Journal, ISSN 0006-3495, 05/2019, Volume 116, Issue 10, pp. 1856 - 1872
Heat shock protein (Hsp) 104 is a hexameric ATPases associated with diverse cellular activities motor protein that enables cells to survive extreme stress.... 
CLPA CHAPERONE | ATP-DEPENDENT TRANSLOCATION | BIOPHYSICS | DNA | ESCHERICHIA-COLI | STEP-SIZE | CENTRAL PORE | COMMON MECHANISM | SINGLE TURNOVER KINETICS | STOPPED-FLOW | PROTEIN DISAGGREGATION | Proteins | Hydrolysis | Medical colleges | Nervous system diseases | Analysis | Heat shock proteins | Adenosine triphosphatase | Protein binding
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3. Full Text Potentiated Hsp104 Variants Antagonize Diverse Protein Misfolding Events
by Jackrel, Meredith E and DeSantis, Morgan E and Castellano, Laura M and Shorter, James
Biophysical Journal, ISSN 0006-3495, 01/2013, Volume 104, Issue 2, pp. 570a - 570a
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4. Full Text Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events
by Jackrel, Meredith E and DeSantis, Morgan E and Martinez, Bryan A and Castellano, Laura M and Stewart, Rachel M and Caldwell, Guy A and Caldwell, Kim A and Shorter, James
Cell, ISSN 0092-8674, 01/2014, Volume 156, Issue 1-2, pp. 170 - 182
There are no therapies that reverse the proteotoxic misfolding events that underpin fatal neurodegenerative diseases, including amyotrophic lateral sclerosis... 
PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURONS | DISORDERS | TOXICITY | AMYOTROPHIC-LATERAL-SCLEROSIS | MODEL | MUTATIONS | CHAPERONE | AGGREGATION | DISAGGREGATION | CELL BIOLOGY | Parkinson Disease - therapy | Proteostasis Deficiencies - metabolism | Neurons - pathology | Proteostasis Deficiencies - therapy | Humans | Neurons - cytology | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Parkinson Disease - metabolism | Disease Models, Animal | Protein Structure, Tertiary | Parkinson Disease - pathology | Animals, Genetically Modified | Heat-Shock Proteins - metabolism | Proteostasis Deficiencies - pathology | Models, Molecular | RNA-Binding Protein FUS - metabolism | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | Caenorhabditis elegans | Animals | Mutagenesis | Saccharomyces cerevisiae Proteins - metabolism | alpha-Synuclein - metabolism | Heat-Shock Proteins - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Heat shock proteins | Amyotrophic lateral sclerosis | Nervous system diseases | Analysis | Adenosine triphosphatase
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5. Flexible CO2 laser fiber: First look at the learning curve required in gynecological laparoscopy training
by Vanni, Valeria S and Ottolina, Jessica and Candotti, Giorgio and Castellano, Laura M and Tandoi, Iacopo and De Stefano, Francesca and Poppi, Giorgia and Ferrari, Stefano and Candiani, Massimo
Minerva Ginecologica, ISSN 0026-4784, 02/2018, Volume 70, Issue 1, pp. 53 - 57
Laparoscopy | Fiber optic technology | Learning curve | Laser
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6. Flexible CO2 laser fiber: first look at the learning curve required in gynecological laparoscopy training
by Vanni, Valeria S and Ottolina, Jessica and Candotti, Giorgio and Castellano, Laura M and Tandoi, Iacopo and DE Stefano, Francesca and Poppi, Giorgia and Ferrari, Stefano and Candiani, Massimo
Minerva ginecologica, 02/2018, Volume 70, Issue 1, p. 53
The advent of flexible CO2 laser fiber to gynecology arena might represent a turning point in the use of laser energy on a large-scale basis in gynecological... 
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7. The impact on ovarian reserve of CO2 laser fiber vaporization in the treatment of ovarian endometrioma: A prospective clinical trial
by Ottolina, Jessica and Castellano, Laura M and Ferrari, Stefano and Tandoi, Iacopo and Candotti, Giorgio and De Stefano, Francesca and Bartiromo, Ludovica and Candiani, Massimo
Journal of Endometriosis and Pelvic Pain Disorders, ISSN 2284-0265, 07/2017, Volume 9, Issue 3, pp. 206 - 210
laser | Endometrioma | Surgery | Ovarian reserve | Fiber
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8. Full Text Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure–activity relationships
by Cabrera, Mauricio and Simoens, Macarena and Falchi, Gabriela and Lavaggi, M. Laura and Piro, Oscar E and Castellano, Eduardo E and Vidal, Anabel and Azqueta, Amaia and Monge, Antonio and de Ceráin, Adela López and Sagrera, Gabriel and Seoane, Gustavo and Cerecetto, Hugo and González, Mercedes
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 10, pp. 3356 - 3367
A wide series of synthetic flavonoids, with druglikeness properties, were developed and evaluated as antitumoral agents against TK-10, MCF-7, and HT-29 human... 
Flavonoids | Antitumoral | QSAR | Comet assay | ANTIOXIDANT ACTIVITY | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | CELL LINES | CHEMISTRY, ORGANIC | CANCER | 2-HYDROXYCHALCONES | INHIBITION | comet assay | POTENTIAL HYPOXIC CYTOTOXINS | ANTICANCER | antitumoral | BEARING | flavonoids | N-OXIDE DERIVATIVES | Magnetic Resonance Spectroscopy | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Chromatography, Thin Layer | Comet Assay | DNA, Neoplasm - drug effects | Flavones - chemical synthesis | Spectrophotometry, Infrared | Chalcones - chemical synthesis | Chromosome Aberrations - drug effects | X-Ray Diffraction | Mass Spectrometry | Chalcones - pharmacology | Cell Line, Tumor | Indicators and Reagents | Antineoplastic Agents - pharmacology | DNA Damage | Flavones - pharmacology | Drug Screening Assays, Antitumor
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9. Full Text Suramin inhibits Hsp104 ATPase and disaggregase activity
by Torrente, Mariana P and Castellano, Laura M and Shorter, James
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e110115
Hsp104 is a hexameric AAA+ protein that utilizes energy from ATP hydrolysis to dissolve disordered protein aggregates as well as amyloid fibers. Interestingly,... 
FIREFLY LUCIFERASE | SACCHAROMYCES-CEREVISIAE HSP104 | AGENT GUANIDINIUM CHLORIDE | PRION PROPAGATION | MULTIDISCIPLINARY SCIENCES | AGGREGATED PROTEINS | PROMISCUOUS INHIBITORS | COMMON MECHANISM | NUCLEOTIDE-BINDING | MIDDLE DOMAIN | PROTEIN DISAGGREGATION | Molecular Chaperones | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Heat-Shock Proteins - metabolism | Adenosine Triphosphatases - metabolism | Heat-Shock Proteins - antagonists & inhibitors | Protein Aggregation, Pathological - drug therapy | Suramin - chemistry | Saccharomyces cerevisiae - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | Small Molecule Libraries - chemistry | Animals | Protein Binding - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Small Molecule Libraries - isolation & purification | Protein Aggregation, Pathological - metabolism | Suramin - pharmacology | Heat-Shock Proteins - chemistry | Protein Aggregates - drug effects | Protein Structure, Tertiary - drug effects | Saccharomyces cerevisiae Proteins - chemistry | Hydrolysis | Heat shock proteins | Adenosine triphosphatase | Suramin | ClpB protein | Disease | Homology | Biochemistry | Translocase | Parasites | Kinases | Fibers | Proteins | E coli | Cell cycle | Amyloid | Inhibition | African trypanosomiasis | Adenosine triphosphate | Vector-borne diseases | Hexamers | Glycerol | Hsp70 protein | Biophysics | Hsp40 protein | Medical screening | Side effects | Inhibitors | Collaboration | Mutation | Binding sites | Heat shock | Structure-function relationships
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10. Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior
by Turner, Jill R and Castellano, Laura M and Blendy, Julie A
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 08/2010, Volume 334, Issue 2, pp. 665 - 672
Clinical and preclinical studies suggest that nicotinic acetylcholine receptors are involved in affective disorders; therefore, the potential therapeutic value... 
INDUCED HYPOPHAGIA TEST | SMOKING-CESSATION | DEPRESSION | ACETYLCHOLINE-RECEPTORS | ANTIDEPRESSANTS | RAT | PHARMACOLOGY & PHARMACY | FORCED SWIM TEST | MICE | FLUOXETINE | ALPHA-4-BETA-2 | Mood Disorders - drug therapy | Drug Partial Agonism | Mood Disorders - psychology | Varenicline | Anxiety - psychology | Male | Anxiety - drug therapy | Azetidines - pharmacology | Benzazepines - pharmacology | Nicotinic Agonists - therapeutic use | Nicotine - pharmacology | Quinoxalines - pharmacology | Depression - drug therapy | Animals | Azetidines - therapeutic use | Benzazepines - therapeutic use | Depression - psychology | Behavior, Animal - drug effects | Mice | Pyridines - pharmacology | Nicotinic Agonists - pharmacology | Chimera | Pyridines - therapeutic use | Quinoxalines - therapeutic use
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11. Full Text Impact of an Online Training Program in Smoking Cessation Interventions in Hospitals
by Martínez, Cristina and Castellano, Yolanda and Andrés, Ana and Fu, Marcela and Feliu, Ariadna and Antón, Laura and Ballbè, Montse and Fernández, Paz and Cabrera, Sandra and Riccobene, Ana and Gavilan, Eva and Baena, Antoni and Margalef, Mercè and Tigova, Olena and Quirós, Núria and Guillen, Olga and Company, Assumpta and Fernández, Esteve
Journal of Nursing Scholarship, ISSN 1527-6546, 07/2019, Volume 51, Issue 4, pp. 449 - 458
Purpose To assess changes in the self‐reported performance of smoking cessation interventions according to the 5A's model (Ask; Advise; Assess; Assist; and... 
brief intervention | tobacco cessation | smoking cessation | Barriers | healthcare workers | online training | health organizations | nurses | METAANALYSIS | DETERMINANTS | NURSING | KNOWLEDGE | PRACTICE NURSES INTENTION | EDUCATION | PREVALENCE | CARE PROVIDERS | ATTITUDES | SMOKERS | BEHAVIORS | Training | Smoking cessation programs | Services | Usage | Hospitals | Nurses | Practice | Intervention | Health care | Incorporation | Nurse practitioners | Competence | Physicians | Self | Implementation | Smoking cessation | Motivation | Education | Questionnaires | Online instruction | Preparedness | Clinical training | Assistance | Medical personnel | Behavioural aspects | Cessation | Change agents | Clinical practice | Tobacco | Nursing | Facilitators | Clinical medicine | Organizational factors | Smoking
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12. Full Text Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events
by Michalska, Karolina and Zhang, Kaiming and March, Zachary M and Hatzos-Skintges, Catherine and Pintilie, Grigore and Bigelow, Lance and Castellano, Laura M and Miles, Leann J and Jackrel, Meredith E and Chuang, Edward and Jedrzejczak, Robert and Shorter, James and Chiu, Wah and Joachimiak, Andrzej and SLAC National Accelerator Lab., Menlo Park, CA (United States) and Argonne National Lab. (ANL), Argonne, IL (United States)
Structure, ISSN 0969-2126, 03/2019, Volume 27, Issue 3, pp. 449 - 463.e7
Hsp104 is an AAA+ protein disaggregase with powerful amyloid-remodeling activity. All nonmetazoan eukaryotes express Hsp104 while eubacteria express an Hsp104... 
DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPONENTS | MODEL | MICROSCOPY | CELL BIOLOGY | REFINEMENT | BIOPHYSICS | MAPS | MUTATIONS | PROTEINS | BINDING | PLASTICITY | Heat shock proteins | Medical colleges | Nervous system diseases | Structure | Molecular biology | Crystals | BASIC BIOLOGICAL SCIENCES
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13. Full Text Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline
by Turner, Jill R and Castellano, Laura M and Blendy, Julie A
Nicotine and Tobacco Research, ISSN 1462-2203, 2011, Volume 13, Issue 1, pp. 41 - 46
Introduction: Clinical and preclinical studies suggest that regulation of nicotinic acetylcholine receptors (nAChR) maybe involved in the etiology of... 
CHOLINERGIC-RECEPTOR | SMOKING-CESSATION | PARTIAL AGONISTS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SAZETIDINE-A | MARBLE-BURYING BEHAVIOR | SMOKERS | ABSTINENCE | IN-VIVO | SENSITIVITY | SUBSTANCE ABUSE | BRAIN | Receptors, Nicotinic - metabolism | Thalamus - metabolism | Varenicline | Male | Benzazepines - pharmacology | Hippocampus - drug effects | Thalamus - drug effects | Cerebral Cortex - metabolism | Nicotine - pharmacology | Quinoxalines - pharmacology | Up-Regulation - drug effects | Hippocampus - metabolism | Animals | Substance Withdrawal Syndrome - metabolism | Mice | Cerebral Cortex - drug effects | Smoking Cessation | Brief Reports
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14. Full Text A molecular tweezer antagonizes seminal amyloids and HIV infection
by Lump, Edina and Castellano, Laura M and Meier, Christoph and Seeliger, Janine and Erwin, Nelli and Sperlich, Benjamin and Stürzel, Christina M and Usmani, Shariq and Hammond, Rebecca M and Von Einem, Jens and Gerold, Gisa and Kreppel, Florian and Bravo-Rodriguez, Kenny and Pietschmann, Thomas and Holmes, Veronica M and Palesch, David and Zirafi, Onofrio and Weissman, Drew and Sowislok, Andrea and Wettig, Burkhard and Heid, Christian and Kirchhoff, Frank and Weil, Tanja and Klärner, Frank-Gerrit and Schrader, Thomas and Bitan, Gal and Sanchez-Garcia, Elsa and Winter, Roland and Shorter, James and Münch, Jan
eLife, ISSN 2050-084X, 08/2015, Volume 4, Issue 2015
Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components... 
FIBRIL FORMATION | REPLICATION | HEPATITIS-C VIRUS | ALZHEIMERS-DISEASE | BIOLOGY | CANDIDATE MICROBICIDES | FORCE-FIELD | HUMAN-IMMUNODEFICIENCY-VIRUS | CELL-LINES | SEXUAL TRANSMISSION | SEMEN-MEDIATED ENHANCEMENT | Anti-HIV Agents - pharmacology | Amyloid - antagonists & inhibitors | HIV Infections - prevention & control | Humans | Semen - chemistry | Semen - drug effects | Male | Disease Transmission, Infectious - prevention & control | Organophosphates - pharmacology | Bridged-Ring Compounds - pharmacology | HIV Infections - transmission | Semen - virology | Antimetabolites - pharmacology
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15. Full Text Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection
by Castellano, Laura M and Bart, Stephen M and Holmes, Veronica M and Weissman, Drew and Shorter, James
Chemistry & Biology, ISSN 1074-5521, 08/2015, Volume 22, Issue 8, pp. 1074 - 1086
Naturally occurring proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) form amyloid fibrils in... 
NEURODEGENERATIVE DISEASE | FIBRIL FORMATION | PRION PROPAGATION | SEMEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING DOMAIN | DISORDERS | SEXUAL TRANSMISSION | MIDDLE DOMAIN | PEPTIDE | PROTEIN DISAGGREGATION | Anti-HIV Agents - pharmacology | HIV-1 | Amyloid - antagonists & inhibitors | Cell Line | Saccharomyces cerevisiae Proteins - pharmacology | Humans | Semen - chemistry | Semen - drug effects | Male | Peptide Fragments - pharmacology | Amyloid - chemistry | Saccharomyces cerevisiae Proteins - chemical synthesis | Heat-Shock Proteins - pharmacology | Anti-HIV Agents - chemical synthesis | Peptide Fragments - chemical synthesis | Amyloidogenic Proteins - metabolism | Anti-HIV Agents - chemistry | Peptide Fragments - chemistry | Heat-Shock Proteins - chemical synthesis | Proteolysis | HIV Infections - drug therapy | Heat-Shock Proteins - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Virus diseases | Heat shock proteins | HIV (Viruses) | Proteases | Health aspects | HIV infection | Medical colleges | Phosphatases
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