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chemistry (11) 11
heterocyclic compounds (11) 11
metallurgy (11) 11
organic chemistry (11) 11
index medicus (9) 9
article (8) 8
female (8) 8
animals (7) 7
breast cancer (7) 7
cell line, tumor (7) 7
human necessities (7) 7
humans (7) 7
hygiene (7) 7
medical or veterinary science (7) 7
metastasis (7) 7
preparations for medical, dental, or toilet purposes (7) 7
breast neoplasms - pathology (6) 6
mice (6) 6
oncology (6) 6
apoptosis (5) 5
breast neoplasms - drug therapy (5) 5
cancer (5) 5
cell proliferation - drug effects (5) 5
resveratrol (5) 5
antineoplastic agents - pharmacology (4) 4
breast-cancer cells (4) 4
human breast-cancer (4) 4
investigating or analysing materials by determining theirchemical or physical properties (4) 4
measuring (4) 4
physics (4) 4
rac (4) 4
testing (4) 4
tumors (4) 4
vitis - chemistry (4) 4
activation (3) 3
bioavailability (3) 3
catechin - pharmacology (3) 3
cell survival - drug effects (3) 3
down-regulation (3) 3
ehop-016 (3) 3
growth (3) 3
inhibitors (3) 3
kinases (3) 3
mcf-7 cells (3) 3
mice, nude (3) 3
polyphenols (3) 3
proteins (3) 3
proto-oncogene proteins c-akt - metabolism (3) 3
quercetin (3) 3
quercetin - pharmacology (3) 3
research (3) 3
rho-gtpases (3) 3
skin and connective tissue diseases (3) 3
small-molecule inhibitor (3) 3
specific therapeutic activity of chemical compounds ormedicinal preparations (3) 3
stilbenes - pharmacology (3) 3
actin (2) 2
actin cytoskeleton (2) 2
akt protein (2) 2
ampk (2) 2
angiogenesis (2) 2
apoptosis - drug effects (2) 2
biochemistry & molecular biology (2) 2
breast neoplasms - genetics (2) 2
breast neoplasms - metabolism (2) 2
breast tumors (2) 2
carbazoles - chemistry (2) 2
carbazoles - pharmacology (2) 2
catechin (2) 2
catechin - therapeutic use (2) 2
cdc42 (2) 2
cell cycle - drug effects (2) 2
cell migration (2) 2
cell movement - drug effects (2) 2
cells (2) 2
chromatography, high pressure liquid - methods (2) 2
development and progression (2) 2
drug design (2) 2
estrogen (2) 2
food and beverages (2) 2
grape polyphenols (2) 2
grapes (2) 2
in-vivo (2) 2
inhibition (2) 2
invasion (2) 2
mass spectrometry (2) 2
mda-mb-435 cells (2) 2
metastases (2) 2
mice, scid (2) 2
migration (2) 2
neoplasm metastasis (2) 2
nutrition & dietetics (2) 2
quercetin - therapeutic use (2) 2
rac1 gtp-binding protein - antagonists & inhibitors (2) 2
rac1 gtp-binding protein - chemistry (2) 2
rac1 gtp-binding protein - genetics (2) 2
red wine polyphenols (2) 2
research article (2) 2
rodents (2) 2
seed extract (2) 2
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1. Full Text Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade
by Rivera Rivera, Amilcar and Castillo-Pichardo, Linette and Gerena, Yamil and Dharmawardhane, Suranganie
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 6, pp. e0157251 - e0157251
The Akt/adenosine monophosphate protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway has emerged as a critical signaling nexus for regulating... 
MOLECULAR TARGETS | INHIBITION | MAMMARY-TUMOR GROWTH | RED WINE POLYPHENOLS | PI3K PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | AMPK | FLAVONOID QUERCETIN | GRAPE SEED EXTRACT | CELL-LINE | AMP-Activated Protein Kinases - metabolism | Vitis - chemistry | Stilbenes - therapeutic use | TOR Serine-Threonine Kinases - metabolism | Humans | Stilbenes - chemistry | Stilbenes - pharmacology | Breast - metabolism | Breast Neoplasms - metabolism | Neoplasm Metastasis - prevention & control | Resveratrol | Catechin - therapeutic use | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Catechin - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Breast - pathology | Quercetin - chemistry | Quercetin - therapeutic use | Antineoplastic Agents, Phytogenic - chemistry | Mice, SCID | Breast Neoplasms - drug therapy | Animals | Quercetin - pharmacology | Signal Transduction - drug effects | Breast - drug effects | Breast Neoplasms - pathology | Mice, Nude | Neoplasm Metastasis - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Catechin - chemistry | Complications and side effects | Care and treatment | Development and progression | Rapamycin | Breast cancer | Metastasis | Research | Health aspects | Risk factors | Energy metabolism | Body weight | AKT protein | Biochemistry | Metastases | Proteins | Angiogenesis | Signal transduction | Cell growth | Polyphenols | Tumorigenesis | Inhibition | Growth factors | AMP | Metabolism | Mammals | Fatty acids | Disease prevention | Ribosomal protein S6 kinase | Energy balance | Flavonoids | Grapes | Protein synthesis | Weight reduction | Quercetin | Mice | Cell migration | Metabolic disorders | TOR protein | Cell proliferation | Surgical implants | Phosphorylation | Homeostasis | Kinases | Cell cycle | G1 phase | Catechin | Adenosine monophosphate | Medicine | Signaling | Protein kinase | Adenosine kinase | Apoptosis | Tumors | Cancer | Index Medicus
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2. Full Text Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice
by Castillo-Pichardo, Linette and Cubano, Luis A and Dharmawardhane, Suranganie
BMC Complementary and Alternative Medicine, ISSN 1472-6882, 01/2013, Volume 13, Issue 1, pp. 6 - 6
Background: Resveratrol, a polyphenol from grapes and red wine has many health beneficial effects, including protection against cardiovascular and... 
Breast cancer | Metastasis | Rac | Resveratrol | Grape polyphenols | APOPTOSIS | ACTIVATION | MECHANISMS | BIOAVAILABILITY | BREAST-CANCER CELLS | INHIBITION | MDA-MB-435 CELLS | INTEGRATIVE & COMPLEMENTARY MEDICINE | ESTROGEN | RECEPTORS | MODULATION | Stilbenes - adverse effects | Receptors, Estrogen - metabolism | Vitis - chemistry | Immunologic Deficiency Syndromes - complications | Breast Neoplasms - etiology | Mice, Hairless | p21-Activated Kinases - metabolism | Breast Neoplasms - metabolism | Estrogen Receptor beta - metabolism | Neoplasm Metastasis | Animals | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Estrogen Receptor alpha - metabolism | Female | Polyphenols - adverse effects | Mice | Breast Neoplasms - chemically induced | Proto-Oncogene Proteins c-akt - metabolism | Plant Extracts - adverse effects | Wine | Nervous system diseases | Breast tumors | Growth | Estrogen | Dietary supplements | Research | Statistics | Prevention | Grapes | Physiological aspects | Polyphenols | Cancer | Proteins | Studies | Medical research | Rodents | Kinases | Tumors
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3. Full Text Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein
by de la Parra, Columba and Castillo-Pichardo, Linette and Cruz-Collazo, Ailed and Cubano, Luis and Redis, Roxana and Calin, George A and Dharmawardhane, Suranganie
Nutrition and Cancer, ISSN 0163-5581, 01/2016, Volume 68, Issue 1, pp. 154 - 164
We previously reported that dietary genistein inhibits mammary tumor growth and metastasis of the highly metastatic MDA-MB-435 cancer cells in... 
APOPTOSIS | IN-VITRO | HISTONE MODIFICATION | NUTRITION & DIETETICS | ONCOLOGY | PROSTATE-CANCER CELLS | TUMOR-SUPPRESSOR GENES | GROWTH | CYCLE ARREST | HUMAN BREAST-CANCER | UP-REGULATION | RENAL-CANCER | Cell Survival - drug effects | Breast Neoplasms - genetics | MCF-7 Cells | Breast Neoplasms - pathology | MicroRNAs - analysis | Down-Regulation | Humans | PTEN Phosphohydrolase - analysis | Genistein - pharmacology | Female | Antineoplastic Agents - pharmacology | Breast Neoplasms - drug therapy | Breast cancer | Metastasis | Soy products | Apoptosis
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4. Full Text Abstract 4185: The novel Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer
by Crespo, Grace E. Velez and Hernández, Eliud and Vlaar, Cornelis and Dharmawardhane, Suranganie and Castillo-Pichardo, Linette
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4185 - 4185
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5. Full Text Abstract 1905: New targeted therapeutics for gastric cancer
by Calderon, Jean F. Ruiz and Cruz-Correa, Marcia and Calin, George A and Castillo-Pichardo, Linette and Dharmawardhane, Suranganie
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1905 - 1905
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6. Full Text Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer
by Castillo-Pichardo, Linette and Dharmawardhane, Suranganie F
Nutrition and Cancer, ISSN 0163-5581, 10/2012, Volume 64, Issue 7, pp. 1058 - 1069
We recently reported that a combination of dietary grape polyphenols resveratrol, quercetin, and catechin (RQC), at low concentrations, was effective at... 
TYROSINE KINASE INHIBITORS | MAMMALIAN TARGET | RED WINES | GROWTH-FACTOR RECEPTOR | QUERCETIN | RESVERATROL | NUTRITION & DIETETICS | ONCOLOGY | PHASE-II | PHENOLIC CONTENT | SEED EXTRACT | TUMOR-GROWTH | Vitis - chemistry | Antibiotics, Antineoplastic - pharmacology | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Polyphenols - pharmacology | Stilbenes - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | TOR Serine-Threonine Kinases - genetics | Adenylate Kinase - metabolism | Caspase 3 - genetics | Female | Antineoplastic Agents - pharmacology | Catechin - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Gene Expression Regulation | Mice, SCID | Breast Neoplasms - drug therapy | Sirolimus - pharmacology | Xenograft Model Antitumor Assays | Animals | Quercetin - pharmacology | Breast Neoplasms - pathology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Quinazolines - pharmacology | Adenylate Kinase - genetics | AMPK | gefitinib | grape polyphenols | Akt | mTOR signaling | potentiation
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7. Full Text Abstract 181: Discovery of novel targeted therapeutics for metastatic breast cancer
by Valle, Cristina Del and Hernández, Eliud and Vlaar, Cornelis P and Cubano, Luis A and Dharmawardhane, Suranganie and Castillo-Pichardo, Linette
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 181 - 181
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8. Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer
by Linette Castillo-Pichardo and Suranganie F Dharmawardhane
Nutrition and Cancer, ISSN 0163-5581, 10/2012, Volume 64, Issue 7, p. 1058
  We recently reported that a combination of dietary grape polyphenols resveratrol, quercetin, and catechin (RQC), at low concentrations, was effective at... 
Proteins | Rodents | Polyphenols | Breast cancer | Metastasis | Apoptosis | Tumors
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9. Full Text Characterization of a dual Rac/Cdc42 Inhibitor MBQ-167 in metastatic cancer
by Humphries-Bickley, Tessa and Castillo-Pichardo, Linette and Hernandez-O'Farrill, Eliud and Borrero-Garcia, Luis D and Forestier-Roman, Ingrid and Gerena, Yamil and Blanco, Manuel and Rivera-Robles, Michael J and Rodriguez-Medina, José R and Cubano, Luis A and Vlaar, Cornelis P and Dharmawardhane, Suranganie
Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 805 - 818
The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer... 
P21-ACTIVATED KINASE | EHOP-016 | CELLS | ACTIVATION | ACTIN | ONCOLOGY | RAC | STAT3 | PAK | HUMAN BREAST-CANCER | SMALL-MOLECULE INHIBITOR | Cell Survival - drug effects | Pyrimidines - administration & dosage | Humans | Carbazoles - administration & dosage | Breast Neoplasms - drug therapy | Neovascularization, Pathologic - pathology | Cell Movement - drug effects | Neoplasm Metastasis | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Neovascularization, Pathologic - drug therapy | cdc42 GTP-Binding Protein - genetics | cdc42 GTP-Binding Protein - antagonists & inhibitors | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Female | Neovascularization, Pathologic - genetics | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | rac1 GTP-Binding Protein - genetics | Cdc42 protein | Mesenchyme | Epithelial cells | Downstream effects | Homology | AKT protein | Malignancy | Metastasis | Kinases | Cell surface | Metastases | Cell adhesion & migration | Angiogenesis | Actin | Polarity | Mammary gland | Incubation | Stat3 protein | Cell division | p21-activated kinase | MAP kinase | Breast cancer | Botulinum toxin | Substrates | Signaling | Detachment | Inhibitors | Viability | Cell migration | Cancer | Tumors | Apoptosis | anoikis | breast cancer | Rac | Cdc42 inhibitor | Cdc42
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10. Full Text Abstract 2197: Characterization of immunoliposomes as delivery vehicles for the Rac inhibitor Ehop-016 in HER2 type breast cancer
by Rivera-Robles, Michael J and Vivas-Mejia, Pablo E and Castillo-Pichardo, Linette and Vlaar, Cornelis and Hernández, Eliud and Dharmawardhane, Suranganie
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2197 - 2197
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11. Full Text Abstract 4923: Pharmacokinetics of the metastatic cancer inhibitor MBQ-167 in mice
by Maldonado, Maria del Mar and Castillo-Pichardo, Linette and Bloom, Joseph and Duconge, Jorge and Rodriguez-Orengo, Jose F and Hernandez-O'Farrill, Eliud and Vlaar, Cornelis and Dharmawardhane, Suranganie
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4923 - 4923
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12. Full Text Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase
by Montalvo-Ortiz, Brenda L and Castillo-Pichardo, Linette and Hernández, Eliud and Humphries-Bickley, Tessa and De La Mota-Peynado, Alina and Cubano, Luis A and Vlaar, Cornelis P and Dharmawardhane, Suranganie
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 16, pp. 13228 - 13238
The Rho GTPase Rac regulates actin cytoskeleton reorganization to form cell surface extensions (lamellipodia) required for cell migration/invasion during... 
BREAST-CANCER CELLS | VAV PROTEINS | SIGNALING PATHWAYS | INVASION | FAMILY SMALL GTPASES | SPLICE VARIANT | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC TARGETS | NUCLEOTIDE-EXCHANGE FACTORS | RHO-GTPASES | RATIONAL DESIGN | Cell Survival - drug effects | rho GTP-Binding Proteins - antagonists & inhibitors | Pyrimidines - chemical synthesis | Humans | Enzyme Inhibitors - pharmacology | Carbazoles - chemical synthesis | Pyrimidines - pharmacology | Recombinant Fusion Proteins - chemistry | Enzyme Inhibitors - chemical synthesis | Breast Neoplasms - drug therapy | Recombinant Fusion Proteins - antagonists & inhibitors | Breast Neoplasms - enzymology | Breast Neoplasms - pathology | Drug Design | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Female | Carbazoles - pharmacology | rac1 GTP-Binding Protein - chemistry | Aminoquinolines - pharmacology | Binding Sites - drug effects | rac1 GTP-Binding Protein - genetics | Molecular Bases of Disease | Enzyme Inhibitors | Rho GTPases | Actin | Guanine Nucleotide Exchange Factor (GEF) | Rac | Rho | Rac Inhibitor, Ehop-016, Rac GEFs | GTPase | Cdc42
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13. Full Text Abstract 4390: Non-coding RNAs in EGFR therapy resistance in breast cancer
by Borrero-García, Luis D and Castillo-Pichardo, Linette and Redis, Roxana S and Calin, George A and Dharmawardhane, Suranganie
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 4390 - 4390
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14. Full Text Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols
by Castillo-Pichardo, Linette and Martínez-Montemayor, Michelle M and Martínez, Joel E and Wall, Kristin M and Cubano, Luis A and Dharmawardhane, Suranganie
Clinical and Experimental Metastasis, ISSN 0262-0898, 08/2009, Volume 26, Issue 6, pp. 505 - 516
The cancer preventive properties of grape products such as red wine have been attributed to polyphenols enriched in red wine. However, much of the studies on... 
Catechin | Breast cancer | Metastasis | Quercetin | Resveratrol | NUDE-MICE | DOWN-REGULATION | SEED EXTRACT | KAPPA-B | HUMAN BREAST-CANCER | MDA-MB-435 CELLS | ONCOLOGY | RED WINE POLYPHENOLS | IN-VIVO | MCF-7 CELLS | Liver Neoplasms, Experimental - secondary | Vitis - chemistry | Stilbenes - therapeutic use | Apoptosis - drug effects | Quercetin - therapeutic use | Humans | Bone Neoplasms - secondary | NF-kappa B - metabolism | Stilbenes - pharmacology | Liver Neoplasms, Experimental - prevention & control | Animals | Quercetin - pharmacology | Bone Neoplasms - prevention & control | Mammary Neoplasms, Experimental - pathology | Cell Line, Tumor | Catechin - therapeutic use | Female | Cell Proliferation - drug effects | Mice | Catechin - pharmacology | Cell Cycle - drug effects | Mammary Neoplasms, Experimental - drug therapy | Wine | Medical colleges | Image processing | Growth | Oncology, Experimental | Liver | Fluorescence | Development and progression | Research | Analysis | Equipment and supplies | Cancer
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15. Full Text Abstract 2142: Dietary grape polyphenol resveratrol regulates Rac activity to increase mammary tumor growth and metastasis
by Castillo-Pichardo, Linette and Cubano, Luis A and Dharmawardhane, Suranganie
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 2142 - 2142
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16. Full Text Abstract B29: Anti-breast cancer effects of the Vav/Rac inhibitor Ehop-016 in the tumor microenvironment
by Castillo-Pichardo, Linette and Valle, Cristina Del and Morales, Jessica and Washington, Valance and Rohena-Rivera, Krizia and Martinez, Magaly and Cubano, Luis and Dharmawardhane, Suranganie
Molecular Cancer Research, ISSN 1541-7786, 02/2016, Volume 14, Issue 2 Supplement, pp. B29 - B29
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17. Full Text Abstract 3076: Characterization of an improved derivative of the Rac/PAK inhibitor EHop-016 in breast cancer
by Castillo-Pichardo, Linette and Humphries-Bickley, Tessa and Forrestier-Roman, Ingrid and Borrero-Garcia, Luis and Pagan Melendez, Fabiola and Hernandez, Eliud and Vlaar, Cornelis and Cubano, Luis A and Dharmawardhane, Surangani
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 3076 - 3076
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18. Full Text Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents
by Vlaar, Cornelis P and Castillo-Pichardo, Linette and Medina, Julia I and Marrero-Serra, Cathyria M and Vélez, Ericka and Ramos, Zulma and Hernández, Eliud
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 02/2018, Volume 26, Issue 4, pp. 884 - 890
Based on the efficacy of EHop-016 as an inhibitor of migration and Rac1 activation, a new series of carbazole derivatives has been synthesized. Cytotoxic and... 
Rac1 inhibitor | Migration | EHop-016 | Breast cancer | Rac1 | Metastasis | Carbazole | ANTIPROLIFERATIVE ACTIVITY | CHEMISTRY, MEDICINAL | 1,4-DIMETHYLCARBAZOLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CANCER CELL-GROWTH | BREAST | INHIBITORS | RHO-GTPASES | PROGRESSION | Protein Structure, Tertiary | Carbazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Cell Movement - drug effects | MCF-7 Cells | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Docking Simulation | Carbazoles - pharmacology | rac1 GTP-Binding Protein - chemistry | Binding Sites | rac1 GTP-Binding Protein - metabolism | Carbazoles - metabolism | Breast Cancer
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19. Full Text Abstract 4868: Dietary resveratrol promotes breast cancer progression in immunocompromised mice
by Castillo-Pichardo, Linette and Cubano, Luis A and Rodríguez-Orengo, José F and Dharmawardhane, Suranganie
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 4868 - 4868
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20. Full Text The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model
by Castillo-Pichardo, Linette and Humphries-Bickley, Tessa and De La Parra, Columba and Forestier-Roman, Ingrid and Martinez-Ferrer, Magaly and Hernandez, Eliud and Vlaar, Cornelis and Ferrer-Acosta, Yancy and Washington, Anthony V and Cubano, Luis A and Rodriguez-Orengo, Jose and Dharmawardhane, Suranganie
Translational Oncology, ISSN 1936-5233, 2014, Volume 7, Issue 5, pp. 546 - 555
Abstract Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop... 
Oncology | ACTIVATION | INVASION | ONCOLOGY | CYCLIN D1 | CELL-MIGRATION | DOWN-REGULATION | ACTIN CYTOSKELETON | HUMAN BREAST-CANCER | RHO-GTPASES | FACTOR RECEPTOR | SMALL-MOLECULE INHIBITOR
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