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1. Full Text Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
by Beecham, Ashley H and Patsopoulos, Nikolaos A and Xifara, Dionysia K and Davis, Mary F and Kemppinen, Anu and Cotsapas, Chris and Shah, Tejas S and Spencer, Chris and Booth, David and Goris, An and Oturai, Annette and Saarela, Janna and Fontaine, Bertrand and Hemmer, Bernhard and Martin, Claes and Zipp, Frauke and D'Alfonso, Sandra and Martinelli-Boneschi, Filippo and Taylor, Bruce and Harbo, Hanne F and Kockum, Ingrid and Hillert, Jan and Olsson, Tomas and Ban, Maria and Oksenberg, Jorge R and Hintzen, Rogier and Barcellos, Lisa F and Agliardi, Cristina and Alfredsson, Lars and Alizadeh, Mehdi and Anderson, Carl and Andrews, Robert and Søndergaard, Helle Bach and Baker, Amie and Band, Gavin and Baranzini, Sergio E and Barizzone, Nadia and Barrett, Jeffrey and Bellenguez, Céline and Bergamaschi, Laura and Bernardinelli, Luisa and Berthele, Achim and Biberacher, Viola and Binder, Thomas M.C and Blackburn, Hannah and Bomfim, Izaura L and Brambilla, Paola and Broadley, Simon and Brochet, Bruno and Brundin, Lou and Buck, Dorothea and Butzkueven, Helmut and Caillier, Stacy J and Camu, William and Carpentier, Wassila and Cavalla, Paola and Celius, Elisabeth G and Coman, Irène and Comi, Giancarlo and Corrado, Lucia and Cosemans, Leentje and Cournu-Rebeix, Isabelle and Cree, Bruce A.C and Cusi, Daniele and Damotte, Vincent and Defer, Gilles and Delgado, Silvia R and Deloukas, Panos and Di Sapio, Alessia and Dilthey, Alexander T and Donnelly, Peter and Dubois, Bénédicte and Duddy, Martin and Edkins, Sarah and Elovaara, Irina and Esposito, Federica and Evangelou, Nikos and Fiddes, Barnaby and Field, Judith and Franke, Andre and Freeman, Colin and Frohlich, Irene Y and Galimberti, Daniela and Gieger, Christian and Gourraud, Pierre-Antoine and Graetz, Christiane and Graham, Andrew and Grummel, Verena and Guaschino, Clara and Hadjixenofontos, Athena and Hakonarson, Hakon and Halfpenny, Christopher and Hall, Gillian and Hall, Per and Hamsten, Anders and Harley, James and Harrower, Timothy and Hawkins, Clive and Hellenthal, Garrett and Hillier, Charles and ... and Wellcome Trust Case Control Consor and Int IBD Genetics Consortium IIBDGC and International Multiple Sclerosis Genetics Consortium (IMSGC) and Wellcome Trust Case Control Consortium 2 (WTCCC2) and International IBD Genetics Consortium (IIBDGC) and Institutionen för fysik, kemi och biologi and Linköpings universitet and Bioinformatik and Tekniska högskolan
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 11, pp. 1353 - 1362
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants... 
AUTOIMMUNE | ALLELES | METAANALYSIS | GENOTYPE IMPUTATION | GENETIC RISK | INFORMATION | ANNOTATION | PRIMARY BILIARY-CIRRHOSIS | DISEASE | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Genetic Variation | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Multiple Sclerosis - immunology | Genotype | Multiple Sclerosis - genetics | Chromosome Mapping | Polymorphism, Single Nucleotide | Genetic Loci | Multiple sclerosis | Chromosome mapping | Genetic susceptibility | Genetic variation | Genetic aspects | Identification and classification | Methods | Testing | Confidence intervals | Disease | Quality control | Genomes | Stratigraphy | Autoimmune diseases | Gene expression | Meta-analysis | Teknik och teknologier | TEKNIKVETENSKAP | Engineering and Technology | TECHNOLOGY
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2. Full Text Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 Controls
by Baranzini, Sergio E and Khankhanian, Pouya and Patsopoulos, Nikolaos A and Li, Michael and Stankovich, Jim and Cotsapas, Chris and Søndergaard, Helle Bach and Ban, Maria and Barizzone, Nadia and Bergamaschi, Laura and Booth, David and Buck, Dorothea and Cavalla, Paola and Celius, Elisabeth G and Comabella, Manuel and Comi, Giancarlo and Compston, Alastair and Cournu-Rebeix, Isabelle and D’alfonso, Sandra and Damotte, Vincent and Din, Lennox and Dubois, Bénédicte and Elovaara, Irina and Esposito, Federica and Fontaine, Bertrand and Franke, Andre and Goris, An and Gourraud, Pierre-Antoine and Graetz, Christiane and Guerini, Franca R and Guillot-Noel, Léna and Hafler, David and Hakonarson, Hakon and Hall, Per and Hamsten, Anders and Harbo, Hanne F and Hemmer, Bernhard and Hillert, Jan and Kemppinen, Anu and Kockum, Ingrid and Koivisto, Keijo and Larsson, Malin and Lathrop, Mark and Leone, Maurizio and Lill, Christina M and Macciardi, Fabio and Martin, Roland and Martinelli, Vittorio and Martinelli-Boneschi, Filippo and McCauley, Jacob L and Myhr, Kjell-Morten and Naldi, Paola and Olsson, Tomas and Oturai, Annette and Pericak-Vance, Margaret A and Perla, Franco and Reunanen, Mauri and Saarela, Janna and Saker-Delye, Safa and Salvetti, Marco and Sellebjerg, Finn and Sørensen, Per Soelberg and Spurkland, Anne and Stewart, Graeme and Taylor, Bruce and Tienari, Pentti and Winkelmann, Juliane and Zipp, Frauke and Ivinson, Adrian J and Haines, Jonathan L and Sawcer, Stephen and DeJager, Philip and Hauser, Stephen L and Oksenberg, Jorge R and Wellcome Trust Case Control Consor and Int Multiple Sclerosis Genetics Co and International Multiple Sclerosis Genetics Consortium
The American Journal of Human Genetics, ISSN 0002-9297, 06/2013, Volume 92, Issue 6, pp. 854 - 865
Multiple sclerosis (MS) is an inflammatory CNS disease with a substantial genetic component, originally mapped to only the human leukocyte antigen (HLA)... 
RISK ALLELES | GENE | VARIANTS | SNP | 7 COMMON DISEASES | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | TRAITS | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Genome-Wide Association Study | Protein Interaction Maps - genetics | Epistasis, Genetic | Humans | Multiple Sclerosis - genetics | Risk | Models, Genetic | Polymorphism, Single Nucleotide | Genetic Loci | Case-Control Studies | Linkage Disequilibrium | Hälsovetenskap | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Klinisk medicin | Medicin och hälsovetenskap | Reumatologi och inflammation
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3. Full Text Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis
by Sorosina, Melissa and Esposito, Federica and Guaschino, Clara and Clarelli, Ferdinando and Barizzone, Nadia and Osiceanu, Ana Maria and Brambilla, Paola and Mascia, Elisabetta and Cavalla, Paola and Gallo, Paolo and Martinelli, Vittorio and Leone, Maurizio and Comi, Giancarlo and D’Alfonso, Sandra and Martinelli Boneschi, Filippo and PROGRESSO and PROGEMUS
Multiple Sclerosis Journal, ISSN 1352-4585, 10/2015, Volume 21, Issue 11, pp. 1463 - 1467
We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in... 
relapsing–remitting | relapsing-remitting | multiple sclerosis | genetic risk | weighted genetic risk score | Primary-progressive | age of onset | NEUROSCIENCES | CLINICAL NEUROLOGY | Multiple Sclerosis, Chronic Progressive - physiopathology | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Risk | Multiple Sclerosis, Relapsing-Remitting - physiopathology | Multiple Sclerosis, Chronic Progressive - epidemiology | Disease Progression | Young Adult | Adolescent | Age of Onset | Multiple Sclerosis, Relapsing-Remitting - epidemiology | Adult | Female | Italy - epidemiology | Aged | Child | Cohort Studies
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4. Full Text Pregnancy in multiple sclerosis: Data from an administrative claims database
by Cavalla, Paola and Gilmore, Wendy
Neurology, ISSN 0028-3878, 10/2018, Volume 91, Issue 17, pp. 771 - 773
NEED | CLINICAL NEUROLOGY | MANAGEMENT
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5. Full Text Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
by Sawcer, Stephen and Hellenthal, Garrett and Pirinen, Matti and Spencer, Chris C.A and Patsopoulos, Nikolaos A and Moutsianas, Loukas and Dilthey, Alexander and Su, Zhan and Freeman, Colin and Hunt, Sarah E and Edkins, Sarah and Gray, Emma and Booth, David R and Potter, Simon C and Goris, An and Band, Gavin and Oturai, Annette Bang and Strange, Amy and Saarela, Janna and Bellenguez, Céline and Fontaine, Bertrand and Gillman, Matthew and Hemmer, Bernhard and Gwilliam, Rhian and Zipp, Frauke and Jayakumar, Alagurevathi and Martin, Roland and Leslie, Stephen and Hawkins, Stanley and Giannoulatou, Eleni and D'Alfonso, Sandra and Blackburn, Hannah and Boneschi, Filippo Martinelli and Liddle, Jennifer and Harbo, Hanne F and Perez, Marc L and Spurkland, Anne and Waller, Matthew J and Mycko, Marcin P and Ricketts, Michelle and Comabella, Manuel and Hammond, Naomi and Kockum, Ingrid and McCann, Owen T and Ban, Maria and Whittaker, Pamela and Kemppinen, Anu and Weston, Paul and Hawkins, Clive and Widaa, Sara and Zajicek, John and Dronov, Serge and Robertson, Neil and Bumpstead, Suzannah J and Barcellos, Lisa F and Ravindrarajah, Rathi and Abraham, Roby and Alfredsson, Lars and Ardlie, Kristin and Aubin, Cristin and Baker, Amie and Baker, Katharine and Baranzini, Sergio E and Bergamaschi, Laura and Bergamaschi, Roberto and Bernstein, Allan and Berthele, Achim and Boggild, Mike and Bradfield, Jonathan P and Brassat, David and Broadley, Simon A and Buck, Dorothea and Butzkueven, Helmut and Capra, Ruggero and Carroll, William M and Cavalla, Paola and Celius, Elisabeth G and Cepok, Sabine and Chiavacci, Rosetta and Clerget-Darpoux, Françoise and Clysters, Katleen and Comi, Giancarlo and Cossburn, Mark and Cournu-Rebeix, Isabelle and Cox, Mathew B and Cozen, Wendy and Cree, Bruce A.C and Cross, Anne H and Cusi, Daniele and Daly, Mark J and Davis, Emma and De Bakker, Paul I.W and Debouverie, Marc and D'Hooghe, Marie Beatrice and Dixon, Katherine and Dobosi, Rita and Dubois, Bénédicte and Ellinghaus, David and Elovaara, Irina and Esposito, Federica and ... and Wellcome Trust Case Control Consor and Int Multiple Sclerosis Genetics Co and Wellcome Trust Case Control Consortium 2 and International Multiple Sclerosis Genetics Consortium and The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7359, pp. 214 - 219
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically... 
HETEROGENEITY | ALLELES | VARIANTS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | HAPLOTYPES | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Immunity, Cellular - genetics | Major Histocompatibility Complex - genetics | Humans | Multiple Sclerosis - genetics | Europe - ethnology | Genome, Human - genetics | HLA-DR Antigens - genetics | Cell Differentiation - immunology | Immunity, Cellular - immunology | Sample Size | T-Lymphocytes, Helper-Inducer - immunology | HLA-DRB1 Chains | Alleles | HLA-A Antigens - genetics | T-Lymphocytes, Helper-Inducer - cytology | Multiple Sclerosis - immunology | Polymorphism, Single Nucleotide - genetics | Physiological aspects | Multiple sclerosis | Genetic aspects | Immune response | Research | Epidemiology | Genealogy | Disease | Quality control | Genetics | Genomes | Statistical methods | Mutation | Regression analysis | Autoimmune diseases | Meta-analysis | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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6. Full Text Demyelination, Inflammation, and Neurodegeneration in Multiple Sclerosis Deep Gray Matter
by Vercellino, Marco and Masera, Silvia and Lorenzatti, Marcella and Condello, Cecilia and Merola, Aristide and Mattioda, Alessandra and Tribolo, Antonella and Capello, Elisabetta and Mancardi, Giovanni Luigi and Mutani, Roberto and Giordana, Maria Teresa and Cavalla, Paola
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 05/2009, Volume 68, Issue 5, pp. 489 - 502
Gray matter (GM) lesions are recognized as important components of the pathology of multiple sclerosis (MS), and involvement of the deep gray matter (DGM) is... 
Basal ganglia | Caudate | Multiple sclerosis | Neuronal loss | Excitotoxicity | Thalamus | Gray matter | AXONAL DAMAGE | ATROPHY | THALAMIC NEURODEGENERATION | PATHOLOGY | GLUTAMATE UPTAKE | CORTICAL-LESIONS | NEUROSCIENCES | CEREBRAL-CORTEX | CLINICAL NEUROLOGY | VOXEL-BASED MORPHOMETRY | MICROGLIA | NEURONAL EXPRESSION | Inflammation - pathology | Neurons - pathology | Neurodegenerative Diseases - etiology | Neuroglia - pathology | Humans | Middle Aged | Male | Antigens, CD - metabolism | Inflammation - complications | Adult | Female | Demyelinating Diseases - etiology | Demyelinating Diseases - pathology | HLA-DR Antigens - metabolism | Neurodegenerative Diseases - pathology | Myelin Basic Protein - metabolism | Amyotrophic Lateral Sclerosis - complications | Multiple Sclerosis - complications | Nerve Tissue Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Staining and Labeling | Fibrinogen - metabolism | Brain - pathology | Multiple Sclerosis - pathology | Aged
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7. Full Text Predicting the profile of increasing disability in multiple sclerosis
by Tomassini, Valentina and Fanelli, Fulvia and Prosperini, Luca and Cerqua, Raffaella and Cavalla, Paola and Pozzilli, Carlo
Multiple Sclerosis Journal, ISSN 1352-4585, 8/2019, Volume 25, Issue 9, pp. 1306 - 1315
Background: Effective therapeutic strategies to preserve function and delay progression in multiple sclerosis (MS) require early recognition of individual... 
predictors | Multiple sclerosis | MRI | relapse | disability | age | RELAPSES | PROGNOSTIC-FACTORS | SECONDARY PROGRESSIVE MS | NATURAL-HISTORY | MRI LESIONS | NEUROSCIENCES | CLINICAL NEUROLOGY | PATHOGENESIS | TRIAL | INTERFERON BETA-1B | ONSET | Clinical trials | Nuclear magnetic resonance--NMR | Magnetic resonance imaging | Age | Original Research Papers
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8. Full Text Early diagnosis of progressive multifocal leucoencephalopathy: Longitudinal lesion evolution
by Scarpazza, Cristina and Signori, Alessio and Prosperini, Luca and Sormani, Maria Pia and Cosottini, Mirco and Capra, Ruggero and Gerevini, Simonetta and Altieri, Marta and Amato, Maria Pia and Artusi, Carlo Alberto and Bandini, Fabio and Barcella, Valeria and Bertolotto, Antonio and Morra, Vincenzo Brescia and Capobianco, Marco and Cavaletti, Guido and Cavalla, Paola and Centonze, Diego and Chiusole, Maurizia and Clerico, Marinella and Cordioli, Cinzia and D'Aleo, Giangaetano and De Luca, Giovanna and De Riz, Milena and De Rossi, Nicola and Deotto, Luciano and Durelli, Luca and Falcini, Mario and Ferrante, Claudio and Ferrari, Ernesta and Fusco, Maria Luisa and Gasperini, Claudio and Ghezzi, Angelo and Grimaldi, Luigi and Guidotti, Mario and Laroni, Alice and Lugaresi, Alessandra and Moiola, Lucia and Naldi, Paola and Pane, Chiara and Palmeri, Barbara and Perrone, Patrizia and Pizzorno, Matteo and Pozzilli, Carlo and Rezzonico, Monica and Rottoli, Maria Rosa and Rovaris, Marco and Salemi, Giuseppe and Salvetti, Marco and Santuccio, Giuseppe and Scarpini, Elio and Sessa, Edoardo and Solaro, Claudio and Stenta, Gianola and Tabiadon, Giulietta and Tortorella, Carla and Trojano, Maria and Valentino, Paola and Rottoli, Maira Rosa and Italian PML Grp and Italian PML Group
Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, 2018, Volume 90, Issue 3, pp. 261 - 267
Objective Early diagnosis of natalizumab-related progressive multifocal leucoencephalopathy (NTZ-PML) in multiple sclerosis has been deemed a major priority by... 
STATEMENT | SURVIVAL | SURGERY | ASYMPTOMATIC PML | MRI | PSYCHIATRY | MS | GUIDELINES | NATALIZUMAB-ASSOCIATED PML | RISK | CLINICAL NEUROLOGY | PLASMA | MULTIPLE-SCLEROSIS | Neurology | Multiple sclerosis | Nuclear magnetic resonance--NMR | Brain research | Surveillance | Laboratories | Medical diagnosis | Patients | Psychiatry
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9. Full Text The Italian multiple sclerosis register
by Trojano, Maria and Bergamaschi, Roberto and Amato, Maria Pia and Comi, Giancarlo and Ghezzi, Angelo and Lepore, Vito and Marrosu, Maria Giovanna and Mosconi, Paola and Patti, Francesco and Ponzio, Michela and Zaratin, Paola and Battaglia, Mario Alberto and Italian Multiple Sclerosis and Italian Multiple Sclerosis Register Centers Group and on behalf of the Italian Multiple Sclerosis Register Centers Group
Neurological Sciences, ISSN 1590-1874, 1/2019, Volume 40, Issue 1, pp. 155 - 165
The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS... 
Neurology | Multiple sclerosis | Medicine & Public Health | Register | Neurosurgery | Psychiatry | Epidemiology | Neuroradiology | Quality of care | DATABASE | RISK | INTERFERON-BETA | NEUROSCIENCES | CLINICAL NEUROLOGY | Databases | Decision making | Patients | Collaboration | Computer programs | Original
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10. Full Text Overexpression of sphingosine-1-phosphate receptors on reactive astrocytes drives neuropathology of multiple sclerosis rebound after fingolimod discontinuation
by Giordana, Maria Teresa and Cavalla, Paola and Uccelli, Antonio and Laroni, Alice and Bandini, Fabio and Vercellino, Marco and Mancardi, Gianluigi
Multiple Sclerosis Journal, ISSN 1352-4585, 7/2018, Volume 24, Issue 8, pp. 1133 - 1137
We present the neuropathological description of an autoptic case of fatal rebound of disease activity after fingolimod discontinuation in a multiple sclerosis... 
histopathology | post mortem | Fingolimod | glia | demyelination | multiple sclerosis | WITHDRAWAL | NEUROSCIENCES | CLINICAL NEUROLOGY | CESSATION | Multiple sclerosis | Gliosis | Magnetic resonance imaging | Neuropathology | Astrocytes | Demyelination | Substantia alba | Sphingosine 1-phosphate
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11. Full Text Association of HLA class I markers with multiple sclerosis in the Italian and UK population: Evidence of two independent protective effects
by Bergamaschi, Laura and Ban, Maria and Barizzone, Nadia and Leone, Maurizio and Ferrante, Daniela and Fasano, Maria Edvige and Guerini, Franca R and Corrado, Lucia and Naldi, Paola and Dametto, Ennia and Agliardi, Cristina and Salvetti, Marco and Mechelli, Rosella and Galimberti, Daniela and Scarpini, Elio and Cavalla, Paola and Bargiggia, Valeria and Caputo, Domenico and Cordera, Susanna and Monaco, Francesco and Momigliano-Richiardi, Patricia and D'Alfonso, Sandra
Journal of Medical Genetics, ISSN 0022-2593, 07/2011, Volume 48, Issue 7, pp. 485 - 492
Background The association of HLA A*02 with multiple sclerosis (MS) was recently confirmed by the authors, and it was observed that the combined presence of... 
ALLELE | SUSCEPTIBILITY | GENETICS & HEREDITY | HAPLOTYPES | RISK | MAJOR HISTOCOMPATIBILITY COMPLEX | LOCUS | HLA-DRB1 | REGION | Haplotypes | Genetic Predisposition to Disease | Genetic Association Studies | Humans | Middle Aged | Gene Expression Regulation | Male | Multiple Sclerosis - genetics | United Kingdom | Histocompatibility Antigens Class I - genetics | Case-Control Studies | HLA-DR Antigens - genetics | Young Adult | Alleles | Adult | Female | Italy | Gene Order | Multiple sclerosis | Usage | Demographic aspects | Physiological aspects | Genetic aspects | Diagnosis | Research | Biological markers
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