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1. Full Text Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family
by Haun, William and Coffman, Andrew and Clasen, Benjamin M and Demorest, Zachary L and Lowy, Anita and Ray, Erin and Retterath, Adam and Stoddard, Thomas and Juillerat, Alexandre and Cedrone, Frederic and Mathis, Luc and Voytas, Daniel F and Zhang, Feng
Plant Biotechnology Journal, ISSN 1467-7644, 09/2014, Volume 12, Issue 7, pp. 934 - 940
Soybean oil is high in polyunsaturated fats and is often partially hydrogenated to increase its shelf life and improve oxidative stability. The trans‐fatty... 
linoleic acid | metabolic engineering | targeted mutagenesis | fatty acid desaturase | oleic acid | Targeted mutagenesis | Metabolic engineering | Fatty acid desaturase | Oleic acid | Linoleic acid | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EFFECTOR NUCLEASES | PLANTS | FUNCTIONAL GENOMICS | M23 | PLANT SCIENCES | Fatty Acid Desaturases - genetics | Nutritive Value - genetics | Oleic Acid - metabolism | Mutagenesis, Site-Directed | Seeds - metabolism | Seeds - genetics | Plants, Genetically Modified - chemistry | Seeds - enzymology | Soybean Oil - chemistry | Molecular Sequence Data | Soybeans - genetics | Soybeans - metabolism | Plant Proteins - genetics | Sequence Alignment | Plants, Genetically Modified - metabolism | Base Sequence | Soybeans - enzymology | Mutation | Fatty Acids - metabolism | Monounsaturated fatty acids | Genetic engineering | Genetically modified crops | Genes | Oils & fats | Fatty acids | Index Medicus
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2. Full Text Improving cold storage and processing traits in potato through targeted gene knockout
by Clasen, Benjamin M and Stoddard, Thomas J and Luo, Song and Demorest, Zachary L and Li, Jin and Cedrone, Frederic and Tibebu, Redeat and Davison, Shawn and Ray, Erin E and Daulhac, Aurelie and Coffman, Andrew and Yabandith, Ann and Retterath, Adam and Haun, William and Baltes, Nicholas J and Mathis, Luc and Voytas, Daniel F and Zhang, Feng
Plant Biotechnology Journal, ISSN 1467-7644, 01/2016, Volume 14, Issue 1, pp. 169 - 176
Cold storage of potato tubers is commonly used to reduce sprouting and extend postharvest shelf life. However, cold temperature stimulates the accumulation of... 
transcription activator‐like effector nucleases | vacuolar invertase | acrylamide reduction | cold‐induced sweetening | gene editing | potato | Transcription activator-like effector nucleases | Cold-induced sweetening | Potato | Acrylamide reduction | Gene editing | Vacuolar invertase | TRANSFORMATION | QUALITY | SPECIFICITY | PROTOPLASTS | transcription activator-like effector nucleases | PLANT SCIENCES | INVERTASE GENE | cold-induced sweetening | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | ACRYLAMIDE | Acrylamide - analysis | Gene Targeting | Vacuoles - enzymology | Cold Temperature | Genes, Plant | Transcription Activator-Like Effector Nucleases - metabolism | Gene Knockout Techniques | Mutation - genetics | Cryopreservation - methods | beta-Fructofuranosidase - genetics | Base Sequence | Plants, Genetically Modified | Carbohydrates - analysis | Solanum tuberosum - genetics | RNA | Genes | Genomics | Genetic engineering | Plants | Glucose | Fructose | Dextrose | Sugar | Sucrose | Transcription | Potatoes | Invertase | Amino acids | Shelf life | Genomes | Transgenic plants | Accumulation | Tubers | Acrylamide | Carcinogens | Technology | Temperature effects | Autotetraploid | Temporal variations | Deoxyribonucleic acid--DNA | Sugars | RNA-mediated interference | Chips | Interference | Bitter taste | Cold storage | Ribonucleic acid--RNA | Gene expression | Gene silencing | Silence | Mutation | Index Medicus | Mutations | Plants (organisms)
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3. Full Text Multiplexed, targeted gene editing in Nicotiana benthamiana for glyco‐engineering and monoclonal antibody production
by Li, Jin and Stoddard, Thomas J and Demorest, Zachary L and Lavoie, Pierre‐Olivier and Luo, Song and Clasen, Benjamin M and Cedrone, Frederic and Ray, Erin E and Coffman, Andrew P and Daulhac, Aurelie and Yabandith, Ann and Retterath, Adam J and Mathis, Luc and Voytas, Daniel F and D'Aoust, Marc‐André and Zhang, Feng
Plant Biotechnology Journal, ISSN 1467-7644, 02/2016, Volume 14, Issue 2, pp. 533 - 542
Biopharmaceutical glycoproteins produced in plants carry N‐glycans with plant‐specific residues core α(1,3)‐fucose and β(1,2)‐xylose, which can significantly... 
transcription activator‐like effector nucleases | glyco‐engineering | Gene editing | plant‐derived pharmaceuticals | Transcription activator-like effector nucleases | Plant-derived pharmaceuticals | Glyco-engineering | RECOMBINATION | ARABIDOPSIS-THALIANA | N-GLYCANS | GLYCOSYLATION | transcription activator-like effector nucleases | EXPRESSION SYSTEM | NUCLEASES | PLANT SCIENCES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | glyco-engineering | PLANTS | GENERATION | plant-derived pharmaceuticals | SYNTHETIC BIOLOGY | BREAK-INDUCED REPLICATION | Genetic Engineering - methods | Transformation, Genetic | Xylose - metabolism | Antibodies, Monoclonal - biosynthesis | Fucose - metabolism | Transcription Activator-Like Effector Nucleases - metabolism | Glycosylation | Mutation - genetics | Polysaccharides - metabolism | Protoplasts - metabolism | Rituximab - biosynthesis | Tobacco - genetics | Base Sequence | Plants, Genetically Modified | Polysaccharides - chemistry | Gene Editing - methods | Plant Proteins - metabolism | Polysaccharides | Biological products | Analysis | Genes | Monoclonal antibodies | Genetic research | Genetic engineering | Glycoproteins | Sugars | Monosaccharides | Multiplexing | Residues | Transcription | Peptides | Protoplasts | Employees | Genomes | Proteins | Genetic modification | Deoxyribonucleic acid--DNA | Recombinant | Plants (botany) | CRISPR | Phenotypes | Gene families | Rituximab | Xylose | Gamma rays | Mutagenesis | Immunogenicity | Alleles | Mutation | Fucose | Pharmaceuticals | Mutations | Antibodies | Plants (organisms) | Power plants
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4. Full Text Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells
by Grosse, Stéphanie and Huot, Nicolas and Mahiet, Charlotte and Arnould, Sylvain and Barradeau, Sébastien and Clerre, Diane Le and Chion-Sotinel, Isabelle and Jacqmarcq, Cécile and Chapellier, Benoît and Ergani, Ayla and Desseaux, Carole and Cédrone, Frédéric and Conseiller, Emmanuel and Pâques, Frédéric and Labetoulle, Marc and Smith, Julianne
Molecular Therapy, ISSN 1525-0016, 04/2011, Volume 19, Issue 4, pp. 694 - 702
Herpes simplex virus type 1 (HSV1) is a major health problem. As for most viral diseases, current antiviral treatments are based on the inhibition of viral... 
MEDICINE, RESEARCH & EXPERIMENTAL | DNA-BINDING | DOUBLE-STRAND BREAKS | VIRUS TYPE-1 LATENCY | ZINC-FINGER NUCLEASES | MAMMALIAN-CELLS | SACCHAROMYCES-CEREVISIAE | DIRECTED EVOLUTION | OCULAR HERPES-SIMPLEX | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | HOMING ENDONUCLEASES | GENE-THERAPY | Cell Line | Cricetinae | Cricetulus | Humans | Cercopithecus aethiops | Blotting, Western | Deoxyribonucleases - metabolism | Herpesviridae Infections - prevention & control | Deoxyribonucleases - genetics | Animals | Herpesvirus 1, Human - genetics | COS Cells | Herpesvirus 1, Human - pathogenicity | CHO Cells | Original
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5. Full Text Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases
by Daboussi, Fayza and Zaslavskiy, Mikhail and Poirot, Laurent and Loperfido, Mariana and Gouble, Agnès and Guyot, Valerie and Leduc, Sophie and Galetto, Roman and Grizot, Sylvestre and Oficjalska, Danusia and Perez, Christophe and Delacôte, Fabien and Dupuy, Aurélie and Chion-Sotinel, Isabelle and Le Clerre, Diane and Lebuhotel, Céline and Danos, Olivier and Lemaire, Frédéric and Oussedik, Kahina and Cédrone, Frédéric and Epinat, Jean-Charles and Smith, Julianne and Yáñez-Muñoz, Rafael J and Dickson, George and Popplewell, Linda and Koo, Taeyoung and Vandendriessche, Thierry and Chuah, Marinee K and Duclert, Aymeric and Duchateau, Philippe and Pâques, Frédéric
Nucleic Acids Research, ISSN 0305-1048, 07/2012, Volume 40, Issue 13, pp. 6367 - 6379
The ability to specifically engineer the genome of living cells at precise locations using rare-cutting designer endonucleases has broad implications for... 
RECOMBINATION | CELLS | GENE | REPAIR PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERSPECTIVES | DOUBLE-STRAND BREAKS | HOMING ENDONUCLEASES | MEGANUCLEASES | ZINC-FINGER NUCLEASES | Cell Line | Gene Targeting | Cricetinae | DNA Restriction Enzymes - chemistry | Cricetulus | DNA Restriction Enzymes - metabolism | Humans | Chromosomal Position Effects | Animals | Genetic Engineering | Mutagenesis | Genome, Human | CHO Cells | Synthetic Biology and Chemistry
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6. Generation and Analysis of Mesophilic Variants of the Thermostable Archaeal I-DmoI Homing Endonuclease
by Prieto, Jesus and Epinat, Jean-Charles and Redondo, Pilar and Ramos, Elena and Padro, Daniel and Cedrone, Frederic and Montoya, Guillermo and Paques, Frederic and Blanco, Francisco J
Journal of Biological Chemistry, ISSN 0021-9258, 02/2008, Volume 283, Issue 7, pp. 4364 - 4374
The hyperthermophilic archaeon Desulfurococcus mobilis I-DmoI protein belongs to the family of proteins known as homing endonucleases (HEs). HEs are highly... 
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7. Full Text Multiplexed, targeted gene editing inNicotiana benthamianafor glyco-engineering and monoclonal antibody production
by Li, Jin and Stoddard, Thomas J and Demorest, Zachary L and Lavoie, Pierre-Olivier and Luo, Song and Clasen, Benjamin M and Cedrone, Frederic and Ray, Erin E and Coffman, Andrew P and Daulhac, Aurelie and Yabandith, Ann and Retterath, Adam J and Mathis, Luc and Voytas, Daniel F and D'Aoust, Marc-André and Zhang, Feng
Plant Biotechnology Journal, ISSN 1467-7644, 02/2016, Volume 14, Issue 2, pp. 533 - 542
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8. Full Text Meganucleases for gene therapy
by Paques, Frederic and Duchateau, Philippe and Smith, Julianne and Gouble, Agnes and Perez, Christophe and Cabaniols, Jean-Pierre and Grizot, Sylvestre and Galetto, Roman and Daboussi, Fayza and Delacote, Fabien and Cedrone, Frederic and Epinat, Jean-Charles and Arnould, Sylvain and Duclert, Aymeric
Human Gene Therapy, ISSN 1043-0342, 10/2008, Volume 19, Issue 10, p. 1066
Nucleases | Physiological aspects | Genetic aspects | Research | Gene therapy | Health aspects | Methods
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9. Full Text Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops
by Laffly, Emmanuelle and Pelat, Thibaut and Cédrone, Frédéric and Blésa, Stéphane and Bedouelle, Hugues and Thullier, Philippe
Journal of Molecular Biology, ISSN 0022-2836, 2008, Volume 378, Issue 5, pp. 1094 - 1103
The enhancement of antibody affinity by mutagenesis targeting only complementarity determining regions has the advantage of respecting the framework regions,... 
Bacillus anthracis | antibody | enhancement | phage display | affinity | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | HIGH-AFFINITY | MONOCLONAL-ANTIBODY | IN-VITRO EVOLUTION | LETHAL FACTOR | ANTI-CD22 IMMUNOTOXIN | BACILLUS-ANTHRACIS | PICOMOLAR AFFINITY | PROTECTIVE ANTIGEN | Protein Structure, Tertiary | Amino Acid Sequence | Complementarity Determining Regions - genetics | Reproducibility of Results | Antigens, Bacterial - chemistry | Immunoglobulin Fab Fragments - genetics | Humans | Models, Molecular | Molecular Sequence Data | Neutralization Tests | Peptide Library | Random Allocation | Bacterial Toxins - chemistry | Bacterial Toxins - metabolism | Animals | Adsorption | Immunoglobulin Fab Fragments - metabolism | Mutagenesis | Complementarity Determining Regions - chemistry | Immunoglobulin Fab Fragments - chemistry | Antigens, Bacterial - metabolism | Viral antibodies | Antibodies | Index Medicus
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10. Full Text European Society of Gene and Cell TherapyFrench Society of Cell and Gene TherapyCollaborative Congress 2012October 25–29, 2012Palais des Congrès de VersaillesVersailles, France
by Schmidt, Manfred and Verhoeyen, Els and Gobbo, Emilie and Divers, Dominique and Oudrhiri, Noufissa and Griscelli, Frank and Bennaceur-Griscelli, Annelise and Klatzmann, David and Anguela, Xavier M and Sharma, Rajiv and Sharma, Rajiv and Li, Hojun and Li, Hojun and Haurigot, Virginia and Haurigot, Virginia and Haurigot, Virginia and Bhagwat, Anand and Bhagwat, Anand and Davidson, Robert and Davidson, Robert and Zhou, Shangzhen and Zhou, Shangzhen and Zhou, Shangzhen and Doyon, Yannick and Gregory, Philip D and Gregory, Philip D and Gregory, Philip D and Holmes, Michael C and Holmes, Michael C and Holmes, Michael C and High, Katherine A and Carbonaro, Denise and Shaw, Kit and Jin, Xiangyang and Geiger, Sabine and Mishra, Suparna and Cooper, Aaron and DeOliveira, Satiro and Sokolic, Rob and Candotti, Fabio and Carmo, Marlene and Arumugam, Paritha and Alonso-Ferrero, Maria and Schambach, Axel and Schambach, Axel and Baum, Christopher and Baum, Christopher and Baum, Christopher and Risma, Kimberly and Malik, Punam and Jordan, Michael and Rivat, Christine and Booth, Claire and Thrasher, Adrian and Whilding, Lynsey and Archibald, Kyra and Oberg, Daniel and Golan, Talia and Hubert, Ayala and Shemi, Amotz and Khvalevsky, Elina Zorde and Gabai-Malka, Racheli and Focht, Gili and Brunschwig, Zivia and Raskin, Stephen and Goldberg, Nahum and Ben-David, Eli and Peretz, Tamar and Eliakim, Rami and Dankur, Alan and Galun and Rachmur, Itzik and Domb, Avi and Kopelman, Yael and Hantz, Yael and Lahav, Mor and Arbel-Alon, Sagit and Dickson, George and Barkats, Martine and Daboussi, Fayza and Silva, Georges and Cedrone, Frederic and Epinat, Jean Charles and Juillerat, Alexandre and Valton, Julien and Montini, Eugenio and Biffi, Alessandra and Biffi, Alessandra and Calabria, Andrea and Calabria, Andrea and Biasco, Luca and Biasco, Luca and Cesani, Martina and Cesani, Martina and Benedicenti, Fabrizio and Benedicenti, Fabrizio and Plati, Tiziana and Leo, Simone and Zanetti, Gianluigi and Aiuti, Alessandro and ...
Human Gene Therapy, ISSN 1043-0342, 10/2012, Volume 23, Issue 10, pp. A1 - A173
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11. Full Text Gene Correction of a Duchenne Muscular Dystrophy Mutation by Meganuclease-Enhanced Exon Knock-In
by Popplewell, Linda and Koo, Taeyoung and Leclerc, Xavier and Duclert, Aymeric and Mamchaoui, Kamel and Gouble, Agnés and Mouly, Vincent and Voit, Thomas and Pâques, Frédéric and Cédrone, Frédéric and Isman, Olga and Yáñez-Muñoz, Rafael J and Dickson, George
Human Gene Therapy, ISSN 1043-0342, 07/2013, Volume 24, Issue 7, pp. 692 - 701
Duchenne muscular dystrophy (DMD) is a severe inherited, muscle-wasting disorder caused by mutations in the DMD gene. Gene therapy development for DMD has... 
Research Articles | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CANINE MODEL | MUSCLE | MECHANISMS | CONTEXT | GENOME | MORPHOLINO OLIGOMERS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | RESTORE | HOMOLOGOUS RECOMBINATION | EXPRESSION | Humans | Exons - genetics | INDEL Mutation - genetics | DNA Repair - genetics | Mutation - genetics | Lentivirus | Blotting, Western | Deoxyribonucleases - metabolism | Genetic Vectors - genetics | Targeted Gene Repair - methods | Myoblasts - metabolism | Oligonucleotides, Antisense - genetics | High-Throughput Nucleotide Sequencing | Muscular Dystrophy, Duchenne - genetics | Muscular Dystrophy, Duchenne - therapy | Gene Knock-In Techniques - methods | Genetic Therapy - methods
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12. Full Text British Society for Gene Therapy 2012March 9, 2012UCL Institute of Child Health, London
by Cheng, Seng H and Smart, Nicola and Cartier, Nathalie and Cartier, Nathalie and Pizzitola, I and Anjos-Afonso, F and Marin, V and Lassailly, F and Finney, H and Pule, M and Biondi, A and Biagi, E and Bonnet, D and Carmo, Marlene and Carmo, Marlene and Arumugam, Paritha and Montiel-Equihua, Claudia A and Montiel-Equihua, Claudia A and Alonso-Ferrero, Maria E and Alonso-Ferrero, Maria E and Alonso-Ferrero, Maria E and Schambach, Axel and Baum, Christopher and Risma, Kimberly and Malik, Punam and Thrasher, Adrian J and Thrasher, Adrian J and Thrasher, Adrian J and Jordan, Michael B and Gaspar, Bobby and Gaspar, Bobby and Gicquel, Evelyne and Charton, Karine and Daniele, Nathalie and Richard, Isabelle and Bendle, Gavin M and Linnemann, Carsten and Bies, Laura and Song, Ji-Ying and Schumacher, Ton N and Singh, Charanjit and Munkonge, Felix M and Smith, Stephen N and Griesenbach, Uta and Carzaniga, Raffaella and Pape, Tillmann and Cheng, Seng H and Rogers, Andrew and Dewar, Ann and Alton, Eric W F W and Sung, Peggy and Sung, Peggy and Mukherjee, Sayandip and Mukherjee, Sayandip and Thrasher, Adrian J and Thrasher, Adrian J and Gubernator, Miriam and Riu, Federica and Mitchell, Kathryn and Katare, Rajesh and Spinetti, Gaia and Prandi, Francesca and Pesce, Maurizio and Madeddu, Paolo and Ruffert, Karelia and Fourcade, Stéphane and Ferrer, Isidre and Portero-Otin, Manuel and L'Homme, Bruno and Bièche, Ivan and Laurendeau, Ingrid and Ahouansou, Ornella and Fouquet, Françoise and Guidoux-Boralévi, Sylvie and Aubourg, Patrick and Aubourg, Patrick and Pujol, Aurora and Ghorashian, Sara and Holler, Angelika and Holler, Angelika and Flutter, Barry and Xue, Shao-An and Fallah-Arani, Farnaz and Sivakumaran, Janani and Bennett, Clare and Morris, Emma and Stauss, Hans J and Chakraverty, Ronjon and Mitchell, Kathryn J and Beltrami, Antonio P and Popplewell, Linda and Koo, Taeyoung and Kymäläinen, Hanna and Leclerc, Xavier and Duclert, Aymeric and Mouly, Vincent and Voit, Thomas and Paques, Frédéric and Cedrone, Frederic and Yáñez-Muñoz, Rafael J and ...
Human Gene Therapy, ISSN 1043-0342, 05/2012, Volume 23, Issue 5, pp. A1 - A22
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13. MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM THE DYSTROPHIN GENE AND USES THEREOF
by CEDRONE FREDERIC
06/2013
The invention relates to meganuclease variants which cleave a DNA target sequence from the human dystrophin gene (DMD), to vectors encoding such variants, to a... 
WINE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
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14. MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM THE DYSTROPHIN GENE AND USES THEREOF
by CEDRONE, FREDERIC
03/2013
WINE | HYGIENE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MICROBIOLOGY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
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15. MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE IN THE WAS GENE AND USES THEREOF
by CEDRONE, FREDERIC
04/2012
Meganuclease variants cleaving DNA target sequences of the WAS gene, vectors encoding such variants, and cells expressing them. Methods of using meganuclease... 
WINE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
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16. Full Text Directed Evolution of the Epoxide Hydrolase from Aspergillus niger
by Cedrone, Frederic and Niel, Sebastien and Roca, Sanja and Bhatnagar, Tej and Ait-abdelkader, Nadra and Torre, Claudia and Krumm, Holger and Maichele, Andrea and T. Reetz, Manfred and C. Baratti, Jacques
Biocatalysis and Biotransformation, ISSN 1024-2422, 12/2003, Volume 21, Issue 6, pp. 357 - 364
An efficient and genetically stable expression system for the directed evolution of epoxide hydrolase from Aspergillus niger (ANEH) has been constructed. Error... 
Expression system | Catalytic efficiency | Directed evolution | Enantioselectivity | Enzyme engineering | Epoxide hydrolase | enantioselectivity | BIOCATALYSTS | enzyme engineering | MUTAGENESIS | expression system | CIS PROLINE MUTANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | RESOLUTION | ENANTIOSELECTIVE CATALYSTS | ENZYME | RIBONUCLEASE-A | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | epoxide hydrolase | CHEMISTRY | EXPRESSION | directed evolution | catalytic efficiency
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17. MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE IN THE WAS GENE AND USES THEREOF
by CEDRONE, FREDERIC
01/2012
Meganuclease variants cleaving DNA target sequences of the WAS gene, vectors encoding such variants, and cells expressing them. Methods of using meganuclease... 
WINE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
Patent
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18. MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM THE DYSTROPHIN GENE AND USES THEREOF
by CEDRONE, FREDERIC
11/2011
The invention relates to meganuclease variants which cleave a DNA target sequence from the human dystrophin gene (DMD), to vectors encoding such variants, to a... 
WINE | HYGIENE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MICROBIOLOGY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
Patent
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19. MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM THE DYSTROPHIN GENE AND USES THEREOF
by CEDRONE, FREDERIC
11/2011
The invention relates to meganuclease variants which cleave a DNA target sequence from the human dystrophin gene (DMD), to vectors encoding such variants, to a... 
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