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Science, ISSN 0036-8075, 8/2006, Volume 313, Issue 5790, pp. 1137 - 1140
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2640 - 2650
Journal Article
Nature, ISSN 0028-0836, 07/2007, Volume 447, Issue 7147, pp. 959 - 965
Journal Article
Science, ISSN 0036-8075, 10/2004, Volume 306, Issue 5695, pp. 457 - 461
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show... 
Obesity | Phosphorylation | Receptors | Quantification | Liver | Lead | Insulin resistance | Type 2 diabetes mellitus | Insulin | Research Article | Type 1 diabetes mellitus | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | ER STRESS | JNK | MULTIDISCIPLINARY SCIENCES | KINASE | IRE1 | RESISTANCE | TRANSCRIPTION FACTOR | XBP-1 | TRANSLATIONAL CONTROL | eIF-2 Kinase - metabolism | Endoplasmic Reticulum - metabolism | Homeostasis | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Phosphoproteins - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Adipose Tissue - metabolism | Insulin Receptor Substrate Proteins | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Liver - metabolism | Cells, Cultured | Insulin Resistance | Rats | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Obesity - metabolism | Insulin - metabolism | Animals | Mitogen-Activated Protein Kinase 8 | Tunicamycin - pharmacology | Glucose - metabolism | Mice, Obese | Receptor, Insulin - metabolism | Mice | Mice, Inbred BALB C | Transcription Factors | Mutation | Mitogen-Activated Protein Kinases - metabolism | Type 2 diabetes | Causes of | Stress (Physiology) | Research | Endoplasmic reticulum | Cell culture | Enzymes | Medical research | Diabetes | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 2006, Volume 4, Issue 6, pp. 465 - 474
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2640 - 2650
Journal Article
Nature, ISSN 0028-0836, 11/2002, Volume 420, Issue 6913, pp. 333 - 336
Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of... 
APOPTOSIS | LIPID-METABOLISM | PROTEIN-KINASE | GLUCOSE | MULTIDISCIPLINARY SCIENCES | C-JUN ACTIVATION | TNF-ALPHA | DIFFERENTIATION | STRESS | Phosphorylation | Diabetes Mellitus, Type 2 - genetics | Adipose Tissue - physiopathology | Homeostasis | Phosphoproteins - metabolism | Obesity - genetics | Adipose Tissue - metabolism | Insulin Resistance - physiology | Gene Deletion | Insulin Receptor Substrate Proteins | Hyperinsulinism - enzymology | Hyperinsulinism - genetics | Diabetes Mellitus, Type 2 - complications | Disease Models, Animal | Hyperinsulinism - physiopathology | Insulin - pharmacology | Hyperinsulinism - complications | Obesity - complications | Diabetes Mellitus, Type 2 - enzymology | Lipid Metabolism | Obesity - physiopathology | Mice, Knockout | Mitogen-Activated Protein Kinases - deficiency | Animals | Diabetes Mellitus, Type 2 - physiopathology | Mitogen-Activated Protein Kinase 8 | Diet | Mitogen-Activated Protein Kinase 9 | Signal Transduction - drug effects | Insulin Resistance - genetics | Mice, Obese | Mitogen-Activated Protein Kinases - genetics | Receptor, Insulin - metabolism | Adipose Tissue - enzymology | Mice | Obesity - enzymology | Blood Glucose - metabolism | Mitogen-Activated Protein Kinases - metabolism | Obesity | Diabetes | Cytokines | Health risk assessment | Insulin | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2012, Volume 109, Issue 27, pp. E1868 - E1877
Atherosclerosis and insulin resistance are major components of the cardiometabolic syndrome, a global health threat associated with a systemic inflammatory... 
Obesity | Biotherapy | Cardiovascular diseases | Collagen | Diabetes mellitus | biotherapy | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | collagen | OSTEOGENIC DIFFERENTIATION | diabetes mellitus | cardiovascular diseases | AORTIC-VALVE CALCIFICATION | NONPRODUCTIVE ANGIOGENESIS | MACROPHAGE ACTIVATION | INHIBITS TUMOR-GROWTH | IMMUNE-SYSTEM | INSULIN-RESISTANCE | NF-KAPPA-B | obesity | ADIPOSE-TISSUE | Receptors, Notch - metabolism | Humans | Adipocytes - cytology | Intracellular Signaling Peptides and Proteins - immunology | Metabolic Syndrome - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Adipose Tissue - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Atherosclerosis - therapy | Immunity, Innate - physiology | Insulin Resistance - physiology | Chemokine CCL2 - metabolism | Membrane Proteins - metabolism | Metabolic Syndrome - immunology | Intracellular Signaling Peptides and Proteins - genetics | Saphenous Vein - cytology | Macrophages - immunology | Aortic Valve Insufficiency - metabolism | Receptors, LDL - genetics | Atherosclerosis - immunology | Endothelial Cells - metabolism | Membrane Proteins - genetics | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Metabolic Syndrome - therapy | Mice, Transgenic | 3T3-L1 Cells | Atherosclerosis - metabolism | Aortic Valve Insufficiency - immunology | Macrophages - metabolism | Animals | Endothelial Cells - cytology | Adipocytes - metabolism | Mice, Obese | Signal Transduction - physiology | Mice | Intercellular Signaling Peptides and Proteins - immunology | Cell culture | Global health | Molecules | Signal transduction | Rodents | Atherosclerosis | Insulin resistance | Metabolic disorders | Index Medicus | Biological Sciences | PNAS Plus
Journal Article