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1. Full Text Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1-4 in Italy
by Bertoli, Ada and Sorbo, Maria Chiara and Aragri, Marianna and Lenci, Ilaria and Teti, Elisabetta and Polilli, Ennio and Di Maio, Velia Chiara and Gianserra, Laura and Biliotti, Elisa and Masetti, Chiara and Magni, Carlo F and Babudieri, Sergio and Nicolini, Laura A and Milana, Martina and Cacciatore, Pierluigi and Sarmati, Loredana and Pellicelli, Adriano and Paolucci, Stefania and Craxì, Antonio and Morisco, Filomena and Palitti, Valeria Pace and Siciliano, Massimo and Coppola, Nicola and Iapadre, Nerio and Puoti, Massimo and Rizzardini, Giuliano and Taliani, Gloria and Pasquazzi, Caterina and Andreoni, Massimo and Parruti, Giustino and Angelico, Mario and Perno, Carlo Federico and Cento, Valeria and Ceccherini-Silberstein, Francesca and Andreone, Pietro and Baldanti, Fausto and Barbarini, Giorgio and Boccaccio, Vincenzo and Boglione, Lucio and Bolis, Matteo and Bonora, Stefano and Borghi, Vanni and Brancaccio, Giuseppina and Bruno, Savino and Bruzzone, Bianca and Calvaruso, Vincenza and Caporaso, Nicola and Ciaccio, Antonio and Ciancio, Alessia and Colombatto, Piero and Cozzolongo, Raffaele and D'Ambrosio, Cecilia and D'Ettorre, Gabriella and De Leonardis, Francesco and De Luca, Andrea and Di Biagio, Antonio and Di Perri, Giovanni and Francioso, Simona and Gaeta, Giovanni Battista and Gasbarrini, Antonio and Ghisetti, Valeria and Giorgini, Alessia and Grieco, Antonio and Gubertini, Guido and Gulminetti, Roberto and Lambiase, Lara and Landonio, Simona and Lichtner, Miriam and Maida, Ivana and Marenco, Simona and Marinaro, Letizia and Maserati, Renato and Melis, Michela and Menzaghi, Barbara and Meregalli, Elisa and Micheli, Valeria and Niero, Fosca and Paoloni, Maurizio and Pieri, Alessandro and Rendina, Maria and Romagnoli, Dante and Rossetti, Barbara and Ruggiero, Tina and Sangiovanni, Vincenzo and Starace, Mario and Sticchi, Laura and Tarquini, Pierluigi and Toniutto, Pierluigi and Vullo, Vincenzo and Zazzi, Maurizio and Hcv Virology Italian Resistance Ne and HCV Virology Italian Resistance Network (VIRONET-C)
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 8988 - 11
Natural resistance-associated substitutions (RASs) are reported with highly variable prevalence across different HCV genotypes (GTs). Frequency of natural RASs... 
GLECAPREVIR | TREATMENT-NAIVE | REAL-LIFE | PIBRENTASVIR | CIRRHOSIS | MULTIDISCIPLINARY SCIENCES | SIMEPREVIR PLUS SOFOSBUVIR | RESPONSE RATES | DIRECT-ACTING ANTIVIRALS | 1 INFECTION | OPEN-LABEL | Hepatitis C | Disease resistance | Genotypes
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2. Full Text Multiclass HCV resistance to direct‐acting antiviral failure in real‐life patients advocates for tailored second‐line therapies
by Di Maio, Velia C and Cento, Valeria and Lenci, Ilaria and Aragri, Marianna and Rossi, Piera and Barbaliscia, Silvia and Melis, Michela and Verucchi, Gabriella and Magni, Carlo F and Teti, Elisabetta and Bertoli, Ada and Antonucci, FrancescoPaolo and Bellocchi, Maria C and Micheli, Valeria and Masetti, Chiara and Landonio, Simona and Francioso, Simona and Santopaolo, Francesco and Pellicelli, Adriano M and Calvaruso, Vincenza and Gianserra, Laura and Siciliano, Massimo and Romagnoli, Dante and Cozzolongo, Raffaele and Grieco, Antonio and Vecchiet, Jacopo and Morisco, Filomena and Merli, Manuela and Brancaccio, Giuseppina and Di Biagio, Antonio and Loggi, Elisabetta and Mastroianni, Claudio M and Pace Palitti, Valeria and Tarquini, Pierluigi and Puoti, Massimo and Taliani, Gloria and Sarmati, Loredana and Picciotto, Antonino and Vullo, Vincenzo and Caporaso, Nicola and Paoloni, Maurizio and Pasquazzi, Caterina and Rizzardini, Giuliano and Parruti, Giustino and Craxì, Antonio and Babudieri, Sergio and Andreoni, Massimo and Angelico, Mario and Perno, Carlo F and Ceccherini‐Silberstein, Francesca and Mariani, R and Iapadre, N and Grimaldi, A and Cozzolongo, R and Andreone, P and Verucchi, G and Menzaghi, B and Quirino, T and Pisani, V and Torti, C and Vecchiet, J and Bruzzone, B and De Maria, A and Marenco, S and Nicolini, L.A and Viscoli, C and Casinelli, K and Delle Monache, M and Lichtner, M and Aghemo, A and Boccaccio, V and Bruno, S and Cerrone, M and Colombo, M and D'Arminio Monforte, A and Danieli, E and Donato, F and Gubertini, G and Lleo, A and Magni, C.F and Mancon, A and Monico, S and Niero, F and Russo, M.L and Gnocchi, M and Orro, A and Milanesi, L and Baldelli, E and Bertolotti, M and Borghi, V and Mussini, C and Brancaccio, G and Gaeta, G.B and Lembo, V and Sangiovanni, V and Di Marco, V and Mazzola, A and Petta, S and D'Amico, E and Cacciatore, P and ... and HCV Italian Resistance Network Stu and HCV Italian Resistance Network Study Group and the HCV Italian Resistance Network Study Group
Liver International, ISSN 1478-3223, 04/2017, Volume 37, Issue 4, pp. 514 - 528
Background & Aims Despite the excellent efficacy of direct‐acting antivirals (DAA) reported in clinical trials, virological failures can occur, often... 
hepatitis C virus | direct‐acting antivirals | resistance test | antiviral therapy | resistance‐associated substitutions | resistance-associated substitutions | direct-acting antivirals | LONG-TERM PERSISTENCE | VARIANTS | SOFOSBUVIR | RIBAVIRIN | GENOTYPE 1 | TREATMENT-NAIVE | HEPATITIS-C VIRUS | NS5A | INFECTION | RETREATMENT | GASTROENTEROLOGY & HEPATOLOGY | Hepacivirus - drug effects | Sofosbuvir - therapeutic use | Recurrence | Antiviral Agents - therapeutic use | Humans | Middle Aged | Ribavirin - therapeutic use | Hepacivirus - genetics | Viral Nonstructural Proteins - genetics | Genotype | Male | Interferons - therapeutic use | Hepatitis C, Chronic - drug therapy | Sequence Analysis, DNA | Drug Resistance, Viral - genetics | Treatment Failure | Female | Italy | Aged | Mutation | Sustained Virologic Response | Drug Therapy, Combination | Care and treatment | Interferon | Biological response modifiers | Hepatitis C virus | Hepatitis C | Analysis | Medical research | Failure analysis | Genes | Clinical trials | Patients | Failure | Ribavirin
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3. Full Text THU-117-Evaluation of risk factors associated with failure to a first-line NS5A-containing regimen in HCV-infected patients naive to direct acting antivirals: Particular focus on natural resistance
by Barbaliscia, Silvia and Maio, Velia Chiara Di and Teti, Elisabetta and Aragri, Marianna and Paolucci, Stefania and Masetti, Chiara and D’ambrosio, Roberta and Polilli, Ennio and Palitti, Valeria Pace and Fiorentino, Gianluca and Cento, Valeria and Scutari, Rossana and Bruzzone, Bianca and Calvaruso, Vincenza and Nicola, Coppola and Gaeta, Giovanni Battista and Morsica, Giulia and Ghisetti, Valeria and Bertoli, Ada and Milana, Martina and Foroghi, Luca and Nicolini, Laura Ambra and Borghi, Vanni and Campoli, Riccardo and Galli, Silvia and Magni, Carlo Federico and Micheli, Valeria and Boccaccio, Vincenzo and Maserati, Renato and Bonora, Stefano and Iapadre, Nerio and Morisco, Filomena and Siciliano, Massimo and Andreone, Pietro and Lichtner, Miriam and Paba, Pierpaolo and Sarmati, Loredana and Puoti, Massimo and Craxi, Antonio and Pellicelli, Adriano and Babudieri, Sergio and Rizzardini, Giuliano and Taliani, Gloria and Lampertico, Pietro and Pasquazzi, Caterina and Parruti, Giustino and Mario, Angelico and Andreoni, Massimo and Perno, Carlo Federico and Silberstein, Francesca Ceccherini
Journal of Hepatology, ISSN 0168-8278, 04/2019, Volume 70, Issue 1, pp. e209 - e210
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4. Full Text Frequent NS5A and multiclass resistance in almost all HCV genotypes at DAA failures: What are the chances for second-line regimens?
by Di Maio, Velia Chiara and Cento, Valeria and Aragri, Marianna and Paolucci, Stefania and Pollicino, Teresa and Coppola, Nicola and Bruzzone, Bianca and Ghisetti, Valeria and Zazzi, Maurizio and Brunetto, Maurizia and Bertoli, Ada and Barbaliscia, Silvia and Galli, Silvia and Gennari, William and Baldanti, Fausto and Raimondo, Giovanni and Perno, Carlo Federico and Ceccherini-Silberstein, Francesca and Andreone, Pietro and Andreoni, Massimo and Angelico, Mario and Babudieri, Sergio and Barbarini, Giorgio and Boccaccio, Vincenzo and Boglione, Lucio and Bolis, Matteo and Bonora, Stefano and Borghi, Vanni and Brancaccio, Giuseppina and Bruno, Savino and Cacciatore, Pierluigi and Calvaruso, Vincenza and Caporaso, Nicola and Ciaccio, Antonio and Ciancio, Alessia and Colombatto, Piero and Cozzolongo, Raffaele and Craxì, Antonio and D'Ambrosio, Cecilia and D'Ettorre, Gabriella and De Luca, Andrea and Di Biagio, Antonio and Di Perri, Giovanni and Francioso, Simona and Gaeta, Giovanni Battista and Giorgini, Alessia and Grieco, Antonio and Gubertini, Guido and Gulminetti, Roberto and Lambiase, Lara and Lenci, Ilaria and Lichtner, Miriam and Maida, Ivana and Marenco, Simona and Marinaro, Letizia and Maserati, Renato and Masetti, Chiara and Melis, Michela and Meregalli, Elisa and Micheli, Valeria and Morisco, Filomena and Niero, Fosca and Nicolini, Laura Ambra and Palitti, Valeria Pace and Paoloni, Maurizio and Parruti, Giustino and Pasquazzi, Caterina and Pellicelli, Adriano and Polilli, Ennio and Ponti, Maria Laura and Puoti, Massimo and Rendina, Maria and Rizzardini, Giuliano and Rossetti, Barbara and Ruggiero, Tina and Sangiovanni, Vincenzo and Starace, Mario and Sticchi, Laura and Tarquini, Pierluigi and Toniutto, Pierluigi and Vullo, Vincenzo and HCV Virology Italian Resistance Network (VIRONET-C)
Journal of Hepatology, ISSN 0168-8278, 03/2018, Volume 68, Issue 3, pp. 597 - 600
GASTROENTEROLOGY & HEPATOLOGY | DRUGS
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5. Full Text Study of Genotypic and Phenotypic HIV-1 Dynamics of Integrase Mutations During Raltegravir Treatment: A Refined Analysis by Ultra-Deep 454 Pyrosequencing
by Daniele Armenia and Ina Vandenbroucke and Lavinia Fabeni and Herwig Van Marck and Valeria Cento and Roberta D'Arrigo and Liesbeth Van Wesenbeeck and Fernanda Scopelliti and Valeria Micheli and Bianca Bruzzone and Sergio Lo Caputo and Jeroen Aerssens and Giuliano Rizzardini and Valerio Tozzi and Pasquale Narciso and Andrea Antinori and Lieven Stuyver and Carlo Federico Perno and Francesca Ceccherini-Silberstein
The Journal of Infectious Diseases, ISSN 0022-1899, 2/2012, Volume 205, Issue 4, pp. 557 - 567
Background. The dynamics of raltegravir-resistant variants and their impact on virologie response in 23 HIV-1-infected patients, who started a salvage... 
Haplotypes | HIV/AIDS | Antiretrovirals | HIV | RNA | Viruses | Evolution | Genetic mutation | Sequencing | HIV 1 | Virology | INFECTIOUS DISEASES | PHYLOGENIES | INHIBITOR RALTEGRAVIR | MICROBIOLOGY | DRUG-RESISTANCE | IMMUNOLOGY | FAILURE | MINORITY VARIANTS | THERAPY | EVOLUTION | FREQUENCY | EFAVIRENZ | TREATMENT-NAIVE PATIENTS | HIV Infections - virology | Humans | Drug Resistance, Viral | Molecular Sequence Data | Genotype | Male | Mutation, Missense | Phylogeny | HIV-1 - genetics | HIV-1 - classification | Anti-HIV Agents - administration & dosage | Microbial Sensitivity Tests | Pyrrolidinones - administration & dosage | Phenotype | HIV Integrase - genetics | HIV-1 - isolation & purification | Adult | Female | HIV Infections - drug therapy | HIV-1 - enzymology | Raltegravir Potassium | Sequence Analysis, DNA - methods | Salvage Therapy - methods | HIV patients | Care and treatment | Health aspects | Raltegravir | Major and Brief Reports
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6. Full Text THU-133-Resistance-guided retreatment of HCV infected patients with a previous failure to an NS5A inhibitor-containing regimen: Italian real life experience
by Maio, Velia Chiara Di and Aragri, Marianna and Masetti, Chiara and Paolucci, Stefania and Bruzzone, Bianca and Degasperi, Elisabetta and Barbaliscia, Silvia and Pollicino, Teresa and Minichini, Carmine and Calvaruso, Vincenza and Rendina, Maria Grazia and Cento, Valeria and Teti, Elisabetta and Micheli, Valeria and Ghisetti, Valeria and Polilli, Ennio and Palitti, Valeria Pace and Landonio, Simona and Lenci, Ilaria and Donnarumma, Laura and Nicolini, Laura Ambra and Bertoli, Ada and Pasquazzi, Caterina and Callegaro, Maria Paola and Morisco, Filomena and Cenderrello, Giovanni and Marenco, Simona and Gulminetti, Roberto and Novati, Stefano and Andreone, Pietro and Ciancio, Alessia and Sangiovanni, Vincenzo and Cuomo, Nunzia and Morsica, Giulia and Borghi, Vanni and Maida, Ivana Rita and Brunetto, Maurizia and Cozzolongo, Raffaele and Santis, Adriano De and Lichtner, Miriam and Babudieri, Sergio and Taliani, Gloria and Santantonio, Teresa and Paternoster, Claudio and Ganga, Roberto and Puoti, Massimo and Rizzardini, Giuliano and Pellicelli, Adriano and Lampertico, Pietro and Parruti, Giustino and Nicola, Coppola and Zazzi, Maurizio and Raimondo, Giovanni and Andreoni, Massimo and Craxi, Antonio and Mario, Angelico and Perno, Carlo Federico and Ceccherini, Silberstein Francesca
Journal of Hepatology, ISSN 0168-8278, 04/2019, Volume 70, Issue 1, pp. e218 - e219
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7. Full Text Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens
by Cento, Valeria and Nguyen, Thi Huyen Tram and Di Carlo, Domenico and Biliotti, Elisa and Gianserra, Laura and Lenci, Ilaria and Di Paolo, Daniele and Calvaruso, Vincenza and Teti, Elisabetta and Cerrone, Maddalena and Romagnoli, Dante and Melis, Michela and Danieli, Elena and Menzaghi, Barbara and Polilli, Ennio and Siciliano, Massimo and Nicolini, Laura Ambra and Di Biagio, Antonio and Magni, Carlo Federico and Bolis, Matteo and Antonucci, Francesco Paolo and Di Maio, Velia Chiara and Alfieri, Roberta and Sarmati, Loredana and Casalino, Paolo and Bernardini, Sergio and Micheli, Valeria and Rizzardini, Giuliano and Parruti, Giustino and Quirino, Tiziana and Puoti, Massimo and Babudieri, Sergio and Monforte, Antonella D'Arminio and Andreoni, Massimo and Craxì, Antonio and Angelico, Mario and Pasquazzi, Caterina and Taliani, Gloria and Guedj, Jeremie and Perno, Carlo Federico and Ceccherini-Silberstein, Francesca
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177352
Background Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by... 
PROTEASE INHIBITOR | INTERFERON-ALPHA | TELAPREVIR | HEPATITIS-C VIRUS | MULTIDISCIPLINARY SCIENCES | TREATMENT-EXPERIENCED PATIENTS | TRIPLE THERAPY | ALANINE AMINOTRANSFERASE | INFECTED-CELLS | RIBAVIRIN | DYNAMICS IN-VIVO | Hepatitis C - drug therapy | Humans | Middle Aged | Hepacivirus - genetics | Male | RNA, Viral - blood | Alanine Transaminase - blood | Simeprevir - administration & dosage | Ribavirin - administration & dosage | Female | Drug Therapy, Combination | Antiviral Agents - pharmacology | Sofosbuvir - pharmacology | Administration, Oral | Interferons - pharmacology | Treatment Outcome | Antiviral Agents - administration & dosage | Simeprevir - pharmacology | Sofosbuvir - administration & dosage | Aged | Oligopeptides - administration & dosage | Alanine Transaminase - metabolism | Kinetics | Oligopeptides - pharmacology | Viral Nonstructural Proteins - antagonists & inhibitors | Ribavirin - pharmacology | Care and treatment | RNA | Dynamics | Interferon | Alanine aminotransferase | Research | Drug therapy | Hepatitis C | Liver cirrhosis | Syngeneic grafts | Liver | Proteinase | Antiinfectives and antibacterials | Tropical diseases | Hepatitis | Genotype & phenotype | Surgery | Damage | Liver diseases | Mortality | Cirrhosis | Chemotherapy | Hospitals | Infectious diseases | Inhibitors | Hepatocytes | Adults | Clinical medicine | Liver transplantation | Drugs | Health sciences | Microbiology | Medical services | Population studies | Viruses | Transplantation | Infections | Immunosuppressive agents | Biomedical materials | Reduction | Hepatology | Gastroenterology | Mathematical models | Clinical microbiology | Enzyme-linked immunosorbent assay | CpG islands | Antiviral agents | Alanine | Receiving | Health | Markers | Antimicrobial agents | Pharmacology | Ribonucleic acid--RNA | Medicine | Cell death | Decay | Ribonucleic acid
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8. Full Text Two-drug regimens with dolutegravir plus rilpivirine or lamivudine in HIV-1 treatment-naïve, virologically-suppressed patients: latest evidences from the literature on their efficacy and safety
by Cento, Valeria and Perno, Carlo Federico
Journal of Global Antimicrobial Resistance, ISSN 2213-7165, 08/2019
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9. Full Text Optimal cure rate by personalized HCV regimens in real-life: A proof-of-concept study
by Cento, Valeria and Aragri, Marianna and Teti, Elisabetta and Polilli, Ennio and Bertoli, Ada and Foroghi, Luca and Barbaliscia, Silvia and Di Maio, Velia Chiara and Pieri, Alessandro and Palitti, Valeria Pace and Sarmati, Loredana and Parruti, Giustino and Andreoni, Massimo and Perno, Carlo Federico and Ceccherini-Silberstein, Francesca
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 12/2017, Volume 72, Issue 12, pp. 3420 - 3424
Background: Pretreatment evaluation of HCV-infected patients is a complex interplay between multiple clinical and viral parameters, leading to a tailored... 
INFECTIOUS DISEASES | NS5A | CIRRHOSIS | RESISTANCE-ASSOCIATED SUBSTITUTIONS | SIMEPREVIR PLUS SOFOSBUVIR | GENOTYPE 1 INFECTION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PREVALENCE | PHASE-3 | ANTIVIRAL DRUGS
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10. Full Text The Genotypic False Positive Rate Determined by V3 Population Sequencing Can Predict the Burden of HIV-1 CXCR4-using Species Detected by Pyrosequencing
by Svicher, Valentina and Cento, Valeria and Rozera, Gabriella and Abbate, Isabella and Santoro, Maria Mercedes and Armenia, Daniele and Fabeni, Lavinia and Bruselles, Alessandro and Latini, Alessandra and Palamara, Guido and Micheli, Valeria and Rizzardini, Giuliano and Gori, Caterina and Forbici, Federica and Ippolito, Giuseppe and Andreoni, Massimo and Antinori, Andrea and Ceccherini-Silberstein, Francesca and Capobianchi, Maria Rosaria and Perno, Carlo Federico
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53603
Objective: The false-positive rate (FPR) is a percentage-score provided by Geno2Pheno-algorithm indicating the likelihood that a V3-sequence is falsely... 
IMPACT | 1ST | TROPISM | MULTIDISCIPLINARY SCIENCES | LOOP | CORECEPTOR USAGE | MARAVIROC | GP120 | TOOLS | HIV Envelope Protein gp120 - genetics | Protein Structure, Tertiary | Temperature | Humans | Genotype | Male | False Positive Reactions | Genotyping Techniques | HIV-1 - genetics | Viral Load - genetics | Receptors, CXCR4 - metabolism | Genetic Variation | Base Sequence | Adult | Female | HIV Envelope Protein gp120 - chemistry | Sequence Analysis, DNA - methods | Antiviral agents | Algorithms | Analysis | HIV testing | Nucleotide sequencing | HIV (Viruses) | DNA sequencing | Tropism | CCR5 protein | Viremia | Clinical trials | Amino acids | Patients | CXCR4 protein | Medicine | Studies | Human immunodeficiency virus--HIV | Low cost | Surgery | Population | Sensitivity enhancement | Clinical medicine | Mutation | HIV | Human immunodeficiency virus
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11. Two-drug regimens with dolutegravir plus rilpivirine or lamivudine in HIV-1 treatment-naïve, virologically-suppressed patients: latest evidences from the literature on their efficacy and safety
by Cento, Valeria and Perno, Carlo Federico
Journal of global antimicrobial resistance, 08/2019
In HIV-positive population, a paradigm shift from three-drug regimens to dolutegravir-based two-drug regimens as both initial and switch treatment approach is... 
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12. Full Text Hepatitis C virus gene sequencing as a tool for precise genotyping in the era of new direct antiviral agents
by Ceccherini Silberstein, Francesca and Di Maio, Velia Chiara and Aragri, Marianna and Ciotti, Marco and Cento, Valeria and Perno, Carlo Federico
Hepatology, ISSN 0270-9139, 03/2016, Volume 63, Issue 3, pp. 1058 - 1059
Hepacivirus - genetics | Sequence Analysis, RNA | Genotyping Techniques | Molecular Targeted Therapy | Genotyping | Hepatitis C | Antiviral agents
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13. Full Text HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors
by Cento, Valeria and Mirabelli, Carmen and Salpini, Romina and Dimonte, Salvatore and Artese, Anna and Costa, Giosuè and Mercurio, Fabio and Svicher, Valentina and Parrotta, Lucia and Bertoli, Ada and Ciotti, Marco and Di Paolo, Daniele and Sarrecchia, Cesare and Andreoni, Massimo and Alcaro, Stefano and Angelico, Mario and Perno, Carlo Federico and Ceccherini-Silberstein, Francesca
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e39652
Background: Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific HCV-genotypes are differently prone to develop... 
PLUS RIBAVIRIN | TELAPREVIR | REPLICATION | PEGINTERFERON ALPHA-2B | BIOLOGY | HEPATITIS-C-VIRUS | 1 INFECTION | NS3/4A PROTEASE | ANTIVIRAL EFFICACY | GENETIC BARRIER | DRUG-RESISTANCE | Hepacivirus - drug effects | Amino Acid Sequence | Antiviral Agents - pharmacology | Hepatitis C - drug therapy | Antiviral Agents - therapeutic use | Humans | Drug Resistance, Viral | Hepacivirus - genetics | Molecular Sequence Data | Protease Inhibitors - chemistry | Viral Nonstructural Proteins - genetics | Genotype | Genetic Variation | Protease Inhibitors - pharmacology | Sequence Alignment | Viral Nonstructural Proteins - chemistry | RNA, Viral - chemistry | RNA, Viral - genetics | Antiviral Agents - chemistry | Protein Conformation | Molecular Docking Simulation | Nucleic Acid Conformation | Protease Inhibitors - therapeutic use | Medical research | RNA | Protease inhibitors | Proteases | Analysis | Medicine, Experimental | Amino acids | Genetic aspects | Drug resistance | Hepatitis C virus | Residues | Internal medicine | Variability | Clinical trials | Viruses | Proteinase inhibitors | Ribonucleic acid--RNA | Virology | Medicine | Hepatitis | Protease | Gastroenterology | Mutation | Catalysis | Hepatitis C | Genotypes | Public health | Ribonucleic acid
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14. Full Text Efficacy and safety of sofosbuvir/simeprevir plus flat dose ribavirin in genotype 1 elderly cirrhotic patients: A real‐life study
by Pellicelli, Adriano M and Pace Palitti, Valeria and Vignally, Pascal and Ceccherini‐Silberstein, Francesca and Siciliano, Massimo and Giannelli, Valerio and Moretti, Alessandra and Tarquini, Pierluigi and Scifo, Gaetano and Messina, Vincenzo and Ascione, Antonio and Izzi, Antonio and Marignani, Massimo and D'Ambrosio, Cecilia and Fondacaro, Lucia and Ettorre, Giuseppe M and Ialongo, Pasquale and Sacco, Rodolfo and Perno, Carlo F and Barbarini, Giorgio and Miglioresi, Lucia and Villani, Roberto and Cento, Valeria and Chiesara, Francesca W and Alessio, Loredana and Fontanella, Luca and Imperatrice, Barbara and Begini, Paola and Vennarecci, Giovanni and Barlattani, Angelo and Armignacco, Orlando and Di Candilo, Francesco and CLEO Grp and CLEO Group and the CLEO Group
Liver International, ISSN 1478-3223, 05/2017, Volume 37, Issue 5, pp. 653 - 661
Background & Aims The proportion of HCV‐infected patients over age 65 years in Western countries is increasing. This growth and the advent of new antiviral... 
sofosbuvir | genotype 1 | simeprevir | elderly | hepatitis C | cirrhosis | LEDIPASVIR | PEGYLATED INTERFERON | ADVANCED FIBROSIS | INFECTION | RECURRENCE | GASTROENTEROLOGY & HEPATOLOGY | HEPATITIS-C | Multivariate Analysis | Humans | Middle Aged | Hepacivirus - genetics | Male | Simeprevir - adverse effects | Simeprevir - administration & dosage | Ribavirin - administration & dosage | Aged, 80 and over | Adult | Female | Retrospective Studies | Sofosbuvir - adverse effects | Drug Therapy, Combination | Anemia - etiology | Liver Cirrhosis - drug therapy | Drug Administration Schedule | Logistic Models | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Liver Cirrhosis - virology | Sofosbuvir - administration & dosage | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Italy | Aged | Sustained Virologic Response | Elderly people | Cirrhosis | Genotype & phenotype | Anemia | Diabetes mellitus | Safety | Elderly | Patients | Ribavirin | Geriatrics
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