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Diabetes, ISSN 0012-1797, 04/2013, Volume 62, Issue 4, pp. 1227 - 1237
Journal Article
Diabetes, ISSN 0012-1797, 2002, Volume 51, pp. S53 - S59
The cellular and molecular mechanisms of insulin secretion are being intensively investigated, yet most researchers are seemingly unaware of the complexity of... 
Insulin - metabolism | Animals | Glucose - physiology | Islets of Langerhans - metabolism | Humans | Signal Transduction - physiology | Diabetes Mellitus, Type 2 - metabolism | Insulin Secretion | Disease Models, Animal
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2009, Volume 4, Issue 3, pp. e4954 - e4954
Background: Palmitate is a potent inducer of endoplasmic reticulum ( ER) stress in beta-cells. In type 2 diabetes, glucose amplifies fatty-acid toxicity for... 
MULTIDISCIPLINARY SCIENCES | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Multiprotein Complexes | Oxidative Stress - physiology | Endoplasmic Reticulum - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | Mechanistic Target of Rapamycin Complex 1 | Proteins | Insulin-Secreting Cells - metabolism | Palmitates - pharmacology | Endoplasmic Reticulum - drug effects | Insulin-Secreting Cells - cytology | Membrane Proteins - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Transcription Factors - genetics | Sirolimus - pharmacology | Cycloheximide - pharmacology | Transcription Factors - metabolism | Animals | Gerbillinae | Insulin-Secreting Cells - drug effects | Glucose - metabolism | Signal Transduction - physiology | Mice | Palmitates - metabolism | TOR Serine-Threonine Kinases | Enzyme Activation | Oxidative Stress - drug effects | Toxicity | Activation | Glucose | Palmitic acid | Kinases | Rodents | Fibroblasts | Inhibition | Pancreas | Stresses | Diabetes mellitus | Protein biosynthesis | JNK protein | Rapamycin | Embryo fibroblasts | Fatty acids | Embryos | Insulin | Stress | Amplification | TSC2 protein | Anisomycin | Protein synthesis | Cell death | Insulin resistance | Endoplasmic reticulum | Cellular stress response | Apoptosis | Index Medicus
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2018, Volume 20, Issue S2, p. 95
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, p. e28804
Thioredoxin-interacting protein (TXNIP) regulates critical biological processes including inflammation, stress and apoptosis. TXNIP is upregulated by glucose... 
APOPTOSIS | CARBOHYDRATE RESPONSE ELEMENT | METABOLISM | ISLETS | GLUCOSE | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | CHREBP | GENE-EXPRESSION | BINDING PROTEIN | FAILURE | Enzyme Activators - pharmacology | AMP-Activated Protein Kinases - metabolism | Palmitic Acid - pharmacology | Rats, Wistar | Apoptosis - drug effects | AMP-Activated Protein Kinases - antagonists & inhibitors | Humans | Metformin - pharmacology | Rats | Glucose - pharmacology | Protein Transport - drug effects | Enzyme Activation - drug effects | Gene Knockdown Techniques | Oleic Acid - pharmacology | Animals | Carrier Proteins - metabolism | Cell Nucleus - metabolism | Insulin-Secreting Cells - drug effects | Isoenzymes - metabolism | Deoxyglucose - pharmacology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Insulin-Secreting Cells - cytology | Cell Nucleus - drug effects | Insulin-Secreting Cells - enzymology | Type 2 diabetes | Pancreatic beta cells | Hyperglycemia | Glucose | Thioredoxin | Protein kinases | Fatty acids | Dextrose | Protein binding | Apoptosis | Carbohydrates | Transcription | AMP | Diabetes mellitus | Homeostasis | Pharmacology | Palmitic acid | Kinases | AMP-activated protein kinase | Esterification | Biological activity | Recruitment | Beta cells | Rodents | Modulation | Nutrients | Oxidation | Inhibition | Pancreas
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2017, Volume 19, Issue S1, pp. 3 - 3
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 12/2017, Volume 34, Issue 12, pp. 2873 - 2890
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2017, Volume 19, Issue S1, pp. 63 - 75
Glucose‐stimulated insulin secretion (GSIS) involves interplay between metabolic and cationic events. Seminal contributions from multiple laboratories affirm... 
farnesylation | G‐proteins | islet β‐cell | Rac1 | NADPH oxidase | geranylgeranylation | islet β-cell | G-proteins | NORMAL RAT ISLETS | ALPHA-SUBUNIT | NADPH OXIDASE NOX2 | INDUCED INSULIN-SECRETION | GTP-BINDING PROTEINS | SIGNAL-TRANSDUCTION | islet -cell | PROMOTES ACTIVATION | MEDIATED ACTIVATION | REQUISITE ROLE | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | Diabetes Mellitus - enzymology | rab27 GTP-Binding Proteins - genetics | Humans | cdc42 GTP-Binding Protein - metabolism | Exocytosis | Insulin - blood | GTP-Binding Proteins - genetics | Protein Prenylation | Islets of Langerhans - metabolism | Islets of Langerhans - physiopathology | ADP-Ribosylation Factors - metabolism | ADP-Ribosylation Factors - genetics | Insulin Secretion | Islets of Langerhans - physiology | Signal Transduction | Islets of Langerhans - enzymology | Diabetes Mellitus - metabolism | rab27 GTP-Binding Proteins - metabolism | Protein Transport | Gene Expression Regulation, Enzymologic | Insulin - metabolism | Animals | Diabetes Mellitus - physiopathology | Models, Biological | cdc42 GTP-Binding Protein - genetics | Endoplasmic Reticulum Stress | Blood Glucose - metabolism | rac1 GTP-Binding Protein - metabolism | Apoptosis | GTP-Binding Proteins - metabolism | rac1 GTP-Binding Protein - genetics | Oxidases | Proteins | Pancreatic beta cells | Analysis | Beta cells | Rodents | Glucose | Diabetes | Metabolism | Insulin
Journal Article
Journal of Cell Science, ISSN 0021-9533, 08/2018, Volume 131, Issue 15, p. jcs212969
AMPK-mTORC1 signaling senses nutrient availability, thereby regulating autophagy. Surprisingly, we found that, in beta-cells, the AMPK activator... 
Adenosine | Nucleic acids | β-cell | Autophagy | Insulin secretion | HEPATOCYTES | HOMEOSTASIS | ACTIVATED PROTEIN-KINASE | AMP | PHOSPHORYLATION | INSULIN-SECRETION | RECEPTOR | CELL BIOLOGY | DEPENDENT KINASE | beta-cell | ADENOSINE KINASE | GROWTH
Journal Article