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1. Full Text Career perspective: Paolo Cerretelli
by Cerretelli, Paolo
Extreme Physiology and Medicine, ISSN 2046-7648, 04/2013, Volume 2, Issue 1, pp. 13 - 13
This article is an autobiographical account of my career as a human physiologist. I have spent 55 years traversing mountains, continents, seas, and skies,... 
High altitude | Tibetans vs. Caucasians | Anaerobic glycolysis | Muscle proteomics | V′O2max | Cardiac output | Chemoreflexogenic ventilatory drive | Acute and chronic hypoxia | Skeletal muscle | Muscles | Physicians | Interviews
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2. Full Text Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humans
by Bruno Grassi and Silvia Pogliaghi and Susanna Rampichini and Valentina Quaresima and Marco Ferrari and Claudio Marconi and Paolo Cerretelli
Journal of Applied Physiology, ISSN 8750-7587, 07/2003, Volume 95, Issue 1, pp. 149 - 158
Near-infrared spectroscopy (NIRS) was utilized to gain insights into the kinetics of oxidative metabolism during exercise transitions. Ten untrained young men... 
Functional evaluation | Oxidative metabolism | Oxygen uptake kinetics | Skeletal muscle | Near-infrared spectroscopy | oxidative metabolism | SPORT SCIENCES | near-infrared spectroscopy | PHYSIOLOGY | PHOSPHOCREATINE KINETICS | functional evaluation | SITU CANINE MUSCLE | O-2 DELIVERY | WORK RATE | HUMAN SKELETAL-MUSCLE | INTENSITY EXERCISE | PYRUVATE-DEHYDROGENASE | DYNAMICS | skeletal muscle | oxygen uptake kinetics | ONSET | Carbon Dioxide - metabolism | Humans | Hemoglobins - metabolism | Male | Muscle, Skeletal - metabolism | Oxygen Consumption - physiology | Pulmonary Gas Exchange - physiology | Exercise Test | Algorithms | Bicycling - physiology | Spectroscopy, Near-Infrared | Models, Biological | Adult | Exercise - physiology | Kinetics | Respiratory Mechanics - physiology | Skinfold Thickness | Body Composition - physiology
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3. Full Text Energy metabolism in hypoxia: reinterpreting some features of muscle physiology on molecular grounds
by Cerretelli, Paolo and Cerretelli, Paolo and Gelfi, Cecilia and Gelfi, Cecilia
European Journal of Applied Physiology, ISSN 1439-6319, 3/2011, Volume 111, Issue 3, pp. 421 - 432
An holistic approach for interpreting classical data on the adaptation of the animal and, particularly, of the human body to hypoxic stress was promoted by the... 
Biomedicine | Oxygen sensing | Human Physiology | Sports Medicine | Occupational Medicine/Industrial Medicine | Energy turnover | Hypoxia | Muscle proteome | Metabolic signaling | SPORT SCIENCES | OXIDATIVE STRESS | PHYSIOLOGY | INDUCIBLE FACTOR-I | HIGH-ALTITUDE | MYOGLOBIN | EXERCISE | SKELETAL-MUSCLE | OXIDASE | RESPIRATION | ADAPTATION | EXPRESSION | Humans | Hypoxia-Inducible Factor 1 - physiology | Muscles - physiology | Adaptation, Physiological - physiology | Rats | Male | Signal Transduction - genetics | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia - metabolism | Hypoxia-Inducible Factor 1 - genetics | Hypoxia - genetics | Animals | Adaptation, Physiological - genetics | Models, Biological | Hypoxia - physiopathology | Signal Transduction - physiology | Energy Metabolism - genetics | Energy Metabolism - physiology | Muscles - metabolism
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4. Full Text Changes in muscle proteomics in the course of the Caudwell Research Expedition to Mt. Everest
by Levett, Denny Z. H and Viganò, Agnese and Capitanio, Daniele and Vasso, Michele and De Palma, Sara and Moriggi, Manuela and Martin, Daniel S and Murray, Andrew J and Cerretelli, Paolo and Grocott, Mike P. W and Gelfi, Cecilia
PROTEOMICS, ISSN 1615-9853, 01/2015, Volume 15, Issue 1, pp. 160 - 171
This study employed differential proteomic and immunoassay techniques to elucidate the biochemical mechanisms utilized by human muscle (vastus lateralis) in... 
Altitude hypoxia | α‐Ketoglutarate | Biomedicine | α-Ketoglutarate | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | alpha-Ketoglutarate | MITOCHONDRIA | BIOCHEMICAL RESEARCH METHODS | HUMAN SKELETAL-MUSCLE | GLUTAMINE-METABOLISM | OXYGEN | CHRONIC HYPOXIA | ADAPTATION | EXPRESSION | CELL | MODULATION | Humans | Muscle Proteins - analysis | Muscle Proteins - metabolism | Proteomics | Stress, Physiological | Acclimatization | Adult | Female | Male | Muscle, Skeletal - metabolism | Ketoglutaric Acids - metabolism | Altitude | Protein C | Muscle proteins | Ligases | Myosin | Glutamine | Protein binding | Proteins | Enzymes | Hypoxia | Kinases | Autophagy
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5. Full Text Effects of 17-day spaceflight on electrically evoked torque and cross-sectional area of the human triceps surae
by Narici, Marco and Kayser, Bengt and Barattini, Paolo and Cerretelli, Paolo
European Journal of Applied Physiology, ISSN 1439-6319, 10/2003, Volume 90, Issue 3, pp. 275 - 282
The effects of spaceflight on triceps surae muscle torque and cross-sectional area (CSA) were investigated on four astronauts using electrically evoked... 
Electrical stimulation | Muscle atrophy | LifeSciences | Muscle contraction | Spaceflight | Disuse | muscle contraction | electrical stimulation | SPORT SCIENCES | PHYSIOLOGY | SKELETAL-MUSCLE FUNCTION | RAT | SOLEUS MUSCLE | ENVIRONMENT | ADAPTATIONS | spaceflight | WEIGHT-BEARING | CONTRACTILE | SIMULATED MICROGRAVITY | GASTROCNEMIUS | disuse | muscle atrophy | BED REST | Torque | Leg - physiology | Humans | Middle Aged | Male | Muscular Disorders, Atrophic - physiopathology | Muscle, Skeletal - physiology | Space Flight | Muscular Atrophy - physiopathology | Muscle Relaxation - physiology | Muscle Contraction - physiology | Muscle, Skeletal - physiopathology | Weightlessness - adverse effects | Recovery of Function - physiology | Adult | Astronauts | Leg - physiopathology | Muscle Fatigue - physiology | Electric Stimulation - methods | Space shuttle | Muscular system
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6. Full Text Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest
by Salanova, Michele and Gambara, Guido and Moriggi, Manuela and Vasso, Michele and Ungethuem, Ute and Belavý, Daniel L and Felsenberg, Dieter and Cerretelli, Paolo and Gelfi, Cecilia and Blottner, Dieter
Scientific Reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, p. 17027
Disuse-induced muscle atrophy is a major concern in aging, in neuromuscular diseases, post-traumatic injury and in microgravity life sciences affecting health... 
PATHWAYS | OXIDATIVE STRESS | PROTEIN | ATROPHY | MITOCHONDRIAL | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | LIMB IMMOBILIZATION | MECHANISMS | ADAPTATIONS | COUNTERMEASURES | Bed Rest | Proteome - genetics | Vibration | Humans | Gene Expression Regulation | Transcriptome | Male | Muscle, Skeletal - metabolism | Muscle Proteins - genetics | Resistance Training | Mechanotransduction, Cellular | Metabolic Networks and Pathways | Muscle Proteins - metabolism | Proteome - metabolism | Adaptations | Tricarboxylic acid cycle | Phosphorylation | Neuromuscular diseases | Transcription | Mental disorders | Contractility | Immobilization | Unloading | Space flight | Gene expression | Soleus muscle | Muscle contraction | Skeletal muscle | Atrophy | Musculoskeletal system | Oxidative phosphorylation | Glycolysis | Metabolic pathways | Lipid metabolism | Microgravity | Fitness
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7. Full Text Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle
by Robach, Paul and Cairo, Gaetano and Gelfi, Cecilia and Bernuzzi, Francesca and Pilegaard, Henriette and Viganò, Agnese and Santambrogio, Paolo and Cerretelli, Paolo and Calbet, José A. L and Moutereau, Stéphane and Lundby, Carsten
Blood, ISSN 0006-4971, 06/2007, Volume 109, Issue 11, pp. 4724 - 4731
Iron is essential for oxygen transport because it is incorporated in the heme of the oxygen-binding proteins hemoglobin and myoglobin. An interaction between... 
POSTTRANSCRIPTIONAL REGULATION | TRANSCRIPTIONAL ACTIVATION | METABOLISM | FERROPORTIN | GENE-EXPRESSION | HEPCIDIN | ALTITUDE | SOLUBLE TRANSFERRIN RECEPTOR | HEMATOLOGY | EXERCISE | FERRITIN SYNTHESIS | Erythropoiesis | Down-Regulation | Humans | Iron - chemistry | Male | Muscle, Skeletal - metabolism | Iron-Regulatory Proteins - metabolism | RNA, Messenger - metabolism | Iron - metabolism | Muscles - pathology | Myoglobin - biosynthesis | Biopsy | Oxygen - chemistry | Adult | Hypoxia | Altitude
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8. Full Text Diversity of human skeletal muscle in health and disease: Contribution of proteomics
by Gelfi, Cecilia and Vasso, Michele and Cerretelli, Paolo
Journal of Proteomics, ISSN 1874-3919, 2011, Volume 74, Issue 6, pp. 774 - 795
Muscle represents a large fraction of the human body mass. It is an extremely heterogeneous tissue featuring in its contractile structure various proportions... 
Muscle | DIGE | Mass spectrometry | Proteomics | RAT SOLEUS MUSCLE | DEPENDENT DIABETES-MELLITUS | VASTUS-LATERALIS MUSCLE | ACTIVATED PROTEIN-KINASE | BIOCHEMICAL RESEARCH METHODS | INCLUSION-BODY MYOSITIS | 2-DIMENSIONAL GEL-ELECTROPHORESIS | LIGHT-CHAIN PHOSPHORYLATION | DEFECTIVE MEMBRANE REPAIR | HPLC-ESI-MS/MS | TWO-DIMENSIONAL ELECTROPHORESIS | Cold Temperature | Humans | Mitochondria, Muscle - metabolism | Muscle Fibers, Skeletal - metabolism | Muscle, Skeletal - physiology | Proteome - analysis | Physical Conditioning, Animal - physiology | Myosin Heavy Chains - metabolism | Neuromuscular Diseases - genetics | Hypoxia - metabolism | Muscle Proteins - genetics | Animals | Immobilization - physiology | Insulin Resistance - physiology | Muscle, Skeletal - chemistry | Myositis, Inclusion Body - metabolism | Exercise - physiology | Aging - metabolism
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9. Full Text TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans
by Capitanio, Daniele and Fania, Chiara and Torretta, Enrica and Viganò, Agnese and Moriggi, Manuela and Bravatà, Valentina and Caretti, Anna and Levett, Denny Z. H and Grocott, Michael P. W and Samaja, Michele and Cerretelli, Paolo and Gelfi, Cecilia
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 9723 - 16
In mammals, hypoxic stress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their labile a... 
HYPOXIA-INDUCIBLE FACTOR | LACTATE PARADOX | PROTEIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | PROTEOMIC ANALYSIS | BED REST | PROLYL HYDROXYLASES | EXERCISE | GLUTAMINE-METABOLISM | MOLECULAR-MECHANISMS | Tricarboxylic acid cycle | Human subjects | Musculoskeletal system | Rodents | Proteomics | Homeostasis | Hypoxia | Metabolism | Skeletal muscle | Glutamine
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10. Full Text Acid–base balance at exercise in normoxia and in chronic hypoxia. Revisiting the "lactate paradox"
by Cerretelli, Paolo and Samaja, Michele
European Journal of Applied Physiology, ISSN 1439-6319, 11/2003, Volume 90, Issue 5, pp. 431 - 448
Transitions between rest and work, in either direction, and heavy exercise loads are characterized by changes of muscle pH depending on the buffer power and... 
Bicarbonate | Exercise | Lactate paradox | Hemoglobin | Hypoxia | Lactate transport | Muscle | LifeSciences | Acid-base status | Altitude | Paradox | Lactate | Bicarbonate exercise | Glycolysis - physiology | Energy Metabolism | Adenosine Triphosphate - metabolism | Humans | Lactic Acid - metabolism | Homeostasis | Hypoxia - physiopathology | Acid-Base Equilibrium - physiology | Exercise - physiology | Muscle, Skeletal - physiology | Hydrogen-Ion Concentration
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11. Full Text Urinary physiology and hypoxia: a pilot study of moderate-altitude trekking effects on urodynamic indexes
by Verratti, V and Mrakic-Sposta, S and Moriggi, M and Tonacci, A and Bhandari, S and Migliorelli, D and Bajracharya, A and Bondi, D and Agro, EF and Cerretelli, P
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 10/2019, Volume 317, Issue 4, pp. F1081 - F1086
Exposure to high altitude is one of the most widely used models to study the adaptive response to hypoxia in humans. However, little is known about the related... 
WALL | PHYSIOLOGY | autonomic nervous system | trekking | urinary physiology | urodynamics | altitude hypoxia | UROFLOWMETRY | UROLOGY & NEPHROLOGY | HEART-RATE | BLADDER | MOTILITY | REVEALS
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12. Full Text Blood lactate accumulation and muscle deoxygenation during incremental exercise
by Bruno Grassi and Valentina Quaresima and Claudio Marconi and Marco Ferrari and Paolo Cerretelli
Journal of Applied Physiology, ISSN 8750-7587, 07/1999, Volume 87, Issue 1, pp. 348 - 355
Near-infrared spectroscopy (NIRS) could allow insights into controversial issues related to blood lactate concentration ([La]b) increases at submaximal... 
Lactate threshold | Near-infrared spectroscopy | lactate threshold | SPORT SCIENCES | near-infrared spectroscopy | PHYSIOLOGY | OXYGENATION | HEART-FAILURE | TISSUE | HUMANS | ANAEROBIC THRESHOLD | MAGNETIC-RESONANCE SPECTROSCOPY | SKELETAL-MUSCLE | METABOLISM | IN-VIVO | Oxyhemoglobins - metabolism | Lactic Acid - blood | Humans | Oxygen Consumption | Hemoglobins - metabolism | Male | Muscle, Skeletal - metabolism | Oxygen - metabolism | Exercise Test | Spectroscopy, Near-Infrared | Acidosis, Lactic - blood | Acidosis, Lactic - metabolism | Adult | Acidosis, Lactic - etiology | Exercise - physiology | Muscle, Skeletal - blood supply
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13. Full Text Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: Evidence from structural and proteomic analysis
by Salanova, Michele and Gelfi, Cecilia and Moriggi, Manuela and Vasso, Michele and Viganò, Agnese and Minafra, Luigi and Bonifacio, Gaetano and Schiffl, Gudrun and Gutsmann, Martina and Felsenberg, Dieter and Cerretelli, Paolo and Blottner, Dieter
FASEB Journal, ISSN 0892-6638, 11/2014, Volume 28, Issue 11, pp. 4748 - 4763
In the present bed rest (BR) study, 23 volunteers were randomized into 3 subgroups: 60 d BR control (Ctr); BR with resistive exercise (RE; lower-limb load);... 
Atrophy | Countermeasures | Protein expression | Bed rest | Ultrastructure | PROTEIN | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | countermeasures | ultrastructure | HEAVY-CHAIN ISOFORMS | CELL BIOLOGY | FIBERS | TERM BED REST | bed rest | BIOLOGY | atrophy | FOCAL ADHESION KINASE | SHORTENING VELOCITY | protein expression | EXPRESSION | FAST HINDLIMB | TENASCIN-C | Vibration | Muscular Atrophy - metabolism | Humans | Middle Aged | Muscular Atrophy - therapy | Male | Muscle, Skeletal - metabolism | Exercise Therapy | Bed Rest - methods | Young Adult | Muscle Contraction - physiology | Proteomics | Adult | Muscle, Skeletal - pathology | Index Medicus
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14. Full Text Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
by Capri, Miriam and Morsiani, Cristina and Santoro, Aurelia and Moriggi, Manuela and Conte, Maria and Martucci, Morena and Bellavista, Elena and Fabbri, Cristina and Giampieri, Enrico and Albracht, Kirsten and Flück, Martin and Ruoss, Severin and Brocca, Lorenza and Canepari, Monica and Longa, Emanuela and Di Giulio, Irene and Bottinelli, Roberto and Cerretelli, Paolo and Salvioli, Stefano and Gelfi, Cecilia and Franceschi, Claudio and Narici, Marco and Rittweger, Jörn
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 04/2019, Volume 33, Issue 4, pp. 5168 - 5180
The Sarcolab pilot study of 2 crewmembers, investigated before and after a 6-mo International Space Station mission, has demonstrated the substantial muscle... 
proteasome | inflamma-miRs | microRNA-206 | SERPINA1 | CIRCULATING MICRORNAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXERCISE | CELL BIOLOGY | SKELETAL-MUSCLE | LONGEVITY | INFLAMMATION | RELEVANCE | BIOLOGY | MIR-21 | SENESCENCE | TISSUES | EXPRESSION | Research
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15. Full Text Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation
by Moriggi, Manuela and Vasso, Michele and Fania, Chiara and Capitanio, Daniele and Bonifacio, Gaetano and Salanova, Michele and Blottner, Dieter and Rittweger, Jörn and Felsenberg, Dieter and Cerretelli, Paolo and Gelfi, Cecilia
PROTEOMICS, ISSN 1615-9853, 11/2010, Volume 10, Issue 21, pp. 3756 - 3774