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Nature genetics, ISSN 1546-1718, 2018, Volume 50, Issue 5, pp. 645 - 651
Journal Article
by Zehir, Ahmet and Benayed, Ryma and Shah, Ronak H and Syed, Aijazuddin and Middha, Sumit and Kim, Hyunjae R and Srinivasan, Preethi and Gao, Jianjiong and Chakravarty, Debyani and Devlin, Sean M and Hellmann, Matthew D and Barron, David A and Schram, Alison M and Hameed, Meera and Dogan, Snjezana and Ross, Dara S and Hechtman, Jaclyn F and DeLair, Deborah F and Yao, JinJuan and Mandelker, Diana L and Cheng, Donavan T and Chandramohan, Raghu and Mohanty, Abhinita S and Ptashkin, Ryan N and Jayakumaran, Gowtham and Prasad, Meera and Syed, Mustafa H and Rema, Anoop Balakrishnan and Liu, Zhen Y and Nafa, Khedoudja and Borsu, Laetitia and Sadowska, Justyna and Casanova, Jacklyn and Bacares, Ruben and Kiecka, Iwona J and Razumova, Anna and Son, Julie B and Stewart, Lisa and Baldi, Tessara and Mullaney, Kerry A and Al-Ahmadie, Hikmat and Vakiani, Efsevia and Abeshouse, Adam A and Penson, Alexander V and Jonsson, Philip and Camacho, Niedzica and Chang, Matthew T and Won, Helen H and Gross, Benjamin E and Kundra, Ritika and Heins, Zachary J and Chen, Hsiao-Wei and Phillips, Sarah and Zhang, Hongxin and Wang, Jiaojiao and Ochoa, Angelica and Wills, Jonathan and Eubank, Michael and Thomas, Stacy B and Gardos, Stuart M and Reales, Dalicia N and Galle, Jesse and Durany, Robert and Cambria, Roy and Abida, Wassim and Cercek, Andrea and Feldman, Darren R and Gounder, Mrinal M and Hakimi, A Ari and Harding, James J and Iyer, Gopa and Janjigian, Yelena Y and Jordan, Emmet J and Kelly, Ciara M and Lowery, Maeve A and Morris, Luc G T and Omuro, Antonio M and Raj, Nitya and Razavi, Pedram and Shoushtari, Alexander N and Shukla, Neerav and Soumerai, Tara E and Varghese, Anna M and Yaeger, Rona and Coleman, Jonathan and Bochner, Bernard and Riely, Gregory J and Saltz, Leonard B and Scher, Howard I and Sabbatini, Paul J and Robson, Mark E and Klimstra, David S and Taylor, Barry S and Baselga, Jose and Schultz, Nikolaus and Hyman, David M and Arcila, Maria E and Solit, David B and Ladanyi, Marc and Berger, Michael F
Nature medicine, ISSN 1546-170X, 2017, Volume 23, Issue 6, pp. 703 - 713
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 8, pp. 3041 - 3046
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4700 - 4711
Advanced human thyroid cancers, particularly those that are refractory to treatment with radioiodine (RAI), have a high prevalence of BRAF (v-raf murine... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-INHIBITION | BRAF(V600E) MUTATION | CARCINOMA CELLS | GENE | RAS | ANTISENSE RNA | KINASE | SENSITIVITY | PROLIFERATION | EXPRESSION | MAP Kinase Signaling System - physiology | Proto-Oncogene Proteins B-raf - physiology | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Mutation, Missense | Indoles - administration & dosage | Benzamides - administration & dosage | Neoplasm Proteins - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Benzamides - toxicity | Diphenylamine - therapeutic use | Carcinoma, Papillary - drug therapy | Mice, Transgenic | Diphenylamine - toxicity | Sulfonamides - pharmacology | Antineoplastic Combined Chemotherapy Protocols - toxicity | Protein Kinase Inhibitors - administration & dosage | Indoles - therapeutic use | Mice | DNA Damage | Thyroid Gland - metabolism | Sulfonamides - administration & dosage | Thyroid Neoplasms - metabolism | Carcinoma, Papillary - genetics | Diphenylamine - pharmacology | Neoplasm Proteins - physiology | Carcinoma, Papillary - metabolism | Diphenylamine - analogs & derivatives | Benzamides - therapeutic use | Indoles - pharmacology | Benzamides - pharmacology | Diphenylamine - administration & dosage | Genes, Synthetic - drug effects | Indoles - toxicity | Enzyme Activation - drug effects | Iodine Radioisotopes - pharmacokinetics | Carcinoma, Papillary - pathology | Point Mutation | Thyroid Neoplasms - genetics | Animals | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Thyroid Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Protein Kinase Inhibitors - toxicity | Sulfonamides - toxicity | Protein Kinase Inhibitors - pharmacology | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Thyroid Neoplasms - pathology | Care and treatment | Thyroid cancer | Cancer cells | Genetic aspects | Diagnosis | Properties | Isotopes | Health aspects | Mitogen-activated protein kinases | Iodine
Journal Article
by Shen, Hui and Shih, Juliann and Hollern, Daniel P and Wang, Linghua and Bowlby, Reanne and Tickoo, Satish K and Thorsson, Vésteinn and Mungall, Andrew J and Newton, Yulia and Hegde, Apurva M and Armenia, Joshua and Sánchez-Vega, Francisco and Pluta, John and Pyle, Louise C and Mehra, Rohit and Reuter, Victor E and Godoy, Guilherme and Jones, Jeffrey and Shelley, Carl S and Feldman, Darren R and Vidal, Daniel O and Lessel, Davor and Kulis, Tomislav and Cárcano, Flavio M and Leraas, Kristen M and Lichtenberg, Tara M and Brooks, Denise and Cherniack, Andrew D and Cho, Juok and Heiman, David I and Kasaian, Katayoon and Liu, Minwei and Noble, Michael S and Xi, Liu and Zhang, Hailei and Zhou, Wanding and ZenKlusen, Jean C and Hutter, Carolyn M and Felau, Ina and Zhang, Jiashan and Schultz, Nikolaus and Getz, Gad and Meyerson, Matthew and Stuart, Joshua M and Akbani, Rehan and Wheeler, David A and Laird, Peter W and Nathanson, Katherine L and Cortessis, Victoria K and Hoadley, Katherine A and Wheeler, David and Hughes, Daniel and Covington, Kyle and Jayaseelan, Joy C and Korchina, Viktoriya and Lewis, Lora and Hu, Jianhong and Doddapaneni, HarshaVardhan and Muzny, Donna and Gibbs, Richard and Hollern, Daniel and Vincent, Benjamin G and Chai, Shengjie and Smith, Christof C and Auman, J. Todd and Shi, Yan and Meng, Shaowu and Skelly, Tara and Tan, Donghui and Veluvolu, Umadevi and Mieczkowski, Piotr A and Jones, Corbin D and Wilkerson, Matthew D and Balu, Saianand and Bodenheimer, Tom and Hoyle, Alan P and Jefferys, Stuart R and Mose, Lisle E and Simons, Janae V and Soloway, Matthew G and Roach, Jeffrey and Parker, Joel S and Hayes, D. Neil and Perou, Charles M and Saksena, Gordon and Cibulskis, Carrie and Schumacher, Steven E and Beroukhim, Rameen and Gabriel, Stacey B and Ally, Adrian and Balasundaram, Miruna and Carlsen, Rebecca and Cheung, Dorothy and Chuah, Eric and Dhalla, Noreen and Holt, Robert A and Jones, Steven J.M and Ma, Yussanne and Mayo, Michael and Moore, Richard A and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell reports (Cambridge), ISSN 2211-1247, 2018, Volume 23, Issue 11, pp. 3392 - 3406
Journal Article
Journal Article
by Kim, Jihun and Bowlby, Reanne and Mungall, Andrew J and Robertson, A. Gordon and Odze, Robert D and Cherniack, Andrew D and Shih, Juliann and Pedamallu, Chandra Sekhar and Cibulskis, Carrie and Dunford, Andrew and Meier, Samuel R and Kim, Jaegil and Raphael, J and Wu, Hsin-Ta and Wong, Alexandra M and Willis, Joseph E and Bass, Adam J and Derks, Sarah and Garman, Katherine and McCall, Shannon J and Wiznerowicz, MacIej and Pantazi, Angeliki and Parfenov, Michael and Thorsson, Vésteinn and Shmulevich, Ilya and Dhankani, Varsha and Miller, Michael and Sakai, Ku Leuven Ryo and Wang, Kenneth and Schultz, Nikolaus and Shen, Ronglai and Arora, Arshi and Weinhold, Nils and Sánchez-Vega, Francisco and Kelsen, David P and Zhang, Julia and Felau, Ina and Demchok, John and Rabkin, Charles S and Camargo, M. Constanza and Zenklusen, Jean Claude and Bowen, Jay and Leraas, Kristen and Lichtenberg, Tara M and Curtis, Christina and Seoane, Jose A and Ojesina, Akinyemi I and Beer, David G and Gulley, Margaret L and Pennathur, Arjun and Luketich, James D and Zhou, Zhongren and Weisenberger, Daniel J and Akbani, Rehan and Lee, Ju-Seog and Liu, Wenbin and Mills, Gordon B and Zhang, Wei and Reid, Brian J and Hinoue, Toshinori and Laird, Peter W and Shen, Hui and Piazuelo, M. Blanca and Schneider, Barbara G and McLellan, Michael and Taylor-Weiner, Amaro and Lawrence, Michael and Cibulskis, Kristian and Stewart, Chip and Getz, Gad and Lander, Eric and Gabriel, Stacey B and DIng, Li and McLellan, Michael D and Miller, Christopher A and Appelbaum, Elizabeth L and Cordes, Matthew G and Fronick, Catrina C and Fulton, Lucinda A and Mardis, Elaine R and Wilson, Richard K and Schmidt, Heather K and Fulton, Robert S and Ally, Adrian and Balasundaram, Miruna and Carlsen, Rebecca and Chuah, Eric and Dhalla, Noreen and Holt, Robert A and Jones, Steven J. M and Kasaian, Katayoon and Brooks, Denise and Li, Haiyan I and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Moore, Richard A and Mungall, Karen L and Schein, Jacqueline E and Sipahimalani, Payal and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Data Coordination Center: CSRA Inc and Duke University and Ribeirão Preto Medical School and Israelitisches Krankenhaus Hamburg and Project Team: National Institutes of Health and Tissue Source Sites: Analytic Biologic Services and Nationwide Children’s Hospital and Greater Poland Cancer Centre and Brown University and University of Michigan and Mayo Clinic and Broad Institute and Keimyung University School of Medicine and Asan Medical Center and Barretos Cancer Hospital and University of Alabama and Indiana University School of Medicine and Invidumed and National Cancer Center Goyang and Yonsei University College of Medicine and Vanderbilt University and University of North Carolina at Chapel Hill and Cureline and Cancer Genome Atlas Research Network and Institute of Oncology of Moldova and University of Pittsburgh School of Medicine and University of Pittsburgh and Genome Characterization Centers: BC Cancer Agency and Analysis Working Group: Asan University and University of Texas MD Anderson Cancer Center and Case Western Reserve University and National Cancer Institute and Genome Data Analysis Centers: Broad Institute and St. Joseph’s Hospital &Medical Center and University of Southern California and Institute for Systems Biology and Ontario Tumour Bank and University of Washington and University of Rochester and Harvard Medical School and KU Leuven and Genome Sequencing Center: Broad Institute and Brigham and Women’s Hospital and Memorial Sloan Kettering Cancer Center and Disease Working Group: Duke University and Erasmus University and Christiana Care Health System and University of Kansas Medical Center and Research Institute at Nationwide Children’s Hospital and International Genomics Consortium and Tayside Tissue Bank and Peter MacCallum Cancer Centre and Pusan National University Medical School and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and BioreclamationIVT and Dana-Farber Cancer Institute and University of Southern California Epigenome Center and Stanford University and BC Cancer Agency and Chonnam National University Medical School and St. Petersburg Academic University and University of North Carolina and University of Dundee and Van Andel Research Institute and Washington University in St. Louis and Emory University and Washington University and University of California Santa Cruz and Biospecimen Core Resource: International Genomics Consortium and Asterand Bioscience and Botkin Municipal Clinic
Nature (London), ISSN 1476-4687, 2017, Volume 541, Issue 7636, pp. 169 - 175
Journal Article
by Brennan, Cameron W and Verhaak, Roel G.W and McKenna, Aaron and Campos, Benito and Noushmehr, Houtan and Salama, Sofie R and Zheng, Siyuan and Chakravarty, Debyani and Sanborn, J. Zachary and Berman, Samuel H and Beroukhim, Rameen and Bernard, Brady and Wu, Chang-Jiun and Genovese, Giannicola and Shmulevich, Ilya and Barnholtz-Sloan, Jill and Zou, Lihua and Vegesna, Rahulsimham and Shukla, Sachet A and Ciriello, Giovanni and Yung, W.K and Zhang, Wei and Sougnez, Carrie and Mikkelsen, Tom and Aldape, Kenneth and Bigner, Darell D and Van Meir, Erwin G and Prados, Michael and Sloan, Andrew and Black, Keith L and Eschbacher, Jennifer and Finocchiaro, Gaetano and Friedman, William and Andrews, David W and Guha, Abhijit and Iacocca, Mary and O’Neill, Brian P and Foltz, Greg and Myers, Jerome and Weisenberger, Daniel J and Penny, Robert and Kucherlapati, Raju and Perou, Charles M and Hayes, D. Neil and Gibbs, Richard and Marra, Marco and Mills, Gordon B and Lander, Eric and Spellman, Paul and Wilson, Richard and Sander, Chris and Weinstein, John and Meyerson, Matthew and Gabriel, Stacey and Laird, Peter W and Haussler, David and Getz, Gad and Chin, Lynda and Benz, Christopher and Barrett, Wendi and Ostrom, Quinn and Wolinsky, Yingli and Bose, Bikash and Boulos, Paul T and Boulos, Madgy and Brown, Jenn and Czerinski, Christine and Eppley, Matthew and Kempista, Thelma and Kitko, Teresa and Koyfman, Yakov and Rabeno, Brenda and Rastogi, Pawan and Sugarman, Michael and Swanson, Patricia and Yalamanchii, Kennedy and Otey, Ilana P and Liu, Yingchun Spring and Xiao, Yonghong and Auman, J.Todd and Chen, Peng-Chieh and Hadjipanayis, Angela and Lee, Eunjung and Lee, Semin and Park, Peter J and Seidman, Jonathan and Yang, Lixing and Kalkanis, Steven and Poisson, Laila M and Raghunathan, Aditya and Scarpace, Lisa and Bressler, Ryan and Eakin, Andrea and Iype, Lisa and Kreisberg, Richard B and Leinonen, Kalle and Reynolds, Sheila and Rovira, Hector and Thorsson, Vesteinn and Annala, Matti J and ... and TCGA Research Network and TCGA Res Network
Cell (Cambridge), ISSN 0092-8674, 2013, Volume 155, Issue 2, pp. 462 - 477
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors... 
PATHWAYS | GLIOMAS | PDGFRA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GENES | GRADE | COPY-NUMBER ALTERATION | EXPRESSION | DRIVER MUTATIONS | EGFR | CELL BIOLOGY | Platelet-derived growth factor | RNA | Gene mutations | Analysis | Methylation | Glioblastoma multiforme | Telomerase
Journal Article