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Journal Article
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 6/2006, Volume 33, Issue 3, pp. 281 - 311
We have modelled the Unified Parkinson’s Disease Rating Scale (UPDRS) scores collected in 800 subjects followed for 8 years. Newly diagnosed and previously... 
Biochemistry, general | deprenyl | bromocriptine | pharmacodynamics | Veterinary Medicine | disease progression | Biomedical Engineering | Biomedicine | levodopa | Pharmacy | Pharmacology/Toxicology | pergolide | Parkinson’s disease | Pergolide | Pharmacodynamics | Parkinson's disease | Bromocriptine | Deprenyl | Disease progression | Levodopa | TOCOPHEROL TREATMENT | 1ST 4 YEARS | MODEL | ELLDOPA TRIAL | IMPACT | REQUIRING LEVODOPA | THERAPY | DISABILITY | PHARMACOLOGY & PHARMACY | DATATOP | Antiparkinson Agents - pharmacology | Humans | Selegiline - pharmacology | Dopamine Agonists - therapeutic use | Levodopa - pharmacokinetics | Parkinson Disease - drug therapy | Pergolide - pharmacology | Bromocriptine - therapeutic use | Antiparkinson Agents - therapeutic use | Selegiline - pharmacokinetics | Bromocriptine - pharmacokinetics | Drug Therapy, Combination | Selegiline - therapeutic use | Dopamine Agonists - pharmacology | Levodopa - pharmacology | Parkinson Disease - pathology | Levodopa - therapeutic use | Dopamine Agonists - pharmacokinetics | Treatment Outcome | Bromocriptine - pharmacology | Pergolide - pharmacokinetics | Disease Progression | Pergolide - therapeutic use | Randomized Controlled Trials as Topic | Antiparkinson Agents - pharmacokinetics | Algorithms | Models, Biological | Bayes Theorem | Development and progression | Analysis | Drug therapy | Parkinsons disease | Index Medicus
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 4/2007, Volume 24, Issue 4, pp. 791 - 802
To externally validate the model predictions of a DATATOP cohort analysis through application of clinical trial simulation with the study design of the ELLDOPA... 
Biomedical Engineering | Biochemistry, general | Biomedicine | Pharmacy | Medical Law | DATATOP | Pharmacology/Toxicology | ELLDOPA | disease progress model | Parkinson’s disease | clinical trial simulation | protective treatment
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 08/2005, Volume 32, Issue 3-4, p. 307
The purpose of the study was to describe the population pharmacokinetics of levodopa in patients with Parkinson's disease studied in 5 trials (10 occasions)... 
Parkinsons disease
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 08/2005, Volume 32, Issue 3, pp. 307 - 331
The purpose of the study was to describe the population pharmacokinetics of levodopa in patients with Parkinson’s disease studied in 5 trials (10 occasions)... 
Biochemistry, general | Biomedical Engineering | within subject variability | Biomedicine | population approach | levodopa | Pharmacy | pharmacokinetics | Veterinary Medicine | Pharmacology/Toxicology | Parkinson’s disease
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 08/2005, Volume 32, Issue 3, pp. 459 - 484
The purpose of this analysis is to describe how levodopa pharmacokinetic and pharmacodynamic parameters change over the first 4 years of long-term levodopa... 
Biochemistry, general | Biomedical Engineering | Biomedicine | levodopa | fluctuations | Pharmacy | pharmacodynamics | pharmacokinetics | Veterinary Medicine | disease progression | Pharmacology/Toxicology | Parkinson’s disease
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 10/2017, Volume 6, Issue 10, pp. 647 - 650
Journal Article
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