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Nature Cell Biology, ISSN 1465-7392, 10/2015, Volume 17, Issue 10, pp. 1270 - 1281
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve... 
CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | ACTIVATION | CONFORMATIONAL-CHANGE | MEMBERS | PROAPOPTOTIC BAX | BH3 DOMAINS | PUMA | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Cytochromes c - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Mitochondria - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Models, Biological | Fibroblasts - cytology | Intestine, Small - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genotype | Genetic aspects | Properties | Cell death | Cellular control mechanisms
Journal Article
Science Signaling, ISSN 1945-0877, 03/2013, Volume 6, Issue 268, pp. ra20 - ra20
The clinical efficacy of tyrosine kinase inhibitors supports the dependence of distinct subsets of cancers on specific driver mutations for survival, a... 
LUNG ADENOCARCINOMAS | HER2 AMPLIFICATION | BREAST-CANCER CELLS | MITOCHONDRIAL APOPTOSIS | DEPENDENT CELL-DEATH | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | KINASE INHIBITORS | BH3 DOMAINS | FOXO TRANSCRIPTION FACTORS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | Immunohistochemistry | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Humans | Receptor, ErbB-2 - metabolism | Apoptosis - genetics | Immunoblotting | Quinazolines | Oncogenes - physiology | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Chromatin Immunoprecipitation | Nitrophenols - pharmacology | RNA Interference | Plasmids - genetics | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Oncogenes - genetics | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Cell Line, Tumor | Signal Transduction - physiology | Mice | Gene Silencing - physiology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal Article
Journal of Stroke and Cerebrovascular Diseases, ISSN 1052-3057, 2017, Volume 26, Issue 6, pp. 1349 - 1356
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2016, Volume 119, Issue 6, pp. 839 - 844
Abstract Current risk model for long-term survival prediction in isolated coronary artery bypass graft surgery (CABG) is complicated while a simple useful... 
Cardiovascular
Journal Article