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Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 4/2017, Volume 101, Issue 7, pp. 2747 - 2766
D2C7-(scdsFv)-PE38KDEL (D2C7-IT) is a novel recombinant Pseudomonas exotoxin A-based immunotoxin (IT), targeting both wild-type epidermal growth factor... 
Life Sciences | Malignant glioma | Biotechnology | Recombinant immunotoxin | Microbiology | Microbial Genetics and Genomics | Mutant EGFR variant III | Good laboratory practice | Epidermal growth factor receptor | GROWTH-FACTOR-RECEPTOR | PROGNOSTIC VALUE | CANCER | HUMAN-BRAIN-TUMORS | HAIRY-CELL LEUKEMIA | AMPLIFICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PSEUDOMONAS EXOTOXIN | EXPRESSION | STABILIZED FV-IMMUNOTOXINS | EGF RECEPTOR | Receptor, Epidermal Growth Factor - genetics | Virulence Factors - genetics | Drug Stability | Electrophoresis, Polyacrylamide Gel | Humans | Fermentation | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Receptor, Epidermal Growth Factor - metabolism | Immunotoxins - therapeutic use | Escherichia coli - genetics | Exotoxins - genetics | Immunotoxins - metabolism | Cell Line, Tumor | Adult | Bacterial Toxins - genetics | Immunotoxins - chemistry | Glioblastoma - drug therapy | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Quality Control | Clinical trials | Product development | Medical centers | Brain tumors | Quality control | Studies | Epidermal growth factor | Brain cancer | Analysis | Protein expression | Toxins | Genetic recombination | Index Medicus | recombinant immunotoxin | good laboratory practice | malignant glioma | epidermal growth factor receptor | mutant EGFR variant III
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2013, Volume 132, Issue 10, pp. 2339 - 2348
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 7/2018, Volume 138, Issue 3, pp. 489 - 498
Journal Article
Protein Engineering, Design and Selection, ISSN 1741-0126, 09/2017, Volume 30, Issue 9, pp. 639 - 647
Journal Article
Journal for immunotherapy of cancer, ISSN 2051-1426, 05/2019, Volume 7, Issue 1, pp. 142 - 142
D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in... 
Care and treatment | Usage | Radiotherapy | Glioblastoma multiforme | Brain tumors | Adenosine | Brain cancer | Cytotoxicity | Oncology | Systematic review | Radiation therapy | Patients | Cancer therapies | Proteins | Chemotherapy | Epidermal growth factor | Lymphocytes | Ligands | Tumors | Apoptosis | Immunotoxin | Immune checkpoint inhibitors | Malignant gliomas | T cells | EGFR
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2018, Volume 24, Issue 17, pp. 4175 - 4186
Purpose: T-cell dysfunction is a hallmark of glioblastoma (GEM). Although anergy and tolerance have been well characterized, T-cell exhaustion remains... 
PRIMARY BRAIN-TUMORS | MALIGNANT GLIOMA | SURVIVAL | HETEROGENEITY | IMMUNE CHECKPOINTS | ONCOLOGY | MELANOMA PATIENTS | CHRONIC VIRAL-INFECTION | PD-1 | CANCER | PRIMARY INTRACRANIAL TUMORS | Index Medicus | T Cell Exhaustion | Immune Checkpoint | Immunotherapy | Glioblastoma
Journal Article
Investigational New Drugs, ISSN 0167-6997, 4/2016, Volume 34, Issue 2, pp. 149 - 158
Journal Article
Journal Article
Journal Article
Journal Article
OncoImmunology, ISSN 2162-4011, 12/2013, Volume 2, Issue 12, pp. 1 - 2
Both the amplification of the gene coding for wild-type (wt) epidermal growth factor receptor (EGFR) and the overexpression of the EGFR deletion mutant,... 
bispecific antibody | brain tumors | convection-enhanced delivery | glioma-associated antigens | Pseudomonasexotoxin | Glioma-associated antigens | Pseudomonas exotoxin | Convection-enhanced delivery | Bispecific antibody | Brain tumors | GROWTH-FACTOR-RECEPTOR | ONCOLOGY | IDH1 | ANTIBODY | IMMUNOLOGY | Author's View
Journal Article