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1. Full Text Comparative analysis of ginsenosides in human glucocorticoid receptor binding, transactivation, and transrepression
by Hu, Catherine and Lau, Aik Jiang and Wang, RuiQi and Chang, Thomas K.H
European journal of pharmacology, ISSN 0014-2999, 11/2017, Volume 815, pp. 501 - 511
Dexamethasone (PubChem CID: 5743) | Ginsenoside Rh2 (PubChem CID: 119307) | Ginsenoside | Ginsenoside Rb2 (PubChem CID: 6917976) | Ginsenoside Rd (PubChem CID: 11679800) | 20(S)-Protopanaxadiol (PubChem CID: 11213350) | Protopanaxadiol | Ginsenoside Compound K (PubChem CID: 9852086) | Protopanaxatriol | Ginsenoside Rb1 (PubChem CID: 9898279) | Ginsenoside Rc (PubChem CID: 12855889) | Glucocorticoid receptor | Transrepression | 20(S)-Protopanaxatriol (PubChem CID: 11468733) | Compound A (PubChem CID: 9838147) | Transactivation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Transcriptional Activation - drug effects | Receptors, Glucocorticoid - genetics | Protein Binding | Protein Domains | Ligands | Ginsenosides - metabolism | Ginsenosides - pharmacology | Receptors, Glucocorticoid - metabolism | Receptors, Glucocorticoid - chemistry | Hep G2 Cells | Tyrosine | Dexamethasone | RNA | Central nervous system depressants | Luciferase | Colorectal cancer | Comparative analysis | Gene expression | Steroids | Index Medicus
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2. Full Text 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease
by Lau, Aik Jiang and Chang, Thomas K.H
Pharmacological research, ISSN 1043-6618, 10/2015, Volume 100, pp. 64 - 72
ABCB1 | Flavonol | CYP3A4 | CYP3A5 | Pregnane X receptor | 3-Hydroxyflavone | 3-Hydroxyflavonea | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Inflammatory Bowel Diseases - drug therapy | Receptors, Steroid - metabolism | Humans | Cell Line, Tumor | Genes, Reporter - drug effects | Ligands | Flavonoids - pharmacology | Structure-Activity Relationship | Inflammatory Bowel Diseases - metabolism | Hep G2 Cells | RNA, Messenger - drug effects | Gastrointestinal diseases | Index Medicus
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3. Full Text The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins
by Erickson, Sarah L and Alston, Laurie and Nieves, Kristoff and Chang, Thomas K. H and Mani, Sridhar and Flannigan, Kyle L and Hirota, Simon A
The FASEB journal, ISSN 0892-6638, 02/2020, Volume 34, Issue 2, pp. 2198 - 2212
Clostridioides difficile | eosinophils | Nr1i2 | pregnane X receptor | toxin | neutrophils | Index Medicus
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4. Full Text Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors
by Sharma, Devinder and Lau, Aik Jiang and Sherman, Matthew A and Chang, Thomas K.H
Biochemical pharmacology, ISSN 0006-2952, 06/2013, Volume 85, Issue 11, pp. 1700 - 1711
Nevirapine | Rilpivirine | Efavirenz | Etravirine | Pregnane X receptor | Delavirdine | Pregnane | X receptor | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Steroid Hydroxylases - metabolism | Hydroxylation | Nitriles - pharmacology | Humans | Reverse Transcriptase Inhibitors - pharmacology | Pyridazines - pharmacology | Pyrimidines - pharmacology | Receptors, Steroid - agonists | Reverse Transcriptase Polymerase Chain Reaction | Dose-Response Relationship, Drug | Two-Hybrid System Techniques | Cell Line, Tumor | Fluorescence Resonance Energy Transfer | Real-Time Polymerase Chain Reaction | Genes, Reporter | Nucleosides | DNA polymerases | Antiviral agents | Analysis | Anti-HIV agents | Index Medicus | Cell culture
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5. Full Text Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines
by Chang, Thomas K. H
The AAPS journal, ISSN 1550-7416, 9/2009, Volume 11, Issue 3, pp. 590 - 601
Biochemistry, general | Biotechnology | Biomedicine | constitutive androstane receptor | Pharmacy | pregnane X receptor | Pharmacology/Toxicology | herbal medicine | Herbal medicine | Constitutive androstane receptor | Pregnane X receptor | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Animals | Humans | Rats | Receptors, Cytoplasmic and Nuclear - agonists | Plants - classification | Receptors, Steroid - agonists | Herbal Medicine | Drugs | Glucose metabolism | Medicine, Botanic | Physiological aspects | Medicine, Herbal | DNA binding proteins | Universities and colleges | Bilirubin | Glucose | Automobiles | Dextrose | Deoxycholic acid | Index Medicus
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6. Full Text Negative regulation of human pregnane X receptor by MicroRNA-18a-5p: Evidence for suppression of MicroRNA-18a-5p expression by rifampin and rilpivirine
by Sharma, Devinder and Turkistani, Abdullah A and Chang, Wenjun and Hu, Catherine and Xu, Zhaoming and Chang, Thomas K.H
Molecular pharmacology, ISSN 0026-895X, 07/2017, Volume 92, Issue 1, pp. 48 - 56
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Gene Expression | MicroRNAs - antagonists & inhibitors | Luciferases, Renilla | Humans | Reverse Transcriptase Inhibitors - pharmacology | MicroRNAs - biosynthesis | Receptors, Steroid - antagonists & inhibitors | Receptors, Steroid - agonists | Dose-Response Relationship, Drug | Receptors, Steroid - biosynthesis | Rilpivirine - pharmacology | Cell Line, Tumor | MicroRNAs - genetics | Rifampin - pharmacology | Index Medicus
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7. Full Text Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation
by Hudson, Grace and Flannigan, Kyle L and Venu, Vivek Krishna Pulakazhi and Alston, Laurie and Sandall, Christina F and MacDonald, Justin A and Muruve, Daniel A and Chang, Thomas K H and Mani, Sridhar and Hirota, Simon A
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 07/2019, Volume 370, Issue 1, pp. 44 - 53
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Pregnane X Receptor - agonists | Caspase 1 - metabolism | Pregnane X Receptor - metabolism | Enzyme Activation - drug effects | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | src-Family Kinases - metabolism | Cell Line, Tumor | Receptors, Purinergic P2X7 - metabolism | Ligands | Macrophages - drug effects | Mice | Kinetics | Index Medicus | Inflammation, Immunopharmacology, and Asthma
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8. Full Text Evaluation of in situ generated valproyl 1-O-β-acyl glucuronide in valproic acid toxicity in sandwich-cultured rat hepatocytes
by Surendradoss, Jayakumar and Chang, Thomas K. H and Abbott, Frank S
Drug metabolism and disposition, ISSN 0090-9556, 11/2014, Volume 42, Issue 11, pp. 1834 - 1842
L-Lactate Dehydrogenase - metabolism | Bornanes - pharmacology | Cells, Cultured | Rats | Male | Hepatocytes - metabolism | Rats, Sprague-Dawley | Valproic Acid - toxicity | Animals | Glucuronides - metabolism | beta-Naphthoflavone - pharmacology | Hepatocytes - drug effects | Hepatocytes - enzymology | Index Medicus
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9. Full Text Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor
by Lau, Aik Jiang and Politi, Regina and Yang, Guixiang and Chang, Thomas K.H
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 10/2016, Volume 163, pp. 59 - 67
CYP24A1 | Flavonol | TRPV6 | Vitamin D receptor | Quercetin | 3-Hydroxyflavone | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Caco-2 Cells | Osteopontin - genetics | Quercetin - analogs & derivatives | Vitamin D3 24-Hydroxylase - genetics | Humans | Osteopontin - metabolism | Structure-Activity Relationship | Receptors, Calcitriol - metabolism | Receptors, Calcitriol - genetics | Hep G2 Cells | Gene Expression Regulation - drug effects | Disaccharides - pharmacology | Animals | Quercetin - pharmacology | Receptors, Calcitriol - agonists | Calcitriol - pharmacology | HEK293 Cells | Flavonoids - pharmacology | Kaempferols - pharmacology | Mice | Molecular Docking Simulation | Transgenes | Vitamin D3 24-Hydroxylase - metabolism | Flavonoids | Flavones | Vitamin D | Bioflavonoids | Analysis | Calcifediol | Alfacalcidol | Cytochrome P-450 | Gene expression | Rifampin | Index Medicus
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10. Full Text Pregnane x receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibiting cytokine-induced myosin light-chain kinase expression and c-jun n-terminal kinase 1/2 activation
by Garg, Aditya and Zhao, Angela and Erickson, Sarah L and Mukherjee, Subhajit and Lau, Aik Jiang and Alston, Laurie and Chang, Thomas K. H and Mani, Sridhar and Hirota, Simon A
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 10/2016, Volume 359, Issue 1, pp. 91 - 101
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Gene Expression Regulation, Enzymologic - drug effects | Inflammation - pathology | Intestinal Mucosa - metabolism | Receptors, Steroid - metabolism | Humans | Colitis - pathology | Male | NF-kappa B - metabolism | Intestinal Mucosa - drug effects | Inflammation - metabolism | Colitis - chemically induced | Caco-2 Cells | Dextran Sulfate - pharmacology | Mitogen-Activated Protein Kinase 9 - metabolism | Myosin-Light-Chain Kinase - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Activation - drug effects | Toll-Like Receptor 4 - metabolism | Hep G2 Cells | Tumor Necrosis Factor-alpha - pharmacology | Animals | Signal Transduction - drug effects | Colitis - metabolism | Mice | Pregnane X Receptor | Cytokines - pharmacology | Interferon-gamma - pharmacology | Intestinal Mucosa - pathology | Index Medicus | Gastrointestinal, Hepatic, Pulmonary, and Renal
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