Kidney International, ISSN 0085-2538, 12/2014, Volume 86, Issue 6, pp. 1150 - 1160
Albuminuria is both a hallmark and a risk factor for progressive glomerular disease, and results in increased exposure of podocytes to serum albumin with its...
albuminuria | acute kidney injury | inflammation | proteinuria | podocyte | Podocyte | Inflammation | Albuminuria | Acute kidney injury | Proteinuria | PROTEIN-OVERLOAD PROTEINURIA | FATTY-ACIDS | ENDOPLASMIC-RETICULUM STRESS | GLOMERULAR PODOCYTES | NEPHROTIC-SYNDROME | MESSENGER-RNA | EPITHELIAL-CELLS | UROLOGY & NEPHROLOGY | CYCLOOXYGENASE-2 EXPRESSION | PPAR-GAMMA AGONIST | PUROMYCIN AMINONUCLEOSIDE | B7-1 Antigen - genetics | Gene Expression - drug effects | Podocytes - enzymology | Chemokine CXCL1 - genetics | RNA, Messenger - metabolism | HSP27 Heat-Shock Proteins - genetics | Heat-Shock Proteins - genetics | Cyclooxygenase 2 - genetics | Neoplasm Proteins - genetics | Thiazolidinediones - pharmacology | Serum Albumin, Bovine - pharmacology | NF-kappa B - antagonists & inhibitors | AMP-Activated Protein Kinases - antagonists & inhibitors | Cells, Cultured | Rats | Chemokine CCL2 - genetics | HSP70 Heat-Shock Proteins - genetics | Cyclooxygenase 2 - drug effects | Protein Kinase C - antagonists & inhibitors | Podocytes - pathology | Enzyme Activation - drug effects | Albuminuria - enzymology | Animals | MAP Kinase Signaling System - drug effects | Podocytes - drug effects | Cyclooxygenase 2 - metabolism | Glucocorticoids - pharmacology | Mice | Fatty Acids - pharmacology
albuminuria | acute kidney injury | inflammation | proteinuria | podocyte | Podocyte | Inflammation | Albuminuria | Acute kidney injury | Proteinuria | PROTEIN-OVERLOAD PROTEINURIA | FATTY-ACIDS | ENDOPLASMIC-RETICULUM STRESS | GLOMERULAR PODOCYTES | NEPHROTIC-SYNDROME | MESSENGER-RNA | EPITHELIAL-CELLS | UROLOGY & NEPHROLOGY | CYCLOOXYGENASE-2 EXPRESSION | PPAR-GAMMA AGONIST | PUROMYCIN AMINONUCLEOSIDE | B7-1 Antigen - genetics | Gene Expression - drug effects | Podocytes - enzymology | Chemokine CXCL1 - genetics | RNA, Messenger - metabolism | HSP27 Heat-Shock Proteins - genetics | Heat-Shock Proteins - genetics | Cyclooxygenase 2 - genetics | Neoplasm Proteins - genetics | Thiazolidinediones - pharmacology | Serum Albumin, Bovine - pharmacology | NF-kappa B - antagonists & inhibitors | AMP-Activated Protein Kinases - antagonists & inhibitors | Cells, Cultured | Rats | Chemokine CCL2 - genetics | HSP70 Heat-Shock Proteins - genetics | Cyclooxygenase 2 - drug effects | Protein Kinase C - antagonists & inhibitors | Podocytes - pathology | Enzyme Activation - drug effects | Albuminuria - enzymology | Animals | MAP Kinase Signaling System - drug effects | Podocytes - drug effects | Cyclooxygenase 2 - metabolism | Glucocorticoids - pharmacology | Mice | Fatty Acids - pharmacology
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 04/2018, Volume 314, Issue 4, pp. F602 - F613
The p38 MAPK pathway plays a crucial role in various glomerulopathies, with activation being associated with disease and inhibition being associated with...
MK3 | P38 | MK2 | Glomerular disease | Nephrotic syndrome | Inhibition | MAPK | Proteinuria | CRESCENTIC GLOMERULONEPHRITIS | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | proteinuria | RECEPTOR EXPRESSION | inhibition | DOXORUBICIN NEPHROPATHY | DIABETIC-NEPHROPATHY | glomerular disease | nephrotic syndrome | HEAT-SHOCK PROTEINS | p38 | PODOCYTE INJURY | DISEASE | BENZOTHIOPHENE INHIBITORS | UROLOGY & NEPHROLOGY | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | Physiological aspects | Health aspects | Mitogen-activated protein kinases
MK3 | P38 | MK2 | Glomerular disease | Nephrotic syndrome | Inhibition | MAPK | Proteinuria | CRESCENTIC GLOMERULONEPHRITIS | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | proteinuria | RECEPTOR EXPRESSION | inhibition | DOXORUBICIN NEPHROPATHY | DIABETIC-NEPHROPATHY | glomerular disease | nephrotic syndrome | HEAT-SHOCK PROTEINS | p38 | PODOCYTE INJURY | DISEASE | BENZOTHIOPHENE INHIBITORS | UROLOGY & NEPHROLOGY | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | Physiological aspects | Health aspects | Mitogen-activated protein kinases
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 3615 - 3615
Abstract Introduction Thromboembolism is a common complication of nephrotic syndrome (NS). The massive urinary protein loss (proteinuria) of NS results in an...
Journal Article
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 545 - 14
The renal collecting duct consists of intercalated cells (ICs) and principal cells (PCs). We have previously demonstrated that collecting ducts have a role in...
SYSTEM | OSTEOPONTIN | ATPASE | MULTIDISCIPLINARY SCIENCES | VASOPRESSIN | MOUSE KIDNEY | EPIDIDYMIS | MODEL | EXPRESSION
SYSTEM | OSTEOPONTIN | ATPASE | MULTIDISCIPLINARY SCIENCES | VASOPRESSIN | MOUSE KIDNEY | EPIDIDYMIS | MODEL | EXPRESSION
Journal Article
5.
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Disease severity correlates with thrombotic capacity in experimental nephrotic syndrome
Journal of the American Society of Nephrology, ISSN 1046-6673, 12/2015, Volume 26, Issue 12, pp. 3009 - 3019
Thrombotic disease, a major life-threatening complication of nephrotic syndrome, has been associated with proteinuria and hypoalbuminennia severity. However,...
PROPHYLACTIC ANTICOAGULATION | RISK-FACTORS | VENOUS THROMBOEMBOLISM | MODELS | GENE-EXPRESSION | RATS | UROLOGY & NEPHROLOGY | GENERATION | IDIOPATHIC MEMBRANOUS NEPHROPATHY | PUROMYCIN AMINONUCLEOSIDE | PROTEIN-LOSING NEPHROPATHY | Biomarkers - urine | Rats, Wistar | Elasticity | Male | Doxorubicin | Proteinuria - blood | Thrombin - biosynthesis | Hemostasis | Hypoalbuminemia - blood | Nephrotic Syndrome - chemically induced | Disease Models, Animal | Puromycin Aminonucleoside | Severity of Illness Index | Blood Coagulation Disorders - etiology | Rats | Biomarkers - blood | Blood Coagulation Disorders - urine | Nephrotic Syndrome - complications | Animals | Thrombosis - etiology | Antithrombins - blood | Fibrinogen - metabolism | Blood Coagulation Disorders - blood | Blood Coagulation - physiology | Nephrotic Syndrome - blood | Serum Albumin - metabolism | cardiovascular disease | thrombosis | disease | proteinuria | hypoalbuminemia | vascular | nephrotic syndrome | Basic Research
PROPHYLACTIC ANTICOAGULATION | RISK-FACTORS | VENOUS THROMBOEMBOLISM | MODELS | GENE-EXPRESSION | RATS | UROLOGY & NEPHROLOGY | GENERATION | IDIOPATHIC MEMBRANOUS NEPHROPATHY | PUROMYCIN AMINONUCLEOSIDE | PROTEIN-LOSING NEPHROPATHY | Biomarkers - urine | Rats, Wistar | Elasticity | Male | Doxorubicin | Proteinuria - blood | Thrombin - biosynthesis | Hemostasis | Hypoalbuminemia - blood | Nephrotic Syndrome - chemically induced | Disease Models, Animal | Puromycin Aminonucleoside | Severity of Illness Index | Blood Coagulation Disorders - etiology | Rats | Biomarkers - blood | Blood Coagulation Disorders - urine | Nephrotic Syndrome - complications | Animals | Thrombosis - etiology | Antithrombins - blood | Fibrinogen - metabolism | Blood Coagulation Disorders - blood | Blood Coagulation - physiology | Nephrotic Syndrome - blood | Serum Albumin - metabolism | cardiovascular disease | thrombosis | disease | proteinuria | hypoalbuminemia | vascular | nephrotic syndrome | Basic Research
Journal Article
Japanese Journal of Pediatric Nephrology, ISSN 0915-2245, 2017, Volume 30, Issue suppl, pp. 215 - 215
Journal Article
Kidney International Reports, ISSN 2468-0249, 09/2019
Journal Article
8.
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Crucial Roles of the Protein Kinases MK2 and MK3 in a Mouse Model of Glomerulonephritis
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54239
Elevated mitogen-activated protein kinase p38 (p38 MAPK) signaling has been implicated in various experimental and human glomerulopathies, and its inhibition...
SMALL HSP PHOSPHORYLATION | CRESCENTIC GLOMERULONEPHRITIS | IN-VITRO | ACTIVATION | PODOCYTE INJURY | MAPKAP KINASES | MULTIDISCIPLINARY SCIENCES | P38 MAPK | NEPHROTIC SYNDROME | RENAL INJURY | CELLULAR STRESS | Acute Disease | Phosphorylation | Signal Transduction | Heat-Shock Proteins - metabolism | Humans | Gene Expression Regulation | Glomerulonephritis - genetics | Protein-Serine-Threonine Kinases - genetics | Stress, Physiological | p38 Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Glomerulonephritis - metabolism | Kidney Function Tests | Mice, Knockout | Heat-Shock Proteins - genetics | Animals | Gene Deletion | Female | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Glomerulonephritis - physiopathology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Glomerulonephritis | Physiological aspects | Heat shock proteins | Disease susceptibility | Comparative analysis | Health aspects | Mitogens | Epidemiology | Protein kinases | Pediatrics | Animal models | Syngeneic grafts | Biochemistry | Phylogeny | Kinases | Proteins | Signal transduction | Rodents | Gene dosage | Enzymes | Cytokines | MAP kinase | Gene expression | Substrates | Stress | Children & youth | Signaling | Hospitals | Protein kinase | Diabetes | Kidney diseases | Stress proteins | Kidney transplantation
SMALL HSP PHOSPHORYLATION | CRESCENTIC GLOMERULONEPHRITIS | IN-VITRO | ACTIVATION | PODOCYTE INJURY | MAPKAP KINASES | MULTIDISCIPLINARY SCIENCES | P38 MAPK | NEPHROTIC SYNDROME | RENAL INJURY | CELLULAR STRESS | Acute Disease | Phosphorylation | Signal Transduction | Heat-Shock Proteins - metabolism | Humans | Gene Expression Regulation | Glomerulonephritis - genetics | Protein-Serine-Threonine Kinases - genetics | Stress, Physiological | p38 Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Glomerulonephritis - metabolism | Kidney Function Tests | Mice, Knockout | Heat-Shock Proteins - genetics | Animals | Gene Deletion | Female | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Glomerulonephritis - physiopathology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Glomerulonephritis | Physiological aspects | Heat shock proteins | Disease susceptibility | Comparative analysis | Health aspects | Mitogens | Epidemiology | Protein kinases | Pediatrics | Animal models | Syngeneic grafts | Biochemistry | Phylogeny | Kinases | Proteins | Signal transduction | Rodents | Gene dosage | Enzymes | Cytokines | MAP kinase | Gene expression | Substrates | Stress | Children & youth | Signaling | Hospitals | Protein kinase | Diabetes | Kidney diseases | Stress proteins | Kidney transplantation
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 10/2018, Volume 315, Issue 4, pp. F812 - F823
The urinary tract is usually culture negative despite its close proximity to microbial flora. The precise mechanism by which the kidneys and urinary tract...
Innate immunity | Principal cell | Amp | Intercalated cell | Antimicrobial peptide | URINARY-TRACT-INFECTION | PHYSIOLOGY | principal cell | AMP | PRINCIPAL CELLS | CRE RECOMBINASE | intercalated cell | BETA-INTERCALATED CELLS | innate immunity | UROLOGY & NEPHROLOGY | BACTERIAL-INFECTION | RIBONUCLEASE 7 | antimicrobial peptide | KIDNEY | PROMOTER DRIVES EXPRESSION | TRANSGENIC MICE | REAL-TIME
Innate immunity | Principal cell | Amp | Intercalated cell | Antimicrobial peptide | URINARY-TRACT-INFECTION | PHYSIOLOGY | principal cell | AMP | PRINCIPAL CELLS | CRE RECOMBINASE | intercalated cell | BETA-INTERCALATED CELLS | innate immunity | UROLOGY & NEPHROLOGY | BACTERIAL-INFECTION | RIBONUCLEASE 7 | antimicrobial peptide | KIDNEY | PROMOTER DRIVES EXPRESSION | TRANSGENIC MICE | REAL-TIME
Journal Article
American Journal of Physiology (Consolidated), ISSN 0002-9513, 10/2018, Volume 315, Issue 4, p. F812
The urinary tract is usually culture negative despite its close proximity to microbial flora. The precise mechanism by which the kidneys and urinary tract...
Polymerase chain reaction | Immune response | Kidneys | Epithelial cells | Aquaporins | Observations | Health aspects
Polymerase chain reaction | Immune response | Kidneys | Epithelial cells | Aquaporins | Observations | Health aspects
Journal Article
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