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Genes and Development, ISSN 0890-9369, 10/2008, Volume 22, Issue 20, pp. 2767 - 2772
A key cellular response to DNA double-strand breaks ( DSBs) is 5 '-to-3 ' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle... 
DNA damage checkpoint | Exonuclease 1 | DNA resection | DNA repair | RecQ helicases | ATR | RECOMBINATION | RPA | PROTEIN | DEVELOPMENTAL BIOLOGY | DAMAGE CHECKPOINT ACTIVATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | EXONUCLEASE-1 | REPAIR | REPLICATION FORKS | GENETICS & HEREDITY | END RESECTION | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | Bloom Syndrome - metabolism | RecQ Helicases - genetics | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Recombination, Genetic | Bone Neoplasms - genetics | Tumor Cells, Cultured | DNA Helicases - genetics | Osteosarcoma - metabolism | DNA Repair - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | DNA Helicases - metabolism | Plasmids | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Helicases - antagonists & inhibitors | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Nucleases | DNA damage | Analysis | Chemical properties | Research | Helicases | Mutation (Biology) | Research Communication
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 04/2017, Volume 15, Issue 4 Supplement, pp. PR20 - PR20
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 1, pp. 51 - 64
The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two... 
BRCT DOMAINS | ACTIVATION | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | V(D)J RECOMBINATION | TUMOR-SUPPRESSOR | CLASS-SWITCH RECOMBINATION | P53 PATHWAY | PROTEINS | CELL BIOLOGY | Gamma Rays | Endonucleases - genetics | Tumor Suppressor p53-Binding Protein 1 - chemistry | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Protein Multimerization | CRISPR-Associated Protein 9 | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Tumor Suppressor Protein p53 - genetics | MCF-7 Cells | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | Ubiquitin Thiolesterase - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Tumor Suppressor p53-Binding Protein 1 - metabolism | Promoter Regions, Genetic | Protein Conformation, alpha-Helical | Tumor Suppressor p53-Binding Protein 1 - genetics | Signal Transduction | Bacterial Proteins - genetics | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Ubiquitin Thiolesterase - genetics | Gene Editing | Protein Conformation, beta-Strand | DNA Repair | Protein Binding | Bacterial Proteins - metabolism | Tumor Suppressor Protein p53 - chemistry | Ubiquitin Thiolesterase - chemistry | Oligomers | Ubiquitin | Ionizing radiation | Chromatin | Proteases | Genes | Genomics | DNA | Tumor proteins | DNA repair
Journal Article
Science, ISSN 0036-8075, 12/2007, Volume 318, Issue 5856, pp. 1637 - 1640
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 61, Issue 3, pp. 530 - 537
Background & Aims Hepatitis C (HCV) related disease in England is predicted to rise, and it is unclear whether treatment at current levels will be able to... 
Gastroenterology and Hepatology | Back-calculation | Modelling | Treatment | Hepatitis C | Disease burden | Liver disease | UNITED-STATES | MORTALITY | COST-EFFECTIVENESS | VIRUS-INFECTION | INJECTING DRUG-USERS | PREVALENCE | HCV INFECTION | PROGRESSION RATES | KINGDOM | GASTROENTEROLOGY & HEPATOLOGY | Recombinant Proteins - therapeutic use | Carcinoma, Hepatocellular - epidemiology | Ribavirin - economics | Carcinoma, Hepatocellular - prevention & control | Humans | Middle Aged | End Stage Liver Disease - epidemiology | Cost of Illness | Hepatitis C, Chronic - complications | Polyethylene Glycols - economics | Polyethylene Glycols - therapeutic use | Liver Cirrhosis - epidemiology | Health Care Costs - trends | Liver Neoplasms - epidemiology | England - epidemiology | Adult | Retrospective Studies | Liver Neoplasms - prevention & control | Liver Cirrhosis - prevention & control | Antiviral Agents - therapeutic use | Ribavirin - therapeutic use | Risk Factors | Interferon-alpha - therapeutic use | Interferon-alpha - economics | Treatment Outcome | End Stage Liver Disease - prevention & control | Models, Statistical | Hepatitis C, Chronic - drug therapy | Hepatitis C, Chronic - economics | Recombinant Proteins - economics | Antiviral Agents - economics | End Stage Liver Disease - economics | Medicine, Experimental | Medical research | Models | Hepatitis C virus
Journal Article
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7716, pp. 122 - 127
53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1... 
CELLS | REV7 | RESECTION | TRANSLOCATIONS | POL-ZETA | MULTIDISCIPLINARY SCIENCES | BRCA1 DEFICIENCY | CLASS-SWITCH RECOMBINATION | MECHANISMS | POLYMERASE-ZETA | GENE-FUNCTION | Mad2 Proteins - metabolism | Humans | Male | Tumor Suppressor p53-Binding Protein 1 - deficiency | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | DNA End-Joining Repair | Female | Mad2 Proteins - deficiency | Tumor Suppressor p53-Binding Protein 1 - metabolism | Cell Line | DNA, Single-Stranded - metabolism | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | DNA - metabolism | DNA, Single-Stranded - chemistry | V(D)J Recombination - genetics | DNA - chemistry | Multiprotein Complexes - chemistry | Animals | Mad2 Proteins - genetics | Mice | Mutation | Immunoglobulin Class Switching - genetics | Genetic research | Genetic recombination | Recombinant proteins | Analysis | DNA structure | Chromatin | Animal models | Single-stranded DNA | DNA damage | Homology | DNA repair | Genomic instability | Proteins | Immunology | Lymphocytes | Cooperation | Bone marrow | Tumorigenesis | Repair | Deoxyribonucleic acid--DNA | Stability | V(D)J recombination | Immunodeficiency | Crosslinking | Double-strand break repair | Substrates | Class switching | Telomeres | Non-homologous end joining | Instability | Tumors
Journal Article
Physical Review Letters, ISSN 0031-9007, 05/2016, Volume 116, Issue 20, p. 205001
We report the first experimental demonstration of a plasma wave plate based on laser-induced birefringence. An elliptically polarized input was converted into... 
Beams (radiation) | Simulation | Birefringence | Feasibility | Laser beams | Dynamical systems | Delay | Photonics
Journal Article