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CURRENT PHARMACEUTICAL DESIGN, ISSN 1381-6128, 2019, Volume 25, Issue 16, pp. 1828 - 1846
Background: Natural compounds with potential antioxidant properties have been used in the form of food supplements or extracts with the intent to prevent or... 
OXIDATIVE STRESS | HEME OXYGENASE-1 EXPRESSION | NRF2 PATHWAY | hypothyroidism | DETOXIFYING ENZYME EXPRESSION | Personalized nutrition | PHASE-II | goiter | IN-VITRO | hyperthyroidism | thyroid | Nrf2 | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | flavonoid | BROCCOLI SPROUT BEVERAGES | UP-REGULATION | phytochemical | CANCER CELL-LINES
Journal Article
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 05/2014, Volume 370, Issue 18, pp. 1768 - 1768
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 03/2019, Volume 240, Issue 3, pp. 403 - 416
The transcription factor Nrf2 (NF-E2-related factor 2) plays a critical role in oxidative stress responses. Although activation of Nrf2 signaling is known to... 
Insulitis | NOD mice | Nrf2 | Type 1 diabetes | CELLS | type 1 diabetes | OXIDATIVE STRESS | NOD | IFN-GAMMA | PERITONEAL-MACROPHAGES | MODEL | insulitis | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | KEAP1/NRF2 PATHWAY | EXPRESSION | KEAP1-NRF2 SYSTEM
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 08/2019
Nuclear factor, erythroid 2-like 2 (Nrf2) is a transcription factor that has been gaining attention in the field of pharmacology and especially in the... 
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 04/2019, Volume 126, pp. 1 - 6
Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the... 
Clinical trial | Glucoraphanin | Nrf2 | Sulforaphane | Broccoli sprout beverage | Thyroid | ISOTHIOCYANATES | HUMAN PLASMA | FOOD SCIENCE & TECHNOLOGY | AIRBORNE POLLUTANTS | QUANTITATIVE-DETERMINATION | GOITRIN | PHASE | METABOLISM | BRUSSELS-SPROUTS | THIOCYANATE | RICH | TOXICOLOGY | Autoimmunity | Analysis | Thyroxine | Thyroid diseases | Clinical trials | Thyrotropin | Thyroid gland | Beverages | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e34872
Journal Article
Molecular Medicine, ISSN 1076-1551, 07/2011, Volume 17, Issue 7-8, pp. 736 - 740
Journal Article
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 09/2016, Volume 1449, pp. 383 - 393
As a dedicated hormone-secreting organ, the thyroid gland possesses a complement of proteostatic systems, including antioxidant, unfolded protein, and... 
TRIzol | QIAzol | Proteostasis | Micro-RNA | Isolation | Simultaneous | TRI reagent | Guanidinium | RNA and protein | Thyroid | Animals | Proteostasis - physiology | MicroRNAs - metabolism | Guanidine - metabolism | Mice | Proteins - chemistry | Proteins - isolation & purification | RNA, Messenger - metabolism | Thyroid Gland - metabolism
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 12/2016, Volume 101, pp. 116 - 128
Small molecules of plant origin offer presumptively safe opportunities to prevent carcinogenesis, mutagenesis and other forms of toxicity in humans. However,... 
Withaferin A | Pten | Stress response | Nrf2 | Hepatotoxicity | PHOSPHATIDYLINOSITOL 3-KINASE/AKT | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PTEN | BREAST-CANCER CELLS | HEAT-SHOCK RESPONSE | ENDOCRINOLOGY & METABOLISM | WITHANIA-SOMNIFERA | HEME OXYGENASE-1 | METABOLIC ALTERATIONS | TRANSCRIPTION FACTOR | Withanolides - isolation & purification | Male | Phosphatidylinositol 3-Kinases - metabolism | Cytotoxins - toxicity | Proto-Oncogene Proteins c-akt - genetics | Kelch-Like ECH-Associated Protein 1 - genetics | Protective Agents - pharmacology | NF-E2-Related Factor 2 - genetics | Chemical and Drug Induced Liver Injury - pathology | Proto-Oncogene Proteins c-akt - metabolism | Cytotoxins - antagonists & inhibitors | Fibroblasts - metabolism | Chemical and Drug Induced Liver Injury - prevention & control | PTEN Phosphohydrolase - genetics | Signal Transduction | Acetaminophen - toxicity | Mice, Inbred C57BL | Acetaminophen - antagonists & inhibitors | Gene Expression Regulation | PTEN Phosphohydrolase - metabolism | Kelch-Like ECH-Associated Protein 1 - metabolism | Protective Agents - isolation & purification | Chemical and Drug Induced Liver Injury - genetics | NF-E2-Related Factor 2 - deficiency | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Animals | Withanolides - pharmacology | Chemical and Drug Induced Liver Injury - metabolism | Fibroblasts - drug effects | Plant Roots - chemistry | Fibroblasts - cytology | Mice | Primary Cell Culture | Withania - chemistry | Medicine, Ayurvedic | Enzymes | Medical colleges | Analysis | Liver | Cysteine | Phosphatases | stress response | hepatotoxicity
Journal Article