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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 25, pp. 11608 - 11613
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2010, Volume 107, Issue 25, p. 11608
  Ligand-directed signaling has been suggested as a basis for the differences in responses evoked by otherwise receptor-selective agonists. The underlying... 
Proteins | Membranes | Narcotics | Rodents | Kinases | Gene expression | Binding sites
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 06/2010, Volume 107, Issue 25, pp. 11608 - 11613
Ligand-directed signaling has been suggested as a basis for the differences in responses evoked by otherwise receptor-selective agonists. The underlying... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/1996, Volume 93, Issue 8, pp. 3362 - 3367
Ca2+ influx controls multiple neuronal functions including neurotransmitter release, protein phosphorylation, gene expression, and synaptic plasticity. Brain... 
Tetrodotoxin | Proteins | P type calcium channels | Brain | Calcium | Neurons | N methyl D aspartate receptors | Antibodies | Dendrites | Synapses | 2 SIZE FORMS | CHANNEL-ALPHA-1 SUBUNITS | SKELETAL-MUSCLE | NMDA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | CA2+ CHANNELS | DEPENDENT PROTEIN-KINASE | MOLECULAR-CLONING | ALPHA-1 SUBUNIT | BETA-SUBUNIT | AREA CA1 | Aspartate | Calcium channels | Research | Hippocampus (Brain) | Proteases
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 01/2011, Volume 80, Issue 5, pp. 920 - 929
The Kappa -opioid receptor is a widely expressed G-protein-coupled receptor that has been implicated in biological responses to pain, stress, anxiety, and... 
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2019, Volume 294, Issue 45, pp. 16884 - 16896
Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the G(i/o) protein?coupled ? opioid receptor (KOR), ? opioid, and D2... 
peroxiredoxin | OXIDATIVE STRESS | NADPH-OXIDASE | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | opioid | c-Jun N-terminal kinase (JNK) | SPINAL-CORD | DYNORPHIN | MAPK | PHOSPHOLIPASE-A2 | reactive oxygen | p38 | KAPPA | opiate opioid | cell signaling | G protein-coupled receptor (GPCR) | LIGAND | ANTAGONISTS | G protein | AGONIST
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 743 - 14
Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioid antidepressants by... 
Phosphorylation | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Analgesics, Opioid - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Fentanyl - pharmacology | Receptors, Dopamine D2 - metabolism | Pyrrolidines - pharmacology | Peroxiredoxin VI - metabolism | NADPH Oxidases - drug effects | Receptors, Dopamine D2 - drug effects | Benzeneacetamides - pharmacology | Receptors, Opioid - metabolism | JNK Mitogen-Activated Protein Kinases - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - drug effects | Morphine - pharmacology | Enkephalin, Ala-MePhe-Gly- - pharmacology | Receptors, Opioid, mu - drug effects | Receptors, Opioid, mu - metabolism | Drug Tolerance | Receptors, Opioid, kappa - metabolism | Peroxiredoxin VI - drug effects | Receptors, Opioid, kappa - drug effects | Animals | Mice | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Receptors, Opioid - drug effects | Peroxiredoxin | Reactive oxygen species | Transcription factors | G protein-coupled receptors | Palmitoylation | Oxidase | Morphine | Activation | Arrestin | Inactivation | Guanine | Modulators | NAD(P)H oxidase | Recruitment | Proteins | Receptors | Pain | Analgesics | Antidepressants | Drug tolerance | Opioid receptors (type kappa) | Oxidation | Dopamine D2 receptors | Pain perception | Deactivation | Dopamine | Narcotics | c-Jun protein | Receptor mechanisms
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2012, Volume 32, Issue 49, pp. 17582 - 17596
Activation of the dynorphin/kappa-opioid receptor (KOR) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and... 
INTRAVENOUS COCAINE | ACTIVATED PROTEIN-KINASE | ELECTRODE VOLTAMMETRIC MEASUREMENTS | PLACE PREFERENCE | 5-HYDROXYINDOLEACETIC ACID | NUCLEUS-ACCUMBENS SHELL | TRANSPORTER KINETICS | MAJOR DEPRESSION | DORSAL RAPHE NUCLEUS | NEUROSCIENCES | KAPPA-OPIOID-RECEPTOR | Naltrexone - analogs & derivatives | Narcotic Antagonists - administration & dosage | Microinjections - methods | Nucleus Accumbens - metabolism | Dynorphins - physiology | Male | Synaptosomes - metabolism | Stress, Psychological - psychology | Corpus Striatum - metabolism | Raphe Nuclei - metabolism | Nicotine - adverse effects | Brain - metabolism | Naltrexone - pharmacology | Serotonin Plasma Membrane Transport Proteins - genetics | Substance Withdrawal Syndrome - metabolism | Stress, Psychological - metabolism | Membrane Transport Proteins - metabolism | Dynorphins - metabolism | Narcotic Antagonists - pharmacokinetics | Naltrexone - administration & dosage | Dopamine - metabolism | G-Protein-Coupled Receptor Kinase 3 - genetics | Receptors, Opioid, kappa - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - physiology | G-Protein-Coupled Receptor Kinase 3 - physiology | Mice, Inbred C57BL | p38 Mitogen-Activated Protein Kinases - genetics | Mice, Transgenic | Avoidance Learning - physiology | Mice, Knockout | Receptors, Opioid, kappa - physiology | Serotonin Plasma Membrane Transport Proteins - metabolism | Cocaine - pharmacology | Animals | Raphe Nuclei - drug effects | Raphe Nuclei - physiology | Signal Transduction - drug effects | Serotonin - metabolism | Signal Transduction - physiology | Avoidance Learning - drug effects | Mice | Reward | Nucleus Accumbens - drug effects
Journal Article