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index medicus (9) 9
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amino acid sequence (1) 1
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1. Full Text Robust PGT-M of Huntington disease combining triplet-primed PCR of the HTT CAG repeat with multi-microsatellite haplotyping
by Zhao, Mingjue and Cheah, Felicia S.H and Tan, Arnold S.C and Agarwal, Anupriya and Chong, Samuel S
Reproductive BioMedicine Online, ISSN 1472-6483, 04/2019, Volume 38, pp. e29 - e30
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2. Full Text Improved high sensitivity screen for huntington disease using a one-step triplet-primed PCR and melting curve assay
by Zhao, Mingjue and Cheah, Felicia S. H and Chen, Min and Lee, Caroline G and Law, Hai-Yang and Chong, Samuel S
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0180984
Molecular diagnosis of Huntington disease (HD) is currently performed by fluorescent repeat-flanking or triplet-primed PCR (TP-PCR) with capillary... 
Electrophoresis, Capillary | Alleles | Plasmids - genetics | Huntington Disease - genetics | Trinucleotide Repeat Expansion - genetics | Genotype | Polymerase Chain Reaction - methods | Polymerase chain reaction | Care and treatment | Huntington's chorea | Analysis | Diagnosis | Research | Risk factors | Huntingtons disease | Pediatrics | Laboratories | Genomics | Fluorescence | Melting curve | Assaying | Coupling (molecular) | Genetics | Electrophoresis | Expansion | Trinucleotide repeat diseases | Deoxyribonucleic acid--DNA | Melting | Polyglutamine | Capillary electrophoresis | Trinucleotide repeats | Huntington's disease | Medicine | Screening | Sensitivity | Hospitals | Plasmids | Mutation | Sizing | Saliva | Deoxyribonucleic acid | DNA
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3. Full Text tgf[beta]3 regulation of chondrogenesis and osteogenesis in zebrafish is mediated through formation and survival of a subpopulation of the cranial neural crest
by Cheah, Felicia S.H and Winkler, Christoph and Jabs, Ethylin Wang and Chong, Samuel S
Mechanisms of Development, ISSN 0925-4773, 07/2010, Volume 127, Issue 7-8, p. 329
Zebrafish tgf[beta]3 is strongly expressed in a subpopulation of the migrating neural crest cells, developing pharyngeal arches and neurocranial cartilages. To... 
Medical colleges | Analysis | Transforming growth factors
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4. Full Text Identification of Novel Microsatellite Markers Flanking the SMN1 and SMN2 Duplicated Region and Inclusion Into a Single-Tube Tridecaplex Panel for Haplotype-Based Preimplantation Genetic Testing of Spinal Muscular Atrophy
by Zhao, Mingjue and Lian, Mulias and Cheah, Felicia S.H and Tan, Arnold S.C and Agarwal, Anupriya and Chong, Samuel S
Frontiers in Genetics, ISSN 1664-8021, 11/2019, Volume 10
Preimplantation genetic testing for the monogenic disorder (PGT-M) spinal muscular atrophy (SMA) is significantly improved by supplementation of SMN1 deletion... 
multiplex PCR | microsatellite | haplotype | spinal motor neuron (SMN) | preimplantation genetic testing for monogenic disorders (PGT-M) | spinal muscular atrophy (SMA)
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5. Full Text tgfβ3 regulation of chondrogenesis and osteogenesis in zebrafish is mediated through formation and survival of a subpopulation of the cranial neural crest
by Cheah, Felicia S.H and Winkler, Christoph and Jabs, Ethylin Wang and Chong, Samuel S
Mechanisms of Development, ISSN 0925-4773, 07/2010, Volume 127, Issue 7-8, pp. 329 - 344
Zebrafish is strongly expressed in a subpopulation of the migrating neural crest cells, developing pharyngeal arches and neurocranial cartilages. To study the... 
Pharyngeal arch | Cranial neural crest | tgfβ3 | Proliferation | Chondrogenesis | Differentiation | Survival | Neurocranial cartilage | Osteogenesis | Apoptosis | Tgfβ3
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6. Full Text Identification of novel microsatellite markers <1 Mb from the HBB gene and development of a single‐tube pentadecaplex PCR panel of highly polymorphic markers for preimplantation genetic diagnosis of beta‐thalassemia
by Chen, Min and Tan, Arnold S. C and Cheah, Felicia S. H and Saw, Eugene E. L and Chong, Samuel S
ELECTROPHORESIS, ISSN 0173-0835, 12/2015, Volume 36, Issue 23, pp. 2914 - 2924
Beta (β)‐thalassemia is one of the most common monogenic diseases worldwide. Affected pregnancies can be avoided through preimplantation genetic diagnosis... 
Multiplex PCR | Beta‐thalassemia | Microsatellite marker | Preimplantation genetic diagnosis (PGD) | Linkage analysis | Beta-thalassemia | CHEMISTRY, ANALYTICAL | HEMOGLOBINOPATHIES | BIOCHEMICAL RESEARCH METHODS | DISORDERS | HETEROZYGOSITY | CYCLES | MUTATIONS | MAP | Pregnancy | Gene Frequency | Humans | beta-Thalassemia - genetics | Female | Preimplantation Diagnosis - methods | beta-Globins - genetics | beta-Thalassemia - diagnosis | Microsatellite Repeats | Polymerase Chain Reaction - methods | Polymorphism, Genetic | Analysis | Genes | Genomics | Genetic research | Thalassemia | Population genetics | Genetic polymorphisms | Mutations | Panels | Microsatellites | Markers | Genetics | Diagnosis | Polymorphism
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7. Full Text FMR1 CGG repeat expansion mutation detection and linked haplotype analysis for reliable and accurate preimplantation genetic diagnosis of fragile X syndrome
by Rajan-Babu, Indhu-Shree and Lian, Mulias and Cheah, Felicia S.H and Chen, Min and Tan, Arnold S.C and Prasath, Ethiraj B and Loh, Seong Feei and Chong, Samuel S
Expert Reviews in Molecular Medicine, ISSN 1462-3994, 07/2017, Volume 19, p. e10
Fragile X mental retardation 1 (FMR1) full-mutation expansion causes fragile X syndrome. Trans-generational fragile X syndrome transmission can be avoided by... 
MEDICINE, RESEARCH & EXPERIMENTAL | PREMUTATION | PRACTICE GUIDELINES | PRIMED PCR | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | EXPANDED ALLELES | MULTIPLE DISPLACEMENT AMPLIFICATION | CARRIERS | MYOTONIC-DYSTROPHY | FULL-MUTATION | Fragile X Syndrome - genetics | Haplotypes | Trinucleotide Repeats | Reproducibility of Results | Genetic Testing | Humans | Preimplantation Diagnosis | Male | Polymerase Chain Reaction - methods | Pregnancy | Fertilization in Vitro | Pedigree | Alleles | Female | Fragile X Mental Retardation Protein - genetics | Mutation | Fragile X Syndrome - diagnosis | Biotechnology | Laboratories | Genes | Colleges & universities | Genomes | Dimorphism | Assaying | Mental retardation | Genetic screening | Fragile X mental retardation protein | Genetics | Diagnosis | Expansion | Deoxyribonucleic acid--DNA | Lymphoblasts | Microsatellites | Fertilization | Customizing | Markers | Embryos | Polymerase chain reaction | Amplification | Genetic markers | Infertility | Cell lines | Diagnostic systems | Fragile X syndrome | Females | Thermal cycling | In vitro methods and tests
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8. Full Text Germline transgenesis of zebrafish using the medaka Tol1 transposon system
by Koga, Akihiko and Cheah, Felicia S.H and Hamaguchi, Satoshi and Yeo, Gare Hoon and Chong, Samuel S
Developmental Dynamics, ISSN 1058-8388, 09/2008, Volume 237, Issue 9, pp. 2466 - 2474
Tol1 is a DNA‐based transposable element first identified from an albino mutant medaka fish. It has been demonstrated to function as an efficient gene transfer... 
transgenesis | zebrafish | germline | transposable element | transposon, gene transfer | Tol1 | Zebrafish | Transposable element | Transgenesis | Germline | Transposon, gene transfer | gene transfer | ANATOMY & MORPHOLOGY | EFFICIENT GENE DELIVERY | DEVELOPMENTAL BIOLOGY | SLEEPING-BEAUTY TRANSPOSON | transposon | TYROSINASE GENE | MOUSE CELLS | ELEMENT | ORYZIAS-LATIPES | SEQUENCE | FISH | EXCISION | EXPRESSION | Blotting, Southern | Gene Transfer Techniques | Animals, Genetically Modified | Embryo, Nonmammalian - metabolism | Molecular Sequence Data | Zebrafish - genetics | Germ Cells - enzymology | Animals | Base Sequence | Transposases - genetics | DNA Transposable Elements - genetics | Plasmids - genetics | Models, Genetic | Oryzias - genetics | Germ Cells - metabolism
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9. Full Text Bmp4 was associated with nscl/p in an asian population
by Chen, Qianqian and Wang, Hong and Hetmanski, Jacqueline B and Zhang, Tianxiao and Ruczinski, Ingo and Schwender, Holger and Liang, Kung Yee and Fallin, M. Daniele and Redett, Richard J and Raymond, Gerald V and Chou, Yah-Huei and ChenPhilip, Philip Kuo-Ting and Yeow, Vincent and Chong, Samuel S and Cheah, Felicia S. H and Jabs, Ethylin Wang and Scott, Alan F and Beaty, Terri H
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35347
Background: The Bone Morphogenetic Protein 4 gene (BMP4) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft... 
FUSION | VARIANTS | NONSYNDROMIC CLEFT-LIP | 4 GENE POLYMORPHISMS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | PALATE | LINKAGE | LIP/PALATE | Asian Continental Ancestry Group | Cleft Lip - genetics | Genetic Predisposition to Disease - genetics | Bone Morphogenetic Protein 4 - genetics | Humans | Polymorphism, Single Nucleotide - genetics | Female | Genotype | Male | Cleft Palate - genetics | Genetic Linkage - genetics | Genes | Genomics | Bone morphogenetic proteins | Family | Genetic aspects | Genomes | Single nucleotide polymorphisms | Haplotypes | Pediatrics | Bone morphogenetic protein 4 | Animal models | Cloning | Families & family life | Single-nucleotide polymorphism | Epidemiology | Insulin | Cleft lip/palate | Children & youth | Medicine | Studies | Population (statistical) | Hospitals | Population | Diabetes | Chromosome 14 | Public health | Linkage analysis
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10. Full Text Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations
by Omoumi, Ardeshir and Wang, Zihua and Yeow, Vincent and Wu-Chou, Yah-Huei and Chen, Philip K and Ruczinski, Ingo and Cheng, Joanne and Cheah, Felicia S.H and Lee, Caroline G and Beaty, Terri H and Chong, Samuel S
European Journal of Human Genetics, ISSN 1018-4813, 12/2013, Volume 21, Issue 12, pp. 1436 - 1441
ATP-binding cassette (ABC) proteins in the placenta regulate fetal exposure to xenobiotics. We hypothesized that functional polymorphisms in ABC genes... 
cleft lip | cleft palate | placenta | ATP-binding cassette transporters | disease susceptibility | single-nucleotide polymorphism | ABCB1 | HUMAN PLACENTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSPORTER ABCG2 | BIRTH-DEFECTS | DRUG EXPOSURE | P-GLYCOPROTEIN | MDR1 | VARIABLE EXPRESSION | PROTEIN EXPRESSION | GENETICS & HEREDITY | SINGLE NUCLEOTIDE POLYMORPHISMS | Fetus - abnormalities | Genetic Predisposition to Disease - genetics | Singapore | Humans | Genotype | Cleft Palate - genetics | Case-Control Studies | Cleft Lip - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Alleles | Taiwan | Polymorphism, Single Nucleotide - genetics | ATP Binding Cassette Transporter, Sub-Family B | Infant, Newborn | Neonates | Medical research | Pediatrics | Genomics | Fetuses | Single-nucleotide polymorphism | Medicine | Studies | Proteins | Placenta | Hospitals | Maternal effects | Cord blood | Peripheral blood | Genetics | Protein expression | Xenobiotics | Cancer | Polymorphism
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11. Full Text Rapid and reliable preimplantation genetic diagnosis of common hemoglobin Bart's hydrops fetalis syndrome and hemoglobin H disease determinants using an enhanced single‐tube decaplex polymerase chain reaction assay
by Chen, Min and Loh, Seong Feei and Yu, Su Ling and Nair, Suresh and Tan, Heng Hao and Nadarajah, Sadhana and Wong, Peng‐Cheang and Ng, Soon Chye and Prasath, Ethiraj B and Tan, Arnold S.C and Cheah, Felicia S.H and Saw, Eugene E.L and Chong, Samuel S
American Journal of Hematology, ISSN 0361-8609, 09/2015, Volume 90, Issue 9, pp. E194 - E196
HEMATOLOGY | Multiplex Polymerase Chain Reaction - methods | Hydrops Fetalis - diagnosis | Humans | Hemoglobins, Abnormal - chemistry | Genetic Loci | Genetic Markers | Hydrops Fetalis - pathology | Preimplantation Diagnosis - methods | DNA Primers - chemical synthesis | Pregnancy | alpha-Thalassemia - pathology | Hydrops Fetalis - genetics | Hemoglobins, Abnormal - genetics | alpha-Thalassemia - diagnosis | Female | alpha-Thalassemia - genetics | Microsatellite Repeats | Polymerase chain reaction | Hemoglobin
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12. Full Text The FGF and FGFR Gene Family and Risk of Cleft Lip with or Without Cleft Palate
by Wang, Hong and Zhang, Tianxiao and Wu, Tao and Hetmanski, Jacqueline B and Ruczinski, Ingo and Schwender, Holger and Yee Liang, Kung and Murray, Tanda and Daniele Fallin, M and Redett, Richard J and Raymond, Gerald V and Jin, Sheng-Chih and Wu Chou, Yah-Huei and Kuo-Ting Chen, Philip and Yeow, Vincent and Chong, Samuel S and Cheah, Felicia S.H and Ha Jee, Sun and Jabs, Ethylin W and Scott, Alan F and Beaty, Terri H
The Cleft Palate-Craniofacial Journal, ISSN 1055-6656, 1/2013, Volume 50, Issue 1, pp. 96 - 103
Background Isolated, nonsyndromic cleft lip with or without cleft palate is a common human congenital malformation with a complex and heterogeneous etiology.... 
FGF/FGFR | Maternal effects | Gene-gene interaction | Oral clefts | Gene-environment interaction | SURGERY | METAANALYSIS | VARIANTS | gene-environment interaction | OROFACIAL CLEFTS | PATHWAY | maternal effects | DENTISTRY, ORAL SURGERY & MEDICINE | oral clefts | MUTATIONS | HAPLOTYPE | gene-gene interaction | LINKAGE | MATERNAL SMOKING | GENOME-WIDE ASSOCIATION | Haplotypes | Cleft Palate | Cleft Lip - genetics | Polymorphism, Single Nucleotide | Humans | Linkage Disequilibrium | Congenital diseases | Deformities | Genetic disorders | Mouth | FGF | FGFR
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13. Full Text Germline transgenesis of zebrafish using the medakaTol1transposon system
by Koga, Akihiko and Cheah, Felicia S.H and Hamaguchi, Satoshi and Yeo, Gare Hoon and Chong, Samuel S
Developmental Dynamics, ISSN 1058-8388, 09/2008, Volume 237, Issue 9, pp. 2466 - 2474
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14. Full Text Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family
by Yeo, Gare Hoon and Cheah, Felicia S.H and Winkler, Christoph and Jabs, Ethylin Wang and Venkatesh, Byrappa and Chong, Samuel S
Development Genes and Evolution, ISSN 0949-944X, 06/2009, Volume 219, Issue 6, pp. 289 - 300
Four members of the twist gene family (twist1a, 1b, 2, and 3) are found in the zebrafish, and they are thought to have arisen through three rounds of gene... 
Twist | Orthology | Expression | Synteny | Medaka | Zebrafish | Regulation | Phylogeny | DORSOVENTRAL PATTERN | DROSOPHILA-TWIST | DEVELOPMENTAL BIOLOGY | GENOME | CELL BIOLOGY | MESODERMAL CELLS | EVOLUTIONARY BIOLOGY | DERMO-1 | ZYGOTIC GENE | X-TWI | EMBRYOS | Fishes - genetics | Sequence Alignment | Animals | Gene Expression Regulation, Developmental | Embryo, Nonmammalian - metabolism | Twist-Related Protein 1 - genetics | Zebrafish Proteins - genetics | Zebrafish - embryology | Zebrafish - genetics | Evolution, Molecular | Proteins | Genetic research | Medical colleges | Anopheles | Genetic aspects | Developmental biology
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15. Full Text Genomic, cDNA, and embryonic expression analysis of zebrafish transforming growth factor beta 3 (tgfβ3)
by Cheah, Felicia S.H and Jabs, Ethylin Wang and Chong, Samuel S
Developmental Dynamics, ISSN 1058-8388, 04/2005, Volume 232, Issue 4, pp. 1021 - 1030
TGFβ3, a member of the transforming growth factor β family, regulates a spectrum of biological processes and is involved in mammalian pulmonary and... 
transforming growth factor β3 | Danio rerio | pharyngeal arch | palatogenesis | cleft palate | notochord | pectoral fins | lens | heart | Heart | Cleft palate | Pharyngeal arch | Palatogenesis | Pectoral fins | Transforming growth factor β3 | Lens | Notochord | PALATE FUSION | TGF-BETA | ANATOMY & MORPHOLOGY | MOUSE | transforming growth factor beta 3 | DEVELOPMENTAL BIOLOGY | danio rerio | GROWTH-FACTOR-BETA | FLOOR PLATE | GENE | FACTOR-BETA-3 | MICE | DIFFERENTIATION | Zebrafish Proteins - biosynthesis | DNA, Complementary - genetics | Molecular Sequence Data | Zebrafish - embryology | Transforming Growth Factor beta - biosynthesis | Zebrafish - genetics | Animals | Transforming Growth Factor beta - genetics | Base Sequence | Zebrafish Proteins - genetics | Genome | Transforming Growth Factor beta3 | Gene Expression Regulation, Developmental - physiology
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16. Full Text ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population
by Wang, Hong and Hetmanski, Jacqueline B and Ruczinski, Ingo and Liang, Kung Yee and Daniele Fallin, M and Redett, Richard J and Raymond, Gerald V and Wu Chou, Yah-Huei and Chen, Philip Kuo-Ting and Yeow, Vincent and Chong, Samuel S and Cheah, Felicia S.H and Jabs, Ethylin Wang and Scott, Alan F and Beaty, Terri H
中华医学杂志：英文版, ISSN 0366-6999, 2012, Volume 125, Issue 3, pp. 476 - 480
Background The receptor tyrosine kinase-like orphan receptor 2 （ROR2） gene has been recently shown to play important roles in palatal development in animal... 
人口 | 基因测试 | 亚洲 | 综合征 | 单核苷酸多态性 | 风险 | SNPs | 受体酪氨酸激酶 | Cleft palate | Transmission disequilibrium test | Association | Cleft lip | Receptor tyrosine kinase-like orphan receptor 2 | VARIANTS | cleft palate | association | transmission disequilibrium test | LOCI | MODEL | FAMILY | cleft lip | MEDICINE, GENERAL & INTERNAL | LIP | ROBINOW-SYNDROME | receptor tyrosine kinase-like orphan receptor 2 | MUTATIONS | SCAN | LINKAGE | GENOME-WIDE ASSOCIATION | Cleft Lip - genetics | Genetic Predisposition to Disease - genetics | Humans | Asian Continental Ancestry Group - genetics | Linkage Disequilibrium - genetics | Polymorphism, Single Nucleotide - genetics | Genotype | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Cleft Palate - genetics
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17. Full Text Zebrafish twist1 is expressed in craniofacial, vertebral, and renal precursors
by Yeo, Gare-Hoon and Cheah, Felicia S. H and Jabs, Ethylin Wang and Chong, Samuel S
Development Genes and Evolution, ISSN 0949-944X, 12/2007, Volume 217, Issue 11, pp. 783 - 789
TWIST1 encodes a transcription factor that contains a highly conserved basic helix–loop–helix DNA-binding domain and a WR motif. We have isolated a full-length... 
Life Sciences | Biochemistry, general | Neurosciences | Vertebral | Renal | Zebrafish | twist1 | Craniofacial | Developmental Biology | Animal Genetics and Genomics | Cell Biology | Ttwist1 | craniofacial | MOUSE | DROSOPHILA-TWIST | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | renal | MESODERMAL CELLS | EVOLUTIONARY BIOLOGY | ORYZIAS-LATIPES | GENE | vertebral | MEDAKA | zebrafish | DIFFERENTIATION | NEURAL CREST | X-TWI | EMBRYOS | Embryo, Nonmammalian - cytology | Kidney - embryology | Embryo, Nonmammalian - metabolism | Spine - metabolism | Molecular Sequence Data | Phylogeny | Zebrafish - embryology | Neural Crest - metabolism | Somites - cytology | Kidney - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Conserved Sequence | Spine - embryology | Head - embryology | Somites - metabolism | Amino Acid Sequence | Neural Crest - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | Embryonic Development | Zebrafish - genetics | Sequence Homology, Amino Acid | Animals | Zebrafish Proteins - genetics | RNA, Messenger | Basic Helix-Loop-Helix Transcription Factors - chemistry | DNA, Complementary | Genetics | Embryos | Deoxyribonucleic acid--DNA
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