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ChemBioChem, ISSN 1439-4227, 02/2017, Volume 18, Issue 3, p. 291
Inhibition of specific protein-protein interactions is attractive for a range of therapeutic applications, but the large and irregularly shaped contact... 
Peptides | Proteolysis | Vascular endothelial growth factor | Protein-protein interactions | Antigenic determinants | Endothelium
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 04/2015, Volume 112, Issue 15, p. 4552
Peptide-based agents derived from well-defined scaffolds offer an alternative to antibodies for selective and high-affinity recognition of large and... 
Usage | Bioavailability | Biological markers | Analysis | Protein-protein interactions | Proteins | Signal transduction | Peptides | Amino acids | TNF inhibitors | Vascular endothelial growth factor | Binding sites
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 2/2017, Volume 18, Issue 3, pp. 291 - 299
Inhibition of specific protein-protein interactions is attractive for a range of therapeutic applications, but the large and irregularly shaped contact... 
inhibitors | β-peptides | vascular endothelial growth factor | foldamers
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 15, pp. 4552 - 4557
Peptide-based agents derived from well-defined scaffolds offer an alternative to antibodies for selective and high-affinity recognition of large and... 
Molecular recognition | Foldamers | Inhibitors | α/β-peptides | Protein-protein interactions | alpha/beta-peptides | inhibitors | ACTION IN-VIVO | ANGIOGENESIS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | RESOLUTION | foldamers | protein-protein interactions | MOLECULES | BIOLOGY | molecular recognition | RECEPTOR-BINDING | NEXT-GENERATION | HELIX MIMICRY | ENDOTHELIAL GROWTH-FACTOR | Tumor Necrosis Factor-alpha - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Dose-Response Relationship, Drug | Vascular Endothelial Growth Factor A - chemistry | Peptides - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Vascular Endothelial Growth Factor A - pharmacology | Protein Structure, Tertiary | Amino Acid Sequence | Cell Survival - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Peptides - chemistry | Protein Structure, Secondary | Immunoglobulin G - chemistry | Cells, Cultured | Models, Molecular | Binding Sites - genetics | Peptides - pharmacology | Sequence Homology, Amino Acid | Proteins - metabolism | Tumor Necrosis Factor-alpha - chemistry | Protein Binding | Cell Proliferation - drug effects | Proteins - chemistry | Immunoglobulin G - metabolism | Index Medicus | protein–protein interactions | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences | α | Physical Sciences | β-peptides
Journal Article
CHEMBIOCHEM, ISSN 1439-4227, 09/2013, Volume 14, Issue 13, pp. 1564 - 1572
We have used computational methods to improve the affinity of a foldamer ligand for its target protein. The effort began with a previously reported /-peptide... 
CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | HELIX | Mcl-1 | BH3 domain | IN-VIVO | SURFACE RECOGNITION | BIOLOGICAL-ACTIVITY | peptide design | BIM BH3 DOMAIN | peptidomimetics | INHIBITOR | ANTAGONISTS | BH3-ONLY PROTEINS | Peptides | Proteins | Crystal structure | Beta
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2015, Volume 137, Issue 35, pp. 11365 - 11375
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 9/2013, Volume 14, Issue 13, pp. 1564 - 1572
We have used computational methods to improve the affinity of a foldamer ligand for its target protein. The effort began with a previously reported α/β-peptide... 
Mcl-1 | BH3 domain | peptide design | apoptosis | peptides | peptidomimetics | foldamer
Journal Article
03/2016
Described are α/ -peptide mimics of Z-domain scaffold peptides, methods of making them, and methods of using them. The α/ -peptide mimics include -amino acid... 
WINE | ENZYMOLOGY | ORGANIC CHEMISTRY | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | METALLURGY | PEPTIDES | BIOCHEMISTRY | ENZYMES | CHEMISTRY | VINEGAR
Patent
07/2015
Described are α/β-peptide mimics of Z-domain scaffold peptides, methods of making them, and methods of using them. The α/β-peptide mimics include β-amino acid... 
WINE | HYGIENE | ENZYMOLOGY | ORGANIC CHEMISTRY | MICROBIOLOGY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | BIOCHEMISTRY | ENZYMES | CHEMISTRY | VINEGAR
Patent
Current Opinion in Structural Biology, ISSN 0959-440X, 08/2016, Volume 39, pp. 96 - 105
Journal Article
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