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International Journal of Cancer, ISSN 0020-7136, 11/2017, Volume 141, Issue 9, pp. 1921 - 1931
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0167096
Temozolomide (TMZ), an alkylating agent of the imidazotetrazine series, is a first-line chemotherapeutic drug used in the clinical therapy of glioblastoma... 
PATHWAYS | GLIOBLASTOMA-MULTIFORME | MULTIDISCIPLINARY SCIENCES | GENES | TARGETS | PROLIFERATION | MIR-128 | EXPRESSION | P53 | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Antineoplastic Agents, Alkylating - pharmacology | Survival Rate | Insulin-Like Growth Factor I - genetics | Brain Neoplasms - drug therapy | Membrane Potential, Mitochondrial - drug effects | Glioma - genetics | TOR Serine-Threonine Kinases - genetics | Signal Transduction - drug effects | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | MicroRNAs - genetics | Tumor Cells, Cultured | Glioma - drug therapy | Insulin-Like Growth Factor I - metabolism | Care and treatment | MicroRNA | Analysis | Dosage and administration | Temozolomide | Glioblastoma multiforme | Apoptosis | Post-transcription | Transcription factors | Brain cancer | Cytotoxicity | Biochemistry | ADP | Caspase-3 | Cancer therapies | Alkylation | Proteins | Mitochondria | Cell growth | Membrane potential | Inhibition | Bioinformatics | Medical research | Immunoglobulins | Mortality | Rapamycin | Gene expression | Insulin | Chemotherapy | Hospitals | DNA microarrays | Molecular modelling | Pharmacy | Adults | Viability | Phagocytosis | Reactive oxygen species | Toxicity | Insulin-like growth factor I | Gene regulation | Glioblastoma | Biology | Insulin-like growth factors | Neurosurgery | Kinases | Autophagy | Nanoparticles | Ribose | Glioma cells | miRNA | Cell survival | c-Jun protein | Caspase | Ribonucleic acid--RNA | Medicine | Polymerase | Signaling | Brain research | Cell death | MicroRNAs | Medical prognosis | RNA | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173890
MicroRNAs are small noncoding RNAs that post-transcriptionally control the expression of genes involved in glioblastoma multiforme (GBM) development. Although... 
METASTASIS | NFIA | MIR-302B | MULTIDISCIPLINARY SCIENCES | EXPANSION | SENSITIVITY | PROLIFERATION | TRANSCRIPTION FACTOR | CARCINOMA | EXPRESSION | TEMOZOLOMIDE | NFI Transcription Factors - antagonists & inhibitors | Humans | Transcriptome | Cell Survival - genetics | Apoptosis - genetics | MicroRNAs - metabolism | Gene Regulatory Networks | NFI Transcription Factors - genetics | Gene Knockdown Techniques | Glioma - metabolism | Glioma - genetics | NFI Transcription Factors - metabolism | Glioblastoma - genetics | Glioma - pathology | Glioblastoma - metabolism | Astrocytes - cytology | Promoter Regions, Genetic | Signal Transduction | Down-Regulation | Insulin-Like Growth Factor Binding Protein 2 - metabolism | Insulin-Like Growth Factor Binding Protein 2 - genetics | Glioblastoma - pathology | Cell Line, Tumor | Insulin-Like Growth Factor Binding Protein 2 - antagonists & inhibitors | MicroRNAs - genetics | Apoptosis - physiology | Astrocytes - metabolism | Genetic aspects | MicroRNA | Research | Gene expression | Glioblastoma multiforme | Insulin-like growth factor 1 | Post-transcription | Biotechnology | Cell culture | Transcription factors | Target recognition | Insulin-like growth factor-binding protein 2 | Genomics | Genes | Glioblastoma | Biology | Insulin-like growth factors | Biochemistry | Kinases | Tissues | ADP | Caspase-3 | Proteins | Signal transduction | Cell growth | Ribose | Glioma cells | miRNA | Tumorigenesis | Medical research | Immunoglobulins | Astrocytes | Mortality | Caspase | Breast cancer | Tumor cell lines | Ribonucleic acid--RNA | Insulin | Survival | Medicine | Polymerase | Signaling | DNA microarrays | Cell death | MicroRNAs | Pharmacy | Stem cells | Tumor suppressor genes | Viability | Apoptosis | RNA | Ribonucleic acid
Journal Article
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 06/2018, Volume 233, Issue 6, pp. 4972 - 4980
The tumor microenvironment plays an important role in tumor initiation and progression. It is well documented that nicotine participates in cigarette... 
breast cancer | fibroblasts | nicotine | tumor microenvironment | EMT | POPULATION | PHYSIOLOGY | CIGARETTE-SMOKE EXTRACT | PROLIFERATION | ACETYLCHOLINE-RECEPTOR | CELL BIOLOGY | INVASION | GROWTH | EXPRESSION | Smoking - adverse effects | Cancer-Associated Fibroblasts - metabolism | Neoplasm Invasiveness | Humans | Cancer-Associated Fibroblasts - drug effects | Tumor Microenvironment | Epithelial-Mesenchymal Transition - drug effects | alpha7 Nicotinic Acetylcholine Receptor - agonists | Intracellular Signaling Peptides and Proteins - metabolism | Nicotine - toxicity | Breast Neoplasms - metabolism | Carcinogens - toxicity | Cell Movement - drug effects | Cancer-Associated Fibroblasts - pathology | MCF-7 Cells | Signal Transduction - drug effects | Breast Neoplasms - pathology | Paracrine Communication - drug effects | Female | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Transforming Growth Factor beta - metabolism | Connective Tissue Growth Factor - metabolism | Culture Media, Conditioned - metabolism | Cancer cells | Stem cells | Development and progression | Bone morphogenetic proteins | Breast cancer | Metastasis | Transforming growth factors | Smoking | Motility | Mesenchyme | Tumor cells | Connective tissue growth factor | AKT protein | Activation | Cigarette smoking | Connective tissues | Signaling | Fibroblasts | Breast | Acetylcholine receptors (nicotinic) | Tumorigenesis | Conditioning | Growth factors | Cell migration | Cancer | Nicotine
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2008, Volume 205, Issue 12, pp. 2781 - 2789
Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid beta-protein (A beta), the central component of... 
BACE1 | MEDICINE, RESEARCH & EXPERIMENTAL | NOTCH LIGANDS | GLYCOGEN-SYNTHASE KINASE-3 | PRESENILIN/GAMMA-SECRETASE | GAMMA-SECRETASE CLEAVAGE | GENERATION | PRECURSOR PROTEIN | RELEASE | IMMUNOLOGY | MISSENSE MUTATIONS | INTRACELLULAR DOMAIN
Journal Article
The International Journal of Neuropsychopharmacology, ISSN 1461-1457, 2/2012, Volume 15, Issue 1, pp. 77 - 90
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 8, pp. 886 - 890
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e71903
Metastasis is a major cause of mortality in cancer patients. Invadopodia are considered to be crucial structures that allow cancer cells to penetrate across... 
EPITHELIAL-MESENCHYMAL TRANSITION | CONTACT SITES | PLANT FLAVONOIDS | CORTACTIN | MULTIDISCIPLINARY SCIENCES | TUMOR-METASTASIS | SRC SUBSTRATE | CHRONIC LYMPHOCYTIC-LEUKEMIA | DEGRADATION | EMS1 GENE | LUTEOLIN | Neoplasms - metabolism | Humans | Gene Expression Regulation, Neoplastic | Extracellular Matrix - metabolism | Gene Expression Profiling | Matrix Metalloproteinase 9 - metabolism | Neoplasms - genetics | RNA Interference | Matrix Metalloproteinase 9 - genetics | src-Family Kinases - metabolism | Indoles - pharmacology | Matrix Metalloproteinase 9 - secretion | Phosphorylation - drug effects | Cell Surface Extensions - metabolism | Neoplasm Invasiveness | src-Family Kinases - antagonists & inhibitors | Antioxidants - pharmacology | Cortactin - metabolism | Luteolin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Blotting, Western | Cell Movement - drug effects | Microscopy, Confocal | Quercetin - pharmacology | Cell Surface Extensions - drug effects | Cell Line, Tumor | Neoplasms - pathology | Proteins | Cancer cells | Food processing plants | Metastasis | Comparative analysis | Health aspects | Isoflavones | Fertilizers | Phosphorylation | Food plants | Regulators | Boyden chamber | Matrix metalloproteinases | Mesenchyme | Matrix metalloproteinase | Kinases | Metastases | Anticancer properties | Antioxidants | Extracellular matrix | Metalloproteinase | Growth factors | Enzymes | Secretion | Invasiveness | Food production | Gelatinase B | Flavonoids | Gene amplification | Diet | Quercetin | Regulation | Cancer
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 732 - 13
The insulin-like growth factor (IGF)-1 signaling is relevant in regulating cell growth and cytokine secretions by glioblastomas. MicroRNAs determine the cell... 
GLIOMA-CELLS | GENE | MULTIDISCIPLINARY SCIENCES | TUMOR MICROENVIRONMENT | GROWTH | MULTIFORME PATHOGENESIS | CC chemokine receptors | Statistical analysis | Cytokines | Insulin-like growth factor I | Glioblastoma | Insulin-like growth factors | mRNA | Genomes | Secretions | Insulin | CCR1 protein | DNA microarrays | Cell fate | Glioma cells | Interleukin 1 | miRNA | Mathematical models
Journal Article