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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 24, pp. 9663 - 9679
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e55925
Interleukin-1beta (IL-1 beta) is a major cause for induction of various inflammatory mechanisms that are decisively involved to provoke pathogenesis of type 2... 
IN-VITRO RELEASE | GOTO-KAKIZAKI RATS | HOMEOSTASIS MODEL ASSESSMENT | ISLET-ASSOCIATED MACROPHAGES | INTERLEUKIN-1 RECEPTOR ANTAGONIST | HIGH-FAT DIET | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BETA-CELL | TYPE-2 | Interleukin 1 Receptor Antagonist Protein - administration & dosage | Kidney - pathology | Skin - metabolism | Male | Insulin - blood | Hyperglycemia - drug therapy | Antigens, CD - metabolism | Kidney Function Tests | Kidney - metabolism | Islets of Langerhans - metabolism | Diabetes Mellitus, Type 2 - complications | Skin - pathology | Disease Models, Animal | Hyperglycemia - prevention & control | Glucose Tolerance Test | Kidney - drug effects | Gels | Insulin Resistance | Rats | Diabetes Mellitus, Type 2 - blood | Animals | Hyperglycemia - blood | Antigens, Differentiation, Myelomonocytic - metabolism | Poloxamer | Interleukin 1 Receptor Antagonist Protein - adverse effects | Hyperglycemia - etiology | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Hyperglycemia | Blood sugar monitoring | Interleukins | Physiological aspects | Skin | Glucose | Glucose tolerance tests | Dextrose | Drugs | Syngeneic grafts | Pathogenesis | Weaning | Interleukin | Drug delivery | Interleukin 1 receptors | Macrophages | Interleukin 6 | Toxicology | Rodents | Interleukin 1 | Histochemical analysis | Pancreas | Pharmaceutical sciences | Half life | Urine | Kidneys | Cytokines | Interleukin 1 receptor antagonist | Diabetes mellitus | Body temperature | Radioactive half-life | Inflammation | Pharmacology | FDA approval | Metabolism | Insulin | Studies | Glucose tolerance | Insulin resistance | Infiltration | Diabetes | Chemokines | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0141859
Journal Article
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 551 - 564
Hepatic glucose phosphorylation by GK (glucokinase) is regulated by GKRP (GK regulatory protein). GKRP forms a cytosolic complex with GK followed by nuclear... 
Allosteric regulation | Fructose phosphate ester | Glucokinase regulatory protein | Glucokinase | Metabolic regulation | Diabetes | Co-operativity | RAT-LIVER | GLYCEMIC CONTROL | ACTIVATION | fructose phosphate ester | BIOCHEMISTRY & MOLECULAR BIOLOGY | allosteric regulation | co-operativity | glucokinase regulatory protein | HEPATIC GLUCOKINASE | P446L VARIANT | FRUCTOSE | HUMAN GLUCOKINASE | STRUCTURAL BASIS | GLUCOSE | DIABETES THERAPY | diabetes | glucokinase | metabolic regulation | Adaptor Proteins, Signal Transducing - chemistry | Protein Unfolding | Allosteric Regulation | Humans | Protein Multimerization | Tryptophan - chemistry | Fructosephosphates - metabolism | Protein Interaction Domains and Motifs | Protein Stability | Glucokinase - chemistry | Recombinant Proteins - metabolism | Protein Refolding | Models, Molecular | Recombinant Proteins - chemistry | Spectrometry, Fluorescence | Glucokinase - genetics | Mutant Proteins - metabolism | Glucokinase - metabolism | Protein Transport | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Ligands | Protein Conformation | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | T2D, Type 2 diabetes | WT, wild-type | rGKRP, rat GKRP | NPC, nuclear pore complex | PPI, protein–protein interaction | NATA, N-acetyl-L-tryptophanamide | xGKRP, Xenopus GKRP | MH, D-mannoheptulose | GKA, GK activator | hGK, human GK | F6P, fructose 6-phosphate | hGKRP, human GKRP | GCKR | xGK, Xenopus GK | GKRPI, GKRP inhibitor | GK, glucokinase | TF, tryptophan fluorescence | GCK | GKRP, GK regulatory protein | SIS, sugar isomerase | F1P, fructose 1-phosphate
Journal Article
Zhongguo Zhongyao Zazhi, ISSN 1001-5302, 06/2018, Volume 43, Issue 11, pp. 2372 - 2377
Journal Article
Jixie Gongcheng Xuebao = Journal of Mechanical Engineering, ISSN 0577-6686, 01/2018, Issue 14
Aiming at the nonlinear and non-stationary characteristics of equipment fault signals, a fault diagnosis method based on the fast variational mode... 
Decision support systems | Permutations | Interaction parameters | Entropy | Decomposition | Pattern recognition | Clustering | Optimization | Fault diagnosis | Roller bearings | Feature extraction | Swarm intelligence | Fuzzy | Multiscale methods
Journal Article
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, ISSN 1001-5302, 06/2018, Volume 43, Issue 11, p. 2372
To investigate the protective effect of Yiqi Huoxue decoction on the kidney in diabetic goto-Kaizaki (GK) rats. Eight Wistar rats were used as normal control... 
Journal Article