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1. The B7-CD28 family molecules
by Chen, Lieping
2003, ISBN 0306478420, 141
CD antigens | Cell surface antigens | physiology | Antigens, CD80 | Antigens, CD28 | T cells | Immunity, Cellular | Antigens, Differentiation, T-Lymphocyte
Book
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2. Full Text Anti-PD-1/PD-L1 therapy of human cancer: Past, present, and future
by Chen, Lieping and Han, Xue
Journal of Clinical Investigation, ISSN 0021-9738, 09/2015, Volume 125, Issue 9, pp. 3384 - 3391
Major progress has been made toward our understanding of the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway (referred to as the PO pathway).... 
MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | ADVANCED MELANOMA | B7 FAMILY | B7-H1 | CTLA-4 | BLOCKADE | CLINICAL ACTIVITY | PHASE-I | PD-1 | T-CELLS | Neoplasms - therapy | B7-H1 Antigen - antagonists & inhibitors | Immunomodulation | Neoplasms - immunology | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - immunology | B7-H1 Antigen - immunology | Care and treatment | Immunotherapy | Physiological aspects | Research | Health aspects | Apoptosis | Cancer | Laboratories | Cloning | T cell receptors | Radiation therapy | Cancer therapies | Recruitment | Studies | Immunology | Mutagenesis | Lymphocytes | Ligands | Tumors | Review Series
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3. Full Text Molecular mechanisms of T cell co-stimulation and co-inhibition
by Chen, Lieping and Flies, Dallas B
Nature Reviews Immunology, ISSN 1474-1733, 04/2013, Volume 13, Issue 4, pp. 227 - 242
Co-stimulatory and co-inhibitory receptors have a pivotal role in T cell biology, as they determine the functional outcome of T cell receptor (TCR) signalling.... 
SLAM RECEPTORS | B-LYMPHOCYTE | ACTIVATION | DENDRITIC CELLS | IMMUNE-RESPONSES | LYMPHOCYTE ATTENUATOR | COSTIMULATORY MOLECULE | TNF SUPERFAMILY | LIGAND | IMMUNOLOGY | ADAPTER SAP | Receptors, Antigen, T-Cell - metabolism | B7-1 Antigen - immunology | Humans | B7-1 Antigen - metabolism | CD28 Antigens - immunology | CD28 Antigens - metabolism | B7-2 Antigen - metabolism | Signal Transduction - immunology | Lymphocyte Activation - immunology | Models, Immunological | Receptors, Tumor Necrosis Factor, Member 14 - metabolism | T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | B7-2 Antigen - immunology | Receptors, Tumor Necrosis Factor, Member 14 - immunology | Physiological aspects | Antigen receptors, T cell | Receptors | Cellular signal transduction | Research | T cells | T-cell receptor | Cell activation | Molecular modelling | Lymphocytes T | Receptor mechanisms | Differentiation | Structure-function relationships
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4. Full Text Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
by Chen, Lieping
Nature Reviews Immunology, ISSN 1474-1733, 05/2004, Volume 4, Issue 5, pp. 336 - 347
Co-signalling molecules are cell-surface glycoproteins that can direct, modulate and fine-tune T-cell receptor (TCR) signals. On the basis of their functional... 
MATERNAL-FETAL INTERFACE | INTESTINAL INFLAMMATION | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | DENDRITIC CELLS | IN-VIVO | B7 FAMILY | DILATED CARDIOMYOPATHY | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | DEATH-1 PD-1 PATHWAY | TRYPTOPHAN CATABOLISM | Antigens, CD - immunology | B7-1 Antigen - immunology | Humans | CD28 Antigens - immunology | Mice, Knockout | CTLA-4 Antigen | B7-2 Antigen | Signal Transduction - immunology | Animals | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Mice | Membrane Glycoproteins - immunology | Antigens, Differentiation - immunology
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5. Full Text Inhibitory B7-family molecules in the tumour microenvironment
by Zou, Weiping and Chen, Lieping
Nature Reviews Immunology, ISSN 1474-1733, 06/2008, Volume 8, Issue 6, pp. 467 - 477
The B7 family consists of activating and inhibitory co-stimulatory molecules that positively and negatively regulate immune responses. Recent studies have... 
B7 FAMILY-MEMBER | LUNG-CANCER | HERPESVIRUS ENTRY MEDIATOR | B7-H1 PD-L1 | IMMUNE-SYSTEM | DENDRITIC CELLS | T-CELL-ACTIVATION | HUMAN OVARIAN-CARCINOMA | IMMUNOLOGY | PROGRAMMED DEATH-1 LIGAND-1 | CLINICAL-SIGNIFICANCE | Neoplasms - metabolism | Antigens, Neoplasm - genetics | B7-1 Antigen - genetics | Humans | Antigens, Neoplasm - biosynthesis | B7-1 Antigen - physiology | Gene Expression Regulation, Neoplastic - immunology | B7-1 Antigen - metabolism | Animals | Neoplasms - immunology | Antigens, Neoplasm - physiology | Antigens, Neoplasm - metabolism | B7-1 Antigen - biosynthesis | Multigene Family - immunology | Neoplasms - pathology | Care and treatment | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Immunity | Tumors
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6. CD137 pathway
: immunology and diseases
by Chen, Lieping
2006, ISBN 0387313222, xii, 139
This book covers all aspects of CD137/4-1BB pathway research. This pathway is emerging as one of the most important targets for manipulation of immune... 
CD antigens | Pre-clinical Medicine: Basic Sciences | Cell surface antigens | Molecular Medicine | Biomedicine | Immunology | Microbiology
Book
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7. Full Text Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
by Topalian, Suzanne L and Hodi, F. Stephen and Brahmer, Julie R and Gettinger, Scott N and Smith, David C and McDermott, David F and Powderly, John D and Carvajal, Richard D and Sosman, Jeffrey A and Atkins, Michael B and Leming, Philip D and Spigel, David R and Antonia, Scott J and Horn, Leora and Drake, Charles G and Pardoll, Drew M and Chen, Lieping and Sharfman, William H and Anders, Robert A and Taube, Janis M and McMiller, Tracee L and Xu, Haiying and Korman, Alan J and Jure-Kunkel, Maria and Agrawal, Shruti and McDonald, Daniel and Kollia, Georgia D and Gupta, Ashok and Wigginton, Jon M and Sznol, Mario
The New England Journal of Medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 26, pp. 2443 - 2454
Releasing T cells from inhibitory control has been a strategy exploited by the anti–CTLA-4 antibody ipilimumab. Now an antibody against a second checkpoint... 
CELL LUNG-CANCER | MEDICINE, GENERAL & INTERNAL | THERAPY | SOLID TUMORS | RESPONSE CRITERIA | IMMUNOTHERAPY | GUIDELINES | B7 FAMILY | B7-H1 | ANTITUMOR IMMUNITY | BLOCKADE | Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Humans | Antibodies, Monoclonal - adverse effects | Programmed Cell Death 1 Receptor - metabolism | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Melanoma - drug therapy | Adult | Female | Ligands | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Carcinoma, Renal Cell - drug therapy | Prostatic Neoplasms - drug therapy | Drugs | Dose-response relationship (Biochemistry) | Immune response | Anti-antibodies | Dosage and administration | Product/Service Evaluations | Regulation | Research | Drug therapy | Cancer | Fees & charges | Kidneys | Stock options | PD-1 protein | Laboratories | Toxicity | Tumor cells | Body weight | Lung cancer | Colorectal carcinoma | Colorectal cancer | Melanoma | Licenses | Lymphocytes T | Patients | Castration | PD-L1 protein | Antitumor activity | Prostate cancer | Drug dosages | Prostate | Clear cell-type renal cell carcinoma | Tumors | Apoptosis | Index Medicus | Abridged Index Medicus
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