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Cellular Signalling, ISSN 0898-6568, 09/2019, Volume 61, pp. 1 - 9
BCL-XL, an anti-apoptotic BCL-2 family protein, potently inhibits BAK oligomerization and the formation of toxic mitochondrial pores in response to cellular... 
Retrotranslocation | FRET | BAK | BCL-XL | FLIP | Apoptosis | ACTIVATION | PROAPOPTOTIC BAX | ALPHA | BCL-X(L) | CELL-DEATH | BH3 DOMAIN | FAMILY | CELL BIOLOGY | MITOCHONDRIAL BAX | PROTEINS | Oligomers | Cytochrome c | Fluorescence
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2009, Volume 284, Issue 15, pp. 10004 - 10012
The transcription factor hypoxia-inducible factor-1 alpha (HIF-1 alpha) plays pivotal roles in physiology and pathophysiology. Constitutive or hypoxia-induced... 
RNA INTERFERENCE | FACTOR 1-ALPHA | LUNG-CANCER | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER CELLS | DOWN-REGULATION | FACTOR-I | UP-REGULATION | EXPRESSION | CELLULAR PROLIFERATION | Transcription, Chromatin, and Epigenetics
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2008, Volume 105, Issue 6, pp. 2169 - 2174
Maturation of neuronal synapses is thought to involve mitochondria. Bcl-x L protein inhibits mitochondria-mediated apoptosis but may have other functions in... 
Bcl-2 | ABT-737 | Mitochondria | Cell death | Synaptic transmission | Hippocampus - metabolism | Animals | Dynamins - physiology | bcl-X Protein - physiology | Cells, Cultured | Rats | Mitochondria - metabolism | Hippocampus - cytology | Synapses | Synaptic Transmission | Biological Sciences | synaptic transmission | cell death | mitochondria
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 19, pp. 10195 - 10215
Abstract Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine.... 
SURVIVAL | APOPTOSIS | ELECTROPORATION | RNA | GENE | BREAK REPAIR | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENERATION | HOMOLOGOUS RECOMBINATION | P53 | Molecular Biology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2013, Volume 56, Issue 13, pp. 5514 - 5540
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2008, Volume 122, Issue 9, pp. 1987 - 1998
Abrogation of apoptosis to sustain cell survival is an essential step in development of cancer. Aberrant activation of signal transcription factors NF‐κB or... 
BAX | NF‐κB | BCL‐XL | HNSCC | STAT3 | p53 | NF-κB | BCL-XL | CANCER-CELLS | TRANSCRIPTION FACTORS | CONSTITUTIVE ACTIVATION | BCL-2 FAMILY PROTEINS | TUMOR-SUPPRESSOR P53 | CISPLATIN SENSITIVITY | GROWTH-FACTOR RECEPTOR | NF-kappa B | ONCOLOGY | IN-VIVO | THERAPEUTIC TARGET | PROTEASOME INHIBITOR BORTEZOMIB
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4664 - 4682
Journal Article