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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2014, Volume 111, Issue 13, pp. 4940 - 4945
Age-associated dementia and Alzheimer's disease (AD) are currently epidemic. Neither their cause nor connection to the metabolic syndrome (MS) is clear.... 
Anger | Brain | Advanced glycosylation end products | Diet | Neurons | Mice | Cognition | Type 2 diabetes mellitus | Diabetes | Alzheimers disease | Obesity | Insulin resistance | Nutrition | Caloric restriction | Neural | caloric restriction | neural | MULTIDISCIPLINARY SCIENCES | COGNITIVE FUNCTION | DIABETES-MELLITUS | nutrition | INSULIN-RESISTANCE | AMYLOID-BETA | ALZHEIMERS-DISEASE PATIENTS | insulin resistance | POTENTIAL ROLE | obesity | BRAIN | METHYLGLYOXAL | GLYCATION END-PRODUCTS | CALORIE RESTRICTION | Amyloid Precursor Protein Secretases - genetics | Transcription, Genetic - drug effects | Glycation End Products, Advanced - administration & dosage | Pyruvaldehyde - administration & dosage | Humans | Middle Aged | Dementia - physiopathology | Male | Glycation End Products, Advanced - toxicity | PPAR gamma - metabolism | Metabolic Syndrome - blood | Time Factors | Amyloid beta-Peptides - metabolism | Pyruvaldehyde - toxicity | Receptor for Advanced Glycation End Products | Dementia - pathology | Administration, Oral | Membrane Proteins - genetics | Brain - physiopathology | Cognition - drug effects | Brain - drug effects | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Brain - pathology | Dementia - blood | Metabolic Syndrome - pathology | Oxidative Stress - drug effects | ADAM Proteins - genetics | Pyruvaldehyde - blood | Memory - drug effects | Sirtuin 1 - metabolism | Pyruvaldehyde - adverse effects | Gliosis - physiopathology | Gliosis - pathology | Nicotinamide Phosphoribosyltransferase - metabolism | Metabolic Syndrome - physiopathology | Female | Glycation End Products, Advanced - adverse effects | Membrane Proteins - metabolism | Insulin - pharmacology | Cytokines - metabolism | Gliosis - metabolism | Mice, Inbred C57BL | ADAM10 Protein | Sirtuin 1 - antagonists & inhibitors | Animals | Aged | Receptors, Immunologic - metabolism | Causes of | Metabolic diseases | Toxins | Health aspects | Dementia | Oxidative stress | Metabolic syndrome | Gene expression | Index Medicus | Biological Sciences
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 479 - 483
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development(1,2), yet lesions of the genes encoding these transcription... 
ENERGY STRESS | ACTIVATION | GENE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | REGULATORY NETWORK | DIFFERENTIATION | MINIMAL RESIDUAL DISEASE | EXPRESSION | Glucocorticoids - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Gene Expression Regulation, Neoplastic | Receptors, Glucocorticoid - metabolism | PAX5 Transcription Factor - deficiency | Carrier Proteins - agonists | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Chromatin Immunoprecipitation | Adenosine Triphosphate - metabolism | Cell Death | Pyruvic Acid - metabolism | Female | Ikaros Transcription Factor - metabolism | Energy Metabolism - genetics | B-Lymphocytes - metabolism | PAX5 Transcription Factor - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | AMP-Activated Protein Kinases - antagonists & inhibitors | Carcinogenesis - genetics | PAX5 Transcription Factor - genetics | Mice, Transgenic | Citric Acid Cycle | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | B-Lymphocytes - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Animals | Carrier Proteins - metabolism | Sequence Analysis, RNA | Glucocorticoids - pharmacology | Glucose - metabolism | Mice | Physiological aspects | Transcription factors | B cells | Proteins | Metabolites | Rodents | Cloning | Leukemia | Glucose | Kinases | Metabolism | Gene expression | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7552, pp. 357 - 361
B cells are selected for an intermediate level of B-cell antigen receptor (BCR) signalling strength: attenuation below minimum(for example, non-functional... 
MOTIFS | RECEPTOR | ACTIVATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DELETION | Protein-Tyrosine Kinases - metabolism | Receptors, Antigen, B-Cell - deficiency | Humans | Precursor Cells, B-Lymphoid - metabolism | Inositol Polyphosphate 5-Phosphatases | Intracellular Signaling Peptides and Proteins - metabolism | Precursor Cells, B-Lymphoid - drug effects | Receptors, Antigen, B-Cell - metabolism | Antigens, CD - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor Cells, B-Lymphoid - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Gene Deletion | Female | B-Lymphocytes - pathology | Cell Death - drug effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Syk Kinase | B-Lymphocytes - metabolism | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Enzyme Activation - drug effects | Mice, SCID | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Fusion Proteins, bcr-abl - genetics | Tyrosine - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Cell Transformation, Neoplastic | Intracellular Signaling Peptides and Proteins - agonists | Cell Line, Tumor | Mice, Inbred NOD | Receptors, Antigen, B-Cell - genetics | Mice | Amino Acid Motifs - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Receptors, Immunologic - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Receptors, Immunologic - metabolism | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Acute lymphocytic leukemia | B cells | Signal transduction | Rodents | Leukemia | Mutation | Drug resistance | Kinases | Cells | Index Medicus
Journal Article
Journal Article
Human Pathology, ISSN 0046-8177, 2012, Volume 43, Issue 3, pp. 423 - 434
Summary We and other research groups have previously shown that various cancer types can express immunoglobulin G, but investigation on of immunoglobulin G... 
Pathology | Ki67 | Tumor grade | Immunoglobulin G | Esophageal cancer | Recombination-activating genes 1 and 2 | SPECIFICITY | V(D)J RECOMBINATION | GAMMA-GLOBULIN | PATHOLOGY | LINES | GENE TRANSCRIPTS | MULTIPLE MANAGEMENT MODALITIES | NEONATAL FC-RECEPTOR | CHAIN CONSTANT-REGION | EPITHELIAL CANCER-CELLS | MAMMARY-GLAND | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Homeodomain Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Ki-67 Antigen - metabolism | Male | Gene Expression Profiling | RNA, Messenger - metabolism | Carcinoma, Squamous Cell - diagnosis | DNA-Binding Proteins - metabolism | Immunoglobulin Light Chains - genetics | Neoplasm Grading | Esophageal Neoplasms - metabolism | Esophageal Neoplasms - diagnosis | Female | Nuclear Proteins - genetics | Cytidine Deaminase - genetics | Esophagectomy | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Immunoglobulin Light Chains - metabolism | Immunoglobulin G - genetics | Esophageal Neoplasms - genetics | Cytidine Deaminase - metabolism | Cell Line, Tumor | Immunoglobulin Heavy Chains - metabolism | Carcinoma, Squamous Cell - secondary | Neoplasm Staging | Immunoglobulin Heavy Chains - genetics | Immunoglobulin G - metabolism | Immunohistochemistry | Squamous cell carcinoma | Genes | Oncology, Experimental | Research | Messenger RNA | Analysis | Genetic research | DNA polymerases | Tumors | Cancer | Proteins | Breast cancer | Mortality | Immune system | Index Medicus
Journal Article