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1. Full Text Microarray Analysis of DCLK1-positive Intestinal Tumor Stem Cells Yuichi Yamaga, Hiroshi Seno, Tsutomu Chiba
by Yamaga, Y and Seno, H and Chiba, T
GASTROENTEROLOGY, ISSN 0016-5085, 04/2015, Volume 148, Issue 4, pp. S572 - S572
GASTROENTEROLOGY & HEPATOLOGY
Conference Proceeding
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2. A study of accent
: research into its nature and scope in the light of experimental phonetics
by Chiba, Tsutomu
1935, ii, 123 p. chart.
Phonetics
Book
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3. The vowel, its nature and structure
by Chiba, Tsutomu, 1883 and Kajiyama, Masato, 1909
1958, 236
Voice | Vowels
Book
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4. Full Text Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011
by Umehara, Hisanori and Okazaki, Kazuichi and Masaki, Yasufumi and Kawano, Mitsuhiro and Yamamoto, Motohisa and Saeki, Takako and Matsui, Shoko and Yoshino, Tadashi and Nakamura, Shigeo and Kawa, Shigeyuki and Hamano, Hideaki and Kamisawa, Terumi and Shimosegawa, Toru and Shimatsu, Akira and Nakamura, Seiji and Ito, Tetsuhide and Notohara, Kenji and Sumida, Takayuki and Tanaka, Yoshiya and Mimori, Tsuneyo and Chiba, Tsutomu and Mishima, Michiaki and Hibi, Toshifumi and Tsubouchi, Hirohito and Inui, Kazuo and Ohara, Hirotaka
Modern Rheumatology, ISSN 1439-7595, 2/2012, Volume 22, Issue 1, pp. 21 - 30
IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by... 
Interstitial nephritis | Immunology | IgG4-related disease | Medicine & Public Health | Orthopedics | Rheumatology | Internal Medicine | Criteria | Autoimmune pancreatitis | Mikulicz’s disease | Mikulicz's disease | LUNG | SERUM | PROPOSAL | RHEUMATOLOGY | MIKULICZS-DISEASE | CASTLEMANS-DISEASE | LYMPHADENOPATHY | RETROPERITONEAL FIBROSIS | CHOLANGITIS | SCLEROSING PANCREATITIS | Mikulicz' Disease - immunology | Mikulicz' Disease - diagnosis | Immunoglobulin G - blood | Nephritis, Interstitial - diagnosis | Humans | Autoimmune Diseases - immunology | Interprofessional Relations | Male | Autoimmune Diseases - diagnosis | Pancreatitis - diagnosis | Plasma Cells - pathology | Pancreatitis - immunology | Female | Nephritis, Interstitial - immunology | Plasma Cells - immunology | Autoimmune diseases | Medical diagnosis | Immunoglobulins | Index Medicus
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5. Full Text Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
by Takashi Aoi and Kojiro Yae and Masato Nakagawa and Tomoko Ichisaka and Keisuke Okita and Kazutoshi Takahashi and Tsutomu Chiba and Shinya Yamanaka
Science, ISSN 0036-8075, 8/2008, Volume 321, Issue 5889, pp. 699 - 641
Induced pluripotent stem (iPS) cells have been generated from mouse and human fibroblasts by the retroviral transduction of four transcription factors.... 
Feeder cells | Adult stem cells | Hepatocytes | Epithelial cells | Induced pluripotent stem cells | Somatic cells | Fibroblasts | Reports | Chimeras | Embryonic stem cells | Cells | DEFINED FACTORS | MULTIDISCIPLINARY SCIENCES | CRE RECOMBINASE | HUMAN FIBROBLASTS | HUMAN SOMATIC-CELLS | SELECTION | EXPRESSION | Embryonic Stem Cells - metabolism | Cell Proliferation | Embryonic Stem Cells - cytology | Neoplasms - etiology | Pluripotent Stem Cells - cytology | Blastocyst - cytology | Gastric Mucosa - cytology | Transcription Factors - genetics | Virus Integration | Cellular Reprogramming | Pluripotent Stem Cells - metabolism | Stem Cell Transplantation | Hepatocytes - cytology | Animals | Transfection | Retroviridae - genetics | Culture Media | Mice, Nude | Cell Differentiation | Clone Cells | Mice | Epithelial Cells - cytology | Genetic Vectors | Chimera | Physiological aspects | Genetic aspects | Properties | Gene expression | Liver cells | Stem cells | Biomedical research | Cellular biology | Rodents | Liver | Gastroenterology | Index Medicus
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6. Full Text Sox9-Dependent Acinar-to-Ductal Reprogramming is Critical for Pancreatic Intraepithelial Neoplasia Formation
by Fukuda, Akihisa|Chiba, Tsutomu
Gastroenterology, ISSN 0016-5085, 2013, Volume 145, Issue 4, pp. 904 - 907
Gastroenterology and Hepatology | Acinar Cells - pathology | Carcinoma, Pancreatic Ductal - pathology | Precancerous Conditions - genetics | SOX9 Transcription Factor - genetics | Humans | Pancreatic Neoplasms - pathology | Index Medicus | Abridged Index Medicus
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7. Proton pump inhibitors
: a balanced view
by Chiba, Tsutomu and Malfertheiner, P. 1950- (Peter) and Satoh, Hiroshi
2013, Frontiers of gastrointestinal research, ISBN 3318024163, Volume 32
drug therapy | Proton Pump Inhibitors | Risk Assessment | pharmacology | Gastroesophageal Reflux | Peptic Ulcer | therapeutic use
Web Resource
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8. Full Text Therapeutic effects of famotidine on chronic symptomatic gastritis: subgroup analysis from FUTURE study
by Kinoshita, Yoshikazu and Chiba, Tsutomu and FUTURE Study Grp and FUTURE study group
Journal of Gastroenterology, ISSN 0944-1174, 4/2012, Volume 47, Issue 4, pp. 377 - 386
A therapeutic strategy for symptomatic patients with chronic gastritis has not been established. Gastric acid has been reported to induce a variety of... 
Chronic gastritis | Epigastralgia | Oncology | Internal Medicine | Epigastric fullness | Functional dyspepsia | Famotidine | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Surgical Oncology | Izumo scale | METAANALYSIS | PH MONITORING-SYSTEM | FUNCTIONAL GASTRODUODENAL DISORDERS | DYSPEPTIC SYMPTOMS | PRIMARY-CARE | NONULCER DYSPEPSIA | HELICOBACTER-PYLORI INFECTION | PLACEBO-CONTROLLED TRIALS | DOUBLE-BLIND | DUODENAL ACID EXPOSURE | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Gastritis - drug therapy | Dyspepsia - drug therapy | Prospective Studies | Humans | Middle Aged | Male | Treatment Outcome | Heartburn - drug therapy | Histamine H2 Antagonists - therapeutic use | Famotidine - therapeutic use | Product Surveillance, Postmarketing | Quality of Life | Adult | Female | Surveys and Questionnaires | Aged | Chronic Disease | Histamine | Medical colleges | Analysis | Gastrointestinal diseases | Universities and colleges | Health aspects | Gastritis | Index Medicus
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9. Full Text Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis
by Kinoshita, Yoshikazu and Furuta, Kenji and Ishimaura, Norihisa and Ishihara, Shunji and Sato, Shuichi and Maruyama, Riruke and Ohara, Shuichi and Matsumoto, Takayuki and Sakamoto, Choitsu and Matsui, Toshiyuki and Ishikawa, Satoshi and Chiba, Tsutomu
Journal of Gastroenterology, ISSN 0944-1174, 3/2013, Volume 48, Issue 3, pp. 333 - 339
The clinical characteristics of Japanese patients with eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE) have not been fully clarified. For... 
Eosinophile | Medicine & Public Health | Computed tomography | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Diarrhea | Inflammation | Dysphagia | Surgical Oncology | Heartburn | ADULTS | PREVALENCE | CHILDREN | DISEASE | GASTROENTEROLOGY & HEPATOLOGY | CONSENSUS RECOMMENDATIONS | ASSOCIATION | ENDOSCOPIC FINDINGS | Japan - epidemiology | Glucocorticoids - therapeutic use | Age Distribution | Prevalence | Enteritis - diagnosis | Humans | Middle Aged | Diarrhea - epidemiology | Male | Tomography, X-Ray Computed | Eosinophilia - epidemiology | Eosinophilic Esophagitis - epidemiology | Young Adult | Eosinophilic Esophagitis - complications | Heartburn - etiology | Adult | Deglutition Disorders - etiology | Female | Endoscopy, Gastrointestinal - methods | Eosinophilia - drug therapy | Heartburn - epidemiology | Enteritis - epidemiology | Eosinophilia - diagnosis | Gastritis - diagnosis | Gastritis - drug therapy | Eosinophilia - etiology | Abdominal Pain - etiology | Eosinophilic Esophagitis - diagnosis | Gastritis - complications | Deglutition Disorders - epidemiology | Treatment Outcome | Enteritis - drug therapy | Abdominal Pain - epidemiology | Gastritis - epidemiology | Health Surveys | Enteritis - complications | Diarrhea - etiology | Eosinophilic Esophagitis - drug therapy | Aged | Eosinophilia - complications | Esophagitis | Medical colleges | Corticosteroids | Gastroenteritis | College graduates | Index Medicus
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10. Full Text Early diagnosis of pancreatic necrosis based on perfusion CT to predict the severity of acute pancreatitis
by Tsuji, Yoshihisa and Takahashi, Naoki and Isoda, Hiroyoshi and Koizumi, Koji and Koyasu, Sho and Sekimoto, Miho and Imanaka, Yuichi and Yazumi, Shujiro and Asada, Masanori and Nishikawa, Yoshihiro and Yamamoto, Hiroshi and Kikuchi, Osamu and Yoshida, Tsukasa and Inokuma, Tetsuro and Katsushima, Shinji and Esaka, Naoki and Okano, Akihiro and Kawanami, Chiharu and Kakiuchi, Nobuyuki and Shiokawa, Masahiro and Kodama, Yuzo and Moriyama, Ichiro and Kajitani, Takafumi and Kinoshita, Yoshikazu and Chiba, Tsutomu
Journal of Gastroenterology, ISSN 0944-1174, 10/2017, Volume 52, Issue 10, pp. 1130 - 1139
Perfusion CT can diagnose pancreatic necrosis in early stage of severe acute pancreatitis, accurately. However, no study to date has examined whether early... 
Medicine & Public Health | Colorectal Surgery | Hepatology | Pancreatic necrosis | Gastroenterology | Abdominal Surgery | Persistent organ failure | Perfusion CT | Severe acute pancreatitis | Surgical Oncology | MORTALITY | MANAGEMENT | ORGAN FAILURE | PARAMETERS | OPERATING CHARACTERISTIC CURVES | FLUID RESUSCITATION | JPN GUIDELINES | MORBIDITY | COMPLICATIONS | ATLANTA CLASSIFICATION | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Perfusion Imaging - methods | Pancreatitis, Acute Necrotizing - physiopathology | Tomography, X-Ray Computed - methods | Male | Adult | Female | ROC Curve | Aged | Early Diagnosis | Pancreatitis, Acute Necrotizing - diagnostic imaging | Cohort Studies | CT imaging | Diagnosis | Pancreatitis | Necrosis | Perfusion | Gangrene | Pancreas | Medical diagnosis | Index Medicus
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11. Full Text 97 BRG1 Plays an Essential Role in Development and Homeostasis of the Duodenum Through Regulation of Notch Signaling
by Takada, Yutaka|Fukuda, Akihisa|Chiba, Tsutomu|Seno, Hiroshi
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S25 - S25
Gastroenterology and Hepatology
Journal Article
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12. Full Text 555 Brg1 Plays an Important Role in Acinar Cell-Derived PanIN Formation Through Regulation of SOX9 Expression
by Tsuda, Motoyuki|Fukuda, Akihisa|Chiba, Tsutomu|Seno, Hiroshi
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S117 - S118
Gastroenterology and Hepatology
Journal Article
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13. Full Text Dclk1 distinguishes between tumor and normal stem cells in the intestine
by Nakanishi, Yuki and Seno, Hiroshi and Fukuoka, Ayumi and Ueo, Taro and Yamaga, Yuichi and Maruno, Takahisa and Nakanishi, Naoko and Kanda, Keitaro and Komekado, Hideyuki and Kawada, Mayumi and Isomura, Akihiro and Kawada, Kenji and Sakai, Yoshiharu and Yanagita, Motoko and Kageyama, Ryoichiro and Kawaguchi, Yoshiya and Taketo, Makoto M and Yonehara, Shin and Chiba, Tsutomu
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 45, Issue 1, pp. 98 - U143
There is great interest in tumor stem cells (TSCs) as potential therapeutic targets; however, cancer therapies targeting TSCs are limited. A drawback is that... 
ORIGIN | DOUBLECORTIN-LIKE | MARKER | POLYPOSIS | GENETICS & HEREDITY | MYELOID-LEUKEMIA | ABLATION | COLON | MICE | IDENTIFICATION | CANCER | Intestines - pathology | Protein-Serine-Threonine Kinases - genetics | Male | Mice, Transgenic | Intestines - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Stem Cells - metabolism | Intestinal Neoplasms - pathology | Intestinal Polyps - genetics | Animals | Neoplastic Stem Cells - metabolism | Intestinal Polyps - pathology | Female | Mice | Intestinal Polyps - metabolism | Gene Order | Intestinal Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Intestines | Stem cells | Physiological aspects | Genetic aspects | Research | Gene expression | Tumors | Medical research | Genetics | Small intestine | Rodents | Index Medicus
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14. Full Text Indigenous Clostridium Species Regulate Systemic Immune Responses by Induction of Colonic Regulatory T Cells
by Chiba, Tsutomu|Seno, Hiroshi
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 3, pp. 1114 - 1116
Gastroenterology and Hepatology
Journal Article
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15. Full Text Toll-like receptor activation in basophils contributes to the development of IgG4-related disease
by Watanabe, Tomohiro and Yamashita, Kouhei and Sakurai, Toshiharu and Kudo, Masatoshi and Shiokawa, Masahiro and Uza, Norimitsu and Kodama, Yuzo and Uchida, Kazushige and Okazaki, Kazuichi and Chiba, Tsutomu
Journal of Gastroenterology, ISSN 0944-1174, 2/2013, Volume 48, Issue 2, pp. 247 - 253
IgG4-related disease (IRD) is characterized by systemic IgG4 antibody responses and by infiltration of IgG4-expressing plasma cells into the affected organs.... 
IgG4-related disease | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | TLR | Surgical Oncology | Basophil | RESPONSES | INFLAMMATORY-BOWEL-DISEASE | AUTOIMMUNE PANCREATITIS | IGE | GASTROENTEROLOGY & HEPATOLOGY | B-Cell Activating Factor - biosynthesis | Humans | Toll-Like Receptors - immunology | Autoimmune Diseases - immunology | Immunity, Innate | Interleukin-13 - biosynthesis | Signal Transduction - immunology | Lymphocyte Activation - immunology | B-Lymphocytes - immunology | Immunoglobulin G - biosynthesis | Immunoglobulin G - immunology | Basophils - immunology | Ligands | Oligomers | Medical colleges | Immunoglobulin G | Index Medicus
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16. Full Text Case of IgG4-associated sclerosing cholangitis with normal serum IgG4 concentration, diagnosed by anti-laminin 511-E8 antibody: a novel autoantibody in patients with autoimmune pancreatitis
by Kato, Yukari and Azuma, Keishiro and Someda, Hitoshi and Shiokawa, Masahiro and Chiba, Tsutomu
Gut, ISSN 0017-5749, 02/2019, p. gutjnl-2018-317934
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17. Full Text A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer
by Kanai, Masashi and Yoshimura, Kenichi and Asada, Masanori and Imaizumi, Atsushi and Suzuki, Chihiro and Matsumoto, Shigemi and Nishimura, Takafumi and Mori, Yukiko and Masui, Toshihiko and Kawaguchi, Yoshiya and Yanagihara, Kazuhiro and Yazumi, Shujiro and Chiba, Tsutomu and Guha, Sushovan and Aggarwal, Bharat B
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2011, Volume 68, Issue 1, pp. 157 - 164
Curcumin, a plant-derived natural polyphenol, could be a promising anti-cancer drug and shows synergic effects with cytotoxic agents. We evaluated the safety... 
Medicine & Public Health | Gemcitabine | Pancreatic cancer | Oncology | Cancer Research | Curcumin | Pharmacology/Toxicology | APOPTOSIS | ACTIVATION | CELL-PROLIFERATION | SUPPRESSION | I CLINICAL-TRIAL | 5-FLUOROURACIL | THERAPY | INHIBITION | ONCOLOGY | GENE-PRODUCTS | PHARMACOLOGY & PHARMACY | EXPRESSION | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - administration & dosage | Curcumin - administration & dosage | Pancreatic Neoplasms - drug therapy | Adenocarcinoma - physiopathology | Antineoplastic Agents - adverse effects | Deoxycytidine - adverse effects | Female | Antineoplastic Agents - pharmacokinetics | Pancreatic Neoplasms - mortality | Deoxycytidine - administration & dosage | Tegafur - adverse effects | Tegafur - therapeutic use | Curcumin - pharmacokinetics | Survival Rate | Curcumin - adverse effects | Adenocarcinoma - drug therapy | Oxonic Acid - adverse effects | Drug Synergism | Medication Adherence | Oxonic Acid - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Antineoplastic Agents - blood | Aged | Pancreatic Neoplasms - physiopathology | Deoxycytidine - analogs & derivatives | Drug Combinations | Adenocarcinoma - mortality | Medical colleges | Care and treatment | Cancer patients | Chemotherapy | Gastrointestinal agents | Oncology, Experimental | Research | Cancer | Index Medicus
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18. Full Text Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
by Chiba, Tsutomu and Azuma, Takeshi and Kou, Tadayuki and Kinoshita, Kazuo and Endo, Yoko and Okazaki, Il-Mi and Marusawa, Hiroyuki and Honjo, Tasuku and Morisawa, Toshiyuki and Matsumoto, Yuko
Nature Medicine, ISSN 1078-8956, 04/2007, Volume 13, Issue 4, pp. 470 - 476
Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer. Here we show that infection of gastric epithelial cells... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | SOMATIC HYPERMUTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-LINES | CANCER | CELL BIOLOGY | P53 MUTATIONS | DNA | CLASS-SWITCH RECOMBINATION | MICE | AID | NF-KAPPA-B | Immunohistochemistry | Stomach Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Mutagenesis - genetics | NF-kappa B - metabolism | Genes, p53 - genetics | DNA Primers | Gastric Mucosa - metabolism | Helicobacter Infections - genetics | Reverse Transcriptase Polymerase Chain Reaction | Stomach Neoplasms - microbiology | Models, Biological | Cytidine Deaminase - metabolism | Bacterial Proteins - metabolism | Helicobacter Infections - metabolism | Signal Transduction - physiology | Antigens, Bacterial - metabolism | Enzymes | Bacteria | Infections | Mutation | Gene expression | Cancer | Index Medicus
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19. Full Text Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture
by Shinsuke Tada and Takumi Era and Chikara Furusawa and Hidetoshi Sakurai and Satomi Nishikawa and Masaki Kinoshita and Kazuki Nakao and Tsutomu Chiba and Shin-Ichi Nishikawa
Development, ISSN 0950-1991, 10/2005, Volume 132, Issue 19, pp. 4363 - 4374
Bipotent mesendoderm that can give rise to both endoderm and mesoderm is an established entity from C. elegans to zebrafish. Although previous studies in mouse... 
Mouse | Goosecoid | ES cell | Endoderm | Mesendoderm | mesendoderm | mouse | goosecoid | DEVELOPMENTAL BIOLOGY | endoderm | Cell Line | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Cadherins - metabolism | Activins - physiology | Transforming Growth Factor beta - physiology | Culture Media, Serum-Free | Green Fluorescent Proteins - genetics | Mesoderm - cytology | Recombinant Fusion Proteins - metabolism | Goosecoid Protein - genetics | Goosecoid Protein - metabolism | Cell Lineage | Animals | Endoderm - cytology | Gene Expression Regulation, Developmental | Multipotent Stem Cells - cytology | Recombinant Fusion Proteins - genetics | Mice | Cell Differentiation - physiology | Nodal Protein | Index Medicus
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