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Hepatology, ISSN 0270-9139, 09/2010, Volume 52, Issue 3, pp. 833 - 844
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2008, Volume 359, Issue 23, pp. 2429 - 2441
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 13, pp. 5995 - 5999
Silymarin, also known as milk thistle extract, inhibits hepatitis C virus (HCV) infection and also displays antioxidant, anti-inflammatory, and... 
T lymphocytes | Antioxidants | Oxidative stress | RNA | Chronic hepatitis | Antivirals | Viruses | Infections | Inhibitory concentration 50 | Hepacivirus | Hepatoprotection | Milk thistle | Hepatitis C | Liver disease | Botanical medicine | OXIDATIVE STRESS | PLUS RIBAVIRIN | ACTIVATION | liver disease | hepatitis C | MULTIDISCIPLINARY SCIENCES | LIVER-DISEASE | CORE PROTEIN | IN-VITRO | HEPATITIS-C VIRUS | MARIANUM MILK THISTLE | INFECTION | botanical medicine | NF-KAPPA-B | milk thistle | hepatoprotection | Flavonolignans - isolation & purification | Antioxidants - chemistry | Hepatitis C - drug therapy | Immunologic Factors - isolation & purification | Humans | NF-kappa B - metabolism | Protective Agents - chemistry | Silymarin - chemistry | Liver - drug effects | Antiviral Agents - chemistry | Protective Agents - pharmacology | T-Lymphocytes - drug effects | Anti-Inflammatory Agents - isolation & purification | Silymarin - pharmacology | Drug Evaluation, Preclinical | Hepatitis C - prevention & control | Antiviral Agents - pharmacology | Immunologic Factors - chemistry | Anti-Inflammatory Agents - pharmacology | Flavonolignans - pharmacology | Liver - metabolism | Protective Agents - isolation & purification | Antioxidants - pharmacology | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Cell Line, Tumor | T-Lymphocytes - immunology | Liver - cytology | Flavonolignans - chemistry | Oxidative Stress - drug effects | Antiviral Agents - isolation & purification | Immunologic Factors - pharmacology | Medicinal plants | Care and treatment | Usage | Flavones | Bioflavonoids | Development and progression | Research | Properties | Flavonoids | Medicine, Botanic | Medicine, Herbal | Health aspects | Hepatitis | T cell receptors | Effects | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article
Cancer, ISSN 0008-543X, 04/2017, Volume 123, Issue 8, pp. 1464 - 1474
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0148764 - e0148764
VTX-2337 (USAN: motolimod) is a selective toll-like receptor 8 (TLR8) agonist, which is in clinical development as an immunotherapy for multiple oncology... 
HEAD | ENHANCE | NK CELLS | CANCER CELLS | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | CRYSTALS | GENERATION | TUMORS | CD8(+) T-CELLS | NALP3 INFLAMMASOME | Neoplasms - metabolism | Leukocytes, Mononuclear - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Macaca fascicularis | Caspase 1 - metabolism | Male | Receptors, IgG - metabolism | Carrier Proteins - agonists | Lymphocyte Activation - immunology | Neoplasms - genetics | Leukocytes, Mononuclear - immunology | Killer Cells, Natural - immunology | Female | Interleukin-1beta - biosynthesis | Disease Models, Animal | Toll-Like Receptor 8 - agonists | Leukocytes, Mononuclear - drug effects | Benzazepines - pharmacology | Cell Degranulation - immunology | Interleukin-18 - biosynthesis | Animals | Benzazepines - therapeutic use | Lymphocyte Activation - drug effects | Neoplasms - immunology | K562 Cells | Cell Line, Tumor | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology | Cell Degranulation - drug effects | Physiological aspects | Toll-like receptors | Killer cells | Genetic aspects | Research | Immunotherapy | Toxicity | Cytotoxicity | Stimulation | Activation | Lymphocytes T | Monkeys | Cancer therapies | Caspase-1 | Metastases | NKG2 antigen | Cell activation | Epidermal growth factor | Lymphocytes | Rodents | Biocompatibility | Neck | Natural killer cells | Antibody-dependent cell-mediated cytotoxicity | Squamous cell carcinoma | Cytokines | Dendritic cells | Tumor cells | Caspase | T cell receptors | Tumor necrosis factor-α | Patients | Interleukin 18 | Medicine | Monocytes | Complement activation | Pyrin protein | Womens health | γ-Interferon | Monoclonal antibodies | Ligands | Lymphomas | Pharmaceuticals | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2017, Volume 23, Issue 10, pp. 2442 - 2450
Purpose: As Toll-like receptors (TLR) are key mediators of immune responses, TLR agonists may be important for augmenting the efficacy of therapies for... 
HEAD | II MULTICENTER | SOLID TUMORS | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | OPEN-LABEL | TOXICITY | ANTIBODY CETUXIMAB | NECK-CANCER | EGFR | CHEMOTHERAPY | Carcinoma, Squamous Cell - blood | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Benzazepines - adverse effects | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Drug-Related Side Effects and Adverse Reactions - pathology | Neoplasm Recurrence, Local - pathology | Neoplasm Metastasis | Squamous Cell Carcinoma of Head and Neck | Antibodies, Monoclonal, Humanized - administration & dosage | Head and Neck Neoplasms - blood | Adult | Female | Antibodies, Monoclonal, Humanized - adverse effects | Head and Neck Neoplasms - drug therapy | Disease-Free Survival | Carcinoma, Squamous Cell - drug therapy | Toll-Like Receptor 8 - genetics | Cetuximab - administration & dosage | Head and Neck Neoplasms - genetics | Aged | Benzazepines - administration & dosage | Killer Cells, Natural - metabolism | Drug-Related Side Effects and Adverse Reactions - classification | Toxicity | Metastasis | Metastases | Anticancer properties | Proteins | Receptors | Safety engineering | Design standards | Toll-like receptors | Bioindicators | Neck | Natural killer cells | Squamous cell carcinoma | Head | Statistical analysis | Immune response | Cytokines | Dendritic cells | Pharmacology | Disease control | Patients | Immune systems | Monocytes | Experimental design | Biomarkers | Antitumor activity | Cancer | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 1, pp. e16464 - e16464
Silymarin prevents liver disease in many experimental rodent models, and is the most popular botanical medicine consumed by patients with hepatitis C.... 
OXIDATIVE STRESS | HEPATOCELLULAR-CARCINOMA | SIGNALING PATHWAYS | PLUS RIBAVIRIN | VIRUS-INFECTION | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | RANDOMIZED-TRIAL | NF-KAPPA-B | MILK THISTLE EXTRACT | RNA-POLYMERASE | Hepacivirus - drug effects | Cell Line | Drug Administration Routes | Virus Replication - drug effects | T-Lymphocytes | Humans | Drug Compounding | Hepacivirus - growth & development | Cell Proliferation - drug effects | Silymarin - administration & dosage | Infection | Flavonoids | Liver diseases | Flavones | RNA | Analysis | Bioflavonoids | Inflammation | Hepatitis C virus | T cells | Health aspects | Cell culture | Intravenous administration | Liver | Biochemistry | Hepatitis | Liver cancer | Signal transduction | Cell growth | Inhibition | NF-κB protein | RNA viruses | Ethanol | Impact factors | RNA polymerase | Bioavailability | Metabolism | Patients | Ribonucleic acids | Silymarin | Life cycle analysis | Silibinin | Cell proliferation | Animal models | Transcription | Laboratories | Fluorescence | Viruses | Lymphocytes T | Infections | DNA-directed RNA polymerase | Immunology | Metabolites | Hepatology | Life cycle engineering | Formulations | Medicine | Polymerase | Progeny | Respiratory syncytial virus | Natural products | Cell lines | Interferon | Liposomes | Hepatitis C | Chemokines | Viral infections | Life cycles | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 136, Issue 1, pp. 138 - 148
Journal Article