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science & technology (59) 59
apoptosis (53) 53
life sciences & biomedicine (50) 50
humans (48) 48
animals (45) 45
mitochondria (32) 32
cell biology (30) 30
biochemistry & molecular biology (25) 25
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mitochondrial membranes - metabolism (15) 15
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proto-oncogene proteins c-bcl-2 - metabolism (14) 14
biological phenomena, cell phenomena, and immunity (13) 13
permeability (13) 13
bcl-2 homologous antagonist-killer protein - metabolism (12) 12
cell death (12) 12
tumor suppressor protein p53 - metabolism (12) 12
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apoptosis regulatory proteins - metabolism (7) 7
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hela cells (7) 7
models, biological (7) 7
momp (7) 7
protein structure, tertiary (7) 7
amino acid sequence (6) 6
analysis (6) 6
apoptosis - physiology (6) 6
bax (6) 6
cell survival (6) 6
cells, cultured (6) 6
gene expression regulation (6) 6
lipids (6) 6
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membrane proteins - metabolism (6) 6
mitochondrial dna (6) 6
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proto-oncogene proteins c-bcl-2 - chemistry (5) 5
tumor suppressor protein p53 - genetics (5) 5
apoptosis - drug effects (4) 4
apoptosis - genetics (4) 4
apoptosis regulatory proteins - chemistry (4) 4
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pathology (4) 4
phosphorylation (4) 4
proto-oncogene proteins - chemistry (4) 4
transcription, genetic (4) 4
tumor suppressor protein p53 - chemistry (4) 4
bak (3) 3
bcl-2 homologous antagonist-killer protein - chemistry (3) 3
bcl-2 homologous antagonist-killer protein - genetics (3) 3
bcl-2 proteins (3) 3
bcl-2-associated x protein - genetics (3) 3
bh3 interacting domain death agonist protein - chemistry (3) 3
bh3 interacting domain death agonist protein - metabolism (3) 3
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1. Full Text How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
by Chipuk, Jerry E and Green, Douglas R
Trends in cell biology, ISSN 0962-8924, 2008, Volume 18, Issue 4, pp. 157 - 164
Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Models, Biological | Humans | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Membrane Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Apoptosis | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Proteins | Index Medicus
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2. Full Text Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
by Jerry E. Chipuk and Tomomi Kuwana and Lisa Bouchier-Hayes and Nathalie M. Droin and Donald D. Newmeyer and Martin Schuler and Douglas R. Green
Science (American Association for the Advancement of Science), ISSN 0036-8075, 2/2004, Volume 303, Issue 5660, pp. 1010 - 1014
Mitochondria | HeLa cells | Cytochromes | Reports | Gene expression regulation | Cellular immunity | Liposomes | Cytosol | Cytoplasm | Oncogenes | Apoptosis | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Intracellular Membranes - physiology | Humans | BH3 Interacting Domain Death Agonist Protein | Proto-Oncogene Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Wheat Germ Agglutinins - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Genes, p53 | Cell Nucleus - metabolism | Ultraviolet Rays | Proto-Oncogene Proteins - metabolism | bcl-X Protein | Cytochromes c - metabolism | Cells, Cultured | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | Permeability | bcl-2-Associated X Protein | Animals | Carrier Proteins - metabolism | Cytosol - metabolism | Liposomes - metabolism | Protein Conformation | Mice | Tumor Suppressor Protein p53 - chemistry | HeLa Cells | Mutation | Mitochondria - physiology | Cell Line, Transformed | Tumor suppressor genes | Chemical properties | Proteins | Membranes | Index Medicus
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3. Full Text PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53
by Jerry E. Chipuk and Lisa Bouchier-Hayes and Tomomi Kuwana and Donald D. Newmeyer and Douglas R. Green
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2005, Volume 309, Issue 5741, pp. 1732 - 1735
Mitochondria | Immunology | HCT116 cells | DNA damage | DNA | Cell lines | Cytochromes | Reports | Gene expression regulation | Cytosol | Apoptosis | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Ageing, cell death | Immunoprecipitation | Humans | Cytoplasm - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Ultraviolet Rays | Tumor Suppressor Proteins - chemistry | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | bcl-X Protein | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Mitochondria - metabolism | Permeability | bcl-2-Associated X Protein | Animals | Apoptosis Regulatory Proteins | Models, Biological | Cell Line, Tumor | Protein Binding | Mice | DNA Damage | Research | Genes | Cytology | Gene expression | Cells | Index Medicus
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4. Full Text GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells
by Greter, Melanie and Helft, Julie and Chow, Andrew and Hashimoto, Daigo and Mortha, Arthur and Agudo-Cantero, Judith and Bogunovic, Milena and Gautier, Emmanuel L and Miller, Jennifer and Leboeuf, Marylene and Lu, Geming and Aloman, Costica and Brown, Brian D and Pollard, Jeffrey W and Xiong, Huabao and Randolph, Gwendalyn J and Chipuk, Jerry E and Frenette, Paul S and Merad, Miriam
Immunity (Cambridge, Mass.), ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 1031 - 1046
Life Sciences & Biomedicine | Immunology | Science & Technology | Homeostasis | Medical colleges | Air pollution | Dendritic cells | T cells | Studies | Spleen | Software | Cytokines | Index Medicus
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5. Full Text Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis
by Chipuk, Jerry E and McStay, Gavin P and Bharti, Archana and Kuwana, Tomomi and Clarke, Christopher J and Siskind, Leah J and Obeid, Lina M and Green, Douglas R
Cell (Cambridge), ISSN 0092-8674, 03/2012, Volume 148, Issue 5, pp. 988 - 1000
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Sphingolipids - metabolism | Mitochondria - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Mitochondrial Membranes - metabolism | Animals | Metabolic Networks and Pathways | Sphingomyelin Phosphodiesterase - metabolism | Female | Liver - cytology | Mice | HeLa Cells | Apoptosis | Proteins | Cytochrome c | Enzymes | Medical colleges | Sphingosine | Physiological aspects | Lipids | Mitochondrial DNA | Index Medicus
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6. Full Text Do inducers of apoptosis trigger caspase-independent cell death?
by Green, Douglas R and Chipuk, Jerry E
Nature reviews. Molecular cell biology, ISSN 1471-0072, 03/2005, Volume 6, Issue 3, pp. 268 - 275
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Caspases - physiology | Animals | DNA Damage - physiology | Humans | Mice | Apoptosis - physiology | Mitochondria - physiology
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7. Full Text How do I kill thee? Let me count the ways: p53 regulates PARP‐1 dependent necrosis
by Elkholi, Rana and Chipuk, Jerry E
BioEssays, ISSN 0265-9247, 01/2014, Volume 36, Issue 1, pp. 46 - 51
PARP‐1 | apoptosis | necrosis | ROS | p53 | PARP-1 | Apoptosis | Necrosis | P53 | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Humans | Tumor Suppressor Protein p53 - metabolism | DNA Damage - genetics | Necrosis - metabolism | Necrosis - genetics | Signal Transduction - genetics | Tumor Suppressor Protein p53 - genetics | Research | Biological assay | Analysis | Gene expression | DNA repair | Deoxyribonucleic acid--DNA | Cell cycle | Index Medicus
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8. Full Text Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
by Serasinghe, Madhavika N and Wieder, Shira Y and Renault, Thibaud T and Elkholi, Rana and Asciolla, James J and Yao, Jonathon L and Jabado, Omar and Hoehn, Kyle and Kageyama, Yusuke and Sesaki, Hiromi and Chipuk, Jerry E
Molecular cell, ISSN 1097-2765, 02/2015, Volume 57, Issue 3, pp. 521 - 536
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | ras Proteins - genetics | Dynamins - metabolism | Phosphorylation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Dynamins - genetics | ras Proteins - metabolism | Mitochondria - metabolism | Mitochondrial Proteins - genetics | Serine - metabolism | HT29 Cells | Animals | GTP Phosphohydrolases - metabolism | MAP Kinase Signaling System - drug effects | Cell Transformation, Neoplastic - genetics | GTP Phosphohydrolases - genetics | Mitochondrial Proteins - metabolism | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Medical colleges | Chemotherapy | Security software | Magneto-electric machines | Machinery | Cells | Cancer | Index Medicus | mitochondria | oncogenes | apoptosis | metabolism | MAPK | targeted therapeutics | DRP1 | mitochondrial dynamics
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9. Full Text The BCL-2 Family Reunion
by Chipuk, Jerry E and Moldoveanu, Tudor and Llambi, Fabien and Parsons, Melissa J and Green, Douglas R
Molecular cell, ISSN 1097-2765, 2010, Volume 37, Issue 3, pp. 299 - 310
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Multigene Family | Proto-Oncogene Proteins c-bcl-2 - physiology | Signal Transduction | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Permeability | Autophagy | Mitochondrial Membranes - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Sequence Alignment | Models, Biological | Mitochondrial Membranes - ultrastructure | Proto-Oncogene Proteins c-bcl-2 - chemistry | Apoptosis | Family | Index Medicus
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