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Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 570 - 575
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 05/2008, Volume 68, Issue 9, pp. 3389 - 3395
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 24, pp. 8895 - 8900
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 42, pp. 16986 - 16991
Macrophages acquire strikingly different properties that enable them to play key roles during the initiation, propagation, and resolution of inflammation.... 
14-3-3 proteins | Bacteriophages | Phosphorylation | Messenger RNA | Antiinflammatories | Cytokines | Secretion | Drug regulation | Genes | Macrophages | MRT67307 | HG-9-91-01 | AMPK-related kinases | Toll-like receptor | MRT199665 | MULTIDISCIPLINARY SCIENCES | CYTOKINE | FAMILY | CROSS-TALK | CREB | IN-VIVO | AMPK | RECEPTORS | POLARIZATION | INNATE IMMUNITY | Pyrimidines - chemical synthesis | DNA, Complementary - genetics | Immunoblotting | DNA Primers - genetics | Pyrimidines - chemistry | RNA Interference | Phenylurea Compounds - chemistry | Cyclobutanes - pharmacology | Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Interleukin-10 - metabolism | Molecular Structure | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Morpholines - chemical synthesis | Cell Line | Cytokines - metabolism | Magnetic Resonance Spectroscopy | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | Inflammation - immunology | Pyrimidines - pharmacology | Cyclobutanes - chemical synthesis | Mice, Knockout | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Phenylurea Compounds - chemical synthesis | Analysis of Variance | Interleukin-10 - genetics | Fluorescent Antibody Technique | Proteomics | Mice | Phenylurea Compounds - pharmacology | Indans - pharmacology | Physiological aspects | Toll-like receptors | Research | Phosphotransferases | Health aspects | Pathogens | Mutation | Kinases | Index Medicus | Biological Sciences
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Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9296 - 9308
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Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 12, pp. 4511 - 4519
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key player in innate immune and inflammatory responses, performing a critical role in signal... 
inactive conformation | kinase | innate immunity | inflammation | Toll-like receptor (TLR) | crystal structure | drug development | type II inhibition | structural biology | IRAK4 | ACTIVATION | INFECTIONS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE | CRYSTAL-STRUCTURES | MODEL | DISCOVERY | MUTATION | OPTIMIZATION | MYD88
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