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1.
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Structures of β-klotho reveal a â € zip code'-like mechanism for endocrine FGF signalling
Nature (London), ISSN 0028-0836, 01/2018, Volume 553, Issue 7689, pp. 501 - 505
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Signal Transduction | Humans | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Extracellular Space - metabolism | Membrane Proteins - chemistry | Receptors, Fibroblast Growth Factor - metabolism | HEK293 Cells | Glycoside Hydrolases - chemistry | Protein Binding | Protein Domains | Ligands | Membrane Proteins - metabolism | Glycoside Hydrolases - metabolism | Binding Sites | Fibroblast growth factor | Fibroblast growth factor 23 | Paracrine signalling | Amino acids | Intracellular signalling | Hormones | Tissues | Cell surface | Experiments | Proteins | Receptors | Fibroblasts | Catalysis | Autocrine signalling | Lipogenesis | Growth factors | Sugar | Crystal structure | Enzymes | Proteoglycans | Energy expenditure | Metabolism | Insulin | Chemical compounds | Biological activity | Klotho protein | Heparan sulfate proteoglycans | Receptor mechanisms | Cooperativity | Sulfate | Fibroblast growth factor receptors | Index Medicus | Ectopic hormones | X-ray crystallography | BASIC BIOLOGICAL SCIENCES
Journal Article
Biochemistry (Easton), ISSN 0006-2960, 06/2007, Volume 46, Issue 23, pp. 6774 - 6783
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Recombinant Proteins - metabolism | Xenopus | Membrane Proteins - isolation & purification | Electron Spin Resonance Spectroscopy | Magnetic Resonance Spectroscopy | Humans | Freeze Drying | Recombinant Proteins - chemistry | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Membrane Proteins - chemistry | Micelles | Cell Line, Tumor | Phosphoproteins - isolation & purification | Female | Membrane Proteins - metabolism | Usage | Nuclear magnetic resonance spectroscopy | Chemical properties | Structure | Protein kinases | Adenosine triphosphatase | Index Medicus | RDC | NMR | FXYD1 | K-ATPase | membrane protein | micelles | structure
Journal Article
Nature (London), ISSN 0028-0836, 01/2018, Volume 553, Issue 7689, p. 501
Journal Article
Biochimica et biophysica acta. Biomembranes, ISSN 0005-2736, 2009, Volume 1788, Issue 11, pp. 2462 - 2470
Micelle | Phospholemman | Phosphorylation, Structure | NMR | FXYD | Na,K-ATPase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cyclic AMP-Dependent Protein Kinases - metabolism | Amino Acid Sequence | Phosphorylation | Membrane Proteins - genetics | Humans | Molecular Sequence Data | Phosphoproteins - genetics | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Sodium-Potassium-Exchanging ATPase - metabolism | Membrane Proteins - chemistry | Protein Conformation | Membrane Proteins - metabolism | Proteins | Physiological aspects | Protein kinases | Analysis
Journal Article
Biochimica et biophysica acta. Biomembranes, ISSN 0005-2736, 2007, Volume 1768, Issue 12, pp. 3216 - 3224
OmpX | Beta barrel | Bilayer | Bicelle | Solid state NMR | Outer membrane protein | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Hydrolases - metabolism | Amino Acid Sequence | Magnetic Resonance Spectroscopy - methods | Bacterial Outer Membrane Proteins - metabolism | Electrophoresis, Polyacrylamide Gel | Bacterial Outer Membrane Proteins - chemistry | Molecular Sequence Data | Escherichia coli Proteins - metabolism | Hydrolases - chemistry | Lipid Bilayers - chemistry | Escherichia coli Proteins - chemistry
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 07/2004, Volume 279, Issue 28, pp. 28954 - 28960
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | bcl-X Protein | Peptide Fragments - metabolism | Humans | BH3 Interacting Domain Death Agonist Protein | Molecular Sequence Data | Mitochondria - metabolism | Protein Folding | Cell Membrane - chemistry | Carrier Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Peptide Fragments - chemistry | Carrier Proteins - metabolism | Micelles | Nuclear Magnetic Resonance, Biomolecular | Carrier Proteins - chemistry | Protein Conformation | Cell Membrane - metabolism | Apoptosis - physiology | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Circular Dichroism | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 04/2019, Volume 116, Issue 16, pp. 7819 - 7824
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Line | Phosphorylation | Membrane Proteins - genetics | Humans | Models, Molecular | Rats | Substrate Specificity | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Animals | Membrane Proteins - chemistry | Protein Binding | Protein Conformation | Signal Transduction - physiology | Membrane Proteins - metabolism | Fibroblast growth factor | Hydrolase | Fibroblast growth factor 23 | Intracellular signalling | Mutants | Proteins | Domains | Receptors | Klotho protein | Fibroblast growth factor receptor 4 | Affinity | Ligands | Catalysis | Receptor mechanisms | Coordination compounds | Growth factors | Binding sites | Crystal structure | Catalytic subunits | Fibroblast growth factor receptors | Index Medicus | endocrine FGF | structural biology | metabolism | BASIC BIOLOGICAL SCIENCES | phosphorylation | cell signaling | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 04/2019, Volume 116, Issue 16, p. 7819
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Bcl‐XL as a fusion protein for the high‐level expression of membrane‐associated proteins
Protein science, ISSN 0961-8368, 04/2005, Volume 14, Issue 4, pp. 948 - 955
CHIF, corticosteroid‐hormone‐induced factor, FXYD4 | HSQC, heteronuclear single quantum coherence | DOPC, 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine | GdnHCl, guanidinium HCl | HSQC‐NOESY, HSQC–nuclear overhauser effect spectroscopy | Bcl‐XL | Mat‐8 | HPLC, high‐performance liquid chromatography | CPMOIST, cross polarization with mismatch‐optimized IS polarization transfer | TLE, a portion of the Trp ΔLE 1413 polypeptide | SDS, sodium dodecyl sulfate | lipid | CNBr, cyanogen bromide | IPTG, isopropyl β‐D‐thiogalactopyranoside | PLM | PAGE, polyacrylamide gel electrophoresis | membrane protein expression | NMR, nuclear magnetic resonance | Bcl‐2, B‐cell leukemia/lymphoma 2 | CHIF | DOPG, 1,2‐dioleoyl‐sn‐glycero‐3‐[phospho‐rac‐(1‐glycerol)] | PISEMA, polarization inversion with spin exchange at the magic angle | Mat‐8, mammary tumor protein 8 kDa, FXYD3 | Bcl‐XL, B‐cell leukemia/lymphoma extra long | PLM, phospholemman, FXYD1 | KSI, ketosteroid isomerase | NMR | FXYD | MALDI‐TOF, matrix‐assisted laser desorption ionization–time of flight | pI, isoelectric point | BCL, Bcl‐XL mutant lacking the hydrophobic C terminus adapted as fusion partner | ER, endoplasmic reticulum | Membrane protein expression | Mat-8 | Bcl-XL | Lipid | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Recombinant Fusion Proteins - isolation & purification | bcl-X Protein | Gene Expression | Membrane Proteins - genetics | Molecular Sequence Data | Recombinant Fusion Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Escherichia coli - genetics | Membrane Proteins - metabolism | Mutation | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus
Journal Article
Journal of molecular biology, ISSN 0022-2836, 2005, Volume 354, Issue 4, pp. 743 - 750
NMR structure | membrane protein | FXYD | gene | Na,K-ATPase | Membrane protein | Gene | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Sodium-Potassium-Exchanging ATPase - genetics | Protein Structure, Secondary | Sodium-Potassium-Exchanging ATPase - chemistry | Exons | Membrane Proteins - genetics | Humans | Rats | Neoplasm Proteins - chemistry | Phosphoproteins - genetics | Sodium Dodecyl Sulfate | Phosphoproteins - chemistry | Potassium Channels - genetics | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Gene Rearrangement | Micelles | Nuclear Magnetic Resonance, Biomolecular | Potassium Channels - chemistry | Mice | Gene Components | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Proteins | Nuclear magnetic resonance spectroscopy | Index Medicus
Journal Article
Magnetic resonance in chemistry, ISSN 0749-1581, 02/2004, Volume 42, Issue 2, pp. 172 - 179
PLM | NMR | membrane proteins | Bcl‐xL | lipid bilayers | Bcl‐2 | apoptosis | FXYD | Mat8 | CHIF | Bcl-2 | Bcl-xl | Lipid bilayers | Apoptosis | Membrane proteins | Spectroscopy | Physical Sciences | Chemistry | Technology | Chemistry, Multidisciplinary | Chemistry, Physical | Science & Technology | Amino Acid Sequence | Magnetic Resonance Spectroscopy - methods | Protein Structure, Secondary | Humans | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - isolation & purification | Lipid Bilayers | Membrane Proteins - chemistry | Neoplasm Proteins | Cloning, Molecular | Conserved Sequence | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - chemistry | Apoptosis - physiology | Index Medicus | Bcl-xL
Journal Article
Chemical biology & drug design, ISSN 1747-0277, 11/2007, Volume 70, Issue 5, pp. 383 - 392
Bcl-2 | peptide | chemical shift mapping | cytoprotection | Humanin | apoptosis | BH3 | Bid | nuclear magnetic resonance | Bcl‐2 | Chemical shift mapping | Nuclear magnetic resonance | Peptide | Apoptosis | Cytoprotection | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Amino Acid Sequence | bcl-2-Associated X Protein - chemistry | Magnetic Resonance Spectroscopy | Apoptosis Regulatory Proteins - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Bcl-2-Like Protein 11 | Cell Death - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Conserved Sequence | Protein Conformation | Mice | Apoptosis - physiology | Intracellular Signaling Peptides and Proteins - physiology | Proteins | Polypeptides | Index Medicus
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