Lancet Oncology, The, ISSN 1470-2045, 2014, Volume 15, Issue 9, pp. 954 - 965
Summary Background Addition of a MEK inhibitor to a BRAF inhibitor enhances tumour growth inhibition, delays acquired resistance, and abrogates paradoxical...
Hematology, Oncology and Palliative Medicine
Hematology, Oncology and Palliative Medicine
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2013, Volume 146, Issue 2, pp. 379 - 384
Background Obesity is a risk factor for increased perioperative morbidity and mortality in surgical patients. There have been limited studies to correlate the...
Cardiothoracic Surgery | body mass index | FEV | confidence interval | forced expiratory volume in 1 second | odds ratio | BMI | chronic obstructive pulmonary disease | COPD | HOSPITAL MORTALITY | SURVIVAL | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | RESECTION | BRONCHOGENIC-CARCINOMA | RISK | IMPACT | RESPIRATORY SYSTEM | BODY-MASS INDEX | COMPLICATIONS | OUTCOMES | Multivariate Analysis | Postoperative Complications - etiology | Pneumonectomy - mortality | Lung Neoplasms - mortality | Humans | Middle Aged | Respiratory Insufficiency - etiology | Male | Postoperative Complications - mortality | Patient Selection | Time Factors | Aged, 80 and over | Adult | Female | Obesity - diagnosis | Retrospective Studies | Obesity - mortality | Odds Ratio | Heart Failure - etiology | Wisconsin | Body Mass Index | Length of Stay | Pneumonectomy - adverse effects | Risk Assessment | Obesity - complications | Risk Factors | Logistic Models | Postoperative Complications - therapy | Treatment Outcome | Postoperative Complications - diagnosis | Lung Neoplasms - complications | Pulmonary Embolism - etiology | Atrial Fibrillation - etiology | Lung Neoplasms - surgery | Aged | Obesity | Medical colleges | Cancer patients | Lung cancer | Surgery | Mortality | Health aspects | Lung Cancer | Peri-operative morbidities
Cardiothoracic Surgery | body mass index | FEV | confidence interval | forced expiratory volume in 1 second | odds ratio | BMI | chronic obstructive pulmonary disease | COPD | HOSPITAL MORTALITY | SURVIVAL | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | RESECTION | BRONCHOGENIC-CARCINOMA | RISK | IMPACT | RESPIRATORY SYSTEM | BODY-MASS INDEX | COMPLICATIONS | OUTCOMES | Multivariate Analysis | Postoperative Complications - etiology | Pneumonectomy - mortality | Lung Neoplasms - mortality | Humans | Middle Aged | Respiratory Insufficiency - etiology | Male | Postoperative Complications - mortality | Patient Selection | Time Factors | Aged, 80 and over | Adult | Female | Obesity - diagnosis | Retrospective Studies | Obesity - mortality | Odds Ratio | Heart Failure - etiology | Wisconsin | Body Mass Index | Length of Stay | Pneumonectomy - adverse effects | Risk Assessment | Obesity - complications | Risk Factors | Logistic Models | Postoperative Complications - therapy | Treatment Outcome | Postoperative Complications - diagnosis | Lung Neoplasms - complications | Pulmonary Embolism - etiology | Atrial Fibrillation - etiology | Lung Neoplasms - surgery | Aged | Obesity | Medical colleges | Cancer patients | Lung cancer | Surgery | Mortality | Health aspects | Lung Cancer | Peri-operative morbidities
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2007, Volume 46, Issue 5, pp. 855 - 863
Objectives Technical proficiency in carotid artery stent (CAS) procedures is paramount to ensure patient safety. If virtual reality (VR) simulation is to be...
Surgery | SURGICAL SIMULATION | SURGERY | ANGIOGRAPHY | TRAINING-PROGRAM | PERFORMANCE | SKILLS | COMPUTER-SIMULATION | PERIPHERAL VASCULAR DISEASE | COMPETENCE | IDENTIFICATION | SURGEONS | ENDARTERECTOMY | Clinical Competence | User-Computer Interface | Radiography, Interventional | Computer Simulation | Humans | Cardiology | Stents | Task Performance and Analysis | Angioplasty, Balloon - education | Stent (Surgery)
Surgery | SURGICAL SIMULATION | SURGERY | ANGIOGRAPHY | TRAINING-PROGRAM | PERFORMANCE | SKILLS | COMPUTER-SIMULATION | PERIPHERAL VASCULAR DISEASE | COMPETENCE | IDENTIFICATION | SURGEONS | ENDARTERECTOMY | Clinical Competence | User-Computer Interface | Radiography, Interventional | Computer Simulation | Humans | Cardiology | Stents | Task Performance and Analysis | Angioplasty, Balloon - education | Stent (Surgery)
Journal Article
American Journal of Otolaryngology--Head and Neck Medicine and Surgery, ISSN 0196-0709, 2012, Volume 33, Issue 3, pp. 349 - 351
Abstract Current treatment of severe epistaxis in patients with hereditary hemorrhagic telangiectasia is not durable in reducing the frequency and severity of...
Otolaryngology | Surgery | OTORHINOLARYNGOLOGY | EPISTAXIS | ENDOTHELIAL GROWTH-FACTOR | Follow-Up Studies | Humans | Middle Aged | Telangiectasia, Hereditary Hemorrhagic - blood | Telangiectasia, Hereditary Hemorrhagic - drug therapy | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Administration, Intranasal | Bevacizumab | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Telangiectasia, Hereditary Hemorrhagic - diagnosis | Antibodies, Monoclonal, Humanized - administration & dosage | Platelet Count | Female | Infusions, Intravenous | Antimitotic agents | Telangiectasis | Angiogenesis inhibitors | Antineoplastic agents | Financial disclosure | Studies | Angiogenesis | Chemotherapy | Medical treatment | Vascular endothelial growth factor | Blood | Cost control
Otolaryngology | Surgery | OTORHINOLARYNGOLOGY | EPISTAXIS | ENDOTHELIAL GROWTH-FACTOR | Follow-Up Studies | Humans | Middle Aged | Telangiectasia, Hereditary Hemorrhagic - blood | Telangiectasia, Hereditary Hemorrhagic - drug therapy | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Administration, Intranasal | Bevacizumab | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Telangiectasia, Hereditary Hemorrhagic - diagnosis | Antibodies, Monoclonal, Humanized - administration & dosage | Platelet Count | Female | Infusions, Intravenous | Antimitotic agents | Telangiectasis | Angiogenesis inhibitors | Antineoplastic agents | Financial disclosure | Studies | Angiogenesis | Chemotherapy | Medical treatment | Vascular endothelial growth factor | Blood | Cost control
Journal Article
Ophthalmology, ISSN 0161-6420, 2015, Volume 122, Issue 9, pp. 1846 - 1853.e5
Purpose To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison...
Ophthalmology | OPHTHALMOLOGY | PHOTORECEPTOR LAYER | RISK | VISUAL-ACUITY LOSS | RANIBIZUMAB | Antibodies, Monoclonal, Humanized - therapeutic use | Prospective Studies | Intravitreal Injections | Tomography, Optical Coherence | Humans | Middle Aged | Geographic Atrophy - physiopathology | Cicatrix - diagnosis | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Bevacizumab | Retinal Pigment Epithelium | Wet Macular Degeneration - drug therapy | Ranibizumab | Angiogenesis Inhibitors - therapeutic use | Retina - pathology | Visual Acuity - physiology | Fluorescein Angiography | Macular degeneration | Clinical trials | Physiological aspects | Comparative analysis | Drug therapy
Ophthalmology | OPHTHALMOLOGY | PHOTORECEPTOR LAYER | RISK | VISUAL-ACUITY LOSS | RANIBIZUMAB | Antibodies, Monoclonal, Humanized - therapeutic use | Prospective Studies | Intravitreal Injections | Tomography, Optical Coherence | Humans | Middle Aged | Geographic Atrophy - physiopathology | Cicatrix - diagnosis | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Bevacizumab | Retinal Pigment Epithelium | Wet Macular Degeneration - drug therapy | Ranibizumab | Angiogenesis Inhibitors - therapeutic use | Retina - pathology | Visual Acuity - physiology | Fluorescein Angiography | Macular degeneration | Clinical trials | Physiological aspects | Comparative analysis | Drug therapy
Journal Article
Ophthalmology, ISSN 0161-6420, 2015, Volume 122, Issue 2, pp. 391 - 398.e5
Objective To compare baseline characteristics, treatment frequency, visual acuity (VA), and morphologic outcomes of eyes with >50% of the lesion composed of...
Ophthalmology | INTRAVITREAL RANIBIZUMAB | TISSUE-PLASMINOGEN ACTIVATOR | SUBRETINAL HEMORRHAGE | BEVACIZUMAB | PIGMENT EPITHELIAL TEARS | OPHTHALMOLOGY | LARGE SUBMACULAR HEMORRHAGE | CHOROIDAL NEOVASCULAR LESIONS | PNEUMATIC DISPLACEMENT | NATURAL-HISTORY | ENDOTHELIAL GROWTH-FACTOR | Choroidal Neovascularization - diagnosis | Prospective Studies | Follow-Up Studies | Intravitreal Injections | Humans | Male | Wet Macular Degeneration - physiopathology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Bevacizumab | Angiogenesis Inhibitors - administration & dosage | Retinal Hemorrhage - diagnosis | Antibodies, Monoclonal, Humanized - administration & dosage | Choroidal Neovascularization - drug therapy | Ranibizumab | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Female | Visual Acuity - physiology | Fluorescein Angiography | Retinal Hemorrhage - physiopathology | Antibodies, Monoclonal, Humanized - therapeutic use | Tomography, Optical Coherence | Treatment Outcome | Choroidal Neovascularization - physiopathology | Wet Macular Degeneration - diagnosis | Wet Macular Degeneration - drug therapy | Aged | Retinal Hemorrhage - drug therapy | Cohort Studies | Macular degeneration | Clinical trials | Physiological aspects | Comparative analysis | Drug therapy
Ophthalmology | INTRAVITREAL RANIBIZUMAB | TISSUE-PLASMINOGEN ACTIVATOR | SUBRETINAL HEMORRHAGE | BEVACIZUMAB | PIGMENT EPITHELIAL TEARS | OPHTHALMOLOGY | LARGE SUBMACULAR HEMORRHAGE | CHOROIDAL NEOVASCULAR LESIONS | PNEUMATIC DISPLACEMENT | NATURAL-HISTORY | ENDOTHELIAL GROWTH-FACTOR | Choroidal Neovascularization - diagnosis | Prospective Studies | Follow-Up Studies | Intravitreal Injections | Humans | Male | Wet Macular Degeneration - physiopathology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Bevacizumab | Angiogenesis Inhibitors - administration & dosage | Retinal Hemorrhage - diagnosis | Antibodies, Monoclonal, Humanized - administration & dosage | Choroidal Neovascularization - drug therapy | Ranibizumab | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Female | Visual Acuity - physiology | Fluorescein Angiography | Retinal Hemorrhage - physiopathology | Antibodies, Monoclonal, Humanized - therapeutic use | Tomography, Optical Coherence | Treatment Outcome | Choroidal Neovascularization - physiopathology | Wet Macular Degeneration - diagnosis | Wet Macular Degeneration - drug therapy | Aged | Retinal Hemorrhage - drug therapy | Cohort Studies | Macular degeneration | Clinical trials | Physiological aspects | Comparative analysis | Drug therapy
Journal Article
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 4, pp. 371 - 384
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we...
BUCCAL CELLS | GENETIC-VARIATION | COMMON VARIANTS | TERT-CLPTM1L LOCUS | REVERSE-TRANSCRIPTASE | SEQUENCE | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | POLYMORPHISM | FIBROBLASTS | GENOME-WIDE ASSOCIATION | Breast cancer | Genetic aspects | Research | Single nucleotide polymorphisms | Risk factors | Ovarian cancer | Genetics | Mutation | Cà ncer de mama | Cà ncer d'ovari | Telòmer | Telomere | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
BUCCAL CELLS | GENETIC-VARIATION | COMMON VARIANTS | TERT-CLPTM1L LOCUS | REVERSE-TRANSCRIPTASE | SEQUENCE | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | POLYMORPHISM | FIBROBLASTS | GENOME-WIDE ASSOCIATION | Breast cancer | Genetic aspects | Research | Single nucleotide polymorphisms | Risk factors | Ovarian cancer | Genetics | Mutation | Cà ncer de mama | Cà ncer d'ovari | Telòmer | Telomere | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Journal of Vascular and Interventional Radiology, ISSN 1051-0443, 2015, Volume 26, Issue 7, pp. 1088 - 1090
Radiology | PERIPHERAL VASCULAR DISEASE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Femoral Neoplasms - chemistry | Immunohistochemistry | Device Removal | Bone Nails | Neoplastic Cells, Circulating - pathology | Biomarkers, Tumor - analysis | Humans | Middle Aged | Embolism, Fat - etiology | Neoplastic Cells, Circulating - chemistry | Treatment Outcome | Vena Cava Filters | Phlebography | Femoral Neoplasms - secondary | Time Factors | Biopsy | Bone Marrow - pathology | Embolism, Fat - prevention & control | Female | Embolism, Fat - pathology | Femoral Neoplasms - surgery | Fracture Fixation, Intramedullary - instrumentation | Fracture Fixation, Intramedullary - adverse effects | Femoral Neoplasms - diagnostic imaging
Journal Article
European Journal of Vascular & Endovascular Surgery, ISSN 1078-5884, 2019, Volume 58, Issue 3, pp. 446 - 454
BackgroundClosed incision negative pressure wound therapy (CiNPT) may be a valuable treatment option for surgical site infections. This systematic review and...
Surgery | Surgical site infections | Vascular surgery | Closed incision negative pressure wound therapy | SURGERY | SURGICAL SITE INFECTION | ARTERIAL RECONSTRUCTION | PREVENTION | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | PATIENT | Care and treatment | Analysis | Online searching | Internet/Web search services | Database searching | Health aspects | Wounds and injuries
Surgery | Surgical site infections | Vascular surgery | Closed incision negative pressure wound therapy | SURGERY | SURGICAL SITE INFECTION | ARTERIAL RECONSTRUCTION | PREVENTION | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | PATIENT | Care and treatment | Analysis | Online searching | Internet/Web search services | Database searching | Health aspects | Wounds and injuries
Journal Article