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PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, pp. e51771 - e51771
This study aimed to explore the influence of SLC22A1, PXR, ABCG2, ABCB1 and CYP3A5 3 genetic polymorphisms on imatinib mesylate (IM) pharmacokinetics in Asian... 
Haplotypes | Piperazines - administration & dosage | Benzamides - pharmacokinetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Organic Cation Transporter 1 - genetics | Young Adult | Benzamides - administration & dosage | Benzamides - therapeutic use | Adult | Female | Antineoplastic Agents - pharmacokinetics | Piperazines - pharmacokinetics | Protein Kinase Inhibitors - pharmacokinetics | Pharmacogenetics | Pyrimidines - administration & dosage | Treatment Outcome | Piperazines - therapeutic use | Imatinib Mesylate | Linkage Disequilibrium | Protein Kinase Inhibitors - administration & dosage | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Adolescent | Malaysia - ethnology | Pyrimidines - pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B | Aged | Polymorphism, Single Nucleotide | Antimitotic agents | Medical research | Analysis | Medicine, Experimental | Genetic aspects | Chronic myeloid leukemia | Antineoplastic agents | Genetic polymorphisms | Enzymes | Imatinib | Statistical analysis | Laboratories | Myeloid leukemia | Leukemia | Genes | Pharmacology | Statistical tests | Kinases | Patients | Minority & ethnic groups | Studies | Statistical models | Interferon | Pharmacokinetics | Drug dosages | Cancer | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 521 - 528
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven malignancies, including chronic myeloid leukemia (CML) and... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GEFITINIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | EYE DISEASES | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | CELL LUNG-CANCER | FACTOR RECEPTOR EGFR | GROWTH | ACTIVATING MUTATIONS | MUTANT EGFR | Enzyme-Linked Immunosorbent Assay - methods | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Follow-Up Studies | Apoptosis - drug effects | Humans | Middle Aged | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Male | BH3 Interacting Domain Death Agonist Protein - genetics | Dose-Response Relationship, Drug | Protein Isoforms - metabolism | Transfection | Bcl-2-Like Protein 11 | Statistics, Nonparametric | Aged, 80 and over | Apoptosis Regulatory Proteins - genetics | Adult | Female | Gene Expression Regulation, Neoplastic - drug effects | Lung Neoplasms - genetics | Annexins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | Gene Frequency | Exons - genetics | Genotype | Proto-Oncogene Proteins - genetics | International Cooperation | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Polymorphism, Genetic - genetics | Aged | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Cohort Studies | Drug Resistance, Neoplasm - drug effects | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Sequence Deletion - genetics | Antimitotic agents | Physiological aspects | Protein tyrosine kinase | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Tumor proteins | Genetic polymorphisms | Inhibitor drugs | Mutation | Kinases | Gene expression | Apoptosis | Polymorphism | Index Medicus
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 9, pp. 1240 - 1247
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2017, Volume 23, Issue 10, pp. 1167 - 1175
Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs), although there are no established biomarkers for predicting response.... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEAD | GEFITINIB | SOLUBLE EGFR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | NECK-CANCER | CHEMOTHERAPY | CELL BIOLOGY | LUNG-CANCER | RECURRENT | EXPRESSION | ERLOTINIB | Cell Proliferation | Mouth Neoplasms - drug therapy | RNA Isoforms | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | ErbB Receptors - genetics | Male | Molecular Targeted Therapy | Gene Knockdown Techniques | RNA Splicing | Squamous Cell Carcinoma of Head and Neck | Aged, 80 and over | Adult | Female | Gefitinib | Mouth Neoplasms - genetics | Esophageal Squamous Cell Carcinoma | Head and Neck Neoplasms - drug therapy | RNA, Long Noncoding - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Carcinoma, Squamous Cell - drug therapy | Esophageal Neoplasms - genetics | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Head and Neck Neoplasms - genetics | Aged | In Vitro Techniques | Esophageal Neoplasms - drug therapy | Development and progression | Squamous cell carcinoma | Care and treatment | Genetic aspects | Gene expression | Health aspects | Clinical trials | Epidermal growth factor | Xenografts | Head and neck | Bioindicators | Mathematical models | Neck | Protein-tyrosine kinase | Genotypes | Tyrosine | Medical research | Head | Splicing | Epidermal growth factor receptors | Neurons | Cultures | Shrinkage | Ribonucleic acid--RNA | Patients | Cells | Sensitivity | Addiction | Biomarkers | Mutation | Cancer | Index Medicus
Journal Article
Current Drug Metabolism, ISSN 1389-2002, 01/2010, Volume 11, Issue 1, pp. 115 - 128
Journal Article
Cancer Epidemiology Biomarkers & Prevention, ISSN 1055-9965, 09/2005, Volume 14, Issue 9, pp. 2245 - 2252
Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial. We... 
cancer | polymorphism | mRNA | codon 72 | p53 | BREAST-CANCER | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | GENE | VARIANTS | ONCOLOGY | ALLELIC EXPRESSION | Genes, p53 | Breast Neoplasms - genetics | Codon | Ethnic Groups | China | Humans | Poland | Female | Gene Expression Profiling | Breast Neoplasms - ethnology | Case-Control Studies | Polymorphism, Genetic | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0154316 - e0154316
Journal Article
Schizophrenia Bulletin, ISSN 0586-7614, 04/2018, Volume 44, Issue suppl_1, pp. S309 - S309
Abstract Background Clozapine has specific indication for use in Treatment Resistant Schizophrenia (TRS) with guidelines for therapeutic drug monitoring.... 
Abstracts
Journal Article
by Aung, T and Ozaki, M and Lee, M.C and Schlotzer-Schrehardt, U and Thorleifsson, G and Mizoguchi, T and Igo, R.P., Jr and Haripriya, A and Williams, S.E and Astakhov, Y.S and Orr, A.C and Burdon, K.P and Nakano, S and Mori, K and Abu-Amero, K and Hauser, M and Li, Z and Prakadeeswari, G and Bailey, J.N and Cherecheanu, A.P and Kang, J.H and Nelson, S and Hayashi, K and Manabe, S.I and Kazama, S and Zarnowski, T and Inoue, K and Irkec, M and Coca-Prados, M and Sugiyama, K and Jarvela, I and Schlottmann, P and Lerner, S.F and Lamari, H and Nilgun, Y and Bikbov, M and Park, K.H and Cha, S.C and Yamashiro, K and Zenteno, J.C and Jonas, J.B and Kumar, R.S.S and Perera, S.A and Chan, A.S.Y and Kobakhidze, N and George, R and Vijaya, L and Do, T and Edward, D.P and Juan Marcos, L. de and Pakravan, M and Moghimi, S and Ideta, R and Bach-Holm, D and Kappelgaard, P and Wirostko, B and Thomas, S and Gaston, D and Bedard, K and Greer, W.L and Yang, Z and Chen, X and Huang, L and Sang, J and Jia, H and Jia, L and Qiao, C and Zhang, H and Liu, X and Zhao, B and Wang, Y.X and Xu, L and Leruez, S and Reynier, P and Chichua, G and Tabagari, S and Uebe, S and Zenkel, M and Berner, D and Mossbock, G and Weisschuh, N and Hoja, U and Welge-Luessen, U.C and Mardin, C and Founti, P and Chatzikyriakidou, A and Pappas, T and Anastasopoulos, E and Lambropoulos, A and Ghosh, A and Shetty, R and Porporato, N and Saravanan, V and Venkatesh, R and Shivkumar, C and Kalpana, N and Sarangapani, S and Kanavi, M.R and Beni, A.N and Yazdani, S and ...
Nature Genetics, ISSN 1061-4036, 2017, Volume 49, Issue 7, pp. 993 - 1004
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1... 
INDIVIDUALS | RISK LOCI | PSEUDOEXFOLIATION SYNDROME | INFLAMMATORY-BOWEL-DISEASE | METAANALYSIS | POLYMORPHISMS | COMMON SEQUENCE VARIANTS | GENETICS & HEREDITY | GLAUCOMA | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | Haplotypes | Humans | Asian Continental Ancestry Group - genetics | Extracellular Matrix - metabolism | Male | Gene Expression Profiling | Mutation, Missense | Amino Acid Oxidoreductases - genetics | Exfoliation Syndrome - ethnology | RNA, Messenger - biosynthesis | Aged, 80 and over | Female | Spheroids, Cellular | Calcium Channels - genetics | Molecular Chaperones - biosynthesis | Eye - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Amino Acid Oxidoreductases - physiology | Molecular Chaperones - genetics | Cell Adhesion | Point Mutation | Alleles | Exfoliation Syndrome - genetics | Amino Acid Substitution | Exfoliatins | Disease susceptibility | Genetic aspects | Analysis | Risk factors | Glaucoma | Genes | Principal components analysis | Cardiovascular disease | Genomes | Biology | Loci | Exfoliation | Studies | Collaboration | Blindness | Alzheimers disease | Index Medicus | Life Sciences | Populations and Evolution | Microbiology and Parasitology | Parasitology | Quantitative Methods | Computer Science | Genetics | Santé publique et épidémiologie | Bioinformatics | Human genetics | Virology
Journal Article