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methylation (3) 3
mutation - genetics (3) 3
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chromosome aberrations (2) 2
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dna copy number variations - genetics (2) 2
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by Waddell, Nicola and Pajic, Marina and Patch, Ann-Marie and Chang, David K and Kassahn, Karin S and Bailey, Peter and Johns, Amber L and Miller, David and Nones, Katia and Quek, Kelly and Quinn, Michael C. J and Robertson, Alan J and Fadlullah, Muhammad Z. H and Bruxner, Tim J. C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wani, Shivangi and Wilson, Peter J and Markham, Emma and Cloonan, Nicole and Anderson, Matthew J and Fink, J. Lynn and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Newell, Felicity and Poudel, Barsha and Song, Sarah and Taylor, Darrin and Waddell, Nick and Wood, Scott and Xu, Qinying and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Lee, Hong C and Jones, Marc D and Nagrial, Adnan M and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Steinmann, Angela M and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Pettitt, Jessica A and Merrett, Neil D and Toon, Christopher and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Jamieson, Nigel B and Graham, Janet S and Niclou, Simone P and Bjerkvig, Rolf and Grützmann, Robert and Aust, Daniela and Hruban, Ralph H and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Falconi, Massimo and Zamboni, Giuseppe and Tortora, Giampaolo and Tempero, Margaret A and Gill, Anthony J and Eshleman, James R and Pilarsky, Christian and Scarpa, Aldo and Musgrove, Elizabeth A and Pearson, John V and Biankin, Andrew V and Grimmond, Sean M and Australian Pancreatic Cancer Genome Initiative and Australian Pancreatic Canc Genome
Nature (London), ISSN 1476-4687, 2015, Volume 518, Issue 7540, pp. 495 - 501
Journal Article
by Bailey, Peter and Chang, David K and Nones, Katia and Johns, Amber L and Patch, Ann-Marie and Gingras, Marie-Claude and Miller, David K and Christ, Angelika N and Bruxner, Tim J. C and Quinn, Michael C and Nourse, Craig and Murtaugh, L. Charles and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourbakhsh, Ehsan and Wani, Shivangi and Fink, Lynn and Holmes, Oliver and Chin, Venessa and Anderson, Matthew J and Kazakoff, Stephen and Leonard, Conrad and Newell, Felicity and Waddell, Nick and Wood, Scott and Xu, Qinying and Wilson, Peter J and Cloonan, Nicole and Kassahn, Karin S and Taylor, Darrin and Quek, Kelly and Robertson, Alan and Pantano, Lorena and Mincarelli, Laura and Sanchez, Luis N and Evers, Lisa and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Jones, Marc D and Colvin, Emily K and Nagrial, Adnan M and Humphrey, Emily S and Chantrill, Lorraine A and Mawson, Amanda and Humphris, Jeremy and Chou, Angela and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Lovell, Jessica A and Merrett, Neil D and Toon, Christopher W and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Moran-Jones, Kim and Jamieson, Nigel B and Graham, Janet S and Duthie, Fraser and Oien, Karin and Hair, Jane and Grützmann, Robert and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Rusev, Borislav and Capelli, Paola and Salvia, Roberto and Tortora, Giampaolo and Mukhopadhyay, Debabrata and Petersen, Gloria M and Munzy, Donna M and Fisher, William E and Karim, Saadia A and Eshleman, James R and Hruban, Ralph H and Pilarsky, Christian and Morton, Jennifer P and Sansom, Owen J and Scarpa, Aldo and Musgrove, Elizabeth A and Bailey, Ulla-Maja Hagbo and Hofmann, Oliver and Sutherland, Robert L and Wheeler, David A and Gill, Anthony J and Gibbs, Richard A and Pearson, John V and Waddell, Nicola and ... and Australian Pancreatic Cancer Genome Initiative and Australian Pancreatic Canc Genome
Nature (London), ISSN 1476-4687, 2016, Volume 531, Issue 7592, pp. 47 - 52
... (ADEX) that correlate with histopathological characteristics. Squamous tumours are enriched for TP53 and KDM6A mutations, upregulation of the TP63 Delta N... 
PATHWAYS | METASTASIS | DUCTAL ADENOCARCINOMA | PACKAGE | MULTIDISCIPLINARY SCIENCES | TUMOR | MUTATIONS | DIFFERENTIATION | Pancreatic Neoplasms - metabolism | Prognosis | Hepatocyte Nuclear Factor 3-beta - genetics | Genomics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Hepatocyte Nuclear Factor 3-gamma - genetics | Gene Regulatory Networks | Histone Demethylases - genetics | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | DNA Methylation | Tumor Suppressor Proteins - genetics | Carcinoma, Pancreatic Ductal - classification | Trans-Activators - genetics | Pancreatic Neoplasms - classification | Transcription, Genetic | Nuclear Proteins - genetics | Carcinoma, Pancreatic Ductal - immunology | Genes, Neoplasm - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Pancreatic Neoplasms - pathology | Zebrafish Proteins | Pancreatic Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Genome, Human - genetics | Homeodomain Proteins - genetics | Animals | Pancreatic Neoplasms - immunology | Survival Analysis | Cell Line, Tumor | Mice | Physiological aspects | Pancreatic cancer | Methods | Genes | Genomes | Mutation | Gene expression | Tumors
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5224
Journal Article
International journal of cancer, ISSN 0020-7136, 2014, Volume 135, Issue 5, pp. 1110 - 1118
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define the genome‐wide pattern of DNA... 
SLIT‐ROBO pathway | stellate cell activation | pancreatic cancer | axon‐guidance | methylation | SLIT-ROBO pathway | axon-guidance | ACTIVATION | HYPERMETHYLATION | MICROARRAY | CANCER | DISCOVERY | CDC42 | PATHWAY GENES | ONCOLOGY | TARGETS | R-PACKAGE | Epigenesis, Genetic | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Pancreatic Ducts - pathology | Integrins - metabolism | Promoter Regions, Genetic - genetics | Carcinoma, Pancreatic Ductal - genetics | RNA, Messenger - biosynthesis | DNA Methylation | Wnt Proteins - genetics | Base Sequence | Aged, 80 and over | Adult | Female | Pancreatic Stellate Cells - pathology | Cell Adhesion - genetics | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Pancreatic Neoplasms - genetics | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Proto-Oncogene Proteins c-met - genetics | Transforming Growth Factor beta - genetics | Integrin alpha2 - genetics | Aged | Receptors, Immunologic - genetics | Epigenetic inheritance | RNA | Genomics | Genomes | Gene expression | Promoters (Genetics) | Analysis | Pancreatic cancer | DNA | Genetic research | Bone morphogenetic proteins | Genetic aspects | Methylation | Integrins | Cancer | DNA methylation | Epigenetics | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal Article
by Biankin, Andrew V and Waddell, Nicola and Kassahn, Karin S and Gingras, Marie-Claude and Muthuswamy, Lakshmi B and Johns, Amber L and Miller, David K and Wilson, Peter J and Patch, Ann-Marie and Wu, Jianmin and Chang, David K and Cowley, Mark J and Gardiner, Brooke B and Song, Sarah and Harliwong, Ivon and Idrisoglu, Senel and Nourse, Craig and Nourbakhsh, Ehsan and Manning, Suzanne and Wani, Shivangi and Gongora, Milena and Pajic, Marina and Scarlett, Christopher J and Gill, Anthony J and Pinho, Andreia V and Rooman, Ilse and Anderson, Matthew and Holmes, Oliver and Leonard, Conrad and Taylor, Darrin and Wood, Scott and Xu, Qinying and Nones, Katia and Lynn Fink, J and Christ, Angelika and Bruxner, Tim and Cloonan, Nicole and Kolle, Gabriel and Newell, Felicity and Pinese, Mark and Scott Mead, R and Humphris, Jeremy L and Kaplan, Warren and Jones, Marc D and Colvin, Emily K and Nagrial, Adnan M and Humphrey, Emily S and Chou, Angela and Chin, Venessa T and Chantrill, Lorraine A and Mawson, Amanda and Samra, Jaswinder S and Kench, James G and Lovell, Jessica A and Daly, Roger J and Merrett, Neil D and Toon, Christopher and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Kakkar, Nipun and Zhao, Fengmei and Qing Wu, Yuan and Wang, Min and Muzny, Donna M and Fisher, William E and Charles Brunicardi, F and Hodges, Sally E and Reid, Jeffrey G and Drummond, Jennifer and Chang, Kyle and Han, Yi and Lewis, Lora R and Dinh, Huyen and Buhay, Christian J and Beck, Timothy and Timms, Lee and Sam, Michelle and Begley, Kimberly and Brown, Andrew and Pai, Deepa and Panchal, Ami and Buchner, Nicholas and De Borja, Richard and Denroche, Robert E and Yung, Christina K and Serra, Stefano and Onetto, Nicole and Mukhopadhyay, Debabrata and Tsao, Ming-Sound and Shaw, Patricia A and Petersen, Gloria M and Gallinger, Steven and Hruban, Ralph H and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Schulick, Richard D and Wolfgang, Christopher L and Morgan, Richard A and ... and Australian Pancreatic Cancer Genome Initiative and Australian Pancreatic Canc Genome
Nature (London), ISSN 1476-4687, 2012, Volume 491, Issue 7424, pp. 399 - 405
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n=142) of early (stage I and II... 
INVASIVE GROWTH | INSTABILITY | DUCTAL ADENOCARCINOMA | RESECTION | MULTIDISCIPLINARY SCIENCES | TUMOR | EXPRESSION | SOMATIC MUTATIONS | Signal Transduction | Humans | Pancreatic Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Genome - genetics | Kaplan-Meier Estimate | Axons - metabolism | Pancreatic Neoplasms - genetics | Gene Dosage | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - genetics | Proteins - genetics | Animals | Mice | Mutation | Index Medicus
Journal Article
by Patch, Ann-Marie and Christie, Elizabeth L and Etemadmoghadam, Dariush and Garsed, Dale W and George, Joshy and Fereday, Sian and Nones, Katia and Cowin, Prue and Alsop, Kathryn and Bailey, Peter J and Kassahn, Karin S and Newell, Felicity and Quinn, Michael C. J and Kazakoff, Stephen and Quek, Kelly and Wilhelm-Benartzi, Charlotte and Curry, Ed and Leong, Huei San and Hamilton, Anne and Mileshkin, Linda and Au-Yeung, George and Kennedy, Catherine and Hung, Jillian and Chiew, Yoke-Eng and Harnett, Paul and Friedlander, Michael and Quinn, Michael and Pyman, Jan and Cordner, Stephen and O’Brien, Patricia and Leditschke, Jodie and Young, Greg and Strachan, Kate and Waring, Paul and Azar, Walid and Mitchell, Chris and Traficante, Nadia and Hendley, Joy and Thorne, Heather and Shackleton, Mark and Miller, David K and Arnau, Gisela Mir and Tothill, Richard W and Holloway, Timothy P and Semple, Timothy and Harliwong, Ivon and Nourse, Craig and Nourbakhsh, Ehsan and Manning, Suzanne and Idrisoglu, Senel and Bruxner, Timothy J. C and Christ, Angelika N and Poudel, Barsha and Holmes, Oliver and Anderson, Matthew and Leonard, Conrad and Lonie, Andrew and Hall, Nathan and Wood, Scott and Taylor, Darrin F and Xu, Qinying and Fink, J. Lynn and Waddell, Nick and Drapkin, Ronny and Stronach, Euan and Gabra, Hani and Brown, Robert and Jewell, Andrea and Nagaraj, Shivashankar H and Markham, Emma and Wilson, Peter J and Ellul, Jason and McNally, Orla and Doyle, Maria A and Vedururu, Ravikiran and Stewart, Collin and Lengyel, Ernst and Pearson, John V and Waddell, Nicola and deFazio, Anna and Grimmond, Sean M and Bowtell, David D. L and The Australian Ovarian Cancer Study Group and Australian Ovarian Canc Study Grp and Australian Ovarian Cancer Study Group
Nature (London), ISSN 1476-4687, 2015, Volume 521, Issue 7553, pp. 489 - 494
Journal Article