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Chemistry – A European Journal, ISSN 0947-6539, 12/2017, Volume 23, Issue 72, pp. 18090 - 18090
Direct C−H difluoromethylation of electron‐deficient positions in nitrogen‐containing heterocycles is attained by difluoromethyl radicals generated in‐situ... 
difluoroacetic acid | difluoromethylation | drug discovery | radicals | fluorine | Silver | Acids | Heterocyclic compounds | Decarboxylation
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 12/2017, Volume 23, Issue 72, pp. 18125 - 18128
A technically simple procedure for direct C−H difluoromethylation of heteroaromatic compounds using off‐the‐shelf difluoroacetic acid as the... 
difluoroacetic acid | difluoromethylation | drug discovery | radicals | fluorine | CHEMISTRY, MULTIDISCIPLINARY | Chemical tests and reagents | Fluorides | Drug discovery | Acids | Heterocyclic compounds | Chemical compounds
Journal Article
BMC Evolutionary Biology, ISSN 1471-2148, 2012, Volume 12, Issue 1, pp. 182 - 182
Journal Article
Plant Physiology, ISSN 0032-0889, 5/2017, Volume 174, Issue 1, pp. 56 - 72
Journal Article
Journal of Natural Products, ISSN 0163-3864, 09/2018, Volume 81, Issue 9, pp. 2134 - 2137
An alternative procedure for isolation of 4β-phorbol from seeds of Croton tiglium has been developed, and an artifact containing a furan ring formed by... 
PHARMACOLOGY & PHARMACY | PROTEIN-KINASE-C | CHEMISTRY, MEDICINAL | CROTON-OIL | ESTERS | PLANT SCIENCES | Phorbols - isolation & purification | Phorbols - chemistry | Seeds - chemistry | Croton - chemistry
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 48, pp. 19656 - 19673
Calcium (Ca2+) is a fundamental regulator of cell signaling and function. Thapsigargin (Tg) blocks the sarco/endoplasmic reticulum (ER) Ca2+-ATPase (SERCA),... 
calcium | CANCER CELLS | CALPAIN | unfolded protein response (UPR) | PROSTATE-SPECIFIC ANTIGEN | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | SARCOPLASMIC-RETICULUM | INACTIVATION | stromal interaction molecule 1 (STIM1) | PRODRUG | endoplasmic reticulum (ER) | CALCIUM-PUMP | STRESS | Cell Biology
Journal Article
Journal Article
Natural Product Research, ISSN 1478-6419, 04/2019, Volume 33, Issue 8, pp. 1135 - 1139
Journal Article
Steroids, ISSN 0039-128X, 05/2015, Volume 97, pp. 2 - 7
•We review isolation and structural elucidation of thapsigargin.•We review medicinal chemistry of thapsigargin.•We review the effect of thapsigargin on the... 
Thapsigargin | Prodrug | Sarco/endoplasmic reticulum (SERCA) | Targeting drugs | Prostate specific antigen (PSA) | Prostate specific membrane antigen (PSMA) | ANALOGS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCOPLASMIC-RETICULUM | TRILOBOLIDE | CA2+-ATPASE | PROSTATE-CANCER CELLS | CALCIUM | ENDOCRINOLOGY & METABOLISM | BINDING-SITE | LIBERATING SESQUITERPENE LACTONES | THAPSIA-GARGANICA L | Apoptosis - drug effects | Humans | Soft Tissue Neoplasms - drug therapy | Male | Prodrugs - isolation & purification | Prodrugs - chemistry | Neovascularization, Pathologic - pathology | Enzyme Inhibitors - chemistry | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Apiaceae - chemistry | Molecular Structure | Prostatic Neoplasms - drug therapy | Thapsigargin - chemistry | Prostatic Neoplasms - pathology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Enzyme Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Enzyme Inhibitors - isolation & purification | Thapsigargin - isolation & purification | Animals | Neovascularization, Pathologic - drug therapy | Soft Tissue Neoplasms - pathology | Thapsigargin - pharmacology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Prodrugs - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Tumors | endoplasmic reticulum (SERCA) | Sarco
Journal Article
Plant Physiology, ISSN 0032-0889, 5/2017, Volume 174, Issue 1, pp. 56 - 72
The secretory ducts in the root of Thapsia garganica harbor the cytotoxin thapsigargin, and the cells lining these ducts express the first enzymes in the... 
Journal Article
Frontiers in Microbiology, ISSN 1664-302X, 04/2017, Volume 8, p. 542
Journal Article