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biochemistry & molecular biology (32) 32
glycogen phosphorylase (32) 32
enzyme inhibitors - chemistry (22) 22
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ISSN 1463-9076, 4/2019, Volume 21, Issue 14, pp. 7685 - 7696
A fluorescence study of N 1 -(β- d -glucopyranosyl)- N 4 -[2-acridin-9(10 H )-onyl]-cytosine (GLAC), the first fluorescent potent inhibitor of glycogen... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2015, Volume 56, Issue 41, p. 5549
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.tetlet.2015.08.037 A... 
Type 2 diabetes | Synthesis | Glycogen | Triazoles | Analysis | Methods
Journal Article
MOLECULES, ISSN 1420-3049, 06/2019, Volume 24, Issue 12, p. 2327
In the case of type 2 diabetes, inhibitors of glycogen phosphorylase (GP) may prevent unwanted glycogenolysis under high glucose conditions and thus aim at the... 
1,6-dioxa-4-azaspiro[4,5]decane | OXIDATION | GLUCOSE ANALOG INHIBITORS | DESIGN | PYRANOSE | NUCLEOSIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | [1,5]-radical translocation | URIDINE | anomeric spironucleosides | CHEMISTRY, MULTIDISCIPLINARY | type 2 diabetes | DERIVATIVES | glycogen phosphorylase | 1,6-dioxa-4-azaspiro[4.5]decane
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2015, Volume 56, Issue 41, pp. 5549 - 5552
A number of leaving groups, including arylsulfonates, triazoles, 3-nitrotriazoles , and tetrazoles, have been studied for the substitution reaction by aryl and... 
Triazoles | N4-Aryl-β-d-glucopyranosylcytosines | Arylamines | Microwaves | Substitution reaction | Aryl-β-D-glucopyranosylcytosines
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1824, pp. 89 - 112
Modern drug discovery and design approaches rely heavily on high-throughput methods and state-of-the-art infrastructures with robotic facilities and... 
Structure-based drug design | Bioinformatics | Structural biology | X-ray protein crystallography | Crystallography, X-Ray - methods | Computational Biology - methods | Proteins - chemistry | Humans | Drug Design
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 11/2010, Volume 18, Issue 22, pp. 7911 - 7922
Glycogen phosphorylase (GP) is a promising target for the treatment of type 2 diabetes. In the process of structure based drug design for GP, a group of 15... 
Active sites
Journal Article
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, ISSN 1463-9076, 04/2019, Volume 21, Issue 14, pp. 7685 - 7696
A fluorescence study of N-1-(-d-glucopyranosyl)-N-4-[2-acridin-9(10H)-onyl]-cytosine (GLAC), the first fluorescent potent inhibitor of glycogen phosphorylase... 
DRUG | SITE | COMPLEX | FLUOROPHORES | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | SOLVATION DYNAMICS | FEMTOSECOND | BINDING | DERIVATIVES | INTRAMOLECULAR CHARGE-TRANSFER | EXCITED-STATES
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 07/2017, Volume 23, Issue 37, p. n/a
Glycogen phosphorylase (GP) plays a key role in glucose regulation. The design and synthesis of a new potent inhibitor of GP is described. By exploiting its... 
X-ray crystallography | acridone based inhibitors | quantum chemistry | optical spectra | glycogen phosphorylase | Glycogen | Synthesis | Inhibitors | Hydrogen | Optical properties | Glycogen phosphorylase | pH | Glucose | Catalysis | Basicity | Bonding | Hydrogen bonding | Phosphorylase
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2016, Volume 108, pp. 444 - 454
Glycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context of type 2 diabetes. This enzyme is responsible for the... 
Type 2 diabetes | Carbohydrates | Glycogen phosphorylase inhibitors | Hepatocytes | Hepatic glucose production | Spiro-isoxazolines | Zucker rats | CHEMISTRY, MEDICINAL | THIOHYDANTOIN | INDOLE-SITE INHIBITORS | EXO-GLYCALS | POTENTIAL ANTIDIABETIC AGENTS | IN-VIVO | 1,3-DIPOLAR CYCLOADDITION | OB/OB MICE | 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL | SUGAR-DERIVATIVES | C-GLYCOSYLMETHYLENE CARBENES | Diabetes Mellitus, Experimental - drug therapy | Diabetes Mellitus, Experimental - enzymology | Glucose - analogs & derivatives | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Isoxazoles - chemical synthesis | Dose-Response Relationship, Drug | Enzyme Inhibitors - chemistry | Spiro Compounds - chemical synthesis | Molecular Structure | Spiro Compounds - chemistry | Disease Models, Animal | Diabetes Mellitus, Type 2 - enzymology | Enzyme Inhibitors - pharmacology | Rats | Glucose - pharmacology | Hypoglycemic Agents - chemistry | Isoxazoles - chemistry | Glycogen Phosphorylase - metabolism | Hypoglycemic Agents - pharmacology | Isoxazoles - pharmacology | Rats, Zucker | Animals | Glucose - chemistry | Hypoglycemic Agents - chemical synthesis | Glycogen Phosphorylase - antagonists & inhibitors | Diabetes Mellitus, Type 2 - drug therapy | Spiro Compounds - pharmacology | Enzymes | Hyperglycemia | Synthesis | Glycogen | Analysis | Oxides | Glucose | Dextrose | Life Sciences | Organic chemistry | Biomolecules | Biochemistry, Molecular Biology | Chemical Sciences
Journal Article
Journal Article
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