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EMBO Molecular Medicine, ISSN 1757-4676, 01/2019, Volume 11, Issue 1, p. n/a
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64670
The Escherichia coli oligoribonuclease, ORN, has a 3' to 5' exonuclease activity specific for small oligomers that is essential for cell viability. The human... 
STRANDED-RNA | COMPLEX | GENE | POLYNUCLEOTIDE PHOSPHORYLASE | HUMAN-CELLS | DNA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | DEGRADATION | AUG CODONS | NUCLEOIDS | Mitochondria - enzymology | RNA, Small Interfering - genetics | Exoribonucleases - genetics | Protein Biosynthesis | 14-3-3 Proteins - antagonists & inhibitors | Humans | Mitochondrial Proteins - genetics | Mitochondria - ultrastructure | Mitochondria - genetics | Nucleic Acids - chemistry | Mitochondrial Proteins - metabolism | Biomarkers, Tumor - metabolism | Mitochondrial Membranes - enzymology | Biomarkers, Tumor - antagonists & inhibitors | 14-3-3 Proteins - genetics | Escherichia coli - enzymology | Mitochondrial Proteins - antagonists & inhibitors | Exoribonucleases - antagonists & inhibitors | 14-3-3 Proteins - metabolism | Escherichia coli - genetics | Mitochondrial Membranes - ultrastructure | Biomarkers, Tumor - genetics | HeLa Cells | Exoribonucleases - metabolism | RNA, Small Interfering - metabolism | Oligomers | Protein biosynthesis | Ribonuclease | RNA | Escherichia coli | Cells | Enzymes | Yeast | Single-stranded DNA | RNA-mediated interference | Homeostasis | Homology | Gene expression | Ribonucleic acid--RNA | Medical schools | Proteins | Mitochondria | Exonuclease | E coli | Cellular biology | Protein synthesis | Aging | Localization | Viability | Deoxyribonucleic acid--DNA | Ribonucleic acid | Deoxyribonucleic acid
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2010, Volume 430, Issue 3, pp. 551 - 558
The bacterial Ras-like protein Era has been reported previously to bind 16S rRNA within the 30S ribosomal subunit and to play a crucial role in ribosome... 
Ribosome assembly | Translation | Era G-protein-like 1 (ERAL1) | rRNA | Mitoribosome | APOPTOSIS | COMPLEX | PROTEIN | ribosome assembly | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | mitoribosome | CELL-CYCLE ARREST | HOMOLOG | DEATH | MESSENGER-RNAS | MAMMALIAN MITOCHONDRIA | translation | Cell Line | RNA-Binding Proteins - genetics | Molecular Chaperones - metabolism | Humans | Molecular Chaperones - genetics | RNA, Ribosomal - metabolism | RNA, Ribosomal, 28S - metabolism | Mitochondrial Proteins - biosynthesis | RNA Stability | GTP-Binding Proteins - genetics | RNA, Ribosomal - genetics | RNA - genetics | Blotting, Northern | RNA Interference | HeLa Cells | RNA, Ribosomal, 28S - genetics | RNA-Binding Proteins - metabolism | GTP-Binding Proteins - metabolism | RNA - metabolism | DAP3, death-associated protein 3 | KH, K homology | NT, non-targeting | UTR, untranslated region | ERAL1, Era G-protein-like 1 | RNP, ribonucleoprotein | ROS, reactive oxygen species | MEM, minimal essential medium | ICT1, immature colon carcinoma transcript 1 | CLIP, cytoplasmic linker protein | COX, cyclo-oxygenase | NDUFA9, NADH dehydrogenase (ubiquinone) 1 α subcomplex 9 | FBS, fetal bovine serum | MTND, mitochondrially encoded NADH dehydrogenase | NEAA, non-essential amino acids | IP, immunoprecipitation | NDUFB8, NADH dehydrogenase (ubiquinone) 1 β subcomplex 8 | siRNA, small interfering RNA | GDH, glutamate dehydrogenase | LSU, large subunit | MGC, mammalian gene collection | HEK-293T, HEK (human embryonic kidney)-293 cells expressing the large T-antigen of SV40 (simian virus 40) | MRP, mammalian ribosomal protein | SSU, small subunit | SD, Shine–Dalgarno | mt, mitochondrial | TFB1M, transcription factor B1, mitochondrial | HSP70, heat-shock protein 70
Journal Article
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 1/2017, Volume 40, Issue 1, pp. 121 - 130
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 01/2014, Volume 1842, Issue 1, pp. 56 - 64
Mitochondrial aminoacyl-tRNA synthetases (aaRSs) are essential enzymes in protein synthesis since they charge tRNAs with their cognate amino acids. Mutations... 
Mitochondria | Aminoacylation | Aminoacyl-tRNA synthetase | Protein synthesis | Mitochondrial disease | Mitochondrial translation | HUMAN-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRAIN-STEM | SIDEROBLASTIC ANEMIA | MISSENSE MUTATIONS | PERRAULT SYNDROME | HEARING-LOSS | LEUKOENCEPHALOPATHY | BIOPHYSICS | CAUSES MYOPATHY | LACTIC-ACIDOSIS | DNA MUTATIONS | Mitochondria - enzymology | Humans | Child, Preschool | Molecular Sequence Data | Male | RNA, Messenger - metabolism | Electron Transport Complex IV - metabolism | Myoblasts - metabolism | Mitochondria - genetics | Cyclooxygenase 2 - genetics | RNA, Transfer - genetics | Epilepsy - genetics | Cytochrome-c Oxidase Deficiency - enzymology | Amino Acyl-tRNA Synthetases - metabolism | Fibroblasts - metabolism | Amino Acyl-tRNA Synthetases - genetics | Epilepsy - enzymology | Amino Acid Sequence | Cytochrome-c Oxidase Deficiency - pathology | Cyclooxygenase 1 - genetics | Cytochrome-c Oxidase Deficiency - complications | Gene Expression | Muscle, Skeletal - enzymology | RNA, Transfer - metabolism | RNA, Messenger - genetics | Electron Transport Complex IV - genetics | Mitochondria - pathology | Myoblasts - pathology | Epilepsy - complications | Cyclooxygenase 2 - metabolism | Fibroblasts - cytology | Cyclooxygenase 1 - metabolism | Muscle, Skeletal - pathology | Mutation | Cytochrome-c Oxidase Deficiency - genetics | Epilepsy - pathology | Cytochrome c | Phenylalanine | Analysis | Epilepsy | Cytochrome oxidase | Protein biosynthesis | Genetic aspects | Aminoacyl-tRNA synthetases | Transfer RNA | Protein binding
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, pp. 12198 - 12201
The recent developments in cryo-EM have revolutionized our access to previously refractory structures. In particular, such studies of mammalian mitoribosomes... 
Mammalian mitochondria | RRNA | Mitochondrial protein synthesis | TRNA | Ribosomes | ribosomes | tRNA | rRNA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | MUTATIONS | mammalian mitochondria | LARGE SUBUNIT | DEFICIENCIES | mitochondrial protein synthesis | Physiological aspects | Mitochondria | RNA | Biological Sciences
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2015, Volume 11, Issue 6, p. e1005227
  First principles would suggest that the permanent presence in the ribosome of a protein that can hydrolyse randomly a nascent peptide from the P-site tRNA... 
GGQ | SEQUENCE | GENETICS & HEREDITY | Animals | Proteins - metabolism | Mitochondria - genetics | Humans | Peptide Chain Termination, Translational | Ribosomes - metabolism | Mitochondria - metabolism | Codon, Terminator | Proteins | Mitochondria | Mitochondrial DNA | Physiology | Mutation | Funding
Journal Article