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1. Full Text Blood-Brain barrier breakdown in the aging human hippocampus
by Montagne, Axel and Barnes, Samuel R and Sweeney, Melanie D and Halliday, Matthew R and Sagare, Abhay P and Zhao, Zhen and Toga, Arthur W and Jacobs, Russell E and Liu, Collin Y and Amezcua, Lilyana and Harrington, Michael G and Chui, Helena C and Law, Meng and Zlokovic, Berislav V
Neuron (Cambridge, Mass.), ISSN 0896-6273, 01/2015, Volume 85, Issue 2, pp. 296 - 302
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Thalamus - metabolism | Humans | Middle Aged | Male | Case-Control Studies | Cerebral Cortex - metabolism | Brain - metabolism | Young Adult | Aged, 80 and over | CA3 Region, Hippocampal - metabolism | Adult | Albumins - cerebrospinal fluid | CA1 Region, Hippocampal - metabolism | Female | Neostriatum - metabolism | Dentate Gyrus - metabolism | Cognitive Dysfunction - metabolism | Pericytes - metabolism | Permeability | Blood-Brain Barrier - metabolism | Caudate Nucleus - metabolism | Hippocampus - metabolism | Magnetic Resonance Imaging | Serum Albumin | Aged | Aging - metabolism | Brain | Alzheimer's disease | Neurophysiology | Medical colleges | Neurons | Cognitive ability | Proteins | Studies | Neurotoxicity | Brain research | Blood-brain barrier | Aging | Biomarkers | Extracellular matrix | Alzheimers disease | Age | Index Medicus | living human brain | high resolution magnetic resonance imaging | cognitive impairment | hippocampus | Blood-brain barrier breakdown
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2. Full Text Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
by Nation, Daniel A and Sweeney, Melanie D and Montagne, Axel and Sagare, Abhay P and D’Orazio, Lina M and Pachicano, Maricarmen and Sepehrband, Farshid and Nelson, Amy R and Buennagel, David P and Harrington, Michael G and Benzinger, Tammie L. S and Fagan, Anne M and Ringman, John M and Schneider, Lon S and Morris, John C and Chui, Helena C and Law, Meng and Toga, Arthur W and Zlokovic, Berislav V
Nature medicine, ISSN 1078-8956, 02/2019, Volume 25, Issue 2, pp. 270 - 276
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Biomarkers - metabolism | Blood-Brain Barrier - pathology | Humans | Amyloid beta-Peptides - cerebrospinal fluid | tau Proteins - cerebrospinal fluid | Cognitive Dysfunction - cerebrospinal fluid | Cognitive Dysfunction - pathology | Imaging, Three-Dimensional | Receptor, Platelet-Derived Growth Factor beta - cerebrospinal fluid | Neuroimaging | Care and treatment | Usage | Research | Hippocampus (Brain) | Biological markers | Alzheimer's disease | Risk factors | Brain | Platelet-derived growth factor | Abnormalities | Magnetic resonance | Cognitive ability | Membrane permeability | Blood vessels | Cerebrospinal fluid | Permeability | Blood | Magnetic resonance imaging | Blood-brain barrier | Tau protein | Magnetic permeability | Vasoactive agents | Breakdown | Biomarkers | Brain damage | Amyloid | Growth factors | Brain injury | Index Medicus
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3. Subcortical Ischemic Vascular Dementia
by Chui, Helena C
Neurologic clinics, ISSN 0733-8619, 08/2007, Volume 25, Issue 3, pp. 717 - 740
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Stroke - pathology | Stroke - prevention & control | Dementia, Vascular - prevention & control | Humans | Risk Factors | Dementia, Vascular - epidemiology | Dementia, Vascular - pathology | Stroke - epidemiology | Incidence | Practice Guidelines as Topic
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4. Full Text Psychometric Characteristics of Cognitive Reserve: How High Education Might Improve Certain Cognitive Abilities in Aging
by Rodriguez, Francisca S and Zheng, Ling and Chui, Helena C and Aging Brain Vasculature Ischemia and Aging Brain: Vasculature, Ischemia, and Behavior Study
Dementia and geriatric cognitive disorders, ISSN 1420-8008, 10/2019, Volume 47, Issue 4-6, pp. 335 - 344
Research Article | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Geriatrics & Gerontology | Science & Technology | Brain - diagnostic imaging | Prospective Studies | Humans | Aging - psychology | Male | Psychometrics | Reaction Time | Educational Status | Neuropsychological Tests | Magnetic Resonance Imaging | Aged, 80 and over | Cognition - physiology | Healthy Aging | Female | Aged | Cognitive Reserve - physiology | Memory, Short-Term | Executive Function | Longitudinal Studies | Cohort Studies | Prevention | Psychological aspects | Academic achievement | Educational aspects | Cognition in old age | Health aspects | Risk factors | Dementia | Index Medicus
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5. Full Text Subcortical ischaemic vascular dementia
by Román, Gustavo C and Erkinjuntti, Timo and Wallin, Anders and Pantoni, Leonardo and Chui, Helena C
Lancet neurology, ISSN 1474-4422, 07/2002, Volume 1, Issue 7, pp. 426 - 436
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Dementia, Vascular - physiopathology | Prevalence | Cerebrovascular Circulation - physiology | Brain - physiopathology | Humans | Risk Factors | Brain Ischemia - physiopathology | Brain Ischemia - etiology | Brain - blood supply | Cerebral Infarction - physiopathology | Nerve Fibers, Myelinated - pathology | Brain Ischemia - pathology | Dementia, Vascular - etiology | Brain - pathology | Cerebral Infarction - etiology | Dementia, Vascular - pathology | Cerebral Infarction - pathology | Hypertension | Heart failure | Sleep apnea syndromes | Vascular dementia | Dementia | Index Medicus
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6. Full Text APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline
by Montagne, Axel and Nation, Daniel A and Sagare, Abhay P and Barisano, Giuseppe and Sweeney, Melanie D and Chakhoyan, Ararat and Pachicano, Maricarmen and Joe, Elizabeth and Nelson, Amy R and D'Orazio, Lina M and Buennagel, David P and Harrington, Michael G and Benzinger, Tammie L. S and Fagan, Anne M and Ringman, John M and Schneider, Lon S and Morris, John C and Reiman, Eric M and Caselli, Richard J and Chui, Helena C and TCW, Julia and Chen, Yining and Pa, Judy and Conti, Peter S and Law, Meng and Toga, Arthur W and Zlokovic, Berislav V
Nature (London), ISSN 0028-0836, 05/2020, Volume 581, Issue 7806, pp. 70 - 76
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclophilin A - cerebrospinal fluid | Apolipoprotein E4 - genetics | Capillaries - pathology | Temporal Lobe - blood supply | Humans | Parahippocampal Gyrus - blood supply | tau Proteins - metabolism | Male | Positron-Emission Tomography | Alzheimer Disease - pathology | Matrix Metalloproteinase 9 - metabolism | Pericytes - pathology | Amyloid beta-Peptides - metabolism | Amyloid beta-Peptides - cerebrospinal fluid | Cognitive Dysfunction - genetics | Female | Cyclophilin A - metabolism | Hippocampus - blood supply | tau Proteins - cerebrospinal fluid | Cognitive Dysfunction - pathology | Receptor, Platelet-Derived Growth Factor beta - cerebrospinal fluid | Blood-Brain Barrier - pathology | Alleles | Heterozygote | Matrix Metalloproteinase 9 - cerebrospinal fluid | Alzheimer Disease - genetics | Blood-brain barrier | Abnormalities | Development and progression | Influence | Forecasts and trends | Cognition disorders | Apolipoproteins | Varieties | Diagnostic reagents industry | Disease susceptibility | Alzheimer's disease | Matrix metalloproteinases | Cognitive ability | Impairment | Cerebrospinal fluid | Matrix metalloproteinase | Neurodegeneration | Breakdown | Dementia disorders | Amyloid | Degeneration | Metalloproteinase | Apolipoprotein E4 | Temporal lobe | Vascular dementia | Neurodegenerative diseases | Therapeutic applications | Positron emission | Permeability | Pathology | Tau protein | Biomarkers | Alzheimers disease | Dementia | Index Medicus
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7. Full Text Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study
by Chen, Jiu‐Chiuan and Wang, Xinhui and Wellenius, Gregory A and Serre, Marc L and Driscoll, Ira and Casanova, Ramon and McArdle, John J and Manson, JoAnn E and Chui, Helena C and Espeland, Mark A
Annals of neurology, ISSN 0364-5134, 09/2015, Volume 78, Issue 3, pp. 466 - 476
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Prospective Studies | Follow-Up Studies | Humans | Particulate Matter - adverse effects | Air Pollution - adverse effects | Organ Size | Memory Disorders - diagnosis | Environmental Exposure - adverse effects | Memory Disorders - etiology | Women's Health - trends | Aged, 80 and over | Brain - pathology | Female | Aged | Cohort Studies | Index Medicus
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8. Full Text Clinical and imaging features of mixed Alzheimer and vascular pathologies
by Chui, Helena C and Ramirez-Gomez, Liliana
Alzheimer's research & therapy, ISSN 1758-9193, 02/2015, Volume 7, Issue 1, pp. 21 - 21
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Prevention | Advertising executives | Medical research | Brain | Care and treatment | PET imaging | Medicine, Experimental | Reports | Diagnosis | Alzheimer's disease | Risk factors | Injuries
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9. Full Text Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
by Naj, Adam C and Jun, Gyungah and Wang, Li-San and Buros, Jacqueline and Buxbaum, Joseph D and Jarvik, Gail P and Bird, Thomas D and Boeve, Bradley F and De Jager, Philip L and Schneider, Julie A and Younkin, Steven G and Kramer, Patricia and Hardy, John and Myers, Amanda J and Barmada, Michael M and Demirci, F Yesim and Baldwin, Clinton T and Green, Robert C and Rogaeva, Ekaterina and George-Hyslop, Peter St and Arnold, Steven E and Barber, Robert and Bigio, Eileen H and Bowen, James D and Boxer, Adam and Cairns, Nigel J and Carney, Regina M and Carroll, Steven L and Chui, Helena C and Corneveaux, Jason and Cotman, Carl W and Dekosky, Steven T and Dick, Malcolm and Faber, Kelley M and Ferris, Steven and Galasko, Douglas R and Ganguli, Mary and Gearing, Marla and Geschwind, Daniel H and Ghetti, Bernardino and Gilbert, John R and Giordani, Bruno and Glass, Jonathan D and Hamilton, Ronald L and Harrell, Lindy E and Head, Elizabeth and Honig, Lawrence S and Hyman, Bradley T and Jicha, Gregory A and Johnson, Nancy and Karlawish, Jason and Karydas, Anna and Kaye, Jeffrey A and Kim, Ronald and Lah, James J and Levey, Allan I and Lieberman, Andrew P and MacK, Wendy J and Marson, Daniel C and Mash, Deborah C and McCormick, Wayne C and McCurry, Susan M and McDavid, Andrew N and McKee, Ann C and Mesulam, Marsel and Parisi, Joseph E and Perl, Daniel P and Petersen, Ronald C and Poon, Wayne W and Rajbhandary, Ruchita A and Raskind, Murray and Ringman, John M and Roberson, Erik D and Rosenberg, Roger N and Sano, Mary and Schneider, Lon S and Smith, Charles D and Sonnen, Joshua A and Spina, Salvatore and Stern, Robert A and Tanzi, Rudolph E and Van Deerlin, Vivianna M and Vonsattel, Jean Paul and Weintraub, Sandra and Woltjer, Randall L and Cantwell, Laura B and Beekly, Duane and Lunetta, Kathryn L and Martin, Eden R and Kamboh, M Ilyas and Saykin, Andrew J and Reiman, Eric M and Morris, John C and Montine, Thomas J and Tsuang, Debby W and Hakonarson, Hakon and Kukull, Walter A and Haines, Jonathan L and Mayeux, Richard and Farrer, Lindsay A
Nature genetics, ISSN 1061-4036, 05/2011, Volume 43, Issue 5, pp. 436 - 443
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Neurology | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Genetic Predisposition to Disease | Genome-Wide Association Study | Multigene Family | Cytoskeletal Proteins - genetics | Membrane Proteins - genetics | Humans | Databases, Genetic | Male | Antigens, CD - genetics | Antigens, Differentiation, Myelomonocytic - genetics | Genetic Variation | Receptor, EphA1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Age of Onset | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Sialic Acid Binding Ig-like Lectin 3 | Alzheimer Disease - genetics | Cohort Studies | Conferences, meetings and seminars | Alzheimer's disease | Medical societies | Studies | Medical research | Genomes | Statistical methods | Alzheimers disease | Independent sample | Meta-analysis | Index Medicus
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