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The New England Journal of Medicine, ISSN 0028-4793, 05/2014, Volume 370, Issue 21, pp. 1983 - 1992
Journal Article
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 5/2019, Volume 76, Issue 9, pp. 1779 - 1794
Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is the major cause of viral persistence and chronic hepatitis B. CRISPR/Cas9 nucleases can... 
Life Sciences | Biomedicine, general | Biochemistry, general | Mutations | Life Sciences, general | Cure | Liver | Therapeutics | Antiviral | NHEJ | Cell Biology | METHYLATION | RNA | PERSISTENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRISPR-CAS9 | HBV GENOME | CELL BIOLOGY | CCCDNA | INHIBITION | CAS9 | HYPERMUTATION | Hepatitis B virus - growth & development | Hepatitis B - therapy | RNA, Guide - genetics | Hepatitis B - genetics | Virus Replication - genetics | Humans | DNA, Viral - metabolism | Streptococcus thermophilus - enzymology | DNA Methylation - genetics | Antiviral Agents - metabolism | CRISPR-Cas Systems - genetics | DNA, Circular - metabolism | Hep G2 Cells | CRISPR-Associated Protein 9 - metabolism | Streptococcus pyogenes - enzymology | Hepatitis B virus - genetics | Cell Line, Tumor | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Antiviral agents | Nucleases | Genomics | Genomes | DNA binding proteins | Circular DNA | Epidemiology | Homeopathy | Materia medica and therapeutics | Research institutes | Hepatitis B virus | Methylation | Hepatitis B | CRISPR | Depth indicators | Viruses | Homology | Gene sequencing | Degradation | Hepatitis | Genetic variance | Streptococcus | Transfection | Mutagenesis | Cell lines | Antiviral activity | Non-homologous end joining | DNA methylation | Deoxyribonucleic acid--DNA | DNA sequencing | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1847 - 11
Chronic hepatitis B is a severe liver disease caused by hepatitis B virus (HBV) infection. Covalently closed circular DNA (cccDNA), a super-spiralized,... 
SYSTEMATIC ANALYSIS | TARGET | HEPATITIS-B-VIRUS | STRAND BREAK REPAIR | RAD51 | MOLECULAR VIROLOGY | MULTIDISCIPLINARY SCIENCES | COMPONENTS | ATM | DELIVERY | Biodegradation | CRISPR | Hepatitis | Protein kinase C | Liver diseases | DNA-dependent protein kinase | DNA damage | Non-homologous end joining | Genomes | Circular DNA | Deoxyribonucleic acid--DNA | Hepatitis B
Journal Article
ANTIVIRAL THERAPY, ISSN 1359-6535, 2018, Volume 23, Issue 8, pp. 705 - 708
Despite very high efficacies of direct-acting antivirals (DAAs) reported in clinical trials, treatment failure in real-life practice can occur in 5-10% of... 
GENOTYPES | INFECTIOUS DISEASES | VIROLOGY | REGIMEN | PHARMACOLOGY & PHARMACY | DACLATASVIR | RETREATMENT | HEPATITIS-C
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54835
Journal Article
Journal Article
Antiviral Therapy, ISSN 1359-6535, 2016, Volume 21, Issue 8, pp. 671 - 678
Background: In this Phase IIIb study, we evaluated the efficacy and safety of the oral nucleotide analogue inhibitor sofosbuvir plus ribavirin, with special... 
DRUG | INFECTIOUS DISEASES | THERAPY | VIROLOGY | HEPATITIS-C VIRUS | VETERANS | PHARMACOLOGY & PHARMACY | ELIGIBILITY | EPIDEMIOLOGY
Journal Article
World Journal of Hepatology, ISSN 1948-5182, 2016, Volume 8, Issue 6, pp. 331 - 339
To evaluate addition of boceprevir to peginterferon/ribavirin (PR) in Russian patients with chronic hepatitis C virus (HCV). Treatment-naive (TN) and... 
Boceprevir | Randomized | Clinical trial | Hepatitis C virus | Sustained virologic response | Peginterferon | Ribavirin | Randomized Controlled Trial
Journal Article
Antiviral therapy, 2018, Volume 23, Issue 8, p. 705
Despite very high efficacies of direct-acting antivirals (DAAs) reported in clinical trials, treatment failure in real-life practice can occur in 5-10% of... 
Journal Article
by Blach, Sarah and Zeuzem, Stefan and Manns, Michael and Altraif, Ibrahim and Duberg, Ann-Sofi and Muljono, David H and Waked, Imam and Alavian, Seyed M and Lee, Mei-Hsuan and Negro, Francesco and Abaalkhail, Faisal and Abdou, Ahmed and Abdulla, Maheeba and Rached, Antoine Abou and Aho, Inka and Akarca, Ulus and Al Ghazzawi, Imad and Al Kaabi, Saad and Al Lawati, Faryal and Al Namaani, Khalid and Al Serkal, Youssif and Al-Busafi, Said A and Al-Dabal, Layla and Aleman, Soo and Alghamdi, Abdullah S and Aljumah, Abdulrahman A and Al-Romaihi, Hamad E and Andersson, Monique I and Arendt, Vic and Arkkila, Perttu and Assiri, Abdullah M and Baatarkhuu, Oidov and Bane, Abate and Ben-Ari, Ziv and Bergin, Colm and Bessone, Fernando and Bihl, Florian and Bizri, Abdul R and Blachier, Martin and Blasco, Antonio J and Mello, Carlos E Brandão and Bruggmann, Philip and Brunton, Cheryl R and Calinas, Filipe and Chan, Henry L Y and Chaudhry, Asad and Cheinquer, Hugo and Chen, Chien-Jen and Chien, Rong-Nan and Choi, Moon Seok and Christensen, Peer B and Chuang, Wan-Long and Chulanov, Vladimir and Cisneros, Laura and Clausen, Mette R and Cramp, Matthew E and Craxi, Antonio and Croes, Esther A and Dalgard, Olav and Daruich, Jorge R and de Ledinghen, Victor and Dore, Gregory J and El-Sayed, Manal H and Ergör, Gul and Esmat, Gamal and Estes, Chris and Falconer, Karolin and Farag, Elmoubashar and Ferraz, Maria L G and Ferreira, Paulo R and Flisiak, Robert and Frankova, Sona and Gamkrelidze, Ivane and Gane, Ed and García-Samaniego, Javier and Khan, Amir Ghafoor and Gountas, Ilias and Goldis, Adrian and Gottfredsson, Magnús and Grebely, Jason and Gschwantler, Michael and Pessôa, Mário Guimarães and Gunter, Jessie and Hajarizadeh, Behzad and Hajelssedig, Omer and Hamid, Saeed and Hamoudi, Waseem and Hatzakis, Angelos and Himatt, Sayed M and Hofer, Harald and Hrstic, Irena and Hui, Yee-Tak and Hunyady, Bela and Idilman, Ramazan and Jafri, Wasim and Jahis, Rohani and Janjua, Naveed Z and Jarčuška, Peter and Jeruma, Agita and Jonasson, Jón G and ... and Polaris Observ HCV Collaborators and Polaris Observatory HCV Collaborators
The Lancet Gastroenterology and Hepatology, ISSN 2468-1253, 03/2017, Volume 2, Issue 3, pp. 161 - 176
Journal Article