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Nature Chemical Biology, ISSN 1552-4450, 08/2015, Volume 11, Issue 8, pp. 611 - 617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally... 
CHIMERIC MOLECULES | CHEMICAL PROTEOMICS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | KINASE INHIBITORS | CARD15 MUTATIONS | BLAU-SYNDROME | ABSOLUTE QUANTIFICATION | LIGASE COMPLEX | CELL-DEATH | Neoplasm Transplantation | Small Molecule Libraries - pharmacology | Receptors, Estrogen - metabolism | Humans | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Ubiquitination | MCF-7 Cells | Proteolysis | Female | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Binding Sites | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Biocatalysis | Receptors, Estrogen - genetics | Models, Molecular | Receptors, Estrogen - antagonists & inhibitors | Ubiquitin - genetics | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Binding | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins | Molecular biology | Biocatalysts
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 444 - 452
Targeted protein degradation, using bifunctional small molecules (Protacs) to remove specific proteins from within cells, has emerged as a novel drug discovery... 
SMALL-MOLECULE PROTACS | TARGET | COMPLEX | CHEMISTRY, MEDICINAL | PROSTATE-CANCER | PROTEASOME SYSTEM | PROTEOLYSIS | THALIDOMIDE | INHIBITORS | KNOCKDOWN | E3 UBIQUITIN LIGASE
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Angewandte Chemie International Edition, ISSN 1433-7851, 01/2012, Volume 51, Issue 5, pp. 1114 - 1122
Journal Article
Nature Chemistry, ISSN 1755-4330, 07/2013, Volume 5, Issue 7, pp. 554 - 555
A simple method to investigate the functional group compatibility and scope of new reaction methodology could improve the speed with which it is adopted by... 
Organic chemistry | Functional groups
Journal Article
Nature Chemistry, ISSN 1755-4330, 07/2013, Volume 5, Issue 7, pp. 554 - 555
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ChemMedChem, ISSN 1860-7179, 05/2013, Volume 8, Issue 5, p. 859
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 496, Issue 7446, pp. 498 - 503
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Journal Article
by Sodergren, Erica and Weinstock, George M and Davidson, Eric H and Cameron, R. Andrew and Gibbs, Richard A and Angerer, Robert C and Angerer, Lynne M and Arnone, Maria Ina and Burgess, David R and Burke, Robert D and Coffman, James A and Dean, Michael and Elphick, Maurice R and Ettensohn, Charles A and Foltz, Kathy R and Hamdoun, Amro and Hynes, Richard O and Klein, William H and Marzluff, William and McClay, David R and Morris, Robert L and Mushegian, Arcady and Rast, Jonathan P and Smith, L. Courtney and Thorndyke, Michael C and Vacquier, Victor D and Wessel, Gary M and Wray, Greg and Zhang, Lan and Elsik, Christine G and Ermolaeva, Olga and Hlavina, Wratko and Hofmann, Gretchen and Kitts, Paul and Landrum, Melissa J and Mackey, Aaron J and Maglott, Donna and Panopoulou, Georgia and Poustka, Albert J and Pruitt, Kim and Sapojnikov, Victor and Song, Xingzhi and Souvorov, Alexandre and Solovyev, Victor and Wei, Zheng and Whittaker, Charles A and Worley, Kim and Durbin, K. James and Shen, Yufeng and Fedrigo, Olivier and Garfield, David and Haygood, Ralph and Primus, Alexander and Satija, Rahul and Severson, Tonya and Gonzalez-Garay, Manuel L and Jackson, Andrew R and Milosavljevic, Aleksandar and Tong, Mark and Killian, Christopher E and Livingston, Brian T and Wilt, Fred H and Adams, Nikki and Bellé, Robert and Carbonneau, Seth and Cheung, Rocky and Cormier, Patrick and Cosson, Bertrand and Croce, Jenifer and Fernandez-Guerra, Antonio and Genevière, Anne-Marie and Goel, Manisha and Kelkar, Hemant and Morales, Julia and Mulner-Lorillon, Odile and Robertson, Anthony J and Goldstone, Jared V and Cole, Bryan and Epel, David and Gold, Bert and Hahn, Mark E and Howard-Ashby, Meredith and Scally, Mark and Stegeman, John J and Allgood, Erin L and Cool, Jonah and Judkins, Kyle M and McCafferty, Shawn S and Musante, Ashlan M and Obar, Robert A and Rawson, Amanda P and Rossetti, Blair J and Gibbons, Ian R and Hoffman, Matthew P and Leone, Andrew and Istrail, Sorin and Materna, Stefan C and Samanta, Manoj P and Stolc, Viktor and Tongprasit, Waraporn and ... and Sea Urchin Genome Sequencing Consortium and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Medicinsk utvecklingsbiologi and Uppsala universitet and Institutionen för neurovetenskap
Science, ISSN 0036-8075, 11/2006, Volume 314, Issue 5801, pp. 941 - 952
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 522, Issue 7556, pp. 315 - 320
Journal Article