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animals (17) 17
mice (17) 17
index medicus (14) 14
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hematology (9) 9
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inflammation (7) 7
blood platelets - physiology (6) 6
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female (5) 5
humans (5) 5
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blood (4) 4
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in-vivo (4) 4
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adhesion (3) 3
article (3) 3
capillary permeability (3) 3
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immunology (3) 3
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platelet activation (3) 3
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extracellular traps - genetics (2) 2
extracellular traps - metabolism (2) 2
gene expression (2) 2
glycoprotein ib-alpha (2) 2
guanine nucleotide exchange factors - deficiency (2) 2
guanine nucleotide exchange factors - genetics (2) 2
guanine nucleotide exchange factors - physiology (2) 2
hemostasis, thrombosis, and vascular biology (2) 2
histones (2) 2
hydrolases - genetics (2) 2
hypoxia (2) 2
in vitro techniques (2) 2
inflammation - genetics (2) 2
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integrins - metabolism (2) 2
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oxidative stress (2) 2
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permeability (2) 2
phagocytes, granulocytes, and myelopoiesis (2) 2
platelet adhesiveness (2) 2
platelet glycoprotein gpib-ix complex - physiology (2) 2
platelets (2) 2
platelets and thrombopoiesis (2) 2
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von willebrand factor - metabolism (2) 2
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1. Full Text ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor InhibitorInduced Thrombotic Microangiopathy
by Erpenbeck, Luise and Demers, Melanie and Zsengellér, Zsuzsanna K and Gallant, Maureen and Cifuni, Stephen M and Stillman, Isaac E and Karumanchi, S. Ananth and Wagner, Denisa D
Journal of the American Society of Nephrology, ISSN 1046-6673, 01/2016, Volume 27, Issue 1, pp. 120 - 131
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2. Full Text P-selectin promotes neutrophil extracellular trap formation in mice
by Etulain, Julia and Martinod, Kimberly and Wong, Siu Ling and Cifuni, Stephen M and Schattner, Mirta and Wagner, Denisa D
Blood, ISSN 0006-4971, 07/2015, Volume 126, Issue 2, pp. 242 - 246
Neutrophil extracellular traps (NETs) can be released in the vasculature. In addition to trapping microbes, they promote inflammatory and thrombotic diseases.... 
CD11B/CD18 | ADHESION | THROMBOSIS | INFLAMMATION | ELEVATED LEVELS | LEUKOCYTE INTERACTION | ATHEROSCLEROSIS | MICROPARTICLES | HEMATOLOGY | ACTIVATED PLATELETS | BLOOD | Recombinant Fusion Proteins - pharmacology | Extracellular Traps - metabolism | Extracellular Traps - genetics | Mice, Inbred C57BL | Vasculitis - pathology | Male | Blood Platelets - physiology | P-Selectin - genetics | Mice, Knockout | P-Selectin - physiology | Platelet Activation - genetics | P-Selectin - pharmacology | Thrombosis - pathology | Vasculitis - genetics | Animals | Extracellular Traps - drug effects | Female | Thrombosis - genetics | Mice | Brief Report | Phagocytes, Granulocytes, and Myelopoiesis
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3. Full Text CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin αIIbβ3 in platelets
by Cifuni, Stephen M and Wagner, Denisa D and Bergmeier, Wolfgang
Blood, ISSN 0006-4971, 09/2008, Volume 112, Issue 5, pp. 1696 - 1703
Abstract Second messenger-mediated inside-out activation of integrin αIIbβ3 is a key step in platelet aggregation. We recently showed strongly impaired but not... 
Hemostasis, Thrombosis, and Vascular Biology
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4. Full Text Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
by Duerschmied, Daniel and Suidan, Georgette L and Demers, Melanie and Herr, Nadine and Carbo, Carla and Brill, Alexander and Cifuni, Stephen M and Mauler, Maximilian and Cicko, Sanja and Bader, Michael and Idzko, Marco and Bode, Christoph and Wagner, Denisa D
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 6, pp. 1008 - 1015
The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked... 
PULMONARY-HYPERTENSION | PERMEABILITY | 5-HYDROXYTRYPTAMINE | ENDOTHELIAL-CELLS | MAST-CELLS | P-SELECTIN | RECEPTOR | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | VON-WILLEBRAND-FACTOR | SELECTIN-DEFICIENT MICE | Blood Platelets - immunology | Endothelium, Vascular - drug effects | Male | Shock, Septic - immunology | Lipopolysaccharides | Serotonin - blood | Inflammation - metabolism | L-Selectin - immunology | Leukocytosis - metabolism | Weibel-Palade Bodies - metabolism | Chemotaxis - immunology | Neutrophils - metabolism | Serotonin - immunology | Serotonin Uptake Inhibitors - immunology | Endothelium, Vascular - immunology | Neutrophil Infiltration - immunology | Fluoxetine - pharmacology | Acute Disease | Neutrophils - drug effects | Leukocytosis - immunology | Chemotaxis - drug effects | Mice, Knockout | Blood Platelets - metabolism | Endothelium, Vascular - metabolism | Mice | Serotonin Uptake Inhibitors - pharmacology | Leukocyte Rolling - drug effects | Weibel-Palade Bodies - immunology | Histamine - immunology | L-Selectin - metabolism | Flow Cytometry | Tryptophan Hydroxylase - deficiency | Blood Platelets - drug effects | Fluoxetine - immunology | Shock, Septic - genetics | Leukocyte Rolling - genetics | Histamine - pharmacology | Shock, Septic - chemically induced | Mice, Inbred C57BL | Kaplan-Meier Estimate | Neutrophils - immunology | Inflammation - immunology | Leukocyte Rolling - immunology | Tryptophan Hydroxylase - genetics | Weibel-Palade Bodies - drug effects | Animals | Serotonin - metabolism | Inflammation - genetics | Leukocytosis - genetics | Phagocytes, Granulocytes, and Myelopoiesis | Platelets and Thrombopoiesis
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5. Full Text Peptidylarginine deiminase 4 promotes age-related organ fibrosis
by Martinod, Kimberly and Witsch, Thilo and Erpenbeck, Luise and Savchenko, Alexander and Hayashi, Hideki and Cherpokova, Deya and Gallant, Maureen and Mauler, Maximilian and Cifuni, Stephen M and Wagner, Denisa D
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 2, pp. 439 - 458
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]),... 
MEDICINE, RESEARCH & EXPERIMENTAL | NEUTROPHIL EXTRACELLULAR TRAPS | DNA TRAPS | PRESSURE-OVERLOAD | OXIDATIVE STRESS | HEART-FAILURE | DEEP-VEIN THROMBOSIS | CHROMATIN DECONDENSATION | CARDIAC FIBROSIS | IMMUNOLOGY | LEFT-VENTRICULAR HYPERTROPHY | PULMONARY-FIBROSIS | Hydrolases - genetics | Reactive Oxygen Species - metabolism | Age Factors | Ventricular Function, Left | Mice, Inbred C57BL | Myocardium - pathology | Extracellular Traps - physiology | Collagen - metabolism | Animals | Hydrolases - physiology | Fibrosis | Mice | Pulmonary Fibrosis - etiology | Heart | Deoxyribonuclease | Chromatin | Animal models | Organs | Leukocytes (neutrophilic) | Inflammation | Recruitment | Proteins | Lungs | Protein-arginine deiminase | Rodents | Collagen | Myocardium | Aging | Ventricle | Heart diseases | Age | 301 | 311
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6. Full Text Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice
by Thomas, Grace M and Carbo, Carla and Curtis, Brian R and Martinod, Kimberly and Mazo, Irina B and Schatzberg, Daphne and Cifuni, Stephen M and Fuchs, Tobias A and Von Andrian, Ulrich H and Hartwig, John H and Aster, Richard H and Wagner, Denisa D
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 26, pp. 6335 - 6343
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related death. The biologic processes contributing to TRALI are poorly... 
FC-GAMMA RECEPTORS | INFLAMMATION | IN-VITRO MODEL | ENDOTHELIAL-CELLS | ACUTE LUNG INJURY | DEATH | NEUTROPHIL ELASTASE | HEMATOLOGY | HISTONES | INNATE IMMUNITY | BLOOD | Neutrophil Activation - immunology | DNA - immunology | Humans | Cells, Cultured | Neutrophils - immunology | Extracellular Space - genetics | Male | DNA - metabolism | Transplantation, Homologous - immunology | Transfusion Reaction | Blood Donors | Animals | Acute Lung Injury - immunology | Transplantation Immunology | Mice | Mice, Inbred BALB C | Acute Lung Injury - etiology | Neutrophils - metabolism | Neutrophils - pathology | Transfusion Medicine
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7. Full Text The Role of Platelet Adhesion Receptor GPIbα Far Exceeds That of Its Main Ligand, von Willebrand Factor, in Arterial Thrombosis
by Wolfgang Bergmeier and Crystal L. Piffath and Tobias Goerge and Stephen M. Cifuni and Zaverio M. Ruggeri and Jerry Ware and Denisa D. Wagner
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2006, Volume 103, Issue 45, pp. 16900 - 16905
GPIbα binding to von Willebrand factor (VWF) exposed at a site of vascular injury is thought to be the first step in the formation of a hemostatic plug.... 
Receptors | Arterioles | Blood vessels | Antibodies | Ligands | Platelets | Thrombosis | Adhesion | Blood | Integrins | BETA-3-INTEGRIN-DEFICIENT MICE | MULTIDISCIPLINARY SCIENCES | FACTOR-VIII | MONOCLONAL-ANTIBODY | adhesion | HIGH-SHEAR | IX-V COMPLEX | INTEGRIN MAC-1 | platelets | GLYCOPROTEIN IB-ALPHA | BERNARD-SOULIER-SYNDROME | P-SELECTIN | INJURED ARTERIOLES | Biological Sciences
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8. Full Text Extracellular DNA Traps Are Associated with Pathogenesis of TRALI in Humans and Mice
by Thomas, Grace M and Carbo, Carla and Curtis, Brian and Martinod, Kimberly and Mazo, Irina B and Schatzberg, Daphne and Cifuni, Stephen M and Fuchs, Tobias A and von Andrian, Ulrich H and Hartwig, John H and Aster, Richard H and Wagner, Denisa D
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 21, pp. 37 - 37
Abstract Abstract 37 Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion occurring within 6 hours of transfusion. It... 
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9. Full Text Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice
by Hayashi, Hideki and Cherpokova, Deya and Martinod, Kimberly and Witsch, Thilo and Wong, Siu Ling and Gallant, Maureen and Cifuni, Stephen M and Guarente, Leonard P and Wagner, Denisa D
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0188341
Inflammation is a common denominator in chronic diseases of aging. Yet, how inflammation fuels these diseases remains unknown. Neutrophils are the primary... 
MITOCHONDRIAL OXIDATIVE STRESS | NADPH-OXIDASE | ACTIVATION | GENE | MANGANESE SUPEROXIDE-DISMUTASE | MULTIDISCIPLINARY SCIENCES | DEEP-VEIN THROMBOSIS | HOMOLOG | RELEASE | PEPTIDYLARGININE DEIMINASE 4 | EXTRACELLULAR TRAPS | Sirtuin 3 - genetics | Animals | Reactive Oxygen Species - metabolism | Blood Platelets - metabolism | Mice, Inbred C57BL | Male | Mice, Transgenic | Mice | Venous Thrombosis - genetics | Neutrophils - metabolism | Sirtuin 3 - physiology | Reactive oxygen species | Chromatin | Neutrophils | Chronic diseases | Aging | Thrombophlebitis | Research | Pediatrics | Disease | Stenosis | Cytotoxicity | Thrombin | Leukocytes | Antithrombin | Antiinfectives and antibacterials | Immunity | Proteins | Elevation | Mitochondria | Cell activation | Microorganisms | Thromboembolism | Deoxyribonucleic acid--DNA | Enzymes | Leukocytes (neutrophilic) | Platelet aggregation | Gene expression | Thrombosis | Trauma | Blood clots | Studies | Nets | Hospitals | Nicotinamide adenine dinucleotide | Nicotinamide | Acetic acid | NADPH | Oxidative stress | Innate immunity | Kinases | Medical schools | Blood platelets | Genotypes | Age | Chronic illnesses | Adenine | Inflammation | Medicine | White blood cells | NAD | Collagen | Platelets | Phorbol 12-myristate 13-acetate | Deoxyribonucleic acid | DNA
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10. Full Text The Role of VWF In BBB Permeability Associated with Hypoxia/Reoxygenation
by Suidan, Georgette L and De Meyer, Simon F and Brill, Alexander and Cifuni, Stephen M and Wagner, Denisa D
Blood, ISSN 0006-4971, 11/2010, Volume 116, Issue 21, pp. 2102 - 2102
Abstract Abstract 2102 Aberrant blood brain barrier (BBB) permeability is a hallmark pathology in many diseases of the central nervous system (CNS) including... 
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11. Full Text Inflammation induces hemorrhage in thrombocytopenia
by Goerge, Tobias and Ho-Tin-Noe, Benoit and Carbo, Carla and Benarafa, Charaf and Remold-O'Donnell, Eileen and Zhao, Bing-Qiao and Cifuni, Stephen M and Wagner, Denisa D
Blood, ISSN 0006-4971, 05/2008, Volume 111, Issue 10, pp. 4958 - 4964
The role of platelets in hemostasis is to produce a plug to arrest bleeding. During thrombocytopenia, spontaneous bleeding is seen in some patients but not in... 
GLYCOPROTEIN-VI | ARTHUS REACTION | IN-VIVO | P-SELECTIN | RECEPTOR | ALPHA | MICE | PLATELET-ADHESION | HEMATOLOGY | VON-WILLEBRAND-FACTOR | SPHINGOSINE 1-PHOSPHATE | Inflammation - complications | Platelet Adhesiveness | Animals | Capillary Permeability | Hemorrhage - etiology | Mice | Blood Platelets - physiology | Thrombocytopenia - pathology | Thrombocytopenia - complications | Hemostasis, Thrombosis, and Vascular Biology
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12. Full Text Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice
by Jansen, A. J. Gerard and Josefsson, Emma C and Rumjantseva, Viktoria and Liu, Qiyong Peter and Falet, Hervé and Bergmeier, Wolfgang and Cifuni, Stephen M and Sackstein, Robert and Von Andrian, Ulrich H and Wagner, Denisa D and Hartwig, John H and Hoffmeister, Karin M
Blood, ISSN 0006-4971, 02/2012, Volume 119, Issue 5, pp. 1263 - 1273
When refrigerated platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sialic... 
PHAGOCYTOSIS | CHILLED BLOOD-PLATELETS | IN-VIVO | GLYCOPROTEIN-IB-ALPHA | SIALIC-ACID | IX-V | HEMATOLOGY | GPVI DOWN-REGULATION | MULTIENZYME COMPLEX | HEMOSTATIC FUNCTION | FAMILY | ADAM17 Protein | ADAM Proteins - physiology | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - chemistry | Male | Blood Platelets - physiology | Metalloproteases - metabolism | Membrane Glycoproteins - physiology | Proteolysis | Refrigeration - methods | Neuraminidase - physiology | von Willebrand Factor - metabolism | Mice, Inbred C57BL | Neuraminidase - metabolism | Blood Preservation - methods | Glycosylation | Protein Processing, Post-Translational - physiology | ADAM Proteins - metabolism | Animals | Metalloproteases - physiology | Blood Platelets - metabolism | Mice | Enzyme Activation | Platelet Glycoprotein GPIb-IX Complex | Transfusion Medicine | Platelets and Thrombopoiesis
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13. Full Text Platelet granule secretion continuously prevents intratumor hemorrhage
by Ho-Tin-Noé, Benoit and Goerge, Tobias and Cifuni, Stephen M and Duerschmied, Daniel and Wagner, Denisa D
Cancer Research, ISSN 0008-5472, 08/2008, Volume 68, Issue 16, pp. 6851 - 6858
Cancer is associated with a prothrombogenic state capable of platelet activation. Platelets, on the other hand, can support angiogenesis, a process involved in... 
HUMAN MEGAKARYOCYTES | GLYCOPROTEIN IB-ALPHA | ONCOLOGY | IN-VIVO | P-SELECTIN | LEUKEMIA-CELLS | ANGIOPOIETIN-1 | TUMOR ANGIOGENESIS | ENDOTHELIAL GROWTH-FACTOR | SPHINGOSINE 1-PHOSPHATE | PLASMA LEAKAGE | Platelet Adhesiveness | Guanine Nucleotide Exchange Factors - physiology | Cell Proliferation | Metalloendopeptidases - metabolism | Hemorrhage - prevention & control | Vascular Endothelial Growth Factor A - metabolism | Angiopoietin-1 - metabolism | Immunoenzyme Techniques | Necrosis | Melanoma, Experimental - prevention & control | Lung Neoplasms - secondary | von Willebrand Factor - physiology | Female | Platelet Glycoprotein GPIb-IX Complex - physiology | Thrombocytopenia - etiology | Mice, Inbred C57BL | Hemoglobins - metabolism | Melanoma, Experimental - pathology | Thrombocytopenia - pathology | Blood Platelets - secretion | Carcinoma, Lewis Lung - prevention & control | Mice, Knockout | P-Selectin - physiology | Animals | Platelet Activation | Serotonin - metabolism | Carcinoma, Lewis Lung - pathology | Thrombocytopenia - prevention & control | Mice | platelet | platelet granules | primary tumor | thrombocytopenia | intratumor hemorrhage
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14. Full Text Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III
by Bergmeier, Wolfgang and Goerge, Tobias and Wang, Hong-Wei and Crittenden, Jill R and Baldwin, Andrew C.W and Cifuni, Stephen M and Housman, David E and Graybiel, Ann M and Wagner, Denisa D
Journal of Clinical Investigation, ISSN 0021-9738, 06/2007, Volume 117, Issue 6, pp. 1699 - 1707
Single gene mutations in beta integrins can account for functional defects of individual cells of the hematopoietic system. In humans, mutations in beta(2)... 
rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Leukocyte-Adhesion Deficiency Syndrome - genetics | Humans | Male | Mice, Knockout | CD18 Antigens - metabolism | Integrin beta1 - metabolism | Leukocyte-Adhesion Deficiency Syndrome - etiology | Integrin beta3 - metabolism | Animals | Blood Platelets - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Leukocyte-Adhesion Deficiency Syndrome - metabolism | Platelet Activation | Thrombosis - etiology | Mice | Mice, Inbred BALB C | Thrombosis - prevention & control | In Vitro Techniques | Neutrophils - metabolism | Guanine Nucleotide Exchange Factors - deficiency | Disease Models, Animal | Genetically modified mice | Usage | Models | Research | Leukocyte disorders
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15. Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis
by Carbo, Carla and Duerschmied, Daniel and Goerge, Tobias and Hattori, Hidenori and Sakai, Jiro and Cifuni, Stephen M and White, Gilbert C and Chrzanowska-Wodnicka, Magdalena and Luo, Hongbo R and Wagner, Denisa D
Journal of Leukocyte Biology, ISSN 0741-5400, 08/2010, Volume 88, Issue 2, pp. 313 - 319
Chemotaxis and integrin activation are essential processes for neutrophil transmigration in response to injury. CalDAG-GEFI plays a key role in the activation... 
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16. Full Text p38 mitogen-activated protein kinase activation during platelet storage: Consequences for platelet recovery and hemostatic function in vivo
by Canault, Matthias and Duerschmied, Daniel and Brill, Alexander and Stefanini, Lucia and Schatzberg, Daphne and Cifuni, Stephen M and Bergmeier, Wolfgang and Wagner, Denisa D
Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 9, pp. 1835 - 1842
Platelets undergo several modifications during storage that reduce their post-transfusion survival and functionality. One important feature of these changes,... 
VITRO | CYTOSOLIC PHOSPHOLIPASE A | ADAM17 | INHIBITION | PHOSPHORYLATION | MAP KINASE | MOUSE MODEL | ALPHA-CONVERTING-ENZYME | ARACHIDONIC-ACID | GLYCOPROTEIN-IB | HEMATOLOGY | ADAM17 Protein | ADAM Proteins - antagonists & inhibitors | Hemostasis - physiology | Platelet Transfusion | Blood Preservation | Humans | Mice, Inbred C57BL | ADAM Proteins - deficiency | Mice, Transgenic | Blood Platelets - enzymology | Blood Platelets - physiology | ADAM Proteins - blood | MAP Kinase Signaling System | Animals | Platelet Glycoprotein GPIb-IX Complex - metabolism | Mice, Mutant Strains | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - blood | Mice | Enzyme Activation | ADAM Proteins - genetics | In Vitro Techniques | Transfusion Medicine
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