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Free Radical Biology and Medicine, ISSN 0891-5849, 12/2015, Volume 89, pp. 287 - 299
In non-small-cell lung cancer (NSCLC) patients, the activation of alternative pathways contributes to the limited efficacy of the epidermal growth factor... 
EGFR tyrosine kinase inhibitors | Oxidative stress | NRF2 | ROS | KEAP1 | VDAC1 | NSCLC cancer | HDACi | HISTONE DEACETYLASE INHIBITOR | FACTOR RECEPTOR INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MESENCHYMAL TRANSITION | LUNG-CANCER | PHASE-II TRIAL | THERAPEUTIC TARGET | ENDOCRINOLOGY & METABOLISM | RESISTANCE | PROTEOMIC ANALYSIS | EXPRESSION | Lung Neoplasms - drug therapy | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Hydroxamic Acids - pharmacology | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Voltage-Dependent Anion Channel 1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Proto-Oncogene Proteins c-myc - metabolism | Blotting, Western | Drug Synergism | Cell Movement - drug effects | NF-E2-Related Factor 2 - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Quinazolines - pharmacology | Voltage-Dependent Anion Channel 1 - genetics | Mitochondrial DNA | Lung cancer, Non-small cell | Health aspects | Porins | Tyrosine | Epidermal growth factor | Drug therapy, Combination
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 10395 - 14
Arsenic and arsenic-derivative compounds, named as arsenicals, represent a worldwide problem for their effect on the human health and, in particular, for their... 
STEM-CELLS | NETWORK | MICRORNA-155 PROMOTES | MULTIDISCIPLINARY SCIENCES | POTENTIAL INVOLVEMENT | IN-VIVO | GENETIC-VARIANTS | DRINKING-WATER | EXPRESSION | RENAL-CELL CARCINOMA | DISEASE PROGRESSION | Drinking water | Molecular modelling | Kidneys | Arsenic | Therapeutic applications | Bladder | Retinoid X receptor α | RelA protein | Prostate cancer | Prostate | Nodes | Chronic exposure
Journal Article
by Pagès, Franck and Mlecnik, Bernhard and Marliot, Florence and Bindea, Gabriela and Ou, Fang-Shu and Bifulco, Carlo and Lugli, Alessandro and Zlobec, Inti and Rau, Tilman T and Berger, Martin D and Berger, Anne and Nagtegaal, Iris D and Vink-Börger, Elisa and Hartmann, Arndt and Geppert, Carol and Kolwelter, Julie and Merkel, Susanne and Grützmann, Robert and Van den Eynde, Marc and Jouret-Mourin, Anne and Kartheuser, Alex and Léonard, Daniel and Remue, Christophe and Wang, Julia Y and Wang, Yili and Bavi, Prashant and Roehrl, Michael H A and Ohashi, Pamela S and Nguyen, Linh T and Han, SeongJun and MacGregor, Heather L and Hafezi-Bakhtiari, Sara and Wouters, Bradly G and Masucci, Giuseppe V and Andersson, Emilia K and Zavadova, Eva and Vocka, Michal and Spacek, Jan and Petruzelka, Lubos and Konopasek, Bohuslav and Dundr, Pavel and Skalova, Helena and Nemejcova, Kristyna and Botti, Gerardo and Tatangelo, Fabiana and Delrio, Paolo and Ciliberto, Gennaro and Maio, Michele and Laghi, Luigi and Grizzi, Fabio and Fredriksen, Tessa and Buttard, Bénédicte and Angelova, Mihaela and Vasaturo, Angela and Maby, Pauline and Church, Sarah E and Angell, Helen K and Lafontaine, Lucie and Bruni, Daniela and El Sissy, Carine and Haicheur, Nacilla and Kirilovsky, Amos and Lagorce, Christine and Meyers, Jeffrey P and Paustian, Christopher and Feng, Zipei and Ballesteros-Merino, Carmen and Dijkstra, Jeroen and van de Water, Carlijn and van Lent-van Vliet, Shannon and Knijn, Nikki and Mușină, Ana-Maria and Scripcariu, Dragos-Viorel and Popivanova, Boryana and Xu, Mingli and Fujita, Tomonobu and Hazama, Shoichi and Suzuki, Nobuaki and Nagano, Hiroaki and Okuno, Kiyotaka and Torigoe, Toshihiko and Sato, Noriyuki and Furuhata, Tomohisa and Takemasa, Ichiro and Itoh, Kyogo and Patel, Jayendrakumar B and Patel, Prabhu S and Vora, Hemangini H and Shah, Birva and Rajvik, Kruti N and Pandya, Shashank J and Shukla, Shilin N and Zhang, Guanjun and Kawakami, Yutaka and Marincola, Francesco M and Ascierto, Paolo A and Sargent, Daniel J and Fox, Bernard A and Galon, Jérôme
The Lancet, ISSN 0140-6736, 05/2018, Volume 391, Issue 10135, pp. 2128 - 2139
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 04/2018, Volume 37, Issue 1, pp. 86 - 10
In the advent of Immune Checkpoint inhibitors (ICI) and of CAR-T adoptive T-cells, the new frontier in Oncology is Cancer Immunotherapy because of its ability... 
CELL LUNG-CANCER | METASTATIC MELANOMA | CTLA-4 BLOCKADE | ONCOLOGY | IMMUNE CHECKPOINT BLOCKADE | IMMUNOTHERAPY | PD-1 BLOCKADE | ANTITUMOR IMMUNITY | TUMOR NEOANTIGENS | SOMATIC MUTATIONS | T-CELLS | Cancer vaccines | Physiological aspects | Genetic aspects | Research | Immunotherapy | Tumor antigens
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 7/2014, Volume 63, Issue 7, pp. 675 - 683
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2012, Volume 3, Issue 8, pp. 744 - 758
Journal Article
Cell Death & Disease, ISSN 2041-4889, 11/2019, Volume 10, Issue 11, pp. 1 - 12
Originally described as interpatient variability, tumour heterogeneity has now been demonstrated to occur intrapatiently, within the same lesion, or in... 
Subpopulations | Melanoma | Evolution | Metastasis | Drug resistance | Tumors | Immune system | Metastases | Index Medicus
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 34, pp. E5005 - E5013
Therapy of melanoma patients harboring activating mutations in the BRAF (V-raf murine sarcoma viral oncogene homolog B1) oncogene with a combination of BRAF... 
miRNA | Drug resistance | Targeted therapy | Melanoma | SURVIVAL | targeted therapy | MULTIDISCIPLINARY SCIENCES | INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | melanoma | VEMURAFENIB RESISTANCE | MALIGNANT-MELANOMA | CANCER | METASTATIC MELANOMA | CUTANEOUS MELANOMA | drug resistance | BRAF-MUTANT MELANOMA | MICRORNA | Proto-Oncogene Proteins c-mdm2 - genetics | Cell Proliferation | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Melanoma - genetics | Skin Neoplasms - mortality | Base Sequence | 3' Untranslated Regions | Binding Sites | Proto-Oncogene Proteins c-mdm2 - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Skin Neoplasms - pathology | Pyrimidinones - therapeutic use | Melanoma - pathology | Disease Progression | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Survival Analysis | Cell Line, Tumor | Indoles - therapeutic use | MicroRNAs - genetics | Pyridones - therapeutic use | Cell Movement | Melanoma - mortality | Care and treatment | MicroRNA | Development and progression | Genetic aspects | Health aspects | Cancer | Biological Sciences | PNAS Plus
Journal Article